Ldhc (lactate dehydrogenase C) - Rat Genome Database

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Gene: Ldhc (lactate dehydrogenase C) Rattus norvegicus
Analyze
Symbol: Ldhc
Name: lactate dehydrogenase C
RGD ID: 69366
Description: Predicted to enable L-lactate dehydrogenase (NAD+) activity. Predicted to be involved in lactate metabolic process and pyruvate catabolic process. Predicted to act upstream of or within ATP biosynthetic process; flagellated sperm motility; and lactate biosynthetic process from pyruvate. Predicted to be located in cytoplasm and motile cilium. Predicted to be active in cytosol and mitochondrion. Orthologous to human LDHC (lactate dehydrogenase C); PARTICIPATES IN cysteine and methionine metabolic pathway; gluconeogenesis pathway; glycolysis pathway; INTERACTS WITH (R)-lipoic acid; 3,4-dihydroxybenzoic acid; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: L-lactate dehydrogenase C chain; lactate dehydrogenase 3 C chain sperm specific; lactate dehydrogenase 3, C chain; lactate dehydrogenase 3, C chain, sperm specific; lactate dehydrogenase C variant 3; LDH testis subunit; LDH-C; LDH-X; Ldh3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81106,522,140 - 106,539,649 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1106,522,236 - 106,542,802 (+)EnsemblGRCr8
mRatBN7.2197,385,984 - 97,403,382 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl197,382,379 - 97,403,378 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1102,779,292 - 102,796,202 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01111,251,274 - 111,268,186 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01104,535,059 - 104,551,715 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01102,914,875 - 102,931,843 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1102,915,191 - 102,931,839 (+)Ensemblrn6Rnor6.0
Rnor_5.01103,989,930 - 104,006,583 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4197,418,622 - 97,435,275 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera191,633,230 - 91,649,970 (+)NCBICelera
RGSC_v3.1197,496,732 - 97,513,382 (+)NCBI
Cytogenetic Map1q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cilium  (IEA,ISO)
cytoplasm  (IEA,ISO)
cytosol  (IEA,ISO)
mitochondrion  (IBA)
motile cilium  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
8. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
9. Evolutionary relationships of lactate dehydrogenases (LDHs) from mammals, birds, an amphibian, fish, barley, and bacteria: LDH cDNA sequences from Xenopus, pig, and rat. Tsuji S, etal., Proc Natl Acad Sci U S A 1994 Sep 27;91(20):9392-6.
Additional References at PubMed
PMID:1996957   PMID:6343385   PMID:11276087   PMID:16687649   PMID:18367675   PMID:21630459   PMID:22537060   PMID:23533145   PMID:31904090  


Genomics

Comparative Map Data
Ldhc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81106,522,140 - 106,539,649 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1106,522,236 - 106,542,802 (+)EnsemblGRCr8
mRatBN7.2197,385,984 - 97,403,382 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl197,382,379 - 97,403,378 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1102,779,292 - 102,796,202 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01111,251,274 - 111,268,186 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01104,535,059 - 104,551,715 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01102,914,875 - 102,931,843 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1102,915,191 - 102,931,839 (+)Ensemblrn6Rnor6.0
Rnor_5.01103,989,930 - 104,006,583 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4197,418,622 - 97,435,275 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera191,633,230 - 91,649,970 (+)NCBICelera
RGSC_v3.1197,496,732 - 97,513,382 (+)NCBI
Cytogenetic Map1q22NCBI
LDHC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381118,412,318 - 18,452,063 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1118,412,306 - 18,452,063 (+)Ensemblhg38GRCh38
GRCh371118,433,865 - 18,473,610 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361118,390,429 - 18,429,366 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341118,390,482 - 18,429,366NCBI
Celera1118,568,783 - 18,608,411 (+)NCBICelera
Cytogenetic Map11p15.1NCBI
HuRef1118,119,079 - 18,158,522 (+)NCBIHuRef
CHM1_11118,433,317 - 18,472,228 (+)NCBICHM1_1
T2T-CHM13v2.01118,510,444 - 18,550,172 (+)NCBIT2T-CHM13v2.0
Ldhc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39746,510,687 - 46,527,571 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl746,510,627 - 46,527,566 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38746,861,263 - 46,878,147 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl746,861,203 - 46,878,142 (+)Ensemblmm10GRCm38
MGSCv37754,116,633 - 54,133,512 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36746,729,305 - 46,746,184 (+)NCBIMGSCv36mm8
Celera742,341,209 - 42,358,089 (+)NCBICelera
Cytogenetic Map7B3NCBI
cM Map730.6NCBI
LOC102020557
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541433,110,120 - 33,138,756 (+)Ensembl
ChiLan1.0NW_00495541433,109,535 - 33,138,756 (+)NCBIChiLan1.0ChiLan1.0
LDHC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2920,729,119 - 20,768,321 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11120,689,477 - 20,728,675 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01118,450,117 - 18,489,321 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11118,132,829 - 18,172,055 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1118,132,829 - 18,172,055 (+)EnsemblpanPan2panpan1.1
LDHC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12140,844,644 - 40,890,407 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2140,844,662 - 40,890,398 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2140,324,373 - 40,369,674 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02141,966,636 - 42,012,586 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2141,966,655 - 42,012,233 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12140,960,921 - 41,006,005 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02141,149,688 - 41,192,528 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02141,527,202 - 41,570,252 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC101970352
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494744,793,662 - 44,828,879 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936528827,758 - 862,393 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936528827,322 - 862,832 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LDHC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl240,748,863 - 40,809,692 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1240,748,567 - 40,810,114 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2243,655,396 - 43,730,838 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LDHC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1146,480,425 - 46,528,307 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666038143,836,012 - 143,883,405 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101715932
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247669,886,618 - 9,921,535 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247669,882,494 - 9,943,079 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Ldhc
300 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:21
Count of miRNA genes:21
Interacting mature miRNAs:21
Transcripts:ENSRNOT00000017851
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)192963855109494029Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1101228864146228864Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1102359314153680016Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)192683681137683681Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)192683681137683681Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)197582336142582336Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1101594089146594089Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1100345976145345976Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)196717367160111531Rat

Markers in Region
BE120592  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2197,403,178 - 97,403,337 (+)MAPPERmRatBN7.2
Rnor_6.01102,931,640 - 102,931,798NCBIRnor6.0
Rnor_5.01104,006,380 - 104,006,538UniSTSRnor5.0
RGSC_v3.4197,435,072 - 97,435,230UniSTSRGSC3.4
Celera191,649,767 - 91,649,925UniSTS
RH 3.4 Map1909.8UniSTS
Cytogenetic Map1q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
10 12 24 81 76 76 46 68 46 6 242 119 10 60 59 80 30 8 8

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001440122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001440123 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_017266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229233 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759344 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109646 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC099150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC078862 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ173138 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ173139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ173140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ173141 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ409364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ409365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ409366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ409367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ409368 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ409369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U07177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000017851   ⟹   ENSRNOP00000017851
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1106,523,031 - 106,542,802 (+)Ensembl
mRatBN7.2 Ensembl197,386,727 - 97,403,378 (+)Ensembl
Rnor_6.0 Ensembl1102,915,191 - 102,931,839 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000079440   ⟹   ENSRNOP00000069268
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1106,523,038 - 106,539,645 (+)Ensembl
mRatBN7.2 Ensembl197,386,727 - 97,403,378 (+)Ensembl
Rnor_6.0 Ensembl1102,915,655 - 102,931,774 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000082718   ⟹   ENSRNOP00000071562
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1106,523,105 - 106,539,645 (+)Ensembl
mRatBN7.2 Ensembl197,382,379 - 97,401,823 (+)Ensembl
Rnor_6.0 Ensembl1102,915,655 - 102,930,272 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000083079   ⟹   ENSRNOP00000070991
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1106,522,236 - 106,539,513 (+)Ensembl
mRatBN7.2 Ensembl197,382,379 - 97,403,246 (+)Ensembl
Rnor_6.0 Ensembl1102,915,655 - 102,931,774 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000088892   ⟹   ENSRNOP00000073654
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1106,523,459 - 106,542,802 (+)Ensembl
mRatBN7.2 Ensembl197,387,191 - 97,403,378 (+)Ensembl
Rnor_6.0 Ensembl1102,915,655 - 102,931,774 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000090520   ⟹   ENSRNOP00000075021
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1106,522,236 - 106,539,645 (+)Ensembl
mRatBN7.2 Ensembl197,382,379 - 97,394,469 (+)Ensembl
Rnor_6.0 Ensembl1102,915,655 - 102,922,930 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000092180   ⟹   ENSRNOP00000072576
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1106,522,236 - 106,539,580 (+)Ensembl
mRatBN7.2 Ensembl197,382,379 - 97,403,313 (+)Ensembl
Rnor_6.0 Ensembl1102,915,655 - 102,931,774 (+)Ensembl
RefSeq Acc Id: NM_017266   ⟹   NP_058962
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81106,522,995 - 106,539,649 (+)NCBI
mRatBN7.2197,386,727 - 97,403,382 (+)NCBI
Rnor_6.01102,915,191 - 102,931,843 (+)NCBI
Rnor_5.01103,989,930 - 104,006,583 (+)NCBI
RGSC_v3.4197,418,622 - 97,435,275 (+)RGD
Celera191,633,230 - 91,649,970 (+)RGD
Sequence:
RefSeq Acc Id: XM_006229233   ⟹   XP_006229295
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81106,523,139 - 106,539,649 (+)NCBI
mRatBN7.2197,386,843 - 97,403,382 (+)NCBI
Rnor_6.01102,915,312 - 102,931,843 (+)NCBI
Rnor_5.01103,989,930 - 104,006,583 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008759344   ⟹   XP_008757566
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81106,522,751 - 106,539,649 (+)NCBI
mRatBN7.2197,386,475 - 97,403,382 (+)NCBI
Rnor_6.01102,914,878 - 102,931,843 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017589063   ⟹   XP_017444552
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81106,528,117 - 106,539,649 (+)NCBI
mRatBN7.2197,387,184 - 97,403,382 (+)NCBI
Rnor_6.01102,915,655 - 102,931,843 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039109646   ⟹   XP_038965574
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81106,522,140 - 106,539,649 (+)NCBI
mRatBN7.2197,385,984 - 97,403,382 (+)NCBI
RefSeq Acc Id: NP_058962   ⟸   NM_017266
- UniProtKB: P19629 (UniProtKB/Swiss-Prot),   Q6AYX2 (UniProtKB/TrEMBL),   A6JBD6 (UniProtKB/TrEMBL),   F7FDE8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229295   ⟸   XM_006229233
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_008757566   ⟸   XM_008759344
- Peptide Label: isoform X2
- UniProtKB: P19629 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017444552   ⟸   XM_017589063
- Peptide Label: isoform X4
- UniProtKB: P19629 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069268   ⟸   ENSRNOT00000079440
Ensembl Acc Id: ENSRNOP00000071562   ⟸   ENSRNOT00000082718
Ensembl Acc Id: ENSRNOP00000072576   ⟸   ENSRNOT00000092180
Ensembl Acc Id: ENSRNOP00000070991   ⟸   ENSRNOT00000083079
Ensembl Acc Id: ENSRNOP00000075021   ⟸   ENSRNOT00000090520
Ensembl Acc Id: ENSRNOP00000073654   ⟸   ENSRNOT00000088892
Ensembl Acc Id: ENSRNOP00000017851   ⟸   ENSRNOT00000017851
RefSeq Acc Id: XP_038965574   ⟸   XM_039109646
- Peptide Label: isoform X1
- UniProtKB: P19629 (UniProtKB/Swiss-Prot)
Protein Domains
Lactate/malate dehydrogenase C-terminal   Lactate/malate dehydrogenase N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P19629-F1-model_v2 AlphaFold P19629 1-332 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690069
Promoter ID:EPDNEW_R593
Type:initiation region
Name:Ldhc_1
Description:lactate dehydrogenase C
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R594  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01102,915,207 - 102,915,267EPDNEW
RGD ID:13690072
Promoter ID:EPDNEW_R594
Type:single initiation site
Name:Ldhc_2
Description:lactate dehydrogenase C
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R593  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01102,915,627 - 102,915,687EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69366 AgrOrtholog
BioCyc Gene G2FUF-59603 BioCyc
BioCyc Pathway PWY-5031 [L-histidine degradation V] BioCyc
BioCyc Pathway Image PWY-5031 BioCyc
Ensembl Genes ENSRNOG00000013103 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000017851 ENTREZGENE
  ENSRNOT00000082718 ENTREZGENE
  ENSRNOT00000090520 ENTREZGENE
Gene3D-CATH 3.90.110.10 UniProtKB/Swiss-Prot
  NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7131609 IMAGE-MGC_LOAD
InterPro L-lactate/malate_DH UniProtKB/Swiss-Prot
  L-lactate_DH UniProtKB/Swiss-Prot
  L-lactate_DH_AS UniProtKB/Swiss-Prot
  Lactate/malate_DH_C UniProtKB/Swiss-Prot
  Lactate/malate_DH_N UniProtKB/Swiss-Prot
  Lactate_DH/Glyco_Ohase_4_C UniProtKB/Swiss-Prot
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot
MGC_CLONE MGC:93523 IMAGE-MGC_LOAD
NCBI Gene 29634 ENTREZGENE
PANTHER L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+)) UniProtKB/Swiss-Prot
  L-LACTATE DEHYDROGENASE C CHAIN UniProtKB/Swiss-Prot
Pfam Ldh_1_C UniProtKB/Swiss-Prot
  Ldh_1_N UniProtKB/Swiss-Prot
PhenoGen Ldhc PhenoGen
PIRSF Lac_mal_DH UniProtKB/Swiss-Prot
PRINTS LLDHDRGNASE UniProtKB/Swiss-Prot
PROSITE L_LDH UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000013103 RatGTEx
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot
  SSF56327 UniProtKB/Swiss-Prot
TIGR TC234106
UniProt A0A0G2JZC1_RAT UniProtKB/TrEMBL
  A0A0G2K3B9_RAT UniProtKB/TrEMBL
  A0A0G2K9J7_RAT UniProtKB/TrEMBL
  A6JBD6 ENTREZGENE, UniProtKB/TrEMBL
  F7FDE8 ENTREZGENE, UniProtKB/TrEMBL
  H9N9H4_RAT UniProtKB/TrEMBL
  I1VWM9_RAT UniProtKB/TrEMBL
  I1VWN0_RAT UniProtKB/TrEMBL
  I1VWN1_RAT UniProtKB/TrEMBL
  LDHC_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6AYX2 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Ldhc  lactate dehydrogenase C    lactate dehydrogenase 3, C chain  Name updated 1299863 APPROVED
2002-06-10 Ldhc  lactate dehydrogenase 3, C chain      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in testis 68808