Cygb (cytoglobin) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Cygb (cytoglobin) Rattus norvegicus
Analyze
Symbol: Cygb
Name: cytoglobin
RGD ID: 69415
Description: Enables heme binding activity; nitric oxide dioxygenase activity, heme protein as donor; and peroxidase activity. Involved in several processes, including negative regulation of collagen biosynthetic process; negative regulation of hepatic stellate cell activation; and nitric oxide catabolic process. Located in cytoplasm. Used to study liver cirrhosis and renal fibrosis. Biomarker of kidney disease and liver cirrhosis. Orthologous to human CYGB (cytoglobin); INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Glnf; globin f; HGb; histoglobin; MGC95105; nitric oxygen dioxygenase CYGB; nitrite reductase CYGB; pseudoperoxidase CYGB; Staap; Stap; stellate cell activation associated protein; stellate cell activation-associated protein; superoxide dismutase CYGB
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810102,376,506 - 102,386,272 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl10102,376,507 - 102,386,272 (-)EnsemblGRCr8
mRatBN7.210101,877,675 - 101,887,442 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10101,877,676 - 101,887,442 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx10106,934,815 - 106,944,558 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010106,397,907 - 106,407,650 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010101,798,546 - 101,808,312 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.010105,618,325 - 105,628,091 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10105,618,326 - 105,628,091 (-)Ensemblrn6Rnor6.0
Rnor_5.010105,280,904 - 105,290,670 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.410106,759,885 - 106,769,651 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera10100,448,536 - 100,458,302 (-)NCBICelera
RGSC_v3.110106,774,389 - 106,784,155 (-)NCBI
Cytogenetic Map10q32.2NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acetamide  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-naphthoflavone  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arachidonic acid  (EXP)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
Benzo[ghi]perylene  (ISO)
beta-naphthoflavone  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
butan-1-ol  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfide  (ISO)
cantharidin  (ISO)
carbon nanotube  (ISO)
cerium trichloride  (ISO)
chlorogenic acid  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
cisplatin  (EXP,ISO)
cocaine  (EXP)
cyclosporin A  (ISO)
cyfluthrin  (ISO)
cypermethrin  (ISO)
D-glucose  (ISO)
dextran sulfate  (ISO)
diallyl disulfide  (EXP)
diarsenic trioxide  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
epalrestat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
ethylparaben  (ISO)
EUK-134  (ISO)
Evodiamine  (ISO)
fenthion  (ISO)
flavonoids  (EXP)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glucose  (ISO)
hydrogen peroxide  (EXP)
inulin  (ISO)
iron(III) nitrilotriacetate  (EXP)
isobutanol  (ISO)
L-cysteine  (EXP)
L-methionine  (EXP)
lanthanum trichloride  (ISO)
lead(0)  (ISO)
Licochalcone B  (ISO)
linoleic acid hydroperoxide  (EXP)
lithium atom  (ISO)
lithium hydride  (ISO)
lycopene  (EXP)
methidathion  (ISO)
microcystin-LR  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-nitrosodiethylamine  (EXP)
nickel sulfate  (ISO)
ochratoxin A  (EXP)
okadaic acid  (ISO)
Osajin  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
permethrin  (EXP)
Pomiferin  (ISO)
puerarin  (ISO)
Pyridostigmine bromide  (EXP)
quercetin  (ISO)
quinolin-8-ol  (ISO)
resveratrol  (ISO)
Rosavin  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
trichloroethene  (EXP)
triclosan  (ISO)
tunicamycin  (ISO)
umbelliferone  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IDA,IEA,ISO,NAS)
cytosol  (IEA,ISO)
neuron projection  (IEA,ISO)
neuronal cell body  (IEA,ISO)
nuclear speck  (IEA,ISO)
nucleus  (IEA,ISO,ISS)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Characterization of a stellate cell activation-associated protein (STAP) with peroxidase activity found in rat hepatic stellate cells. Kawada N, etal., J Biol Chem 2001 Jul 6;276(27):25318-23.
3. Cytoglobin regulates blood pressure and vascular tone through nitric oxide metabolism in the vascular wall. Liu X, etal., Nat Commun. 2017 Apr 10;8:14807. doi: 10.1038/ncomms14807.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Cytoglobin, a novel globin, plays an antifibrotic role in the kidney. Mimura I, etal., Am J Physiol Renal Physiol. 2010 Nov;299(5):F1120-33. doi: 10.1152/ajprenal.00145.2010. Epub 2010 Aug 18.
6. Cytoglobin/STAP, its unique localization in splanchnic fibroblast-like cells and function in organ fibrogenesis. Nakatani K, etal., Lab Invest. 2004 Jan;84(1):91-101.
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Cytoglobin is a respiratory protein in connective tissue and neurons, which is up-regulated by hypoxia. Schmidt M, etal., J Biol Chem. 2004 Feb 27;279(9):8063-9. Epub 2003 Dec 3.
12. Cytoglobin overexpression protects against damage-induced fibrosis. Xu R, etal., Mol Ther. 2006 Jun;13(6):1093-100. Epub 2006 Apr 3.
Additional References at PubMed
PMID:11919282   PMID:12477932   PMID:15489334   PMID:16750520   PMID:19147491   PMID:20230802   PMID:20511233   PMID:21084849   PMID:21224051   PMID:23306842   PMID:23585565   PMID:26312997  


Genomics

Comparative Map Data
Cygb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810102,376,506 - 102,386,272 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl10102,376,507 - 102,386,272 (-)EnsemblGRCr8
mRatBN7.210101,877,675 - 101,887,442 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10101,877,676 - 101,887,442 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx10106,934,815 - 106,944,558 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010106,397,907 - 106,407,650 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010101,798,546 - 101,808,312 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.010105,618,325 - 105,628,091 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10105,618,326 - 105,628,091 (-)Ensemblrn6Rnor6.0
Rnor_5.010105,280,904 - 105,290,670 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.410106,759,885 - 106,769,651 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera10100,448,536 - 100,458,302 (-)NCBICelera
RGSC_v3.110106,774,389 - 106,784,155 (-)NCBI
Cytogenetic Map10q32.2NCBI
CYGB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381776,527,356 - 76,551,193 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1776,527,356 - 76,551,175 (-)Ensemblhg38GRCh38
GRCh371774,523,438 - 74,533,791 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361772,035,035 - 72,045,377 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341772,035,034 - 72,045,377NCBI
Celera1771,115,779 - 71,126,119 (-)NCBICelera
Cytogenetic Map17q25.1NCBI
HuRef1769,951,063 - 69,961,627 (-)NCBIHuRef
CHM1_11774,588,377 - 74,598,946 (-)NCBICHM1_1
T2T-CHM13v2.01777,424,099 - 77,449,394 (-)NCBIT2T-CHM13v2.0
Cygb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911116,536,421 - 116,544,887 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11116,536,421 - 116,545,139 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3811116,645,595 - 116,654,504 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11116,645,595 - 116,654,313 (-)Ensemblmm10GRCm38
MGSCv3711116,506,909 - 116,515,627 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3611116,461,685 - 116,470,403 (-)NCBIMGSCv36mm8
Celera11128,416,859 - 128,425,516 (-)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1181.45NCBI
Cygb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555065,766,006 - 5,775,784 (+)Ensembl
ChiLan1.0NW_0049555065,766,006 - 5,775,722 (+)NCBIChiLan1.0ChiLan1.0
CYGB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21992,570,565 - 92,601,134 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11797,395,777 - 97,406,085 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01770,475,651 - 70,485,987 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11776,167,003 - 76,178,247 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1776,167,947 - 76,179,412 (-)EnsemblpanPan2panpan1.1
CYGB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.194,191,114 - 4,201,438 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl94,184,959 - 4,200,164 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha94,872,569 - 4,881,413 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.094,867,061 - 4,877,257 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl94,867,055 - 4,875,983 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.194,892,392 - 4,901,203 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.095,012,299 - 5,021,092 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.095,093,431 - 5,102,251 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cygb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056024,798,176 - 4,809,539 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365941,604,710 - 1,613,783 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365941,602,436 - 1,613,783 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYGB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1124,977,245 - 4,988,283 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2124,829,817 - 4,840,005 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CYGB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11645,140,130 - 45,151,068 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1645,140,284 - 45,151,082 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607715,877,603 - 15,891,518 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cygb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248016,384,213 - 6,395,979 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248016,385,771 - 6,395,705 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Cygb
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1967,417,071 - 67,426,660 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cygb
29 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:218
Count of miRNA genes:143
Interacting mature miRNAs:181
Transcripts:ENSRNOT00000016067
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093723381107556066Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1058073360103073360Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076951790107713808Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)1079272424102982300Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1073599825107713808Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1089039175107713808Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
1576313Pia25Pristane induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096620293107713808Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
1578672Bmd16Bone mineral density QTL 166.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)1097202388107556066Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1576307Cia28Collagen induced arthritis QTL 28joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096620293107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087807758107713808Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1076128947107713808Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1091127270107556066Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
61436Cia5Collagen induced arthritis QTL 54.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1091727883107713808Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
1578663Bss18Bone structure and strength QTL 183.6femur width (VT:1000666)femoral neck width (CMO:0001695)1097202388107556066Rat

Markers in Region
RH133332  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210101,877,700 - 101,877,883 (+)MAPPERmRatBN7.2
Rnor_6.010105,618,351 - 105,618,533NCBIRnor6.0
Rnor_5.010105,280,930 - 105,281,112UniSTSRnor5.0
RGSC_v3.410106,759,911 - 106,760,093UniSTSRGSC3.4
Celera10100,448,562 - 100,448,744UniSTS
Cytogenetic Map10q32.3UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 153 91 90 59 54 59 6 315 154 11 132 78 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000016067   ⟹   ENSRNOP00000016067
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl10102,376,507 - 102,386,272 (-)Ensembl
mRatBN7.2 Ensembl10101,877,676 - 101,887,442 (-)Ensembl
Rnor_6.0 Ensembl10105,618,326 - 105,628,091 (-)Ensembl
RefSeq Acc Id: NM_130744   ⟹   NP_570100
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810102,376,506 - 102,386,272 (-)NCBI
mRatBN7.210101,877,675 - 101,887,442 (-)NCBI
Rnor_6.010105,618,325 - 105,628,091 (-)NCBI
Rnor_5.010105,280,904 - 105,290,670 (-)NCBI
RGSC_v3.410106,759,885 - 106,769,651 (-)RGD
Celera10100,448,536 - 100,458,302 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_570100 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH88455 (Get FASTA)   NCBI Sequence Viewer  
  CAC59827 (Get FASTA)   NCBI Sequence Viewer  
  EDM06685 (Get FASTA)   NCBI Sequence Viewer  
  EDM06686 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000016067
  ENSRNOP00000016067.4
GenBank Protein Q921A4 (Get FASTA)   NCBI Sequence Viewer  
  SAI82220 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_570100   ⟸   NM_130744
- UniProtKB: Q921A4 (UniProtKB/Swiss-Prot),   A0A1K0GY57 (UniProtKB/TrEMBL),   A6HKY0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016067   ⟸   ENSRNOT00000016067
Protein Domains
GLOBIN

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q921A4-F1-model_v2 AlphaFold Q921A4 1-190 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697920
Promoter ID:EPDNEW_R8445
Type:single initiation site
Name:Cygb_1
Description:cytoglobin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.010105,628,101 - 105,628,161EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69415 AgrOrtholog
BioCyc Gene G2FUF-22592 BioCyc
Ensembl Genes ENSRNOG00000011541 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000016067 ENTREZGENE
  ENSRNOT00000016067.5 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.490.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7127197 IMAGE-MGC_LOAD
InterPro Globin UniProtKB/Swiss-Prot
  Globin-like_sf UniProtKB/Swiss-Prot
  Globin/Proto UniProtKB/Swiss-Prot
  Globin_lamprey/hagfish UniProtKB/Swiss-Prot
KEGG Report rno:170520 UniProtKB/Swiss-Prot
MGC_CLONE MGC:95105 IMAGE-MGC_LOAD
NCBI Gene 170520 ENTREZGENE
PANTHER CYTOGLOBIN UniProtKB/Swiss-Prot
  PTHR46783 UniProtKB/Swiss-Prot
Pfam Globin UniProtKB/Swiss-Prot
PhenoGen Cygb PhenoGen
PRINTS FISHGLOBIN UniProtKB/Swiss-Prot
PROSITE GLOBIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011541 RatGTEx
Superfamily-SCOP SSF46458 UniProtKB/Swiss-Prot
UniProt A0A1K0GY57 ENTREZGENE, UniProtKB/TrEMBL
  A6HKY0 ENTREZGENE, UniProtKB/TrEMBL
  CYGB_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Cygb  cytoglobin  Staap  stellate cell activation associated protein  Symbol and Name updated 1299863 APPROVED
2002-06-10 Staap  stellate cell activation associated protein      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease increased expression in fibrotic liver tissues is induced by thioacetamide (TAA) administration; functions in the development of liver fibrosis 68672
gene_function peroxidase that catabolizes hydrogen peroxide and lipid hydroperoxides 68672
gene_process may play a role as an antifibrotic scavenger of peroxides in the liver 68672
gene_protein 190 amino acids 68672
gene_regulation expression dramatically increased in fibrotic liver tissues induced by thioacetamide (TAA) administration 68672
gene_regulation heavily up-regulated both in in vitro and in vivo activated stellate cells 68672