Obp3 (alpha-2u globulin PGCL4) - Rat Genome Database

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Gene: Obp3 (alpha-2u globulin PGCL4) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Obp3
Name: alpha-2u globulin PGCL4
RGD ID: 708508
Description: Enables odorant binding activity. Predicted to be located in extracellular region. Predicted to be active in extracellular space; INTERACTS WITH 1,4-dichlorobenzene; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: alpha2 urinary globulin; LOC100911890; LOC259247; major urinary protein-like; MGC108576; odorant-binding protein 3
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8579,637,234 - 79,640,810 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl579,637,234 - 79,640,675 (-)EnsemblGRCr8
mRatBN7.2574,842,316 - 74,845,858 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl574,842,316 - 74,845,757 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx576,742,298 - 76,745,735 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0578,563,933 - 78,567,370 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0578,536,108 - 78,539,545 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0577,313,357 - 77,316,875 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0581,534,432 - 81,537,931 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4578,088,876 - 78,092,317 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera573,651,817 - 73,655,258 (-)NCBICelera
RGSC_v3.1578,093,991 - 78,097,430 (-)NCBI
Cytogenetic Map5q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Length heterogeneity in rat salivary gland alpha 2 mu globulin mRNAs: multiple splice-acceptors and polyadenylation sites. Gao F, etal., Nucleic Acids Res 1989 Jun 26;17(12):4629-36.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Tissue-specific control of alpha 2u globulin gene expression: constitutive synthesis in the submaxillary gland. Laperche Y, etal., Cell 1983 Feb;32(2):453-60.
4. Identification of a third rat odorant-binding protein (OBP3). Lobel D, etal., Chem Senses 2001 Jul;26(6):673-80.
5. Odorants of different chemical classes interact with distinct odorant binding protein subtypes. Lobel D, etal., Chem Senses 2002 Jan;27(1):39-44.
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Molecular evidence of complex tissue- and sex-specific mRNA expression of the rat alpha(2u)-globulin multigene family. Saito K, etal., Biochem Biophys Res Commun 2000 Jun 7;272(2):337-44.
Additional References at PubMed
PMID:2439333   PMID:2558970   PMID:12477932   PMID:21536621   PMID:23131471   PMID:24665925   PMID:25109974   PMID:25853804  


Genomics

Variants

.
Variants in Obp3
11 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:46
Count of miRNA genes:44
Interacting mature miRNAs:45
Transcripts:ENSRNOT00000071395
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53801167083011670Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)55266537294894052Rat
1357396Bw44Body weight QTL 444.19body mass (VT:0001259)body weight (CMO:0000012)573779642118779642Rat
6907115Mcs29Mammary carcinoma susceptibility QTL 29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)53800433183004331Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
61380Edpm5Estrogen-dependent pituitary mass QTL 54.50.92pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)573779642103472210Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)538207390136631402Rat
61386Bp49Blood pressure QTL 4916.6cerebrum integrity trait (VT:0010549)brain infarction volume (CMO:0001013)565089051103648916Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)548523123134369373Rat
2302381Bw84Body weight QTL 844.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)573779642118779642Rat
1357402Bw46Body weight QTL 464.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)573779642118779642Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53801167083011670Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53801167083011670Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
1331782Rf36Renal function QTL 363.296kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)539019942102105896Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)53998594884985948Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)5692228281330203Rat
7394708Emca11Estrogen-induced mammary cancer QTL 11mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)573176602118176602Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)53952692484526924Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54852312391770353Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)569474415114474415Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)560601597137492949Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906491770353Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)560511627105511627Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)536460764136631402Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)564589016109589016Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
2290005Mcs24Mammary carcinoma susceptibility QTL 24mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)569835120114835120Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906487027358Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)570969494136328156Rat
2316954Rf57Renal function QTL 570kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)56458901693503770Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)556546393101546393Rat
2312671Scl64Serum cholesterol level QTL 640.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)573779642118779642Rat
2316957Pur21Proteinuria QTL 216.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)56458901691762830Rat

Markers in Region
RH130736  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2575,142,184 - 75,142,391 (+)MAPPERmRatBN7.2
mRatBN7.2575,394,151 - 75,394,358 (+)MAPPERmRatBN7.2
mRatBN7.2574,842,350 - 74,842,557 (+)MAPPERmRatBN7.2
Rnor_6.0577,549,951 - 77,550,157NCBIRnor6.0
Rnor_6.0577,744,252 - 77,744,458NCBIRnor6.0
Rnor_5.0581,870,493 - 81,870,699UniSTSRnor5.0
Rnor_5.0581,680,425 - 81,680,631UniSTSRnor5.0
RH 3.4 Map5556.7UniSTS
Cytogenetic Map5q24UniSTS


Expression

RNA-SEQ Expression

circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
8 10 4 27 21 10 1 6 17

Sequence


Ensembl Acc Id: ENSRNOT00000043056   ⟹   ENSRNOP00000048604
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl579,637,234 - 79,640,675 (-)Ensembl
mRatBN7.2 Ensembl574,842,316 - 74,845,757 (-)Ensembl
RefSeq Acc Id: NM_001033958   ⟹   NP_001029130
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8579,637,234 - 79,640,675 (-)NCBI
mRatBN7.2574,842,316 - 74,845,757 (-)NCBI
RGSC_v3.4578,088,876 - 78,092,317 (-)RGD
Celera573,651,817 - 73,655,258 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001033959   ⟹   NP_001029131
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8579,637,234 - 79,640,675 (-)NCBI
mRatBN7.2574,842,316 - 74,845,757 (-)NCBI
RGSC_v3.4578,088,876 - 78,092,317 (-)RGD
Celera573,651,817 - 73,655,258 (-)NCBI
Sequence:
RefSeq Acc Id: NM_147215   ⟹   NP_671748
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8579,637,234 - 79,640,675 (-)NCBI
mRatBN7.2574,842,316 - 74,845,757 (-)NCBI
RGSC_v3.4578,088,876 - 78,092,317 (-)RGD
Celera573,651,817 - 73,655,258 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039109326   ⟹   XP_038965254
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8579,637,234 - 79,640,810 (-)NCBI
mRatBN7.2574,842,316 - 74,845,858 (-)NCBI
RefSeq Acc Id: XM_063287204   ⟹   XP_063143274
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8579,637,234 - 79,640,788 (-)NCBI
RefSeq Acc Id: NP_671748   ⟸   NM_147215
- Peptide Label: precursor
- UniProtKB: Q78E14 (UniProtKB/TrEMBL),   F8WFF8 (UniProtKB/TrEMBL),   A0A9K3Y8C3 (UniProtKB/TrEMBL),   Q63022 (UniProtKB/TrEMBL),   Q63213 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001029130   ⟸   NM_001033958
- Peptide Label: precursor
- UniProtKB: Q78E14 (UniProtKB/TrEMBL),   F8WFF8 (UniProtKB/TrEMBL),   A0A9K3Y8C3 (UniProtKB/TrEMBL),   Q63022 (UniProtKB/TrEMBL),   Q63213 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001029131   ⟸   NM_001033959
- Peptide Label: precursor
- UniProtKB: Q78E14 (UniProtKB/TrEMBL),   F8WFF8 (UniProtKB/TrEMBL),   A0A9K3Y8C3 (UniProtKB/TrEMBL),   Q63022 (UniProtKB/TrEMBL),   Q63213 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038965254   ⟸   XM_039109326
- Peptide Label: isoform X2
- UniProtKB: F8WFF8 (UniProtKB/TrEMBL),   Q78E14 (UniProtKB/TrEMBL),   A0A9K3Y8C3 (UniProtKB/TrEMBL),   Q63022 (UniProtKB/TrEMBL),   Q63213 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000048604   ⟸   ENSRNOT00000043056
RefSeq Acc Id: XP_063143274   ⟸   XM_063287204
- Peptide Label: isoform X1
- UniProtKB: Q63022 (UniProtKB/TrEMBL),   Q63213 (UniProtKB/TrEMBL)
Protein Domains
Lipocalin/cytosolic fatty-acid binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F8WFF8-F1-model_v2 AlphaFold F8WFF8 1-181 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708508 AgrOrtholog
BioCyc Gene G2FUF-41131 BioCyc
Ensembl Genes ENSRNOG00000065108 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000043056 ENTREZGENE
  ENSRNOT00000043056.8 UniProtKB/TrEMBL
Gene3D-CATH 2.40.128.20 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7369206 IMAGE-MGC_LOAD
InterPro Calycin UniProtKB/TrEMBL
  Lipocalin UniProtKB/TrEMBL
  Lipocalin_CS UniProtKB/TrEMBL
  Lipocln_cytosolic_FA-bd_dom UniProtKB/TrEMBL
  Maj_urinary UniProtKB/TrEMBL
KEGG Report rno:259247 UniProtKB/TrEMBL
MGC_CLONE MGC:108576 IMAGE-MGC_LOAD
NCBI Gene 259247 ENTREZGENE
PANTHER MAJOR URINARY PROTEIN 1-RELATED UniProtKB/TrEMBL
  PTHR11430 UniProtKB/TrEMBL
Pfam Lipocalin UniProtKB/TrEMBL
PhenoGen Obp3 PhenoGen
PRINTS LIPOCALIN UniProtKB/TrEMBL
  MAJORURINARY UniProtKB/TrEMBL
PROSITE LIPOCALIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000065108 RatGTEx
Superfamily-SCOP Calycin UniProtKB/TrEMBL
UniProt A0A9K3Y8C3 ENTREZGENE, UniProtKB/TrEMBL
  F8WFF8 ENTREZGENE
  Q63022 ENTREZGENE
  Q63213 ENTREZGENE, UniProtKB/TrEMBL
  Q78E14 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F8WFF8 UniProtKB/TrEMBL
  Q63022 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-29 Obp3  alpha-2u globulin PGCL4  LOC100911890  major urinary protein-like  Data merged from RGD:6490237 737654 PROVISIONAL
2012-07-05 LOC100911890  major urinary protein-like      Symbol and Name status set to provisional 70820 PROVISIONAL