Slc38a2 (solute carrier family 38, member 2) - Rat Genome Database

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Gene: Slc38a2 (solute carrier family 38, member 2) Rattus norvegicus
Analyze
Symbol: Slc38a2
Name: solute carrier family 38, member 2
RGD ID: 69420
Description: Enables amino acid transmembrane transporter activity. Involved in several processes, including amino acid import; cellular response to mechanical stimulus; and neutral amino acid transport. Located in several cellular components, including brush border; neuronal cell body; and sarcolemma. Biomarker of visual epilepsy. Orthologous to human SLC38A2 (solute carrier family 38 member 2); PARTICIPATES IN glutamate signaling pathway; INTERACTS WITH 1,3,5-trinitro-1,3,5-triazinane; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: amino acid transporter A2; amino acid transporter cationic 2; amino acid transporter cationic 2 (low affinity); amino acid transporter system A2; amino acid transporter, cationic 2 (low affinity); Ata2; Atrc2; Sat2; Snat2; sodium-coupled neutral amino acid symporter 2; sodium-coupled neutral amino acid transporter 2; solute carrier family 38 member 2; system A amino acid transporter 2; system A transporter 1; system N amino acid transporter 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87129,730,450 - 129,742,619 (-)NCBIGRCr8
mRatBN7.27127,851,267 - 127,863,482 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7127,851,267 - 127,863,436 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7129,652,230 - 129,664,397 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07131,877,742 - 131,889,909 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07131,795,866 - 131,808,034 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07138,088,654 - 138,100,869 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7138,088,649 - 138,100,841 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07137,716,131 - 137,728,346 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47135,365,172 - 135,377,341 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17135,441,608 - 135,453,778 (-)NCBI
Celera7124,355,437 - 124,367,606 (-)NCBICelera
Cytogenetic Map7q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(R)-lipoic acid  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3,5-trinitro-1,3,5-triazinane  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (ISO)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
alpha-(methylamino)isobutyric acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzatropine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
CGP 52608  (ISO)
chloropicrin  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clofibrate  (ISO)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP,ISO)
cyclosporin A  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dichloromethane  (ISO)
diuron  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
erythromycin estolate  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
ethylbenzene  (ISO)
fenvalerate  (ISO)
fipronil  (EXP)
flavonoids  (EXP)
fluoranthene  (ISO)
fluoxetine  (ISO)
flusilazole  (EXP)
formaldehyde  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
hexadecanoic acid  (ISO)
indometacin  (ISO)
inulin  (ISO)
iron dichloride  (ISO)
ivermectin  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
levofloxacin  (EXP)
lipoic acid  (ISO)
lipopolysaccharide  (EXP)
methoxyacetic acid  (EXP)
methylmercury chloride  (ISO)
motexafin gadolinium  (ISO)
N(4)-hydroxycytidine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methylformamide  (ISO)
N-nitrosodiethylamine  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
nevirapine  (ISO)
nickel atom  (ISO)
o-xylene  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenethyl caffeate  (EXP)
phenformin  (EXP)
phenobarbital  (ISO)
phorone  (EXP)
pinosylvin  (ISO)
pirinixic acid  (ISO)
potassium chloride  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
ranitidine  (EXP)
rifampicin  (ISO)
rotenone  (EXP)
salubrinal  (ISO)
SB 431542  (ISO)
sevoflurane  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
toluene  (EXP,ISO)
trans-pinosylvin  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
zidovudine  (ISO)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axon  (IDA)
brush border  (IDA)
cytoplasm  (ISO)
dendrite  (IDA)
neuronal cell body  (IDA)
plasma membrane  (IBA,IDA,ISO)
sarcolemma  (IDA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Evidence for allosteric regulation of pH-sensitive System A (SNAT2) and System N (SNAT5) amino acid transporter activity involving a conserved histidine residue. Baird FE, etal., Biochem J. 2006 Jul 15;397(2):369-75. doi: 10.1042/BJ20060026.
2. Bidirectional substrate fluxes through the system N (SNAT5) glutamine transporter may determine net glutamine flux in rat liver. Baird FE, etal., J Physiol. 2004 Sep 1;559(Pt 2):367-81. doi: 10.1113/jphysiol.2003.060293. Epub 2004 Jun 24.
3. Functional expression of two system A glutamine transporter isoforms in rat auditory brainstem neurons. Blot A, etal., Neuroscience. 2009 Dec 15;164(3):998-1008. doi: 10.1016/j.neuroscience.2009.09.015. Epub 2009 Sep 12.
4. Glutamine uptake by neurons: interaction of protons with system a transporters. Chaudhry FA, etal., J Neurosci 2002 Jan 1;22(1):62-72.
5. Identification of a Disulfide Bridge in Sodium-Coupled Neutral Amino Acid Transporter 2(SNAT2) by Chemical Modification. Chen C, etal., PLoS One. 2016 Jun 29;11(6):e0158319. doi: 10.1371/journal.pone.0158319. eCollection 2016.
6. Differential molecular regulation of glutamate in kindling resistant rats. Doi T, etal., Brain Res. 2011 Feb 23;1375:1-6. doi: 10.1016/j.brainres.2010.11.085. Epub 2010 Dec 4.
7. Time-dependent expression of SNAT2 mRNA in the contused skeletal muscle of rats: a possible marker for wound age estimation. Du QX, etal., Forensic Sci Med Pathol. 2013 Dec;9(4):528-33. doi: 10.1007/s12024-013-9482-y. Epub 2013 Sep 18.
8. Transforming growth factor-beta 1 stimulates vascular smooth muscle cell L-proline transport by inducing system A amino acid transporter 2 (SAT2) gene expression. Ensenat D, etal., Biochem J. 2001 Dec 1;360(Pt 2):507-12. doi: 10.1042/0264-6021:3600507.
9. ATA2-mediated amino acid uptake following partial hepatectomy is regulated by redistribution to the plasma membrane. Freeman TL, etal., Arch Biochem Biophys. 2002 Apr 15;400(2):215-22. doi: 10.1016/S0003-9861(02)00006-1.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Membrane topology of rat sodium-coupled neutral amino acid transporter 2 (SNAT2). Ge Y, etal., Biochim Biophys Acta Biomembr. 2018 Jul;1860(7):1460-1469. doi: 10.1016/j.bbamem.2018.04.005. Epub 2018 Apr 18.
12. Immunohistochemical localization of the amino acid transporter SNAT2 in the rat brain. Gonzalez-Gonzalez IM, etal., Neuroscience. 2005;130(1):61-73.
13. Subcellular localization and adaptive up-regulation of the System A (SAT2) amino acid transporter in skeletal-muscle cells and adipocytes. Hyde R, etal., Biochem J 2001 May 1;355(Pt 3):563-8.
14. Insulin promotes the cell surface recruitment of the SAT2/ATA2 system A amino acid transporter from an endosomal compartment in skeletal muscle cells. Hyde R, etal., J Biol Chem 2002 Apr 19;277(16):13628-34. Epub 2002 Feb 7.
15. System A transporter SAT2 mediates replenishment of dendritic glutamate pools controlling retrograde signaling by glutamate. Jenstad M, etal., Cereb Cortex. 2009 May;19(5):1092-106. doi: 10.1093/cercor/bhn151. Epub 2008 Oct 1.
16. Induction of amino acid transporters expression by endurance exercise in rat skeletal muscle. Murakami T and Yoshinaga M, Biochem Biophys Res Commun. 2013 Oct 4;439(4):449-52. doi: 10.1016/j.bbrc.2013.08.094. Epub 2013 Sep 7.
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. System A amino acid transporter SNAT2 shows subtype-specific affinity for betaine and hyperosmotic inducibility in placental trophoblasts. Nishimura T, etal., Biochim Biophys Acta. 2014 May;1838(5):1306-12. doi: 10.1016/j.bbamem.2014.01.004. Epub 2014 Jan 14.
19. Different alterations in rat intestinal glutamine transport during the progression of CLP- and LPS-induced sepsis. Niu L, etal., J Surg Res. 2011 Aug;169(2):284-91. doi: 10.1016/j.jss.2009.11.732. Epub 2009 Dec 21.
20. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
21. Amino acid transport system A resembles system N in sequence but differs in mechanism. Reimer RJ, etal., Proc Natl Acad Sci U S A 2000 Jul 5;97(14):7715-20.
22. Cyclic strain stimulates L-proline transport in vascular smooth muscle cells. Reyna SV, etal., Am J Hypertens. 2004 Aug;17(8):712-7.
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Comprehensive gene review and curation RGD comprehensive gene curation
25. Expression of the SNAT2 amino acid transporter during the development of rat cerebral cortex. Rodriguez A, etal., Int J Dev Neurosci. 2011 Nov;29(7):743-8. doi: 10.1016/j.ijdevneu.2011.05.010. Epub 2011 Jun 22.
26. Prenatal testosterone-induced fetal growth restriction is associated with down-regulation of rat placental amino acid transport. Sathishkumar K, etal., Reprod Biol Endocrinol. 2011 Aug 3;9:110. doi: 10.1186/1477-7827-9-110.
27. Cloning of an amino acid transporter with functional characteristics and tissue expression pattern identical to that of system A. Sugawara M, etal., J Biol Chem 2000 Jun 2;275(22):16473-7.
28. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
29. Selective up-regulation of system a transporter mRNA in diabetic liver. Varoqui H and Erickson JD, Biochem Biophys Res Commun. 2002 Jan 25;290(3):903-8.
30. A novel system A isoform mediating Na+/neutral amino acid cotransport. Yao D, etal., J Biol Chem 2000 Jul 28;275(30):22790-7.
31. Expression and role of SNAT3 in the placenta. Yoshioka C, etal., Placenta. 2009 Dec;30(12):1071-7. doi: 10.1016/j.placenta.2009.09.009. Epub 2009 Nov 5.
32. Highly conserved asparagine 82 controls the interaction of Na+ with the sodium-coupled neutral amino acid transporter SNAT2. Zhang Z, etal., J Biol Chem. 2008 May 2;283(18):12284-92. doi: 10.1074/jbc.M706774200. Epub 2008 Mar 4.
33. A conserved Na(+) binding site of the sodium-coupled neutral amino acid transporter 2 (SNAT2). Zhang Z, etal., J Biol Chem. 2009 Sep 11;284(37):25314-23. doi: 10.1074/jbc.M109.038422. Epub 2009 Jul 9.
Additional References at PubMed
PMID:10930503   PMID:15581851   PMID:16023720   PMID:16787963   PMID:16916910   PMID:17003038   PMID:17070687   PMID:17429052   PMID:18330498   PMID:18358621   PMID:19240036   PMID:21158741  
PMID:21386061   PMID:22215663   PMID:25056967   PMID:25299045   PMID:25701231   PMID:26590355   PMID:27049295   PMID:27742667   PMID:29475006  


Genomics

Comparative Map Data
Slc38a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87129,730,450 - 129,742,619 (-)NCBIGRCr8
mRatBN7.27127,851,267 - 127,863,482 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7127,851,267 - 127,863,436 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7129,652,230 - 129,664,397 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07131,877,742 - 131,889,909 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07131,795,866 - 131,808,034 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07138,088,654 - 138,100,869 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7138,088,649 - 138,100,841 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07137,716,131 - 137,728,346 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47135,365,172 - 135,377,341 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17135,441,608 - 135,453,778 (-)NCBI
Celera7124,355,437 - 124,367,606 (-)NCBICelera
Cytogenetic Map7q35NCBI
SLC38A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381246,358,188 - 46,372,773 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1246,358,188 - 46,372,773 (-)EnsemblGRCh38hg38GRCh38
GRCh371246,751,971 - 46,766,556 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361245,038,238 - 45,052,814 (-)NCBINCBI36Build 36hg18NCBI36
Build 341245,038,238 - 45,052,814NCBI
Celera1245,549,292 - 45,563,966 (-)NCBICelera
Cytogenetic Map12q13.11NCBI
HuRef1243,783,294 - 43,797,966 (-)NCBIHuRef
CHM1_11246,717,042 - 46,731,717 (-)NCBICHM1_1
T2T-CHM13v2.01246,317,747 - 46,332,332 (-)NCBIT2T-CHM13v2.0
Slc38a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391596,585,267 - 96,597,609 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1596,585,273 - 96,597,611 (-)EnsemblGRCm39 Ensembl
GRCm381596,687,392 - 96,699,728 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1596,687,392 - 96,699,730 (-)EnsemblGRCm38mm10GRCm38
MGSCv371596,517,823 - 96,530,129 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361596,515,426 - 96,527,732 (-)NCBIMGSCv36mm8
Celera1598,833,619 - 98,845,915 (-)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1552.6NCBI
Slc38a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555005,516,039 - 5,531,758 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555005,517,323 - 5,530,055 (-)NCBIChiLan1.0ChiLan1.0
SLC38A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21047,794,056 - 47,808,779 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11247,790,814 - 47,805,537 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01242,359,637 - 42,374,251 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11243,230,007 - 43,244,343 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1243,230,007 - 43,244,343 (+)Ensemblpanpan1.1panPan2
SLC38A2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1278,056,289 - 8,068,988 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl278,018,880 - 8,066,331 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2738,238,710 - 38,252,924 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0278,254,344 - 8,268,583 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl278,254,335 - 8,268,583 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1278,062,404 - 8,076,598 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0278,101,404 - 8,115,453 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02738,478,220 - 38,492,460 (-)NCBIUU_Cfam_GSD_1.0
Slc38a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494568,607,736 - 68,620,985 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365124,543,820 - 4,557,142 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365124,543,845 - 4,557,118 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC38A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl577,113,494 - 77,127,650 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1577,113,491 - 77,127,715 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2580,036,344 - 80,050,518 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC38A2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11142,580,934 - 42,595,484 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1142,580,913 - 42,595,484 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037203,832,120 - 203,846,680 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc38a2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248165,888,414 - 5,902,897 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248165,888,447 - 5,902,009 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc38a2
33 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:359
Count of miRNA genes:212
Interacting mature miRNAs:267
Transcripts:ENSRNOT00000039002
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7119513385135012528Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7112729683133492707Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7112308254133492884Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat

Markers in Region
RH129210  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27127,853,601 - 127,853,784 (+)MAPPERmRatBN7.2
Rnor_6.07138,090,989 - 138,091,171NCBIRnor6.0
Rnor_5.07137,718,466 - 137,718,648UniSTSRnor5.0
RGSC_v3.47135,367,507 - 135,367,689UniSTSRGSC3.4
Celera7124,357,772 - 124,357,954UniSTS
RH 3.4 Map71094.6UniSTS
Cytogenetic Map7q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000039002   ⟹   ENSRNOP00000031532
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7127,851,267 - 127,863,436 (-)Ensembl
Rnor_6.0 Ensembl7138,088,649 - 138,100,841 (-)Ensembl
RefSeq Acc Id: NM_181090   ⟹   NP_851604
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87129,730,450 - 129,742,619 (-)NCBI
mRatBN7.27127,851,267 - 127,863,436 (-)NCBI
Rnor_6.07138,088,654 - 138,100,823 (-)NCBI
Rnor_5.07137,716,131 - 137,728,346 (-)NCBI
RGSC_v3.47135,365,172 - 135,377,341 (-)RGD
Celera7124,355,437 - 124,367,606 (-)RGD
Sequence:
RefSeq Acc Id: XM_063263126   ⟹   XP_063119196
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87129,730,450 - 129,741,675 (-)NCBI
RefSeq Acc Id: NP_851604   ⟸   NM_181090
- UniProtKB: Q9JHE5 (UniProtKB/Swiss-Prot),   Q9JI88 (UniProtKB/Swiss-Prot),   A6KC25 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000031532   ⟸   ENSRNOT00000039002
RefSeq Acc Id: XP_063119196   ⟸   XM_063263126
- Peptide Label: isoform X1
Protein Domains
Amino acid transporter transmembrane

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JHE5-F1-model_v2 AlphaFold Q9JHE5 1-504 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695609
Promoter ID:EPDNEW_R6134
Type:single initiation site
Name:Slc38a2_1
Description:solute carrier family 38, member 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07138,100,825 - 138,100,885EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69420 AgrOrtholog
BioCyc Gene G2FUF-32242 BioCyc
Ensembl Genes ENSRNOG00000006305 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055012707 UniProtKB/Swiss-Prot
  ENSRNOG00060006650 UniProtKB/Swiss-Prot
  ENSRNOG00065019116 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000039002.4 UniProtKB/Swiss-Prot
  ENSRNOT00055021710 UniProtKB/Swiss-Prot
  ENSRNOT00060010897 UniProtKB/Swiss-Prot
  ENSRNOT00065032133 UniProtKB/Swiss-Prot
InterPro AA_transpt_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29642 UniProtKB/Swiss-Prot
NCBI Gene 29642 ENTREZGENE
PANTHER AMINO ACID TRANSPORTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Aa_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Slc38a2 PhenoGen
RatGTEx ENSRNOG00000006305 RatGTEx
  ENSRNOG00055012707 RatGTEx
  ENSRNOG00060006650 RatGTEx
  ENSRNOG00065019116 RatGTEx
TIGR TC228698
UniProt A6KC25 ENTREZGENE, UniProtKB/TrEMBL
  Q9JHE5 ENTREZGENE
  Q9JI88 ENTREZGENE
  S38A2_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q9JI88 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Slc38a2  solute carrier family 38, member 2      Symbol and Name updated 629477 APPROVED
2003-03-06 Slc38a2  solute carrier family 38, member 2  Ata2  amino acid transporter system A2  Data merged from RGD:69646 628472 PROVISIONAL
2002-06-10 Ata2  amino acid transporter system A2      Symbol and Name status set to approved 70586 APPROVED
2002-06-10 Slc38a2  solute carrier family 38, member 2      Name updated 70584 APPROVED
2002-02-27 Slc38a2  solute carrier family 38, member 2      Symbol and Name updated to reflect Human and Mouse nomenclature 70292 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localizes to the plasma membrane 68921
gene_function transports short chain neutral amino acids and amino acids with N-methyl substitutions 68921
gene_process functions as a substrate for oxidative metabolism and as a vehicle for nitrogen transport 68921
gene_process may have a role in a-keto glutarate generation 68921
gene_protein 55 kDa 68920
gene_regulation increased localization from endosomal compartments to the plasma membrane is mediated by Insulin 1299211