Lcn2 (lipocalin 2) - Rat Genome Database

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Gene: Lcn2 (lipocalin 2) Rattus norvegicus
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Symbol: Lcn2
Name: lipocalin 2
RGD ID: 69408
Description: Enables enterobactin binding activity; identical protein binding activity; and protease binding activity. Involved in several processes, including cellular response to cytokine stimulus; memory; and regulation of hippocampal neuron apoptotic process. Located in extracellular space. Used to study intrahepatic cholangiocarcinoma and retinal degeneration. Biomarker of several diseases, including acute kidney failure; congenital diaphragmatic hernia; obesity; transient cerebral ischemia; and traumatic brain injury. Human ortholog(s) of this gene implicated in urinary tract infection. Orthologous to human LCN2 (lipocalin 2); INTERACTS WITH (+)-schisandrin B; (-)-citrinin; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: alpha-2-microglobulin-related protein; alpha-2U globulin-related protein; lipocalin 2 (oncogene 24p3); lipocalin 24p3; lipocalin-2; neutrophil gelatinase-associated lipocalin; NGAL; p25; siderocalin LCN2; Sip24
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8336,078,432 - 36,081,851 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl336,078,436 - 36,081,842 (-)EnsemblGRCr8
mRatBN7.2315,680,688 - 15,684,033 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl315,680,687 - 15,684,095 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx318,749,510 - 18,752,856 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0327,334,505 - 27,337,851 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0325,585,359 - 25,588,705 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0311,414,189 - 11,417,534 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl311,414,186 - 11,417,546 (-)Ensemblrn6Rnor6.0
Rnor_5.0316,763,059 - 16,766,404 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4311,511,402 - 11,514,747 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera310,423,569 - 10,426,914 (-)NCBICelera
RGSC_v3.1311,407,773 - 11,411,119 (-)NCBI
Cytogenetic Map3p12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
Abscess  (IEP)
acute cystitis  (ISO)
acute kidney failure  (IEP,ISO)
adult respiratory distress syndrome  (ISO)
amyotrophic lateral sclerosis  (IEP)
Animal Hepatitis  (ISO)
autosomal dominant polycystic kidney disease  (ISO)
beta thalassemia  (ISO)
calcinosis  (ISO)
celiac disease  (ISO)
Cerebral Hemorrhage  (IEP)
Chemical and Drug Induced Liver Injury  (ISO)
Chlamydophila Infections  (ISO)
chronic kidney disease  (ISO)
colon cancer  (IEP)
congenital diaphragmatic hernia  (IEP,ISO)
contact dermatitis  (ISO)
Contrast-Induced Nephropathy  (IEP)
COVID-19  (ISO)
Diabetic Nephropathies  (IEP,ISO)
disease of cellular proliferation  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (ISO)
Escherichia Coli Infections  (ISO)
essential hypertension  (ISO)
Experimental Diabetes Mellitus  (IEP)
Experimental Liver Cirrhosis  (ISO)
Experimental Radiation Injuries  (IEP)
Haemophilus Infections  (ISO)
heart valve disease  (ISO)
Helicobacter Infections  (ISO)
hidradenitis suppurativa  (ISO)
hydronephrosis  (ISO)
hyperuricemia  (ISO)
IgA glomerulonephritis  (ISO)
Inflammation  (ISO)
intrahepatic cholangiocarcinoma  (IDA,ISO)
kidney disease  (ISO)
Kidney Reperfusion Injury  (IEP,ISO)
Klebsiella pneumonia  (ISO)
myocardial infarction  (ISO)
myocarditis  (IEP)
Neoplasm Metastasis  (ISO)
obesity  (IEP,ISO)
oral candidiasis  (ISO)
pneumonia  (ISO)
polycystic kidney disease  (ISO)
pre-eclampsia  (ISO)
pulmonary hypertension  (IEP,ISO)
pulmonary tuberculosis  (ISO)
renal fibrosis  (ISO)
Renal Ischemia  (ISO)
renovascular hypertension  (ISO)
retinal degeneration  (IDA,IMP)
rheumatoid arthritis  (ISO)
Sepsis  (ISO)
Streptococcal Infections  (ISO)
stroke  (ISO)
Subarachnoid Hemorrhage  (ISO)
transient cerebral ischemia  (IEP)
traumatic brain injury  (IEP)
type 2 diabetes mellitus  (ISO)
urinary tract infection  (ISO)
uveitis  (IEP)
West Nile encephalitis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-citrinin  (EXP)
1,1-dichloroethene  (ISO)
1-aminobenzotriazole  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
11-deoxycorticosterone  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-hydroxypropanoic acid  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-dichloroaniline  (EXP,ISO)
3-chloropropane-1,2-diol  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
8-anilinonaphthalene-1-sulfonic acid  (ISO)
9-cis-retinoic acid  (ISO)
acetylsalicylic acid  (EXP)
Actein  (EXP)
adefovir  (EXP)
adefovir pivoxil  (ISO)
adenine  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
agomelatine  (EXP)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (ISO)
allopurinol  (EXP)
aluminium oxide  (ISO)
amlodipine  (EXP)
ammonium chloride  (EXP)
amphotericin B  (ISO)
amphotericin B methyl ester  (ISO)
anethole  (EXP)
anthocyanin  (EXP)
aristolochic acid A  (EXP)
arsenous acid  (ISO)
atorvastatin calcium  (EXP,ISO)
Azoxymethane  (EXP)
bacitracin  (EXP)
benzo[a]pyrene  (ISO)
Benzo[ghi]perylene  (ISO)
berberine  (EXP)
beta-D-glucosamine  (ISO)
beta-lapachone  (ISO)
bicalutamide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
Botulinum toxin type A  (ISO)
brequinar  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (EXP,ISO)
C60 fullerene  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calciol  (EXP)
calcitriol  (ISO)
calcium carbonate  (EXP)
cannabidiol  (ISO)
carbon nanotube  (EXP,ISO)
carmustine  (EXP,ISO)
carnosic acid  (ISO)
chenodeoxycholic acid  (ISO)
chlordecone  (ISO)
chloroquine  (EXP)
cholesterol  (ISO)
choline  (ISO)
cilnidipine  (EXP)
ciprofibrate  (ISO)
ciprofloxacin  (ISO)
cisplatin  (EXP,ISO)
clemizole  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
cordycepin  (ISO)
corn oil  (EXP)
corosolic acid  (ISO)
crocidolite asbestos  (ISO)
curcumin  (EXP,ISO)
cyanuric acid  (EXP)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
D-glucose  (ISO)
dapagliflozin  (EXP)
DDE  (ISO)
decabromodiphenyl ether  (EXP)
deferasirox  (EXP,ISO)
deoxycholic acid  (ISO)
desferrioxamine B  (EXP,ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
Di-n-octyl phthalate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (EXP,ISO)
dieldrin  (EXP)
diethyl phthalate  (EXP,ISO)
diethylstilbestrol  (EXP,ISO)
diisobutyl phthalate  (EXP,ISO)
diisononyl phthalate  (EXP,ISO)
dioxygen  (EXP,ISO)
diquat  (ISO)
diuron  (EXP)
doxorubicin  (EXP,ISO)
doxycycline  (ISO)
enilconazole  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
etoposide  (EXP)
fentanyl  (EXP)
fenvalerate  (EXP)
ferric ammonium citrate  (ISO)
ferrostatin-1  (EXP,ISO)
fluconazole  (EXP)
folic acid  (ISO)
fomepizole  (ISO)
fragrance  (ISO)
fructose  (EXP,ISO)
fumonisin B1  (ISO)
furan  (ISO)
gefitinib  (ISO)
gemfibrozil  (ISO)
genistein  (ISO)
gentamycin  (EXP,ISO)
glafenine  (EXP)
glucose  (ISO)
glycidol  (ISO)
glycidyl methacrylate  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
graphene oxide  (ISO)
graphite  (EXP)
herbacetin  (EXP)
Hexachloro-1,3-butadiene  (EXP)
hexachlorobenzene  (EXP)
hydroquinone  (ISO)
hypoxanthine  (ISO)
icariin  (EXP,ISO)
inositol  (ISO)
iohexol  (EXP)
iomeprol  (EXP)
iron atom  (ISO)
iron(0)  (ISO)
isocyanuric acid  (EXP)
isoniazide  (EXP)
isoprenaline  (ISO)
isotretinoin  (ISO)
ketamine  (ISO)
ketoconazole  (EXP)
L-methionine  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
lovastatin  (ISO)
madecassoside  (ISO)
maleic acid  (EXP)
Mecamylamine  (ISO)
medroxyprogesterone acetate  (ISO)
melamine  (EXP)
mercury atom  (EXP)
mercury dichloride  (EXP,ISO)
mercury(0)  (EXP)
metformin  (EXP)
methimazole  (EXP)
methotrexate  (EXP)
methoxychlor  (EXP)
methylmercury chloride  (EXP,ISO)
microcystin-LR  (ISO)
morphine  (ISO)
Muraglitazar  (EXP)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
natamycin  (ISO)
nevirapine  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP)
nickel sulfate  (ISO)
nifedipine  (EXP)
nitrofen  (EXP)
Nutlin-3  (ISO)
nystatin  (ISO)
ochratoxin A  (EXP,ISO)
Ondansetron  (ISO)
oxybenzone  (ISO)
ozone  (ISO)
palmitoyl ethanolamide  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
phenobarbital  (ISO)
phenylarsine oxide  (ISO)
PhIP  (EXP)
pinostrobin  (EXP)
pirinixic acid  (ISO)
Potassium 2,6-dihydroxytriazinecarboxylate  (ISO)
potassium bromate  (ISO)
prednisolone  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
procymidone  (ISO)
progesterone  (ISO)
propanal  (ISO)
propiconazole  (ISO)
protein kinase inhibitor  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quartz  (EXP)
rac-lactic acid  (ISO)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
Rhynchophylline  (ISO)
ritodrine  (ISO)
rotenone  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
S-nitrosoglutathione  (ISO)
Salinomycin  (ISO)
senecionine  (ISO)
serpentine asbestos  (ISO)
sevoflurane  (ISO)
silicon dioxide  (EXP,ISO)
sirolimus  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium benzoate  (ISO)
sodium dichromate  (EXP)
sodium dodecyl sulfate  (ISO)
Soman  (EXP)
streptozocin  (EXP,ISO)
succimer  (ISO)
tacrolimus hydrate  (EXP,ISO)
tamoxifen  (ISO)
tannic acid  (EXP)
tartrazine  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetrathiomolybdate(2-)  (ISO)
thallium atom  (EXP)
thallium sulfate  (EXP)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (EXP,ISO)
trans-anethole  (EXP)
trichloroethene  (EXP,ISO)
trimethyltin  (ISO)
triptonide  (ISO)
troglitazone  (EXP)
tungsten  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)
vanillin  (EXP)
vildagliptin  (EXP)
vinclozolin  (EXP)
xylazine  (ISO)
zinc protoporphyrin  (EXP)
zoledronic acid  (ISO)
zomepirac  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute-phase response  (IEP)
apoptotic process  (IEA)
cellular response to amyloid-beta  (IEP)
cellular response to hydrogen peroxide  (IDA)
cellular response to hypoxia  (IEP)
cellular response to increased oxygen levels  (IEP)
cellular response to interleukin-1  (IEP)
cellular response to interleukin-6  (IEP)
cellular response to lipopolysaccharide  (IEP)
cellular response to nerve growth factor stimulus  (IEP)
cellular response to nutrient levels  (IEP)
cellular response to tumor necrosis factor  (IEP)
cellular response to X-ray  (IEP)
defense response to bacterium  (IEA,ISO,ISS)
extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
immune system process  (IEA)
innate immune response  (IEA,ISO,ISS)
iron ion transport  (IEA)
long-term memory  (IMP)
monoatomic ion transport  (IEA)
negative regulation of hippocampal neuron apoptotic process  (IMP)
positive regulation of apoptotic process  (IGI)
positive regulation of cell projection organization  (IDA)
positive regulation of cold-induced thermogenesis  (IEA,ISO,ISS)
positive regulation of endothelial cell migration  (IDA)
positive regulation of endothelial tube morphogenesis  (IDA)
positive regulation of gene expression  (IDA)
positive regulation of hippocampal neuron apoptotic process  (IDA)
positive regulation of iron ion import across plasma membrane  (IDA)
positive regulation of neuron apoptotic process  (IMP)
positive regulation of reactive oxygen species biosynthetic process  (IDA)
positive regulation of reactive oxygen species metabolic process  (IMP)
response to bacterium  (IEP,ISO)
response to blue light  (IEP)
response to fructose  (IEP)
response to herbicide  (IDA)
response to iron(II) ion  (IEP)
response to kainic acid  (IEP)
response to lipopolysaccharide  (IEP)
response to mycotoxin  (IEP)
response to nutrient levels  (IEP)
response to oxidative stress  (IEP)
response to toxic substance  (IEP)
response to virus  (ISO)
response to xenobiotic stimulus  (IEP,IMP,ISO)
short-term memory  (IMP)
siderophore transport  (IEA,ISO,ISS)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Urinary NGAL and KIM-1: biomarkers for assessment of acute ischemic kidney injury following nephron sparing surgery. Abassi Z, etal., J Urol. 2013 Apr;189(4):1559-66. doi: 10.1016/j.juro.2012.10.029. Epub 2012 Oct 22.
2. Neutrophil gelatinase-associated lipocalin (NGAL/Lcn2) is upregulated in gastric mucosa infected with Helicobacter pylori. Alpízar-Alpízar W, etal., Virchows Arch. 2009 Sep;455(3):225-33. doi: 10.1007/s00428-009-0825-8.
3. Early urinary and plasma biomarkers for experimental diabetic nephropathy. Alter ML, etal., Clin Lab. 2012;58(7-8):659-71.
4. Diet high in fructose leads to an overexpression of lipocalin-2 in rat fatty liver. Alwahsh SM, etal., World J Gastroenterol. 2014 Feb 21;20(7):1807-21. doi: 10.3748/wjg.v20.i7.1807.
5. Fructose induces tubulointerstitial injury in the kidney of mice. Aoyama M, etal., Biochem Biophys Res Commun. 2012 Mar 9;419(2):244-9. doi: 10.1016/j.bbrc.2012.02.001. Epub 2012 Feb 8.
6. Neutrophil gelatinase-associated lipocalin and interleukin-10 regulate intramacrophage Chlamydia pneumoniae replication by modulating intracellular iron homeostasis. Bellmann-Weiler R, etal., Immunobiology. 2013 Jul;218(7):969-78. doi: 10.1016/j.imbio.2012.11.004. Epub 2012 Nov 21.
7. Lipocalin 2-deficient mice exhibit increased sensitivity to Escherichia coli infection but not to ischemia-reperfusion injury. Berger T, etal., Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1834-9. doi: 10.1073/pnas.0510847103. Epub 2006 Jan 30.
8. Neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule 1 (KIM-1) as predictors of incident CKD stage 3: the Atherosclerosis Risk in Communities (ARIC) Study. Bhavsar NA, etal., Am J Kidney Dis. 2012 Aug;60(2):233-40. doi: 10.1053/j.ajkd.2012.02.336. Epub 2012 Apr 28.
9. Reactive astrocytes secrete lcn2 to promote neuron death. Bi F, etal., Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):4069-74. doi: 10.1073/pnas.1218497110. Epub 2013 Feb 19.
10. Long-term administration of aspirin inhibits tumour formation and triggers anti-neoplastic molecular changes in a pre-clinical model of colon carcinogenesis. Bousserouel S, etal., Oncol Rep. 2010 Feb;23(2):511-7.
11. Induction of neutrophil gelatinase-associated lipocalin in vascular injury via activation of nuclear factor-kappaB. Bu DX, etal., Am J Pathol. 2006 Dec;169(6):2245-53.
12. The primary structure of rat alpha 2 mu globulin-related protein. Chan YL, etal., Nucleic Acids Res 1988 Dec 9;16(23):11368.
13. Lipocalin 2 is required for pulmonary host defense against Klebsiella infection. Chan YR, etal., J Immunol. 2009 Apr 15;182(8):4947-56. doi: 10.4049/jimmunol.0803282.
14. Expression and localisation of brain-type organic cation transporter (BOCT/24p3R/LCN2R) in the normal rat hippocampus and after kainate-induced excitotoxicity. Chia WJ, etal., Neurochem Int. 2015 Aug;87:43-59. doi: 10.1016/j.neuint.2015.04.009. Epub 2015 May 21.
15. Chemopreventive and chemotherapeutic effect of dietary supplementation of vitamin D on cholangiocarcinoma in a Chemical-Induced animal model. Chiang KC, etal., Oncotarget. 2014 Jun 15;5(11):3849-61. doi: 10.18632/oncotarget.2000.
16. Lipocalin-2 Functions as Inhibitor of Innate Resistance to Mycobacterium tuberculosis. Dahl SL, etal., Front Immunol. 2018 Nov 26;9:2717. doi: 10.3389/fimmu.2018.02717. eCollection 2018.
17. The gonadal expression pattern of lipocalin‑2 and 24p3 receptor is modified in the gonads of the offspring of obese rats. De La Chesnaye E, etal., Mol Med Rep. 2020 Aug;22(2):1409-1419. doi: 10.3892/mmr.2020.11226. Epub 2020 Jun 12.
18. Lipocalin-2/Neutrophil Gelatinase-B Associated Lipocalin is Strongly Induced in Hearts of Rats With Autoimmune Myocarditis and in Human Myocarditis. Ding L, etal., Circ J. 2010 Jan 7.
19. Role of iron in brain lipocalin 2 upregulation after intracerebral hemorrhage in rats. Dong M, etal., Brain Res. 2013 Apr 10;1505:86-92. doi: 10.1016/j.brainres.2013.02.008. Epub 2013 Feb 15.
20. Lipocalin 2 and Blood-Brain Barrier Disruption in White Matter after Experimental Subarachnoid Hemorrhage. Egashira Y, etal., Acta Neurochir Suppl. 2016;121:131-4. doi: 10.1007/978-3-319-18497-5_23.
21. Chronic renovascular hypertension is associated with elevated levels of neutrophil gelatinase-associated lipocalin. Eirin A, etal., Nephrol Dial Transplant. 2012 Nov;27(11):4153-61. doi: 10.1093/ndt/gfs370. Epub 2012 Aug 23.
22. Novel urinary biomarkers and the early detection of acute kidney injury after open cardiac surgeries. Elmedany SM, etal., J Crit Care. 2017 Aug;40:171-177. doi: 10.1016/j.jcrc.2017.03.029. Epub 2017 Apr 6.
23. Interleukin-17-induced protein lipocalin 2 is dispensable for immunity to oral candidiasis. Ferreira MC, etal., Infect Immun. 2014 Mar;82(3):1030-5. doi: 10.1128/IAI.01389-13. Epub 2013 Dec 16.
24. Inflammation Profiling of Critically Ill Coronavirus Disease 2019 Patients. Fraser DD, etal., Crit Care Explor. 2020 Jun 22;2(6):e0144. doi: 10.1097/CCE.0000000000000144. eCollection 2020 Jun.
25. Changes of the tubular markers in type 2 diabetes mellitus with glomerular hyperfiltration. Fu WJ, etal., Diabetes Res Clin Pract. 2012 Jan;95(1):105-9. doi: 10.1016/j.diabres.2011.09.031. Epub 2011 Oct 20.
26. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
27. Expression of acute-phase response proteins in retinal Muller cells in diabetes. Gerhardinger C, etal., Invest Ophthalmol Vis Sci. 2005 Jan;46(1):349-57.
28. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
29. Lipocalin-2 deficiency impairs thermogenesis and potentiates diet-induced insulin resistance in mice. Guo H, etal., Diabetes. 2010 Jun;59(6):1376-85. doi: 10.2337/db09-1735. Epub 2010 Mar 23.
30. Increased urinary neutrophil gelatinase associated lipocalin levels in a rat model of upper urinary tract infection. Ichino M, etal., J Urol. 2009 May;181(5):2326-31. Epub 2009 Mar 19.
31. Lipocalin 2 in the central nervous system host response to systemic lipopolysaccharide administration. Ip JP, etal., J Neuroinflammation. 2011 Sep 26;8:124. doi: 10.1186/1742-2094-8-124.
32. The lipocalin 24p3, which is an essential molecule in IL-3 withdrawal-induced apoptosis, is not involved in the G-CSF withdrawal-induced apoptosis. Kamezaki K, etal., Eur J Haematol 2003 Dec;71(6):412-7.
33. Nerve growth factor increases MMP9 activity in annulus fibrosus cells by upregulating lipocalin 2 expression. Kao TH, etal., Eur Spine J. 2015 Sep;24(9):1959-68. doi: 10.1007/s00586-014-3675-2. Epub 2014 Nov 21.
34. Microarray reveals complement components are regulated in the serum-deprived rat retinal ganglion cell line. Khalyfa A, etal., Mol Vis. 2007 Feb 28;13:293-308.
35. Transcriptional analysis of kidneys during repair from AKI reveals possible roles for NGAL and KIM-1 as biomarkers of AKI-to-CKD transition. Ko GJ, etal., Am J Physiol Renal Physiol. 2010 Jun;298(6):F1472-83. doi: 10.1152/ajprenal.00619.2009. Epub 2010 Feb 24.
36. Lipocalin-2 is an autocrine mediator of reactive astrocytosis. Lee S, etal., J Neurosci. 2009 Jan 7;29(1):234-49.
37. Hepatocytes and neutrophils cooperatively suppress bacterial infection by differentially regulating lipocalin-2 and neutrophil extracellular traps. Li H, etal., Hepatology. 2018 Oct;68(4):1604-1620. doi: 10.1002/hep.29919. Epub 2018 May 10.
38. Urinary Biomarkers in Relapsing Antineutrophil Cytoplasmic Antibody-associated Vasculitis. Lieberthal JG, etal., J Rheumatol. 2013 May;40(5):674-683. Epub 2013 Apr 1.
39. Downregulation of lipocalin-2 and Bim expression after remote limb preconditioning in the ischemic rat brain. Liu M, etal., Brain Res. 2018 Jan 15;1679:1-9. doi: 10.1016/j.brainres.2017.11.003. Epub 2017 Nov 6.
40. Enhanced apoptosis and decreased ampa receptors are involved in deficit in fear memory in rin1 knockout rats. Ma L, etal., J Affect Disord. 2020 May 1;268:173-182. doi: 10.1016/j.jad.2020.02.040. Epub 2020 Feb 27.
41. Lipocalin 2 modulates the cellular response to amyloid beta. Mesquita SD, etal., Cell Death Differ. 2014 Oct;21(10):1588-99. doi: 10.1038/cdd.2014.68. Epub 2014 May 23.
42. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
43. Metabolic endotoxemia and saturated fat contribute to circulating NGAL concentrations in subjects with insulin resistance. Moreno-Navarrete JM, etal., Int J Obes (Lond). 2010 Feb;34(2):240-9. doi: 10.1038/ijo.2009.242. Epub 2009 Dec 1.
44. Deletion of phospholipase A2 group IVc induces apoptosis in rat mammary tumour cells by the nuclear factor-κB/lipocalin 2 pathway. Nanashima N, etal., Biochem J. 2015 Jul 15;469(2):315-24. doi: 10.1042/BJ20150064. Epub 2015 May 27.
45. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
46. Bacterial colonization of nasal mucosa induces expression of siderocalin, an iron-sequestering component of innate immunity. Nelson AL, etal., Cell Microbiol. 2005 Oct;7(10):1404-17. doi: 10.1111/j.1462-5822.2005.00566.x.
47. The bacteriostatic protein lipocalin 2 is induced in the central nervous system of mice with west Nile virus encephalitis. Noçon AL, etal., J Virol. 2014 Jan;88(1):679-89. doi: 10.1128/JVI.02094-13. Epub 2013 Oct 30.
48. Bilirubin attenuates the renal tubular injury by inhibition of oxidative stress and apoptosis. Oh SW, etal., BMC Nephrol. 2013 May 17;14(1):105.
49. The effects of obesity and polycystic ovary syndrome on serum lipocalin-2 levels: a cross-sectional study. Panidis D, etal., Reprod Biol Endocrinol. 2010 Dec 9;8:151. doi: 10.1186/1477-7827-8-151.
50. α-Intercalated cells defend the urinary system from bacterial infection. Paragas N, etal., J Clin Invest. 2014 Jul;124(7):2963-76. doi: 10.1172/JCI71630. Epub 2014 Jun 17.
51. Evaluation of urine biomarkers of kidney injury in polycystic kidney disease. Parikh CR, etal., Kidney Int. 2012 Apr;81(8):784-90. doi: 10.1038/ki.2011.465. Epub 2012 Jan 18.
52. High urinary excretion of kidney injury molecule-1 is an independent predictor of end-stage renal disease in patients with IgA nephropathy. Peters HP, etal., Nephrol Dial Transplant. 2011 Nov;26(11):3581-8. doi: 10.1093/ndt/gfr135. Epub 2011 Apr 5.
53. Cardiotrophin-1 administration prevents the renal toxicity of iodinated contrast media in rats. Quiros Y, etal., Toxicol Sci. 2013 Apr;132(2):493-501. doi: 10.1093/toxsci/kft007. Epub 2013 Jan 18.
54. Evaluation of putative biomarkers of nephrotoxicity after exposure to ochratoxin a in vivo and in vitro. Rached E, etal., Toxicol Sci. 2008 Jun;103(2):371-81. Epub 2008 Feb 27.
55. GOA pipeline RGD automated data pipeline
56. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
57. Kidney injury biomarkers in hypertensive, diabetic, and nephropathy rat models treated with contrast media. Rouse RL, etal., Toxicol Pathol. 2013;41(4):662-80. doi: 10.1177/0192623312464122. Epub 2012 Oct 19.
58. Time-dependent hemeoxygenase-1, lipocalin-2 and ferritin induction after non-contusion traumatic brain injury. Russell NH, etal., Brain Res. 2019 Dec 15;1725:146466. doi: 10.1016/j.brainres.2019.146466. Epub 2019 Sep 17.
59. Lipocalin 2-dependent inhibition of mycobacterial growth in alveolar epithelium. Saiga H, etal., J Immunol. 2008 Dec 15;181(12):8521-7. doi: 10.4049/jimmunol.181.12.8521.
60. Calprotectin and neutrophil gelatinase-associated lipocalin in the differentiation of pre-renal and intrinsic acute kidney injury. Seibert FS, etal., Acta Physiol (Oxf). 2013 Apr;207(4):700-8. doi: 10.1111/apha.12064. Epub 2013 Feb 14.
61. Acute phase response, inflammation and metabolic syndrome biomarkers of Libby asbestos exposure. Shannahan JH, etal., Toxicol Appl Pharmacol. 2012 Apr 15;260(2):105-14. doi: 10.1016/j.taap.2012.02.006. Epub 2012 Feb 16.
62. Phosphodiesterase-5 inhibition attenuates early renal ischemia-reperfusion-induced acute kidney injury: assessment by quantitative measurement of urinary NGAL and KIM-1. Sohotnik R, etal., Am J Physiol Renal Physiol. 2013 Apr 15;304(8):F1099-104. doi: 10.1152/ajprenal.00649.2012. Epub 2013 Jan 30.
63. Lipocalin 2 deficiency dysregulates iron homeostasis and exacerbates endotoxin-induced sepsis. Srinivasan G, etal., J Immunol. 2012 Aug 15;189(4):1911-9. doi: 10.4049/jimmunol.1200892. Epub 2012 Jul 11.
64. Lipocalin 2 imparts selective pressure on bacterial growth in the bladder and is elevated in women with urinary tract infection. Steigedal M, etal., J Immunol. 2014 Dec 15;193(12):6081-9. doi: 10.4049/jimmunol.1401528. Epub 2014 Nov 14.
65. Serum Lipocalin2 is a potential biomarker of liver irradiation damage. Sultan S, etal., Liver Int. 2013 Mar;33(3):459-68. doi: 10.1111/liv.12073. Epub 2013 Jan 18.
66. LIPOCALIN-2 is a major acute-phase protein in a rat and mouse model of sterile abscess. Sultan S, etal., Shock. 2012 Feb;37(2):191-6. doi: 10.1097/SHK.0b013e31823918c2.
67. Lipocalin-2 (NGAL) Attenuates Autophagy to Exacerbate Cardiac Apoptosis Induced by Myocardial Ischemia. Sung HK, etal., J Cell Physiol. 2017 Aug;232(8):2125-2134. doi: 10.1002/jcp.25672. Epub 2017 Mar 24.
68. Lipocalin 2 Suppresses Ocular Inflammation by Inhibiting the Activation of NF-κβ Pathway in Endotoxin-Induced Uveitis. Tang W, etal., Cell Physiol Biochem. 2018;46(1):375-388. doi: 10.1159/000488472. Epub 2018 Mar 23.
69. Light-Induced Lipocalin 2 Facilitates Cellular Apoptosis by Positively Regulating Reactive Oxygen Species/Bim Signaling in Retinal Degeneration. Tang W, etal., Invest Ophthalmol Vis Sci. 2018 Dec 3;59(15):6014-6025. doi: 10.1167/iovs.18-25213.
70. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
71. Urine NGAL and KIM-1 in children and adolescents with hyperuricemia. Tomczak J, etal., Pediatr Nephrol. 2013 May 15.
72. Atorvastatin restores endothelial function in offspring of protein-restricted rats in a cholesterol-independent manner. Torrens C, etal., Hypertension. 2009 Apr;53(4):661-7. Epub 2009 Feb 16.
73. Lipocalin 2 as a new biomarker for fetal lung hypoplasia in congenital diaphragmatic hernia. Tsuda H, etal., Clin Chim Acta. 2016 Nov 1;462:71-76. doi: 10.1016/j.cca.2016.08.023. Epub 2016 Aug 31.
74. Lipocalin 2 is essential for chronic kidney disease progression in mice and humans. Viau A, etal., J Clin Invest. 2010 Nov;120(11):4065-76. doi: 10.1172/JCI42004.
75. Up-regulated lipocalin-2 in pulmonary hypertension involving in pulmonary artery SMC resistance to apoptosis. Wang G, etal., Int J Biol Sci. 2014 Jul 17;10(7):798-806. doi: 10.7150/ijbs.9470. eCollection 2014.
76. Genome-wide transcriptome profiling of region-specific vulnerability to oxidative stress in the hippocampus. Wang X, etal., Genomics. 2007 Aug;90(2):201-12. Epub 2007 Jun 5.
77. KIM-1 and NGAL: new markers of obstructive nephropathy. Wasilewska A, etal., Pediatr Nephrol. 2011 Apr;26(4):579-86. doi: 10.1007/s00467-011-1773-5. Epub 2011 Jan 31.
78. Lipocalin-2 is expressed by activated granulocytes and keratinocytes in affected skin and reflects disease activity in acne inversa/hidradenitis suppurativa. Wolk K, etal., Br J Dermatol. 2017 Nov;177(5):1385-1393. doi: 10.1111/bjd.15424. Epub 2017 Sep 19.
79. Lipocalin 2 is protective against E. coli pneumonia. Wu H, etal., Respir Res. 2010 Jul 15;11:96. doi: 10.1186/1465-9921-11-96.
80. Lipocalin-2 enhances angiogenesis in rat brain endothelial cells via reactive oxygen species and iron-dependent mechanisms. Wu L, etal., J Neurochem. 2015 Mar;132(6):622-8. doi: 10.1111/jnc.13023. Epub 2015 Jan 29.
81. Combined biomarkers evaluation for diagnosing kidney injury in preeclampsia. Xiao J, etal., Hypertens Pregnancy. 2013 Nov;32(4):439-49. doi: 10.3109/10641955.2013.827203. Epub 2013 Aug 19.
82. Neuronal production of lipocalin-2 as a help-me signal for glial activation. Xing C, etal., Stroke. 2014 Jul;45(7):2085-92. doi: 10.1161/STROKEAHA.114.005733. Epub 2014 Jun 10.
83. Liver is the major source of elevated serum lipocalin-2 levels after bacterial infection or partial hepatectomy: a critical role for IL-6/STAT3. Xu MJ, etal., Hepatology. 2015 Feb;61(2):692-702. doi: 10.1002/hep.27447.
84. Increased systemic and myocardial expression of neutrophil gelatinase-associated lipocalin in clinical and experimental heart failure. Yndestad A, etal., Eur Heart J. 2009 May;30(10):1229-36. Epub 2009 Mar 26.
85. The role of lipocalin 2 in the regulation of inflammation in adipocytes and macrophages. Zhang J, etal., Mol Endocrinol. 2008 Jun;22(6):1416-26. Epub 2008 Feb 21.
86. Down-regulation of lipocalin 2 contributes to chemoresistance in glioblastoma cells. Zheng LT, etal., J Neurochem. 2009 Dec;111(5):1238-51. Epub 2009 Oct 5.
Additional References at PubMed
PMID:2542864   PMID:12477932   PMID:16377569   PMID:16502470   PMID:16546827   PMID:17490638   PMID:19056867   PMID:20550936   PMID:21457438   PMID:21551085   PMID:22117066   PMID:22278021  
PMID:22349381   PMID:22664934   PMID:22833177   PMID:22889806   PMID:23012479   PMID:23158800   PMID:23360846   PMID:23376485   PMID:23481292   PMID:23533145   PMID:23940770   PMID:24006456  
PMID:24374540   PMID:24816434   PMID:25062286   PMID:25087119   PMID:25148248   PMID:25645918   PMID:25782996   PMID:26463963   PMID:27026710   PMID:27068509   PMID:27087673   PMID:27233602  
PMID:27756197   PMID:27780864   PMID:27865916   PMID:29367586   PMID:29378951   PMID:29402223   PMID:29704511   PMID:29845768   PMID:29980183   PMID:30087458   PMID:30367561   PMID:30404645  
PMID:30871254   PMID:31269059   PMID:31327865   PMID:31480394   PMID:32412814   PMID:32630021   PMID:32845875   PMID:33319934   PMID:33510115   PMID:37672148   PMID:39265498  


Genomics

Comparative Map Data
Lcn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8336,078,432 - 36,081,851 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl336,078,436 - 36,081,842 (-)EnsemblGRCr8
mRatBN7.2315,680,688 - 15,684,033 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl315,680,687 - 15,684,095 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx318,749,510 - 18,752,856 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0327,334,505 - 27,337,851 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0325,585,359 - 25,588,705 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0311,414,189 - 11,417,534 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl311,414,186 - 11,417,546 (-)Ensemblrn6Rnor6.0
Rnor_5.0316,763,059 - 16,766,404 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4311,511,402 - 11,514,747 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera310,423,569 - 10,426,914 (-)NCBICelera
RGSC_v3.1311,407,773 - 11,411,119 (-)NCBI
Cytogenetic Map3p12NCBI
LCN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389128,149,453 - 128,153,453 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9128,149,071 - 128,153,453 (+)Ensemblhg38GRCh38
GRCh379130,911,732 - 130,915,732 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369129,951,553 - 129,955,555 (+)NCBIBuild 36Build 36hg18NCBI36
Build 349127,991,271 - 127,995,288NCBI
Celera9101,562,624 - 101,566,626 (+)NCBICelera
Cytogenetic Map9q34.11NCBI
HuRef9100,525,402 - 100,529,404 (+)NCBIHuRef
CHM1_19131,062,742 - 131,066,744 (+)NCBICHM1_1
T2T-CHM13v2.09140,356,542 - 140,360,542 (+)NCBIT2T-CHM13v2.0
Lcn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39232,274,649 - 32,277,751 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl232,274,645 - 32,278,264 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38232,384,637 - 32,387,739 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl232,384,633 - 32,388,252 (-)Ensemblmm10GRCm38
MGSCv37232,240,157 - 32,243,259 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36232,206,646 - 32,209,748 (-)NCBIMGSCv36mm8
Celera232,090,046 - 32,093,150 (-)NCBICelera
Cytogenetic Map2BNCBI
cM Map222.09NCBI
LCN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21111,199,073 - 11,214,309 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1911,201,421 - 11,216,652 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0999,259,278 - 99,274,494 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19127,940,799 - 127,944,798 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9127,940,799 - 127,944,798 (+)EnsemblpanPan2panpan1.1
LCN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1955,328,118 - 55,342,535 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl955,328,133 - 55,332,038 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha954,522,898 - 54,537,231 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0956,250,316 - 56,264,670 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl956,250,331 - 56,254,237 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1955,010,191 - 55,024,522 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0955,324,906 - 55,339,237 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0955,416,588 - 55,430,934 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Lcn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947195,953,204 - 195,956,869 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648715,721,684 - 15,728,221 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648715,721,752 - 15,725,396 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LCN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1268,609,887 - 268,614,644 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11268,609,975 - 268,614,651 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21302,600,679 - 302,609,836 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LCN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1129,976,278 - 9,981,087 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl129,976,614 - 9,980,870 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660796,251,600 - 6,256,754 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lcn2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v153,243,253 - 3,249,506 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Lcn2
17 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:139
Count of miRNA genes:98
Interacting mature miRNAs:103
Transcripts:ENSRNOT00000018776
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32905627547904329Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10450811Scl73Serum cholesterol level QTL 734.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat
10450808Scl72Serum cholesterol level QTL 724.40.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10450806Scl71Serum cholesterol level QTL 715.80.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)32862533967641995Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)33540319997383526Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)3612543751125437Rat
8693641Alc30Alcohol consumption QTL 3020.739drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)33083238444921701Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3136721849Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3655634751556347Rat
1558657Cm43Cardiac mass QTL 436.63e-08heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31527234860272348Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)32905627547904329Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat

Markers in Region
AA946503  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8336,079,309 - 36,079,668 (+)Marker Load Pipeline
mRatBN7.2315,681,562 - 15,681,921 (+)MAPPERmRatBN7.2
Rnor_6.0311,415,064 - 11,415,422NCBIRnor6.0
Rnor_5.0316,763,934 - 16,764,292UniSTSRnor5.0
RGSC_v3.4311,512,277 - 11,512,635UniSTSRGSC3.4
Celera310,424,444 - 10,424,802UniSTS
RH 3.4 Map360.1UniSTS
Cytogenetic Map3p11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
15 12 66 153 91 90 59 81 59 6 342 180 11 129 80 92 31 9 9

Sequence


Ensembl Acc Id: ENSRNOT00000018776   ⟹   ENSRNOP00000018776
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl336,078,436 - 36,081,842 (-)Ensembl
mRatBN7.2 Ensembl315,680,689 - 15,684,095 (-)Ensembl
Rnor_6.0 Ensembl311,414,186 - 11,417,546 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094191   ⟹   ENSRNOP00000078583
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl315,680,687 - 15,684,095 (-)Ensembl
RefSeq Acc Id: NM_130741   ⟹   NP_570097
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8336,078,435 - 36,081,780 (-)NCBI
mRatBN7.2315,680,688 - 15,684,033 (-)NCBI
Rnor_6.0311,414,189 - 11,417,534 (-)NCBI
Rnor_5.0316,763,059 - 16,766,404 (-)NCBI
RGSC_v3.4311,511,402 - 11,514,747 (-)RGD
Celera310,423,569 - 10,426,914 (-)RGD
Sequence:
RefSeq Acc Id: XM_063283025   ⟹   XP_063139095
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8336,078,432 - 36,081,851 (-)NCBI
RefSeq Acc Id: XM_063283026   ⟹   XP_063139096
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8336,078,432 - 36,081,851 (-)NCBI
RefSeq Acc Id: NP_570097   ⟸   NM_130741
- Peptide Label: precursor
- UniProtKB: Q5HZF1 (UniProtKB/Swiss-Prot),   P30152 (UniProtKB/Swiss-Prot),   A6JU59 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000018776   ⟸   ENSRNOT00000018776
Ensembl Acc Id: ENSRNOP00000078583   ⟸   ENSRNOT00000094191
RefSeq Acc Id: XP_063139096   ⟸   XM_063283026
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063139095   ⟸   XM_063283025
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZNE2 (UniProtKB/TrEMBL)
Protein Domains
Lipocalin/cytosolic fatty-acid binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P30152-F1-model_v2 AlphaFold P30152 1-198 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691985
Promoter ID:EPDNEW_R2510
Type:multiple initiation site
Name:Lcn2_1
Description:lipocalin 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0311,417,542 - 11,417,602EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69408 AgrOrtholog
BioCyc Gene G2FUF-50141 BioCyc
Ensembl Genes ENSRNOG00000013973 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000018776 ENTREZGENE
  ENSRNOT00000018776.6 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.128.20 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7310185 IMAGE-MGC_LOAD
InterPro Calycin UniProtKB/Swiss-Prot
  LCN2/LCN12 UniProtKB/Swiss-Prot
  Lipocalin UniProtKB/Swiss-Prot
  Lipocln_cytosolic_FA-bd_dom UniProtKB/Swiss-Prot
KEGG Report rno:170496 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105339 IMAGE-MGC_LOAD
NCBI Gene 170496 ENTREZGENE
PANTHER NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN UniProtKB/Swiss-Prot
  PTHR11430 UniProtKB/Swiss-Prot
Pfam Lipocalin UniProtKB/Swiss-Prot
PharmGKB LCN2 RGD
PhenoGen Lcn2 PhenoGen
PRINTS LIPOCALIN UniProtKB/Swiss-Prot
  NGELATINASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000013973 RatGTEx
Superfamily-SCOP SSF50814 UniProtKB/Swiss-Prot
TIGR TC207006
UniProt A0A8I5ZNE2 ENTREZGENE
  A6JU59 ENTREZGENE, UniProtKB/TrEMBL
  A6JU60_RAT UniProtKB/TrEMBL
  A6JU61_RAT UniProtKB/TrEMBL
  NGAL_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5HZF1 ENTREZGENE
UniProt Secondary Q5HZF1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Lcn2  lipocalin 2      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference