Spink1 (serine peptidase inhibitor Kazal type 1) - Rat Genome Database

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Gene: Spink1 (serine peptidase inhibitor Kazal type 1) Chinchilla lanigera
Analyze
Symbol: Spink1
Name: serine peptidase inhibitor Kazal type 1 (Ensembl:serine peptidase inhibitor, Kazal type 1)
RGD ID: 8859249
Description: ENCODES a protein that exhibits peptidase inhibitor activity (ortholog); serine-type endopeptidase inhibitor activity (ortholog); INVOLVED IN cellular response to peptide hormone stimulus (ortholog); negative regulation of calcium ion import (ortholog); negative regulation of nitric oxide mediated signal transduction (ortholog); ASSOCIATED WITH Acute Experimental Pancreatitis (ortholog); cervical adenocarcinoma (ortholog); Chronic Experimental Pancreatitis (ortholog); FOUND IN extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: pancreatic secretory trypsin inhibitor; serine peptidase inhibitor, Kazal type 1
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554156,371,059 - 6,378,529 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554156,328,672 - 6,378,611 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
Spink1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554156,371,059 - 6,378,529 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554156,328,672 - 6,378,611 (+)NCBIChiLan1.0ChiLan1.0
SPINK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385147,824,582 - 147,839,196 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5147,824,572 - 147,831,671 (-)EnsemblGRCh38hg38GRCh38
GRCh375147,204,145 - 147,218,759 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365147,184,339 - 147,191,453 (-)NCBINCBI36Build 36hg18NCBI36
Build 345147,184,338 - 147,191,453NCBI
Celera5143,286,018 - 143,293,135 (-)NCBICelera
Cytogenetic Map5q32NCBI
HuRef5142,351,294 - 142,358,402 (-)NCBIHuRef
CHM1_15146,636,518 - 146,643,635 (-)NCBICHM1_1
T2T-CHM13v2.05148,360,276 - 148,374,975 (-)NCBIT2T-CHM13v2.0
Spink1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391843,861,134 - 43,870,302 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1843,861,147 - 43,870,622 (-)EnsemblGRCm39 Ensembl
GRCm381843,728,069 - 43,737,237 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1843,728,082 - 43,737,557 (-)EnsemblGRCm38mm10GRCm38
MGSCv371843,887,723 - 43,896,891 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361843,853,416 - 43,862,528 (-)NCBIMGSCv36mm8
Celera1845,096,166 - 45,111,565 (-)NCBICelera
Cytogenetic Map18B3NCBI
cM Map1823.47NCBI
Spink1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81836,121,626 - 36,133,596 (-)NCBIGRCr8
mRatBN7.21835,870,723 - 35,882,693 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1835,824,550 - 35,882,642 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1835,974,739 - 35,986,709 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01836,693,067 - 36,705,037 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01836,070,012 - 36,081,982 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01838,221,919 - 38,242,092 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1838,221,681 - 38,242,119 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01837,878,841 - 37,898,259 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41837,135,503 - 37,148,282 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Cytogenetic Map18q11NCBI
SPINK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24143,077,196 - 143,091,804 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15141,216,747 - 141,231,379 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05143,273,137 - 143,287,745 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15149,282,828 - 149,297,469 (-)NCBIpanpan1.1PanPan1.1panPan2
SPINK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1242,112,015 - 42,120,738 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl242,112,016 - 42,120,706 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha239,152,835 - 39,161,514 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0242,566,457 - 42,575,135 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl242,566,457 - 42,575,107 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1239,642,905 - 39,651,567 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0240,452,599 - 40,461,319 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0241,275,547 - 41,284,243 (-)NCBIUU_Cfam_GSD_1.0
Spink1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213145,400,956 - 145,407,408 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365046,975,044 - 6,981,304 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365046,975,044 - 6,981,304 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPINK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2149,071,703 - 149,079,499 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12149,072,652 - 149,079,529 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22155,635,045 - 155,641,908 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SPINK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12350,365,686 - 50,373,300 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2350,365,269 - 50,372,814 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603427,392,009 - 27,396,127 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Spink1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247747,281,227 - 7,287,791 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247747,281,298 - 7,287,735 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000014023   ⟹   ENSCLAP00000013867
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554156,371,059 - 6,378,529 (+)Ensembl
RefSeq Acc Id: XM_005380652   ⟹   XP_005380709
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554156,328,672 - 6,378,611 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005380653   ⟹   XP_005380710
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554156,366,318 - 6,378,611 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005380709 (Get FASTA)   NCBI Sequence Viewer  
  XP_005380710 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000013867.1
Reference Protein Sequences
RefSeq Acc Id: XP_005380709   ⟸   XM_005380652
- Sequence:
RefSeq Acc Id: XP_005380710   ⟸   XM_005380653
- Sequence:
RefSeq Acc Id: ENSCLAP00000013867   ⟸   ENSCLAT00000014023
Protein Domains
Kazal-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000009591 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000014023.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.60.30 UniProtKB/TrEMBL
InterPro Kazal_dom UniProtKB/TrEMBL
  Kazal_dom_sf UniProtKB/TrEMBL
  Prot_inh_Kazal-m UniProtKB/TrEMBL
NCBI Gene Spink1 ENTREZGENE
PANTHER SERINE PROTEASE INHIBITOR UniProtKB/TrEMBL
  SERINE PROTEASE INHIBITOR KAZAL-TYPE 1 UniProtKB/TrEMBL
Pfam Kazal_1 UniProtKB/TrEMBL
PRINTS KAZALINHBTR UniProtKB/TrEMBL
PROSITE KAZAL_1 UniProtKB/TrEMBL
  KAZAL_2 UniProtKB/TrEMBL
  PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
SMART KAZAL UniProtKB/TrEMBL
Superfamily-SCOP SSF100895 UniProtKB/TrEMBL
UniProt A0A8C2VJR1_CHILA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-10-08 Spink1  serine peptidase inhibitor Kazal type 1  Spink1  serine peptidase inhibitor, Kazal type 1  Symbol and/or name change 5135510 APPROVED