Tmem158 (transmembrane protein 158) - Rat Genome Database

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Gene: Tmem158 (transmembrane protein 158) Rattus norvegicus
Analyze
Symbol: Tmem158
Name: transmembrane protein 158
RGD ID: 708473
Description: Enables peptide binding activity. Predicted to be located in membrane. Orthologous to human TMEM158 (transmembrane protein 158); INTERACTS WITH acrylamide; alpha-Zearalanol; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 40 kDa BINP-binding protein; BINP receptor; brain specific binding protein; brain-specific binding protein; LOC117582; p40BBP; Ras-induced senescence 1; ras-induced senescence protein 1; Ris1
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88131,791,137 - 131,792,135 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8131,787,277 - 131,796,882 (-)EnsemblGRCr8
mRatBN7.28122,913,675 - 122,914,673 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8122,913,675 - 122,914,673 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8128,503,201 - 128,504,199 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08126,702,152 - 126,703,150 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08124,531,752 - 124,532,750 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08132,344,710 - 132,345,708 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8132,344,710 - 132,345,708 (-)Ensemblrn6Rnor6.0
Rnor_5.08131,497,629 - 131,498,627 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48128,037,014 - 128,038,012 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8122,025,073 - 122,026,071 (-)NCBICelera
RGSC_v3.18128,056,750 - 128,057,749 (-)NCBI
Cytogenetic Map8q32NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-methylcholine  (ISO)
2-palmitoylglycerol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carmustine  (ISO)
chromium(6+)  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dimethylarsinous acid  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
gentamycin  (EXP)
glyphosate  (EXP)
hydrogen peroxide  (ISO)
indometacin  (ISO)
lead diacetate  (ISO)
malathion  (ISO)
medroxyprogesterone acetate  (ISO)
methylmercury chloride  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-nitrosodiethylamine  (ISO)
nickel dichloride  (ISO)
nitrates  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
pentanal  (ISO)
perfluorooctanoic acid  (EXP)
permethrin  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
progesterone  (ISO)
propanal  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sotorasib  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trametinib  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Identification and molecular cloning of a novel brain-specific receptor protein that binds to brain injury-derived neurotrophic peptide. Possible role for neuronal survival. Hama T, etal., J Biol Chem 2001 Aug 24;276(34):31929-35.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:17388661  


Genomics

Comparative Map Data
Tmem158
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88131,791,137 - 131,792,135 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8131,787,277 - 131,796,882 (-)EnsemblGRCr8
mRatBN7.28122,913,675 - 122,914,673 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8122,913,675 - 122,914,673 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8128,503,201 - 128,504,199 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08126,702,152 - 126,703,150 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08124,531,752 - 124,532,750 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08132,344,710 - 132,345,708 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8132,344,710 - 132,345,708 (-)Ensemblrn6Rnor6.0
Rnor_5.08131,497,629 - 131,498,627 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48128,037,014 - 128,038,012 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8122,025,073 - 122,026,071 (-)NCBICelera
RGSC_v3.18128,056,750 - 128,057,749 (-)NCBI
Cytogenetic Map8q32NCBI
TMEM158
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38345,224,466 - 45,226,287 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl345,224,466 - 45,226,287 (-)Ensemblhg38GRCh38
GRCh37345,265,958 - 45,267,779 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36345,240,960 - 45,242,818 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34345,240,961 - 45,242,758NCBI
Celera345,204,342 - 45,206,200 (-)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef345,309,816 - 45,311,719 (-)NCBIHuRef
CHM1_1345,215,889 - 45,217,747 (-)NCBICHM1_1
T2T-CHM13v2.0345,240,829 - 45,242,650 (-)NCBIT2T-CHM13v2.0
Tmem158
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399123,088,122 - 123,089,854 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9123,088,118 - 123,089,829 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm389123,259,057 - 123,260,789 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9123,259,053 - 123,260,764 (-)Ensemblmm10GRCm38
MGSCv379123,168,175 - 123,169,907 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv369123,108,383 - 123,109,243 (-)NCBIMGSCv36mm8
Celera9123,709,260 - 123,710,992 (-)NCBICelera
Cytogenetic Map9F4NCBI
cM Map973.92NCBI
TMEM158
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2245,183,944 - 45,185,513 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1345,188,712 - 45,190,539 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0345,126,759 - 45,128,582 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
TMEM158
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha2043,078,761 - 43,079,621 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02043,647,405 - 43,648,274 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2043,647,405 - 43,648,274 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12042,887,286 - 42,888,152 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02043,294,612 - 43,298,949 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02043,569,752 - 43,570,615 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tmem158
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118198,249,397 - 198,250,438 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936695601,732 - 602,112 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMEM158
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1328,405,187 - 28,406,074 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11328,404,542 - 28,406,369 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21331,445,301 - 31,447,087 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TMEM158
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1226,697,883 - 6,699,713 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl226,698,545 - 6,699,423 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666041160,469,138 - 160,470,999 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmem158
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473075,434,340 - 75,435,125 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473075,434,178 - 75,435,686 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Tmem158
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v18114,389,975 - 114,391,749 (-)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:116
Count of miRNA genes:94
Interacting mature miRNAs:96
Transcripts:ENSRNOT00000006300
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)8102413464132782436Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)8105462581132782436Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)884192326132782436Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)879394435132782436Rat

Markers in Region
RH140682  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28122,914,220 - 122,914,435 (+)MAPPERmRatBN7.2
Rnor_6.08132,345,256 - 132,345,470NCBIRnor6.0
Rnor_5.08131,498,175 - 131,498,389UniSTSRnor5.0
RGSC_v3.48128,037,560 - 128,037,774UniSTSRGSC3.4
Celera8122,025,619 - 122,025,833UniSTS
Cytogenetic Map8q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 11 67 156 87 86 55 51 55 6 297 150 9 134 68 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000006300   ⟹   ENSRNOP00000006300
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8131,790,504 - 131,794,092 (-)Ensembl
mRatBN7.2 Ensembl8122,913,675 - 122,914,673 (-)Ensembl
Rnor_6.0 Ensembl8132,344,710 - 132,345,708 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000124381   ⟹   ENSRNOP00000101884
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8131,789,914 - 131,794,092 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000142661   ⟹   ENSRNOP00000108367
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8131,787,277 - 131,796,882 (-)Ensembl
RefSeq Acc Id: NM_057212   ⟹   NP_476560
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88131,791,137 - 131,792,135 (-)NCBI
mRatBN7.28122,913,675 - 122,914,673 (-)NCBI
Rnor_6.08132,344,710 - 132,345,708 (-)NCBI
Rnor_5.08131,497,629 - 131,498,627 (-)NCBI
RGSC_v3.48128,037,014 - 128,038,012 (-)RGD
Celera8122,025,073 - 122,026,071 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_476560 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAB63459 (Get FASTA)   NCBI Sequence Viewer  
  EDL76762 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000006300
  ENSRNOP00000006300.1
GenBank Protein Q91XV7 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_476560   ⟸   NM_057212
- Peptide Label: precursor
- UniProtKB: Q91XV7 (UniProtKB/Swiss-Prot),   A6I4B5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000006300   ⟸   ENSRNOT00000006300
Ensembl Acc Id: ENSRNOP00000108367   ⟸   ENSRNOT00000142661
Ensembl Acc Id: ENSRNOP00000101884   ⟸   ENSRNOT00000124381

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q91XV7-F1-model_v2 AlphaFold Q91XV7 1-285 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696407
Promoter ID:EPDNEW_R6932
Type:initiation region
Name:Tmem158_1
Description:transmembrane protein 158
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08132,345,794 - 132,345,854EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708473 AgrOrtholog
BioCyc Gene G2FUF-28616 BioCyc
Ensembl Genes ENSRNOG00000004757 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00000072779 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000006300 ENTREZGENE
  ENSRNOT00000006300.4 UniProtKB/Swiss-Prot
InterPro TMEM158 UniProtKB/Swiss-Prot
KEGG Report rno:117582 UniProtKB/Swiss-Prot
NCBI Gene 117582 ENTREZGENE
PANTHER PTHR38324 UniProtKB/Swiss-Prot
  TRANSMEMBRANE PROTEIN 158 UniProtKB/Swiss-Prot
PhenoGen Tmem158 PhenoGen
RatGTEx ENSRNOG00000004757 RatGTEx
  ENSRNOG00000072779 RatGTEx
UniProt A6I4B5 ENTREZGENE, UniProtKB/TrEMBL
  Q91XV7 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-25 Tmem158  transmembrane protein 158  Ris1  Ras-induced senescence 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-08 Ris1  Ras-induced senescence 1  LOC117582  brain specific binding protein  Symbol and Name updated 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation expression increased after kainic acid treatment in rat hippocampal neurons 70532