Ugt2a1 (UDP glucuronosyltransferase family 2 member A1) - Rat Genome Database

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Gene: Ugt2a1 (UDP glucuronosyltransferase family 2 member A1) Rattus norvegicus
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Symbol: Ugt2a1
Name: UDP glucuronosyltransferase family 2 member A1
RGD ID: 69432
Description: Predicted to enable glucuronosyltransferase activity. Predicted to be involved in several processes, including bile acid metabolic process; response to symbiont; and sensory perception of chemical stimulus. Predicted to be located in membrane. Orthologous to human UGT2A1 (UDP glucuronosyltransferase family 2 member A1 complex locus); PARTICIPATES IN ascorbate and aldarate metabolic pathway; O-linked glycan biosynthetic pathway; pentose and glucuronate interconversion pathway; INTERACTS WITH 1,3,5-trinitro-1,3,5-triazinane; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: UDP glucuronosyltransferase 2 family, polypeptide A1; UDP glycosyltransferase 2 family, polypeptide A1; UDP-glucuronosyltransferase 2A1; UDP-glucuronosyltransferase 2A1 precursor; UDPGT 2A1; UGT-OLF; Ugt2a1p
RGD Orthologs
Human
Mouse
Bonobo
Dog
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81420,797,262 - 20,825,111 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1420,800,263 - 20,825,111 (+)EnsemblGRCr8
mRatBN7.21420,521,018 - 20,545,934 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1420,517,951 - 20,545,531 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1420,710,531 - 20,735,385 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01422,029,448 - 22,054,301 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01420,784,808 - 20,809,662 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01422,192,970 - 22,217,094 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01422,107,068 - 22,131,223 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41422,047,612 - 22,071,582 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1419,924,666 - 19,948,530 (+)NCBICelera
RGSC_v3.11422,047,611 - 22,071,582 (+)NCBI
Cytogenetic Map14p21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
4. Odorant signal termination by olfactory UDP glucuronosyl transferase. Lazard D, etal., Nature 1991 Feb 28;349(6312):790-3.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:19858781   PMID:33765098  


Genomics

Comparative Map Data
Ugt2a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81420,797,262 - 20,825,111 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1420,800,263 - 20,825,111 (+)EnsemblGRCr8
mRatBN7.21420,521,018 - 20,545,934 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1420,517,951 - 20,545,531 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1420,710,531 - 20,735,385 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01422,029,448 - 22,054,301 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01420,784,808 - 20,809,662 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01422,192,970 - 22,217,094 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01422,107,068 - 22,131,223 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41422,047,612 - 22,071,582 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1419,924,666 - 19,948,530 (+)NCBICelera
RGSC_v3.11422,047,611 - 22,071,582 (+)NCBI
Cytogenetic Map14p21NCBI
UGT2A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38469,588,417 - 69,653,247 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl469,588,417 - 69,653,249 (-)Ensemblhg38GRCh38
GRCh37470,454,135 - 70,518,965 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36470,488,724 - 70,553,503 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34470,635,732 - 70,694,177NCBI
Celera467,800,177 - 67,871,858 (-)NCBICelera
Cytogenetic Map4q13.3NCBI
HuRef466,252,679 - 66,316,832 (-)NCBIHuRef
CHM1_1470,490,004 - 70,554,806 (-)NCBICHM1_1
T2T-CHM13v2.0472,923,224 - 72,988,049 (-)NCBIT2T-CHM13v2.0
Ugt2a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39587,607,349 - 87,638,730 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl587,607,349 - 87,638,730 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38587,459,490 - 87,490,871 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl587,459,490 - 87,490,871 (-)Ensemblmm10GRCm38
MGSCv37587,888,515 - 87,919,896 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36588,534,953 - 88,561,307 (-)NCBIMGSCv36mm8
Celera584,675,881 - 84,707,263 (-)NCBICelera
Cytogenetic Map5E1NCBI
cM Map543.56NCBI
LOC100973813
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2360,443,397 - 60,503,547 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1460,646,404 - 60,706,533 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0454,585,243 - 54,650,899 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1460,921,852 - 60,987,478 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl460,921,852 - 60,990,978 (+)EnsemblpanPan2panpan1.1
LOC119874467
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ROS_Cfam_1.01359,934,438 - 60,019,180 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1359,934,520 - 60,019,161 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11359,549,283 - 59,634,042 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01359,009,731 - 59,094,347 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01360,154,520 - 60,239,291 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0

Variants

.
Variants in Ugt2a1
227 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:74
Count of miRNA genes:54
Interacting mature miRNAs:56
Transcripts:ENSRNOT00000002704, ENSRNOT00000041514
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14395787821572472Rat
631528Scl11Serum cholesterol level QTL 114.9blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)141787564536079022Rat
7411573Bw139Body weight QTL 1394.70.001body mass (VT:0001259)body weight gain (CMO:0000420)14140068101Rat
9589814Gluco67Glucose level QTL 674.540.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14140068101Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14939329839411170Rat
631212Bw5Body weight QTL55.43retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)141133490630674469Rat
2302277Gluco38Glucose level QTL 385.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141133471628389666Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14395787831121464Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14862139853621398Rat
61420Pia6Pristane induced arthritis QTL 64.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)141891545442433608Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14395787824886169Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1411334716100078267Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141889519263895192Rat
631262Tcas4Tongue tumor susceptibility QTL 47.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)141790672654251504Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141415516Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14131893212Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14862139853621398Rat
1300140Srn3Serum renin concentration QTL 33.19blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)141513759431238250Rat


Expression

RNA-SEQ Expression

mesenchyme
renal system
2 2

Sequence


Ensembl Acc Id: ENSRNOT00000002704   ⟹   ENSRNOP00000002704
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1420,800,263 - 20,825,111 (+)Ensembl
mRatBN7.2 Ensembl1420,517,951 - 20,545,531 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000100605   ⟹   ENSRNOP00000097034
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1420,808,883 - 20,825,111 (+)Ensembl
mRatBN7.2 Ensembl1420,525,532 - 20,545,531 (+)Ensembl
RefSeq Acc Id: NM_022228   ⟹   NP_071564
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81420,800,263 - 20,825,111 (+)NCBI
mRatBN7.21420,521,089 - 20,545,934 (+)NCBI
Rnor_6.01422,192,970 - 22,217,094 (+)NCBI
Rnor_5.01422,107,068 - 22,131,223 (+)NCBI
RGSC_v3.41422,047,612 - 22,071,582 (+)RGD
Celera1419,924,666 - 19,948,530 (+)RGD
Sequence:
RefSeq Acc Id: XM_039092390   ⟹   XP_038948318
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81420,804,454 - 20,825,104 (+)NCBI
mRatBN7.21420,529,710 - 20,545,060 (+)NCBI
RefSeq Acc Id: XM_063273571   ⟹   XP_063129641
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81420,806,641 - 20,825,104 (+)NCBI
RefSeq Acc Id: XM_063273572   ⟹   XP_063129642
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81420,797,262 - 20,825,104 (+)NCBI
RefSeq Acc Id: XM_063273573   ⟹   XP_063129643
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81420,797,280 - 20,825,104 (+)NCBI
RefSeq Acc Id: NP_071564   ⟸   NM_022228
- Peptide Label: precursor
- UniProtKB: P36510 (UniProtKB/Swiss-Prot),   A6KU27 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038948318   ⟸   XM_039092390
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GMC7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000002704   ⟸   ENSRNOT00000002704
Ensembl Acc Id: ENSRNOP00000097034   ⟸   ENSRNOT00000100605
RefSeq Acc Id: XP_063129642   ⟸   XM_063273572
- Peptide Label: isoform X2
- UniProtKB: P36510 (UniProtKB/Swiss-Prot),   A6KU27 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129643   ⟸   XM_063273573
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063129641   ⟸   XM_063273571
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GMC7 (UniProtKB/TrEMBL)

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69432 AgrOrtholog
BioCyc Gene G2FUF-16118 BioCyc
BioCyc Pathway PWY-5874 [heme degradation I] BioCyc
  PWY-6261 [thyroid hormone metabolism II (via conjugation and/or degradation)] BioCyc
  PWY-6313 [serotonin degradation] BioCyc
  PWY-6398 [melatonin degradation I] BioCyc
BioCyc Pathway Image PWY-5874 BioCyc
  PWY-6261 BioCyc
  PWY-6313 BioCyc
  PWY-6398 BioCyc
Ensembl Genes ENSRNOG00000064759 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000002704 ENTREZGENE
  ENSRNOT00000100605 ENTREZGENE
Gene3D-CATH Glycogen Phosphorylase B UniProtKB/Swiss-Prot
InterPro UDP-glycosyltransferase UniProtKB/Swiss-Prot
  UDP_glucos_trans UniProtKB/Swiss-Prot
  UDP_glycos_trans_CS UniProtKB/Swiss-Prot
KEGG Report rno:63867 UniProtKB/Swiss-Prot
NCBI Gene 63867 ENTREZGENE
PANTHER EG:EG0003.4 PROTEIN-RELATED UniProtKB/Swiss-Prot
  UDP-GLUCURONOSYLTRANSFERASE 2A1 UniProtKB/Swiss-Prot
Pfam UDPGT UniProtKB/Swiss-Prot
PhenoGen Ugt2a1 PhenoGen
PROSITE UDPGT UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000064759 RatGTEx
Superfamily-SCOP UDP-Glycosyltransferase/glycogen phosphorylase UniProtKB/Swiss-Prot
UniProt A0A8I6GMC7 ENTREZGENE, UniProtKB/TrEMBL
  A6KU27 ENTREZGENE, UniProtKB/TrEMBL
  G3V687_RAT UniProtKB/TrEMBL
  P36510 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-20 Ugt2a1  UDP glucuronosyltransferase family 2 member A1  Ugt2a1  UDP glucuronosyltransferase 2 family, polypeptide A1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Ugt2a1  UDP glucuronosyltransferase 2 family, polypeptide A1  Ugt2a1  UDP glycosyltransferase 2 family, polypeptide A1  Name updated 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expressed in the olfactory neuroepithelium 69395