G6pc2 (glucose-6-phosphatase catalytic subunit 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: G6pc2 (glucose-6-phosphatase catalytic subunit 2) Rattus norvegicus
Analyze
Symbol: G6pc2
Name: glucose-6-phosphatase catalytic subunit 2
RGD ID: 69398
Description: Orthologous to human G6PC2 (glucose-6-phosphatase catalytic subunit 2); INTERACTS WITH 17beta-estradiol (ortholog); 2,3,7,8-tetrachlorodibenzodioxine (ortholog); aflatoxin B1 (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: G6pc-rs; glucose-6-phosphatase 2; glucose-6-phosphatase catalytic related sequence; glucose-6-phosphatase, catalytic, 2; glucose-6-phosphatase, catalytic, related sequence; Igrp; islet-specific glucose-6-phosphatase catalytic subunit-related protein; LOC681817; similar to glucose-6-phosphatase, catalytic, related
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8374,404,976 - 74,413,391 (+)NCBIGRCr8GRCr8GRCr8
mRatBN7.2353,999,821 - 54,005,539 (+)NCBImRatBN7.2mRatBN7.2
Rnor_6.0355,464,528 - 55,467,170 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0362,071,522 - 62,078,621 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera353,563,645 - 53,566,287 (+)NCBICelera
Cytogenetic Map3q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Cloning and characterization of the human and rat islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP) genes. Martin CC, etal., J Biol Chem 2001 Jul 6;276(27):25197-207.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10787428   PMID:14722102   PMID:16223860   PMID:20668700   PMID:21873635  


Genomics

Comparative Map Data
G6pc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8374,404,976 - 74,413,391 (+)NCBIGRCr8GRCr8GRCr8
mRatBN7.2353,999,821 - 54,005,539 (+)NCBImRatBN7.2mRatBN7.2
Rnor_6.0355,464,528 - 55,467,170 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0362,071,522 - 62,078,621 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera353,563,645 - 53,566,287 (+)NCBICelera
Cytogenetic Map3q21NCBI
G6PC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382168,901,291 - 168,910,000 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2168,901,291 - 168,910,000 (+)Ensemblhg38GRCh38
GRCh372169,757,801 - 169,766,510 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362169,465,996 - 169,474,756 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342169,583,348 - 169,590,096NCBI
Celera2163,383,072 - 163,391,831 (+)NCBICelera
Cytogenetic Map2q31.1NCBI
HuRef2161,653,943 - 161,663,046 (+)NCBIHuRef
CHM1_12169,763,602 - 169,772,361 (+)NCBICHM1_1
T2T-CHM13v2.02169,375,781 - 169,384,490 (+)NCBIT2T-CHM13v2.0
G6pc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39269,041,417 - 69,058,337 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl269,041,417 - 69,058,185 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38269,211,073 - 69,227,993 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl269,211,073 - 69,227,841 (+)Ensemblmm10GRCm38
MGSCv37269,058,055 - 69,066,045 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36269,020,810 - 69,028,689 (+)NCBIMGSCv36mm8
Celera270,886,206 - 70,894,208 (+)NCBICelera
Cytogenetic Map2C2NCBI
cM Map239.66NCBI
G6pc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554495,519,054 - 5,525,310 (-)Ensembl
ChiLan1.0NW_0049554495,519,541 - 5,525,310 (-)NCBIChiLan1.0ChiLan1.0
G6PC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21371,562,022 - 71,570,742 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B71,576,995 - 71,585,315 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B56,178,623 - 56,187,394 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B173,643,660 - 173,652,424 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B173,643,660 - 173,652,424 (+)EnsemblpanPan2panpan1.1
G6PC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13613,723,410 - 13,731,086 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3613,723,358 - 13,731,110 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3613,734,418 - 13,742,067 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03613,839,763 - 13,847,410 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3613,839,759 - 13,847,446 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13613,924,505 - 13,932,153 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03613,912,317 - 13,919,967 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03614,025,318 - 14,032,964 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
G6pc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303130,999,178 - 131,005,326 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646910,612,394 - 10,618,542 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493646910,612,394 - 10,618,542 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
G6PC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1575,382,313 - 75,390,150 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11575,382,442 - 75,388,662 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21584,486,126 - 84,492,343 (+)NCBISscrofa10.2Sscrofa10.2susScr3
G6PC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11054,433,329 - 54,442,623 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666040145,091,870 - 145,098,849 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
G6pc2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247876,635,385 - 6,641,937 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247876,635,361 - 6,643,107 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
G6pc2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1546,537,055 - 46,543,944 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in G6pc2
46 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:29
Count of miRNA genes:26
Interacting mature miRNAs:28
Transcripts:ENSRNOT00000073549
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)351490129111359995Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)373592611110333156Rat
1358293Bw38Body weight QTL 3860.0000031body mass (VT:0001259)body weight (CMO:0000012)374364268119364268Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)35986366387321459Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)373592512136118980Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)35365182698651826Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)34887661993876619Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)34887661993876619Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)33540319997383526Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
631832Sach1Saccharin preference QTL 12.70.02consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)34790417292904172Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)35986366387321459Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35109256196092561Rat
1300169Bp177Blood pressure QTL 1772.96arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)33642511681425116Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)34865774493657744Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)33779691982796919Rat
2302276Bw82Body weight QTL 824.32body mass (VT:0001259)body weight (CMO:0000012)35986366383358329Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)358925062103925062Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)370311536115311536Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)34865774493657744Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)35076614595766145Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)35109256196092561Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)336721849110333156Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)35076614595766145Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)34865774493657744Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)342158111124558371Rat
1582249Bw77Body weight QTL 773.20.0025epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)37359251285062403Rat
2325840Bp345Blood pressure QTL 3450.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)33870893183708931Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)34865774493657744Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)33736373482363734Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)33610140381101403Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)34865774493657744Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)342158111124558371Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
3 1 3 4 22 5 1 4 14 1 2 2

Sequence


RefSeq Acc Id: XM_017592318   ⟹   XP_017447807
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8374,404,976 - 74,413,391 (+)NCBI
mRatBN7.2353,999,821 - 54,005,539 (+)NCBI
Rnor_6.0355,464,528 - 55,467,170 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_017447807 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_017447807   ⟸   XM_017592318
- Sequence:


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69398 AgrOrtholog
BioCyc Gene G2FUF-49513 BioCyc
NCBI Gene G6pc2 ENTREZGENE
PhenoGen G6pc2 PhenoGen


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-22 G6pc2  glucose-6-phosphatase catalytic subunit 2  G6pc2  glucose-6-phosphatase, catalytic, 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-10-03 G6pc2  glucose-6-phosphatase, catalytic, 2  LOC681817  similar to glucose-6-phosphatase, catalytic, related  Data merged from RGD:1590543 737654 APPROVED
2006-11-20 LOC681817  similar to glucose-6-phosphatase, catalytic, related      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 G6pc2  glucose-6-phosphatase, catalytic, 2    glucose-6-phosphatase, catalytic, related sequence  Name updated 1299863 APPROVED
2004-09-10 G6pc2  glucose-6-phosphatase, catalytic, related sequence  G6pc-rs    Symbol and Name updated 1299863 APPROVED
2003-04-09 G6pc-rs  glucose-6-phosphatase, catalytic, related sequence    glucose-6-phosphatase, catalytic, related sequence   Symbol and Name updated 629477 APPROVED
2003-03-19 G6pc-rs  glucose-6-phosphatase, catalytic, related sequence   Igrp  islet-specific glucose-6-phosphatase catalytic subunit-related protein  Data merged from RGD:69652 628472 PROVISIONAL
2002-06-10 G6pc-rs  glucose-6-phosphatase, catalytic, related sequence       Name updated 70584 APPROVED
2002-06-10 Igrp  islet-specific glucose-6-phosphatase catalytic subunit-related protein      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expression is restricted to islets 68671
gene_function homolog of G6Pase catalytic subunit, which catalyzes the terminal step of the gluconeogenic pathway 68671
gene_process may be involved in the regulation of islet metabolism 68671