Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69420
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc38a2
Name: solute carrier family 38, member 2
Acc ID: CHEBI:29866
Term: arsenite(3-)
Definition: An arsenite ion resulting from the removal of all three protons from the hydroxy groups of arsenous acid.
Chemical ID: MESH:C015001
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc38a2increases expressionISOSLC38A2 (Homo sapiens)6480464CTDarsenite results in increased expression of SLC38A2 mRNAPMID:22215663
Slc38a2increases expressionISOSlc38a2 (Mus musculus)6480464CTDarsenite results in increased expression of SLC38A2 mRNAPMID:22215663
Slc38a2multiple interactionsISOSLC38A2 (Homo sapiens)6480464CTDarsenite inhibits the reaction [G3BP1 protein binds to SLC38A2 mRNA]; ATF4 mutant form inhibits the reaction [arsenite results in increased expression of SLC38A2 mRNA]; ATF4 mutant form inhibits the reaction [arsenite results in increased expression of SLC38A2 protein]; SLC38A2 mutant form inhibits the reaction [arsenite results in increased expression of DDIT3 mRNA]; SLC38A2 mutant form inhibits the reaction [arsenite results in increased expression of DDIT3 protein]; SLC38A2 mutant form inhibits the reaction [arsenite results in increased phosphorylation of RPS6KB1 protein]; SLC38A2 mutant form inhibits the reaction [arsenite results in increased splicing of XBP1 mRNA]PMID:22215663 PMID:32406909
Slc38a2multiple interactionsISOSlc38a2 (Mus musculus)6480464CTD4-phenylbutyric acid inhibits the reaction [arsenite results in increased expression of SLC38A2 mRNA]; Acetylcysteine inhibits the reaction [arsenite results in increased expression of SLC38A2 mRNA]; arsenite results in increased expression of and results in increased activity of SLC38A2 protein; SLC38A2 mutant form inhibits the reaction [arsenite results in increased transport of 2-(methylamino)isobutyric acid]PMID:22215663
Go Back to source page   Continue to Ontology report