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Gene: Tpcn1 (two pore segment channel 1) Rattus norvegicus

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Symbol:

Tpcn1

Name:

two pore segment channel 1

RGD ID:

708494

Description:

Predicted to enable several functions, including monoatomic cation channel activity; phosphatidylinositol-3,5-bisphosphate binding activity; and protein homodimerization activity. Predicted to be involved in endocytosis involved in viral entry into host cell; positive regulation of autophagy; and sodium ion transmembrane transport. Predicted to be located in early endosome membrane; endolysosome; and recycling endosome membrane. Predicted to be part of monoatomic ion channel complex. Predicted to be active in endosome membrane and lysosomal membrane. Orthologous to human TPCN1 (two pore segment channel 1); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; INTERACTS WITH (+)-schisandrin B; 6-propyl-2-thiouracil; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC246215; two pore calcium channel protein 1; two pore channel 1; voltage-dependent calcium channel protein TPC1; voltage-gated Ca channel

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TPCN1 (two pore segment channel 1)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, Panther
Mus musculus (house mouse):	Tpcn1 (two pore channel 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Tpcn1 (two pore segment channel 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TPCN1 (two pore segment channel 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TPCN1 (two pore segment channel 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Tpcn1 (two pore segment channel 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TPCN1 (two pore segment channel 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TPCN1 (two pore segment channel 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Tpcn1 (two pore segment channel 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Tpcn1 (two pore segment channel 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Tpcn1 (two pore channel 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	TPCN1 (two pore segment channel 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	tpcn1 (two pore segment channel 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	tpcn1 (two pore segment channel 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	tpcn1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	tpcn1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	41,633,399 - 41,690,200 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	41,633,398 - 41,690,200 (+)	Ensembl				GRCr8
mRatBN7.2	12	35,972,813 - 36,029,632 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	35,972,846 - 36,029,626 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	37,152,476 - 37,208,823 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	37,763,694 - 37,820,042 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	36,816,157 - 36,872,506 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	41,507,784 - 41,566,847 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	41,543,696 - 41,566,847 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	43,365,885 - 43,421,373 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	12	37,140,428 - 37,227,711 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	12	37,634,250 - 37,689,810 (+)	NCBI		Celera
RGSC_v3.1	12	37,003,822 - 37,091,098 (+)	NCBI
Cytogenetic Map	12	q16	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

oligospermia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2-hydroxypropanoic acid (ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

Azoxymethane (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

butanal (ISO)

C60 fullerene (EXP)

cadmium dichloride (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chloroacetaldehyde (ISO)

chlorpyrifos (ISO)

cidofovir anhydrous (ISO)

cisplatin (ISO)

clodronic acid (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

dexamethasone (ISO)

dextran sulfate (ISO)

dioxygen (ISO)

entinostat (ISO)

epoxiconazole (ISO)

ethanol (ISO)

ethyl methanesulfonate (ISO)

fenthion (ISO)

flutamide (EXP)

folic acid (ISO)

formaldehyde (ISO)

FR900359 (ISO)

genistein (ISO)

GSK-J4 (ISO)

indometacin (ISO)

ketoconazole (ISO)

kojic acid (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (EXP,ISO)

metformin (EXP)

methapyrilene (ISO)

methidathion (ISO)

methotrexate (ISO)

methoxychlor (EXP)

methyl methanesulfonate (ISO)

mocetinostat (ISO)

N,N-diethyl-m-toluamide (EXP)

nefazodone (EXP)

nickel atom (ISO)

okadaic acid (ISO)

ozone (ISO)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

permethrin (EXP)

pirinixic acid (ISO)

potassium chromate (ISO)

rac-lactic acid (ISO)

rotenone (ISO)

silicon dioxide (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

tetrachloromethane (EXP)

thimerosal (ISO)

thiram (ISO)

titanium dioxide (ISO)

troglitazone (ISO)

tungsten (ISO)

urethane (ISO)

vorinostat (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

calcium ion transmembrane transport (IEA)

calcium ion transport (IEA)

calcium-mediated signaling (IEA)

endocytosis involved in viral entry into host cell (IEA,ISO)

monoatomic ion transmembrane transport (IEA)

monoatomic ion transport (IEA)

positive regulation of autophagy (IEA,ISO)

sodium ion transmembrane transport (IEA,ISO)

transmembrane transport (IEA)

Cellular Component

early endosome membrane (IEA,ISO,ISS)

endolysosome (IEA,ISO,ISS)

endosome membrane (IBA,IEA,ISO,ISS)

lysosomal membrane (IBA,IEA,ISO,ISS)

membrane (IEA,ISO)

monoatomic ion channel complex (IEA)

recycling endosome membrane (IEA,ISO,ISS)

Molecular Function

calcium channel activity (IEA)

identical protein binding (IEA,ISO)

intracellularly phosphatidylinositol-3,5-bisphosphate-gated monatomic cation channel activity (IEA,ISO,ISS)

ligand-gated sodium channel activity (IEA,ISO,ISS)

monoatomic ion channel activity (IEA)

NAADP-sensitive calcium-release channel activity (IEA,ISO,ISS)

phosphatidylinositol-3,5-bisphosphate binding (IEA,ISO)

protein binding (ISO)

protein homodimerization activity (IEA,ISO)

syntaxin binding (IEA,ISO)

voltage-gated channel activity (IEA)

voltage-gated sodium channel activity (IEA,ISO,ISS)

Molecular Pathway Annotations Click to see Annotation Detail View

calcium transport pathway (ISO)

calcium/calcium-mediated signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Molecular cloning of a novel form (two-repeat) protein related to voltage-gated sodium and calcium channels.	Ishibashi K, etal., Biochem Biophys Res Commun 2000 Apr 13;270(2):370-6.
3.	GOA pipeline	RGD automated data pipeline
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
6.	Comprehensive gene review and curation	RGD comprehensive gene curation
7.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
8.	Calcium signaling via two-pore channels: local or global, that is the question.	Zhu MX, etal., Am J Physiol Cell Physiol. 2010 Mar;298(3):C430-41. doi: 10.1152/ajpcell.00475.2009. Epub 2009 Dec 16.

Additional References at PubMed

PMID:15489334	PMID:16627563	PMID:19620632	PMID:21903581	PMID:22012985	PMID:29562233	PMID:31557916	PMID:34263977

Genomics

Comparative Map Data

Tpcn1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	41,633,399 - 41,690,200 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	41,633,398 - 41,690,200 (+)	Ensembl				GRCr8
mRatBN7.2	12	35,972,813 - 36,029,632 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	35,972,846 - 36,029,626 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	37,152,476 - 37,208,823 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	37,763,694 - 37,820,042 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	36,816,157 - 36,872,506 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	41,507,784 - 41,566,847 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	41,543,696 - 41,566,847 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	43,365,885 - 43,421,373 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	12	37,140,428 - 37,227,711 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	12	37,634,250 - 37,689,810 (+)	NCBI		Celera
RGSC_v3.1	12	37,003,822 - 37,091,098 (+)	NCBI
Cytogenetic Map	12	q16	NCBI

TPCN1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	113,221,464 - 113,298,585 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	113,221,050 - 113,298,589 (+)	Ensembl			hg38	GRCh38
GRCh37	12	113,659,269 - 113,736,390 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	112,143,652 - 112,218,317 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	12	112,121,988 - 112,196,653	NCBI
Celera	12	113,286,083 - 113,363,215 (+)	NCBI		Celera
Cytogenetic Map	12	q24.13	NCBI
HuRef	12	110,671,978 - 110,748,859 (+)	NCBI		HuRef
CHM1_1	12	113,627,519 - 113,704,638 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	113,198,077 - 113,275,213 (+)	NCBI		T2T-CHM13v2.0

Tpcn1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	120,672,222 - 120,726,731 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	120,672,218 - 120,726,738 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	5	120,534,157 - 120,588,678 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	120,534,153 - 120,588,673 (-)	Ensembl			mm10	GRCm38
MGSCv37	5	120,984,166 - 121,038,622 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	5	120,794,774 - 120,849,230 (-)	NCBI		MGSCv36	mm8
Celera	5	117,618,746 - 117,673,755 (-)	NCBI		Celera
Cytogenetic Map	5	F	NCBI
cM Map	5	60.63	NCBI

Tpcn1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955482	9,542,079 - 9,592,972 (+)	Ensembl
ChiLan1.0	NW_004955482	9,538,572 - 9,594,739 (+)	NCBI	ChiLan1.0	ChiLan1.0

TPCN1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	121,275,876 - 121,387,131 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	121,292,962 - 121,383,532 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	110,812,587 - 110,903,033 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	114,209,638 - 114,286,443 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	114,209,638 - 114,286,443 (+)	Ensembl			panPan2	panpan1.1

TPCN1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	10,599,898 - 10,662,269 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	10,599,780 - 10,660,767 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	10,722,333 - 10,784,680 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	10,844,354 - 10,906,738 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	26	10,844,324 - 10,906,732 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	26	10,818,283 - 10,880,655 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	10,880,824 - 10,943,296 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	10,930,100 - 10,992,447 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Tpcn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	148,612,146 - 148,663,274 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936668	3,111,002 - 3,163,396 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936668	3,111,038 - 3,162,163 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TPCN1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	38,683,597 - 38,773,186 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	14	38,698,680 - 38,773,189 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	41,288,818 - 41,314,324 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TPCN1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	108,459,754 - 108,549,933 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	108,475,380 - 108,552,374 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666037	136,539,692 - 136,615,663 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tpcn1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624747	19,179,575 - 19,236,206 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624747	19,179,378 - 19,237,799 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Tpcn1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	16	33,237,316 - 33,293,989 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Tpcn1
484 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	273
Count of miRNA genes:	178
Interacting mature miRNAs:	220
Transcripts:	ENSRNOT00000001866
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631560	Apr1	Acute phase response QTL 1	6.1		orosomucoid 1 amount (VT:0010541)	plasma orosomucoid 1 level (CMO:0001467)	12	24805022	52308831	Rat
70213	Niddm27	Non-insulin dependent diabetes mellitus QTL 27	3.72		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	11200494	52308831	Rat
8552964	Pigfal17	Plasma insulin-like growth factor 1 level QTL 17	3.5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
8693635	Alc28	Alcohol consumption QTL 28	2.7	0.439	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	12	28717718	50386405	Rat
7411641	Foco19	Food consumption QTL 19	27.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
7411643	Foco20	Food consumption QTL 20		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	25989355	52308831	Rat
5684888	Pia42	Pristane induced arthritis QTL 42			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	3489416	48489416	Rat
1641928	Alcrsp5	Alcohol response QTL 5			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	12	18473041	52308831	Rat
1300162	Bp188	Blood pressure QTL 188	3.19		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	37764145	51558799	Rat
8552912	Pigfal6	Plasma insulin-like growth factor 1 level QTL 6	5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200497	52308831	Rat
1549829	Scl48	Serum cholesterol level QTL 48	5		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	12	15264248	52308831	Rat
10059594	Kidm46	Kidney mass QTL 46	3.79	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	12	11743528	52308831	Rat
8552918	Pigfal7	Plasma insulin-like growth factor 1 level QTL 7			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
70169	Eae13	Experimental allergic encephalomyelitis QTL 13		0.032	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	12	29775522	42298555	Rat
1600386	Calcic2	Intracellular calcium level QTL 2		0.001	platelet physiology trait (VT:0005464)	platelet intracellular calcium level (CMO:0000922)	12	33700432	46784661	Rat
61404	Bw120	Body weight QTL 120	5.1		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	12	17464979	46784661	Rat
1556747	Calcic1	Intracellular calcium level QTL 1		3.6	platelet calcium amount (VT:0010500)	platelet intracellular calcium level (CMO:0000922)	12	33700432	46784661	Rat
1300175	Cm5	Cardiac mass QTL 5	3.78		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	12	33700432	51558799	Rat
631829	Alc6	Alcohol consumption QTL 6	4.7		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	12	34243475	43352593	Rat
1331786	Kidm11	Kidney mass QTL 11	3.571		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	12	16187438	52308831	Rat
8693658	Alc33	Alcohol consumption QTL 33	2.1	0.68	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	12	28717718	49212240	Rat
2293699	Bss49	Bone structure and strength QTL 49	5.61	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	12	16135029	52308831	Rat
1331761	Bp218	Blood pressure QTL 218	2.973		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	16187438	51213550	Rat
1331763	Wbc2	White blood cell count QTL 2	3.162		leukocyte quantity (VT:0000217)	total white blood cell count (CMO:0000365)	12	11200494	52308831	Rat
7411547	Bw129	Body weight QTL 129		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	11200494	52308831	Rat
1298081	Cia25	Collagen induced arthritis QTL 25	4.7		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	2747694	47747694	Rat
2303569	Gluco44	Glucose level QTL 44	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	18473041	52308831	Rat
2303575	Insul14	Insulin level QTL 14	4		blood insulin amount (VT:0001560)	blood insulin level (CMO:0000349)	12	3087180	48087180	Rat
7411588	Foco6	Food consumption QTL 6		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
7243862	Mcs30	Mammary carcinoma susceptibility QTL 30	8.62		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	12	5633306	50633306	Rat
2300186	Bmd59	Bone mineral density QTL 59	7.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	12	16135029	52308831	Rat
7411597	Foco10	Food consumption QTL 10		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat

Markers in Region

D12Got83

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	35,998,884 - 35,999,103 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	41,532,976 - 41,533,193	NCBI	Rnor6.0
Celera	12	37,659,135 - 37,659,328	UniSTS
RH 3.4 Map	12	641.4	RGD
RH 3.4 Map	12	641.4	UniSTS
RH 2.0 Map	12	477.1	RGD
Cytogenetic Map	12	q16	UniSTS

RH130280

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	36,029,809 - 36,029,992 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	41,567,031 - 41,567,213	NCBI	Rnor6.0
Rnor_5.0	12	43,421,557 - 43,421,739	UniSTS	Rnor5.0
RGSC_v3.4	12	37,227,895 - 37,228,077	UniSTS	RGSC3.4
Celera	12	37,689,994 - 37,690,176	UniSTS
RH 3.4 Map	12	646.1	UniSTS
Cytogenetic Map	12	q16	UniSTS

RH131571

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	36,029,358 - 36,029,551 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	41,566,580 - 41,566,772	NCBI	Rnor6.0
Rnor_5.0	12	43,421,106 - 43,421,298	UniSTS	Rnor5.0
RGSC_v3.4	12	37,227,444 - 37,227,636	UniSTS	RGSC3.4
Celera	12	37,689,543 - 37,689,735	UniSTS
RH 3.4 Map	12	646.8	UniSTS
Cytogenetic Map	12	q16	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	161	91	90	59	92	59	6	356	192	11	140	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_139332	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089064	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089065	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089066	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089067	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063271044	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB018253	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC062072	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CA339864	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473973	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CK473123	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000079639 ⟹ ENSRNOP00000074914

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	41,633,398 - 41,690,199 (+)	Ensembl
mRatBN7.2 Ensembl	12	35,972,846 - 36,029,626 (+)	Ensembl
Rnor_6.0 Ensembl	12	41,543,696 - 41,564,819 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000083890 ⟹ ENSRNOP00000072420

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	41,633,398 - 41,690,199 (+)	Ensembl
mRatBN7.2 Ensembl	12	35,972,846 - 36,029,626 (+)	Ensembl
Rnor_6.0 Ensembl	12	41,544,411 - 41,566,847 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000143762 ⟹ ENSRNOP00000108808

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	41,633,398 - 41,690,199 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000166140 ⟹ ENSRNOP00000104314

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	41,642,669 - 41,690,200 (+)	Ensembl

RefSeq Acc Id:

NM_139332 ⟹ NP_647548

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	41,633,438 - 41,690,200 (+)	NCBI
mRatBN7.2	12	35,972,853 - 36,029,626 (+)	NCBI
Rnor_6.0	12	41,507,784 - 41,566,847 (+)	NCBI
Rnor_5.0	12	43,365,885 - 43,421,373 (+)	NCBI
RGSC_v3.4	12	37,140,428 - 37,227,711 (+)	RGD
Celera	12	37,634,250 - 37,689,810 (+)	RGD

Sequence:

show sequence

CAGCGGTGAGGCGGCGGTGGCGGCTGCTGAGGCTCCGCTGTGGGGATATTGGCGGCAGCAGCTG
CGGGCTGAGCTGCGCTGTGCAGACCCGGTGCACGGTGCGGGATCCGGGACGGCGCGTCCCCTAG
AAGATGCCCCTGATGGAACGGGCTCTGGGAAGCTTCTCTGGCCCCGTGGCTTTGAACAGGAGCT
CAAGCCGGAGGCCATTTAAAGCCCTGGCTGTTGTATCCTGAGGACCACAGGTCAGGAGAAGATG
TCTGTAATTTTAGACGACGACGTGCTGCTCATCCTGACCTTGGACGAGGAGCTGAGTGCGCCGC
TGACTCCTTCCAACGGCCTGGGCCAAGAAGACCTGCCCAGCAAAAATGGGGGCGGCCAAAGCGG
CCCCAACTCCCAAGTTCCCAGTCTGGTCTCTGGAGCCGACAGTCCCCCCTCCAGTCCCCCCGGA
CACAACTGGGAGATGAATTATCAAGAGGCAGCAATCTACCTCCAGGAAGGCCAGAACAATGACA
AGTTCTTCACCCACCCCAAGGATGCCAGAGCGCTGGCTGCCTACCTCTTCGTACACAACCACTT
CTTTTATATGATGGAGCTGCTCACAGCCCTGCTTCTGCTGCTGCTGTCACTGTGCGAGTCACCC
GCTGTCCCTGCGCTCAAGCTCCGAACTTACGTCCACGCCACCCTGGAGCTGTTCGCCCTCATGG
TGGTGGTATTTGAACTCTGCATGAAATTGCGGTGGCTGGGCTTCCACACATTCGTCAGGCACAA
ACGCACCATGGTCAAGACGTCTGTTTTGGTGGTGCAGTTCATCGAGGCCATTGTGGTGCTGGTG
CGGCAGACGTCCCACGTGCGGGTGACCCGGGCACTACGCTGCATTTTCCTGGTGGACTGTCGGT
ACTGTGGTGGCGTGCGGCGCAACCTGCGGCAGATCTTCCAGTCGCTGCCGCCTTTCATGGACAT
CCTCCTGCTGCTGCTCTTCTTTATGATCATCTTCGCCATCCTCGGTTTCTACTTATTCTCTACG
AACCCTTCCGACCCTTACTTCAACACCCTGGAGAACAGCATCGTCAACCTGTTTGTTCTCCTGA
CCACAGCCAACTTTCCAGACGTCATGATGCCCTCCTACTCCCGGAACCCCTGGTCCTGTGTCTT
CTTTATCGTGTACCTCTCCATTGAGCTGTACTTCATCATGAACCTGCTCCTAGCCGTGGTGTTC
GACACCTTCAACGACATCGAAAAGCACAAGTTCAAGTCCTTGCTGCTGCATAAGCGAACAGCCA
TCCAGCACGCATACCACCTGCTCGTCAGCCAACGGAGGCCGGCCGGCATCTCCTACAGGCAGTT
TGAAGGCTTGATGCGCTTCTACAAGCCCCGGATGAGCGCTAGGGAGCGCTTCCTGACTTTCAAG
GCCCTGAATCAGAGCAACACACCTCTGCTTAGCCTGAAGGACTTCTATGATATTTATGAAGTTG
CTGCTCTGCAGTGGAAGGCAAAGAAGAACAGACAGCACTGGTTTGACGAGCTTCCCCGGACAGC
CTTCCTCATCTTCAAAGGGATTAACATCCTTGTGAATTCCAAGGCCTTCCAGTATTTCATGTAC
CTGGTGGTGGCTGTCAACGGTGTCTGGATCCTAGTGGAGACATTCATGTTGAAAGGTGGGAATT
TCATCTCAAAGCACGTGCCCTGGAGTTACCTCGTGTTTCTTACCATCTATGGAGTTGAGCTGTT
CATGAAGGTGGCTGGCCTGGGCCCTGTGGAGTACTTGTCCTCTGGATGGAACCTGTTCGATTTC
TCAGTCACAGCATTTGCCTTCCTGGGACTGCTCGCGCTGACGCTCAACATGGAGCCCTTCTACT
TTATTGTGGTCCTGCGTCCCCTTCAGCTGCTGAGGTTATTCAAGTTGAAGAAACGCTACCGCAA
TGTGTTGGACACCATGTTTGAGCTGCTGCCACGAATGGCCAGCCTCGGCCTCACACTGCTCACC
TTCTACTACTCCTTCGCCATCGTGGGCATGGAGTTCTTCAGTGGGCGACTGTCCCCCAACTGCT
GCAACTCCAGCACGGTGGCTGACGCCTATCGATTCATCAATCACACGGTGGGCAATAAGACCAA
GGTGGAGGAAGGCTACTACTATCTCAATAACTTTGACAACATCCTCAACAGCTTTGTGACCTTG
TTTGAGCTCACCGTTGTCAACAACTGGTACATCATCATGGAAGGCGTCACCTCGCAGACTTCCC
ACTGGAGCCGCCTGTACTTCATGACCTTTTACATCGTGACCATGGTGGTGATGACCATTATCGT
GGCCTTCATCCTGGAGGCCTTCGTCTTCCGCATGAACTACAGCCGCAAGAGCCAGGAATCGGAA
GTGGACAGTGGCATCGTCATCGAGAAGGAGATGTCCAAGGAGGAGCTTCTGGCCATCCTGGAGC
TTCATCGAGAGGCGCGAGGCACCTCCTCTGACATCACCCGGCTGCTCGACACCCTCTCTCAGAT
GGAGAAATACCAGCAAAACTCCATGGTGTTTCTGGGACGGCGATCGAGAACCAAAAGTGACCTG
AGCCTGAAGATGTACCAGGAGGAGATCCAGGAGTGGTACGAGGAGCATGCCCGGGAACAGGAGC
AGCAGCAGCTCAGGGGCAGCGCGCCAAGCCCTGCAGCCCAGCAGACCCCCGGCAGTCGCCAGCG
CTCCCAGACCGTCACCTAGCCCGGCTCCGTCAAGCCAGCCTCTTCTATGCAATAACACCATAGT
ATTATGTACTACGATGTATGGAAACCATGTGTGTATGTAGACACACTCATATATATGCACATAT
TTACACAGAGAGAGAAAAGGACTAGCCAGGGTCCGTCCGAACCACCTCGCTCTGTCTTCCTGAG
CTCCAGAAATTGGTTTAGGCTGGAGGCTCAGACCTGGCTGAGCTCTTCCTACCATGGAAAATTC
TGGAAGCCCTCCTGCTCAAGAAGGCTGCTTAAATAGGCTGTCTCATCTTAGCAATGCCAGCATT
CCCTGGGGGACCTTGCTGTAGCCTCGGGCTTCGTCCCTGCATTGTTGTCTACTTGTCCTCCAGC
CATCACAGGTGTCTGTGTCTGGTATTAGGGACAAAACCACTAGGAAGAAACCCCACATCCCGCT
GAATGACGTCTGTAGATGACAAAGTGCTAGAAGGTCCCGTTGAGGGAATCAGTGCCTGGGACCC
AGTGAGAAACCGGACAGAGGCCAGAGATGGCTCAGAGACAGCAGAGTGTACTCGCTCAGGCTTC
TAGTCCTTTCTTGTTGCTGAAACCCTTCCACAGCCTCGTAGGGAAGCTCACCCAGCAGGAGAAA
GCCAACTGGAGACCCTGGGAATTTGACTCATTCAGGAAGAGTTCATTTGAACTGGTGCTGAAGG
CAGGTCCCTCACCCCCACACCTCCACTCTTGAAGTAGACACTGTGTTTGGGGAGGGAGCCACAC
ACAGCACAGGGACACTAACTGCCCATCATAGCAGTCCCTGGCTGGCCACCACGCCACGGCTAGC
TGCTTTTCAAGGACTCTGAGGCACAGTGAGTACTGGCGTCCTCCAAGGTTCTCATAAGCTAGGT
GGGTAGGGGAGGAGGGTGAGGTGAGCACTCAGCAGCCTTGTACCGTGCCTTGTGGGGGTTCTTT
TGATGTCACGGTTGGGTAGTGAAGTGGCAGAGGCAGGCGTAGCAGGGGTGGAGCCCTGGTCACT
TCATCCTGCTGTGTTGTCCACAAGGGGTGGGAAGGAGGCAGGGCTGTCTGAAGTTGCCAGGCAG
CCCTGTGAACCTGCCCTTCCGAACCTACTGCTGCCTGGGAATTGGAGTGGGCAGGCAGGCACAG
GTCCCCTCCCGTTCTCCCAGCTGCTGAACCAGGGGCCAAGCCAGAAAGTGGGTGTTTTTACTCT
AAATAAAGCACAGTCTGCCCCACACCGCACCCCCAGGAAAACCACTGGTTTCCACAGAGAGTCA
GGAGACTGGCAAAGTCCCTTCCACCTCAAAGAGCTCTTGGCCTCTACCTAAACTCAACCTAGAC
TCTAGGCCACAGACCTGAGAAGCAACTTCATCTAGCTGGCTGCCTTAGCTTGTGTATGAGTGGC
ATTTTGGAAGCAGAAAGGGGGGAGGCCTATGAAGAGAGCCTAGGGCCTCTGATTAACCCGCCTG
GTTCTAGGCTACCCCAGGTACCCTTGGTCTAGGGGAGCAGGCTCAGGCAGAGGGACTGGTCTTG
GGCCCTGATAGAGGTACTAAAACCCCCAGGTTCAGCACATACCAGCCAGGTGCCTGAGGGAGTT
TGGGCTGTCAGGCCAAACTGAGCTTGTCCTGTAGCCTGAGAAAACCTGTCCCCACAGAAGTCAC
CTTGAGCACACACCAAGCTGACCCTCAAACTTGCTAGCCCAGCAGGGAACAGACTGGGTCACCC
AGGGATGTAAGCTGAGGCCCCTGGGATCCTGTCTAAGCCAGCTTCCCCTTCCCTCAGTTCAGCT
GAGTGGGAACTGGTGGCTCCCTGTCATAGCCTAGCAGGGGCAGCTATGGAACCAGACTGGGGAT
AGGCACTCTTGTGGGAACTGTGCCCGACCCCTCCCCCTTGCTCCTCCTCCCCCACCTCAGCCTT
ACACCGTGCAGACAATCATTTTGTATGTGTTAAGAGCCACGATGGAAGGTTTTATACAGTAATT
TGTTACCTAGGAACCCACTGTGCCCTGATTTTTGTCGTGCCAATAAAGAGCCCCTGCTTTATA

hide sequence

RefSeq Acc Id:

XM_039089064 ⟹ XP_038944992

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	41,633,402 - 41,690,200 (+)	NCBI
mRatBN7.2	12	35,972,823 - 36,029,632 (+)	NCBI

RefSeq Acc Id:

XM_039089065 ⟹ XP_038944993

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	41,633,399 - 41,690,200 (+)	NCBI
mRatBN7.2	12	35,972,813 - 36,029,632 (+)	NCBI

RefSeq Acc Id:

XM_039089066 ⟹ XP_038944994

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	41,637,355 - 41,690,200 (+)	NCBI
mRatBN7.2	12	35,980,106 - 36,029,632 (+)	NCBI

RefSeq Acc Id:

XM_039089067 ⟹ XP_038944995

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	41,633,399 - 41,682,881 (+)	NCBI
mRatBN7.2	12	35,972,813 - 36,022,307 (+)	NCBI

RefSeq Acc Id:

XM_063271044 ⟹ XP_063127114

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	41,634,319 - 41,690,200 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_647548	(Get FASTA)	NCBI Sequence Viewer
	XP_038944992	(Get FASTA)	NCBI Sequence Viewer
	XP_038944993	(Get FASTA)	NCBI Sequence Viewer
	XP_038944994	(Get FASTA)	NCBI Sequence Viewer
	XP_038944995	(Get FASTA)	NCBI Sequence Viewer
	XP_063127114	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH62072	(Get FASTA)	NCBI Sequence Viewer
	BAA76556	(Get FASTA)	NCBI Sequence Viewer
	EDM13777	(Get FASTA)	NCBI Sequence Viewer
	EDM13778	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000072420
	ENSRNOP00000104314
GenBank Protein	Q9WTN5	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_647548 ⟸ NM_139332

- UniProtKB:

Q6P6R1 (UniProtKB/Swiss-Prot), Q9WTN5 (UniProtKB/Swiss-Prot), A0A0G2K2X9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSVILDDDVLLILTLDEELSAPLTPSNGLGQEDLPSKNGGGQSGPNSQVPSLVSGADSPPSSPP
GHNWEMNYQEAAIYLQEGQNNDKFFTHPKDARALAAYLFVHNHFFYMMELLTALLLLLLSLCES
PAVPALKLRTYVHATLELFALMVVVFELCMKLRWLGFHTFVRHKRTMVKTSVLVVQFIEAIVVL
VRQTSHVRVTRALRCIFLVDCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFS
TNPSDPYFNTLENSIVNLFVLLTTANFPDVMMPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVV
FDTFNDIEKHKFKSLLLHKRTAIQHAYHLLVSQRRPAGISYRQFEGLMRFYKPRMSARERFLTF
KALNQSNTPLLSLKDFYDIYEVAALQWKAKKNRQHWFDELPRTAFLIFKGINILVNSKAFQYFM
YLVVAVNGVWILVETFMLKGGNFISKHVPWSYLVFLTIYGVELFMKVAGLGPVEYLSSGWNLFD
FSVTAFAFLGLLALTLNMEPFYFIVVLRPLQLLRLFKLKKRYRNVLDTMFELLPRMASLGLTLL
TFYYSFAIVGMEFFSGRLSPNCCNSSTVADAYRFINHTVGNKTKVEEGYYYLNNFDNILNSFVT
LFELTVVNNWYIIMEGVTSQTSHWSRLYFMTFYIVTMVVMTIIVAFILEAFVFRMNYSRKSQES
EVDSGIVIEKEMSKEELLAILELHREARGTSSDITRLLDTLSQMEKYQQNSMVFLGRRSRTKSD
LSLKMYQEEIQEWYEEHAREQEQQQLRGSAPSPAAQQTPGSRQRSQTVT

hide sequence

Ensembl Acc Id:

ENSRNOP00000074914 ⟸ ENSRNOT00000079639

Ensembl Acc Id:

ENSRNOP00000072420 ⟸ ENSRNOT00000083890

RefSeq Acc Id:	XP_038944993 ⟸ XM_039089065
- Peptide Label:	isoform X2
- UniProtKB:	Q9WTN5 (UniProtKB/Swiss-Prot), Q6P6R1 (UniProtKB/Swiss-Prot)

RefSeq Acc Id:	XP_038944995 ⟸ XM_039089067
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_038944992 ⟸ XM_039089064
- Peptide Label:	isoform X1
- UniProtKB:	Q9WTN5 (UniProtKB/Swiss-Prot), Q6P6R1 (UniProtKB/Swiss-Prot), A0A0G2K2X9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038944994 ⟸ XM_039089066
- Peptide Label:	isoform X3
- UniProtKB:	Q9WTN5 (UniProtKB/Swiss-Prot), Q6P6R1 (UniProtKB/Swiss-Prot)

RefSeq Acc Id:	XP_063127114 ⟸ XM_063271044
- Peptide Label:	isoform X1
- UniProtKB:	Q9WTN5 (UniProtKB/Swiss-Prot), Q6P6R1 (UniProtKB/Swiss-Prot), A0A0G2K2X9 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000104314 ⟸ ENSRNOT00000166140

Ensembl Acc Id:

ENSRNOP00000108808 ⟸ ENSRNOT00000143762

Protein Domains

Ion transport

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9WTN5-F1-model_v2	AlphaFold	Q9WTN5	1-817	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:708494	AgrOrtholog
BioCyc Gene	G2FUF-19178	BioCyc
Ensembl Genes	ENSRNOG00000059344	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000083890	ENTREZGENE
	ENSRNOT00000166140	ENTREZGENE
Gene3D-CATH	1.10.287.70	UniProtKB/Swiss-Prot
	1.20.120.350	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:5599545	IMAGE-MGC_LOAD
InterPro	Ion_trans_dom	UniProtKB/Swiss-Prot
	TPC1	UniProtKB/Swiss-Prot
	Volt_channel_dom_sf	UniProtKB/Swiss-Prot
KEGG Report	rno:246215	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:72293	IMAGE-MGC_LOAD
NCBI Gene	246215	ENTREZGENE
PANTHER	PTHR46474	UniProtKB/Swiss-Prot
	TWO PORE CALCIUM CHANNEL PROTEIN 1	UniProtKB/Swiss-Prot
Pfam	Ion_trans	UniProtKB/Swiss-Prot
PhenoGen	Tpcn1	PhenoGen
RatGTEx	ENSRNOG00000059344	RatGTEx
Superfamily-SCOP	Voltage-gated potassium channels	UniProtKB/Swiss-Prot
UniProt	A0A0G2K2X9	ENTREZGENE, UniProtKB/TrEMBL
	A0A0G2K997_RAT	UniProtKB/TrEMBL
	A0ABK0LHM3_RAT	UniProtKB/TrEMBL
	A0ABK0LS32_RAT	UniProtKB/TrEMBL
	A6J1I8_RAT	UniProtKB/TrEMBL
	A6J1I9_RAT	UniProtKB/TrEMBL
	Q6P6R1	ENTREZGENE
	Q9WTN5	ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary	Q6P6R1	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-12-15	Tpcn1	two pore segment channel 1	Tpcn1	two pore channel 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-12-14	Tpcn1	two pore channel 1	LOC246215	voltage-gated Ca channel	Symbol and Name updated	1299863	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_cellular_localization	localized to the apical membrane of inner medullary collecting ducts in kidney	724765

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

RGD Manual Annotations

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Imported Disease Annotations - CTD

RGD Manual Annotations