Spink1l (serine peptidase inhibitor, Kazal type 1-like) - Rat Genome Database

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Gene: Spink1l (serine peptidase inhibitor, Kazal type 1-like) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Spink1l
Name: serine peptidase inhibitor, Kazal type 1-like
RGD ID: 708468
Description: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be located in extracellular region. Human ortholog(s) of this gene implicated in pancreatitis. Orthologous to human SPINK1 (serine peptidase inhibitor Kazal type 1); INTERACTS WITH 17beta-estradiol; thioacetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: calcium transport inhibitor; caltrin; LOC100911558; LOC266602; pancreatic secretory trypsin inhibitor II; pancreatic secretory trypsin inhibitor type II (PSTI-II); pancreatic secretory trypsin inhibitor-56; Psti; PSTI-56; PSTI-II; serine peptidase inhibitor, Kazal type 1; serine peptidase inhibitor, Kazal type 3; serine protease inhibitor Kazal-type 1-like; serine protease inhibitor Kazal-type 3; serine protease inhibitor Kazal-type 3-like; serine protease inhibitor, Kazal type 3; Spink1; Spink3
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81836,077,512 - 36,086,696 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1836,077,514 - 36,086,714 (-)EnsemblGRCr8
mRatBN7.21835,826,607 - 35,835,791 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1835,930,631 - 35,939,815 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01836,648,945 - 36,658,129 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01836,025,894 - 36,035,078 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01838,177,441 - 38,185,812 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1838,177,441 - 38,185,812 (-)Ensemblrn6Rnor6.0
Rnor_5.01837,834,363 - 37,842,734 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41837,090,934 - 37,099,835 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Cytogenetic Map18q11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. The protective effects of long-acting recombinant human pancreatic secretory trypsin inhibitor (R44S-PSTI) in a rat model of cerulein-induced pancreatitis. Chen YZ, etal., J Int Med Res. 1996 Jan-Feb;24(1):59-68.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. On the cDNA's for two types of rat pancreatic secretory trypsin inhibitor. Horii A, etal., Biochem Biophys Res Commun 1989 Jul 14;162(1):151-9.
4. Differential expression of trypsinogen and tumor-associated trypsin inhibitor (TATI) in bladder cancer. Hotakainen K, etal., Int J Oncol. 2006 Jan;28(1):95-101.
5. Tumor markers CA 125, carcinoembryonic antigen and tumor-associated trypsin inhibitor in patients with cervical adenocarcinoma. Leminen A Gynecol Oncol. 1990 Dec;39(3):358-63.
6. Tumor-associated trypsin inhibitor in normal and malignant renal tissue and in serum of renal-cell carcinoma patients. Lukkonen A, etal., Int J Cancer. 1999 Nov 12;83(4):486-90.
7. Serum levels of the tumour-associated trypsin inhibitor in patients with endometriosis. Medl M, etal., Br J Obstet Gynaecol. 1997 Jan;104(1):78-81.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Protection against chronic pancreatitis and pancreatic fibrosis in mice overexpressing pancreatic secretory trypsin inhibitor. Nathan JD, etal., Pancreas. 2010 Jan;39(1):e24-30. doi: 10.1097/MPA.0b013e3181bc45e9.
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. Expression of trypsinogen-1, trypsinogen-2, and tumor-associated trypsin inhibitor in ovarian cancer: prognostic study on tissue and serum. Paju A, etal., Clin Cancer Res. 2004 Jul 15;10(14):4761-8.
12. Increased expression of tumor-associated trypsin inhibitor, TATI, in prostate cancer and in androgen-independent 22Rv1 cells. Paju A, etal., Eur Urol. 2007 Dec;52(6):1670-9. Epub 2007 Feb 5.
13. Tumor associated trypsin inhibitor as a prognostic factor in renal cell carcinoma. Paju A, etal., J Urol. 2001 Mar;165(3):959-62.
14. Decreased expression of the pancreatic secretory trypsin inhibitor II gene during aging of the rat liver. Panda H, etal., J Biomed Sci. 2004 Jul-Aug;11(4):528-30.
15. TATI (tumor associated trypsin inhibitor) and cancer antigen 125 (CA 125) in patients with early-stage endometrial cancer. Peters-Engl C, etal., Anticancer Res. 1998 Nov-Dec;18(6B):4635-9.
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Urinary levels of tumor-associated trypsin inhibitor (TATI) in the detection of transitional cell carcinoma of the urinary bladder. Shariat SF, etal., Eur Urol. 2005 Sep;48(3):424-31.
20. Elevation of circulating monitor peptide/pancreatic secretory trypsin inhibitor-I (PSTI-61) after turpentine-induced inflammation in rats: hepatocytes produce it as an acute phase reactant. Uda K, etal., J Surg Res. 1994 Nov;57(5):563-8.
21. Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis. Witt H, etal., Nat Genet. 2000 Jun;25(2):213-6.
Additional References at PubMed
PMID:1390891   PMID:1400406   PMID:2110056   PMID:3202973  


Genomics

Variants

.
Variants in Spink1l
93 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:16
Count of miRNA genes:15
Interacting mature miRNAs:16
Transcripts:ENSRNOT00000017969
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182507112683910656Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)182201556261600538Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182349405785487725Rat
1331742Bp228Blood pressure QTL 2283.88752arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
12904668Bw188Body weight QTL 1880.03body mass (VT:0001259)body weight (CMO:0000012)182682218671822186Rat
12904669Cm125Cardiac mass QTL 1250.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)182682218671822186Rat
12904670Cm126Cardiac mass QTL 1260.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)182682218671822186Rat
1331727Bp237Blood pressure QTL 2373.053arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050563968306Rat
12904677Kidm72Kidney mass QTL 720.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)182682218671822186Rat
12904673Cm127Cardiac mass QTL 1270.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)182682218671822186Rat
12904675Am19Aortic mass QTL 190.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)182682218671822186Rat
1331774Bp226Blood pressure QTL 2264.41065arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183199089176990891Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183161050585493247Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181206648285493247Rat
12880368Bw187Body weight QTL 1870.045body mass (VT:0001259)body weight (CMO:0000012)183337915878379158Rat
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18448264849482648Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)183199089176990891Rat
1331753Bp231Blood pressure QTL 2313.643arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18154490981Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181206648285493247Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181564228086134022Rat
11565454Kidm59Kidney mass QTL 590.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)18706572852065728Rat
61375Bp41Blood pressure QTL 412.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)18430735449307354Rat
12904069Cm123Cardiac mass QTL 1230.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)183337915878379158Rat
1331798Bp224Blood pressure QTL 2243.53873arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
2301409Cm70Cardiac mass QTL 700.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)18706572852065728Rat
12904070Cm124Cardiac mass QTL 1240.01heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)183337915878379158Rat
12904071Am18Aortic mass QTL 180.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)183337915878379158Rat
2301413Bp318Blood pressure QTL 3180.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182682218671822186Rat
61383Bp47Blood pressure QTL 4717.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)183152278376522783Rat
12904067Cm122Cardiac mass QTL 1220.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)183337915878379158Rat
12904716Am21Aortic mass QTL 210.005aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)18706572852065728Rat
2301417Bp319Blood pressure QTL 3190.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183337915878379158Rat
12904073Kidm71Kidney mass QTL 710.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)183337915878379158Rat
12904714Cm131Cardiac mass QTL 1310.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)18706572852065728Rat
12904715Cm132Cardiac mass QTL 1320.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)18706572852065728Rat
1331776Bp225Blood pressure QTL 2252.829arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)183161050577371277Rat
6903345Bp349Blood pressure QTL 3493.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18391722648917226Rat
2313082Bss85Bone structure and strength QTL 850.80.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)181522610142690662Rat
1641923Colcr8Colorectal carcinoma resistance QTL 83.10.0014intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)183199089176990891Rat
2312568Glom21Glomerulus QTL 2120.005kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)18546045542690191Rat
631509Sald2Serum aldosterone level QTL 22.9blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)182641582171415821Rat
6903349Bp351Blood pressure QTL 3513.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18391722648917226Rat
6903351Bp352Blood pressure QTL 3523.3arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18391722648917226Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183164450879484311Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18144930869Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181955353285493247Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181206648257066482Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)183199089176990891Rat
61429Cia17Collagen induced arthritis QTL 174.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)183161050572538878Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
6 4 35 33 84 81 57 22 57 6 215 75 15 73 22 24

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_152936 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide D11325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209906 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210000 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210138 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210344 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210766 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210836 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218107 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218422 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M27883 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000017969   ⟹   ENSRNOP00000017969
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1838,177,441 - 38,185,812 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000075695   ⟹   ENSRNOP00000064556
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1835,067,693 - 35,071,619 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000155497   ⟹   ENSRNOP00000112810
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1836,077,514 - 36,086,714 (-)Ensembl
RefSeq Acc Id: NM_152936   ⟹   NP_690919
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81836,077,512 - 36,086,696 (-)NCBI
mRatBN7.21835,826,607 - 35,835,791 (-)NCBI
Rnor_6.01838,177,441 - 38,185,812 (-)NCBI
Rnor_5.01837,834,363 - 37,842,734 (-)NCBI
RGSC_v3.41837,090,934 - 37,099,835 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_690919 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41976 (Get FASTA)   NCBI Sequence Viewer  
  BAA01945 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000112810
GenBank Protein P09656 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_690919   ⟸   NM_152936
- Peptide Label: precursor
- UniProtKB: P09656 (UniProtKB/Swiss-Prot),   A6KUD6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000017969   ⟸   ENSRNOT00000017969
Ensembl Acc Id: ENSRNOP00000064556   ⟸   ENSRNOT00000075695
Ensembl Acc Id: ENSRNOP00000112810   ⟸   ENSRNOT00000155497
Protein Domains
Kazal-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R594-F1-model_v2 AlphaFold M0R594 1-65 view protein structure
AF-P09656-F1-model_v2 AlphaFold P09656 1-79 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700754
Promoter ID:EPDNEW_R11278
Type:initiation region
Name:Spink1l_1
Description:serine peptidase inhibitor, Kazal type 1-like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01838,185,810 - 38,185,870EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708468 AgrOrtholog
BioCyc Gene G2FUF-7678 BioCyc
Ensembl Genes ENSRNOG00000013410 Ensembl
  ENSRNOG00000045991 Ensembl
  ENSRNOG00000090734 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000155497 ENTREZGENE
Gene3D-CATH 3.30.60.30 UniProtKB/Swiss-Prot
InterPro Kazal_dom UniProtKB/Swiss-Prot
  Kazal_dom_sf UniProtKB/Swiss-Prot
  Prot_inh_Kazal-m UniProtKB/Swiss-Prot
KEGG Report rno:266602 UniProtKB/Swiss-Prot
NCBI Gene 266602 ENTREZGENE
PANTHER SERINE PROTEASE INHIBITOR UniProtKB/Swiss-Prot
  SERINE PROTEASE INHIBITOR KAZAL-TYPE 1 UniProtKB/Swiss-Prot
Pfam Kazal_1 UniProtKB/Swiss-Prot
PhenoGen Spink1l PhenoGen
PRINTS KAZALINHBTR UniProtKB/Swiss-Prot
PROSITE KAZAL_1 UniProtKB/Swiss-Prot
  KAZAL_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000013410 RatGTEx
  ENSRNOG00000045991 RatGTEx
  ENSRNOG00000090734 RatGTEx
SMART KAZAL UniProtKB/Swiss-Prot
Superfamily-SCOP SSF100895 UniProtKB/Swiss-Prot
UniProt A6KUD6 ENTREZGENE, UniProtKB/TrEMBL
  ISK1L_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Spink1l  serine peptidase inhibitor, Kazal type 1-like  LOC100911558  serine protease inhibitor Kazal-type 3-like  Data merged from RGD:6491835 737654 PROVISIONAL
2015-05-20 Spink1l  serine peptidase inhibitor, Kazal type 1-like  Spink1  serine peptidase inhibitor, Kazal type 1  Name and Symbol changed 629549 APPROVED
2012-07-05 LOC100911558  serine protease inhibitor Kazal-type 3-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-09-16 Spink1  serine peptidase inhibitor, Kazal type 1  Spink3  serine peptidase inhibitor, Kazal type 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-25 Spink3  serine peptidase inhibitor, Kazal type 3  Spink3  serine protease inhibitor, Kazal type 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-08 Spink3  serine protease inhibitor, Kazal type 3  LOC266602  pancreatic secretory trypsin inhibitor type II (PSTI-II)  Symbol and Name updated 1299863 APPROVED