Nupr1 (nuclear protein 1, transcriptional regulator) - Rat Genome Database

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Gene: Nupr1 (nuclear protein 1, transcriptional regulator) Rattus norvegicus
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Symbol: Nupr1
Name: nuclear protein 1, transcriptional regulator
RGD ID: 69363
Description: Predicted to enable several functions, including acetyltransferase activator activity; chromatin binding activity; and transcription coactivator activity. Involved in several processes, including negative regulation of DNA-binding transcription factor activity; negative regulation of autophagy; and regulation of apoptotic process. Predicted to be located in perinuclear region of cytoplasm. Predicted to be part of protein-DNA complex. Predicted to be active in nucleus. Orthologous to human NUPR1 (nuclear protein 1, transcriptional regulator); INTERACTS WITH 1-naphthyl isothiocyanate; 1-nitropropane; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: candidate of metastasis 1; LOC100912108; nuclear protein 1; nuclear protein 1-like; nuclear protein, transcriptional regulator, 1; nuclear proten 1; nuclear transcriptional regulator protein 1; p8
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
NCBI Annotation Information: Note: This single-copy gene is duplicated in the RGSC5.0 assembly; GeneID:100912108 represents the intended location for the rat Nupr1 gene while GeneID:113900 is most likely an artifact in the RGSC5.0 assembly, based on syntenic gene analysis. [17 Jun 2014]
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81190,643,866 - 190,645,901 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1190,643,867 - 190,645,901 (-)EnsemblGRCr8
mRatBN7.21181,213,292 - 181,215,327 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1181,213,368 - 181,215,281 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1189,564,465 - 189,566,500 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01196,750,541 - 196,752,576 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01189,417,969 - 189,420,004 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01194,767,484 - 194,769,519 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1194,767,474 - 194,769,524 (-)Ensemblrn6Rnor6.0
Rnor_5.01205,021,877 - 205,023,912 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41185,770,310 - 185,772,313 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1178,871,291 - 178,873,326 (-)NCBICelera
Cytogenetic Map1q36NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-nitropropane  (EXP)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
1H-pyrazole  (ISO)
2,2'-Methylenebis(4-methyl-6-tert-butylphenol)  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-diaminotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-nitro-p-phenylenediamine  (EXP)
2-nitrofluorene  (EXP)
2-nitropropane  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-acetylaminofluorene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-nitro-1,2-phenylenediamine  (EXP)
5-fluorouracil  (ISO)
acrylamide  (EXP,ISO)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
amitriptyline  (ISO)
ammonium chloride  (EXP)
antimycin A  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
bromobenzene  (EXP)
C-peptide  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chlorendic acid  (EXP)
chloropicrin  (ISO)
chlorpromazine  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP,ISO)
citalopram  (ISO)
clofibrate  (EXP,ISO)
clomipramine  (ISO)
clozapine  (ISO)
cobalt atom  (ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
cordycepin  (ISO)
coumarin  (EXP)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (EXP)
dibenzo[a,l]pyrene  (EXP)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
diethylstilbestrol  (EXP)
dioxygen  (ISO)
diuron  (EXP)
doxepin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
erythromycin A  (ISO)
ethyl methanesulfonate  (ISO)
ethylparaben  (ISO)
etoposide  (ISO)
fenthion  (ISO)
ferric oxide  (ISO)
flavonoids  (EXP)
flecainide  (ISO)
fluoranthene  (EXP)
fluoxetine  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fonofos  (ISO)
formaldehyde  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glycidol  (ISO)
glycine betaine  (EXP)
haloperidol  (ISO)
hydralazine  (ISO)
imipramine  (ISO)
indole-3-methanol  (EXP)
isoniazide  (ISO)
ivermectin  (ISO)
ketoconazole  (ISO)
L-methionine  (ISO)
Lasiocarpine  (EXP)
lead diacetate  (EXP,ISO)
leflunomide  (ISO)
levofloxacin  (EXP)
lipopolysaccharide  (EXP,ISO)
loratadine  (ISO)
metformin  (EXP)
methapyrilene  (EXP)
methidathion  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
microcystin-LR  (ISO)
Monobutylphthalate  (ISO)
myriocin  (EXP,ISO)
N(4)-hydroxycytidine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
nefazodone  (EXP)
nicotine  (ISO)
nitric oxide  (ISO)
Nutlin-3  (ISO)
ofloxacin  (ISO)
okadaic acid  (ISO)
orphenadrine  (EXP)
ozone  (ISO)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
parathion  (ISO)
pentachlorophenol  (ISO)
pentamidine  (ISO)
perfluorobutyric acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
perhexiline  (ISO)
phenobarbital  (EXP,ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
prothioconazole  (ISO)
quercetin  (ISO)
quinidine  (ISO)
quinolin-8-ol  (ISO)
rac-lactic acid  (ISO)
ranitidine  (EXP)
resorcinol  (ISO)
resveratrol  (EXP)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
sertraline  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP,ISO)
sotalol  (ISO)
SR 144528  (ISO)
streptozocin  (ISO)
succimer  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
terbufos  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
tetraphene  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
thioridazine  (ISO)
thiram  (ISO)
trichloroethene  (EXP)
triptonide  (ISO)
trovafloxacin  (ISO)
Tungsten carbide  (ISO)
ursodeoxycholic acid  (EXP)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
zimeldine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute inflammatory response  (ISO)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  (ISO)
male gonad development  (ISO)
negative regulation of apoptotic process  (IEA,ISO,ISS)
negative regulation of autophagosome assembly  (IEA,ISO,ISS)
negative regulation of autophagy  (IEA,IMP,ISO,ISS)
negative regulation of cardiac muscle cell apoptotic process  (IEA,IMP,ISO,ISS)
negative regulation of cell cycle  (IBA,ISO,ISS)
negative regulation of cell population proliferation  (IBA)
negative regulation of epithelial cell apoptotic process  (IEA,ISO,ISS)
negative regulation of epithelial cell proliferation  (IEA,ISO,ISS)
negative regulation of fibroblast proliferation  (ISO)
negative regulation of glycolytic process  (IEA,ISO,ISS)
negative regulation of programmed necrotic cell death  (IEA,ISO,ISS)
negative regulation of type B pancreatic cell proliferation  (IEA,ISO,ISS)
positive regulation of apoptotic process  (ISO)
positive regulation of cell cycle  (IEA,ISO)
positive regulation of DNA-templated transcription  (IEA)
positive regulation of intrinsic apoptotic signaling pathway  (IEA,IMP,ISO,ISS)
positive regulation of neuroinflammatory response  (IEA,ISO,ISS)
positive regulation of neuron apoptotic process  (IMP)
positive regulation of oxidative phosphorylation  (IEA,ISO,ISS)
positive regulation of proteasomal protein catabolic process  (IEA,ISO,ISS)
positive regulation of protein modification process  (ISO)
protein acetylation  (ISO)
protein-containing complex assembly  (ISO)
regulation of autophagy  (IMP)
regulation of female gonad development  (ISO)
regulation of response to endoplasmic reticulum stress  (IEA,IMP,ISO,ISS)
response to toxic substance  (ISO)
skeletal muscle cell differentiation  (ISO)

Cellular Component
cytoplasm  (IEA,ISO,ISS)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO,ISS)
perinuclear region of cytoplasm  (IEA,ISO,ISS)
protein-DNA complex  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Nupr1/Chop signal axis is involved in mitochondrion-related endothelial cell apoptosis induced by methamphetamine. Cai D, etal., Cell Death Dis. 2016 Mar 31;7:e2161. doi: 10.1038/cddis.2016.67.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Deficiency of the transcriptional regulator p8 results in increased autophagy and apoptosis, and causes impaired heart function. Kong DK, etal., Mol Biol Cell. 2010 Apr 15;21(8):1335-49. doi: 10.1091/mbc.e09-09-0818. Epub 2010 Feb 24.
4. Cloning and expression of the rat p8 cDNA, a new gene activated in pancreas during the acute phase of pancreatitis, pancreatic development, and regeneration, and which promotes cellular growth. Mallo GV, etal., J Biol Chem 1997 Dec 19;272(51):32360-9.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
10. Nupr1 Modulates Methamphetamine-Induced Dopaminergic Neuronal Apoptosis and Autophagy through CHOP-Trib3-Mediated Endoplasmic Reticulum Stress Signaling Pathway. Xu X, etal., Front Mol Neurosci. 2017 Jun 26;10:203. doi: 10.3389/fnmol.2017.00203. eCollection 2017.
Additional References at PubMed
PMID:7667285   PMID:10092851   PMID:11056169   PMID:11896600   PMID:11940591   PMID:12374743   PMID:14660681   PMID:14749270   PMID:15016802   PMID:15632090   PMID:16300740   PMID:16374777  
PMID:16478804   PMID:16480983   PMID:16981138   PMID:17116693   PMID:18495683   PMID:18690848   PMID:19723804   PMID:19775616   PMID:23900510   PMID:27451286   PMID:30451898   PMID:31914690  
PMID:34830471  


Genomics

Comparative Map Data
Nupr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81190,643,866 - 190,645,901 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1190,643,867 - 190,645,901 (-)EnsemblGRCr8
mRatBN7.21181,213,292 - 181,215,327 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1181,213,368 - 181,215,281 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1189,564,465 - 189,566,500 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01196,750,541 - 196,752,576 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01189,417,969 - 189,420,004 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01194,767,484 - 194,769,519 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1194,767,474 - 194,769,524 (-)Ensemblrn6Rnor6.0
Rnor_5.01205,021,877 - 205,023,912 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41185,770,310 - 185,772,313 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1178,871,291 - 178,873,326 (-)NCBICelera
Cytogenetic Map1q36NCBI
NUPR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381628,532,708 - 28,538,974 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1628,532,708 - 28,539,038 (-)Ensemblhg38GRCh38
GRCh371628,544,029 - 28,550,295 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361628,456,163 - 28,457,996 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341628,456,162 - 28,457,831NCBI
Celera1627,653,286 - 27,655,119 (+)NCBICelera
Cytogenetic Map16p11.2NCBI
HuRef1626,574,331 - 26,576,164 (-)NCBIHuRef
CHM1_11629,560,413 - 29,562,246 (-)NCBICHM1_1
T2T-CHM13v2.01628,856,812 - 28,863,107 (+)NCBIT2T-CHM13v2.0
Nupr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397126,222,418 - 126,224,642 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7126,222,421 - 126,230,033 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm387126,623,246 - 126,625,470 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7126,623,249 - 126,630,861 (-)Ensemblmm10GRCm38
MGSCv377133,766,760 - 133,768,984 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv367126,414,394 - 126,416,618 (-)NCBIMGSCv36mm8
Celera7126,472,385 - 126,474,623 (-)NCBICelera
Cytogenetic Map7F3NCBI
cM Map769.21NCBI
Nupr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554936,746,380 - 6,747,763 (-)Ensembl
ChiLan1.0NW_0049554936,746,380 - 6,747,763 (-)NCBIChiLan1.0ChiLan1.0
NUPR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21831,142,620 - 31,144,387 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11634,949,566 - 34,951,364 (+)NCBINHGRI_mPanPan1
PanPan1.11629,015,155 - 29,016,987 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1629,015,155 - 29,016,987 (-)EnsemblpanPan2panpan1.1
NUPR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1618,222,367 - 18,224,015 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl618,222,515 - 18,224,014 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha619,801,224 - 19,802,818 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0618,358,557 - 18,360,151 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl618,358,631 - 18,360,130 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1618,157,477 - 18,159,070 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0618,072,694 - 18,074,288 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0618,388,742 - 18,390,336 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Nupr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344123,900,204 - 123,901,559 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650111,997,834 - 11,999,709 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493650111,998,064 - 11,999,431 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NUPR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl318,402,935 - 18,511,087 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1318,402,781 - 18,404,411 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
NUPR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1526,382,125 - 26,385,605 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl526,382,132 - 26,385,348 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660683,184,304 - 3,186,193 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nupr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478213,042,939 - 13,044,267 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462478213,042,938 - 13,044,298 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Nupr1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1275,285,908 - 75,288,086 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Nupr1
11 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:37
Count of miRNA genes:33
Interacting mature miRNAs:36
Transcripts:ENSRNOT00000072875
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1153679879198679879Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1177339686222339686Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1132760429191848948Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1181059071226059071Rat
61326Eae6Experimental allergic encephalomyelitis QTL 65.3body mass (VT:0001259)change in body weight (CMO:0002045)1182383862191260518Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1181059071226059071Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1153679879205813246Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1182039247227039247Rat
8694166Bw147Body weight QTL 1476.830.001body mass (VT:0001259)body weight gain (CMO:0000420)1153788989198788989Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1183564652228564652Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1160573753210707719Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1181059071226059071Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1160573753210707719Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1165278545210278545Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1161077990206077990Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1181059071226059071Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1168063662213063662Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1159894717207261263Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1109493780193400781Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1163992710208992710Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1182535316227535316Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1155359438194575574Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1181059071226059071Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1116099376191260518Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1181059071226059071Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1132760429191848948Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1162753891207753891Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1180739993225739993Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1172718770228180370Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
2312558Glom17Glomerulus QTL 173.90.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1175967553200707874Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1178547286206690557Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1188241285250779312Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1185979875230979875Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753210707719Rat
1576310Schws2Schwannoma susceptibility QTL 20.029nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1153788989198788989Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1165707719210707719Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1173363824227535316Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429191190115Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1132966869206393015Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1132760429191848948Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2325727Pia41Pristane induced arthritis QTL 41joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1188241285233241285Rat
7411599Foco11Food consumption QTL 1118.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)1153788989198788989Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1160573753210707719Rat
2325725Eae31Experimental allergic encephalomyelitis QTL 31nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1188241285197807511Rat
631670Iddm10Insulin dependent diabetes mellitus QTL 101.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1183564652205813246Rat

Markers in Region
RH131382  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21181,213,400 - 181,214,661 (+)MAPPERmRatBN7.2
Rnor_6.01198,043,226 - 198,044,486NCBIRnor6.0
Rnor_6.01194,767,593 - 194,768,853NCBIRnor6.0
Rnor_5.01201,816,842 - 201,818,102UniSTSRnor5.0
Rnor_5.01205,021,986 - 205,023,246UniSTSRnor5.0
RGSC_v3.41185,770,419 - 185,771,679UniSTSRGSC3.4
Celera1178,871,400 - 178,872,660UniSTS
Cytogenetic Map1q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
14 2 25 75 34 30 18 20 18 6 149 68 11 62 49 55 12 11 11

Sequence


Ensembl Acc Id: ENSRNOT00000025988   ⟹   ENSRNOP00000025988
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1190,643,867 - 190,645,901 (-)Ensembl
mRatBN7.2 Ensembl1181,213,368 - 181,215,281 (+)Ensembl
Rnor_6.0 Ensembl1194,767,474 - 194,769,524 (-)Ensembl
RefSeq Acc Id: NM_053611   ⟹   NP_446063
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81190,643,866 - 190,645,901 (-)NCBI
mRatBN7.21181,213,292 - 181,215,327 (-)NCBI
Rnor_6.01194,767,484 - 194,769,519 (-)NCBI
Rnor_5.01205,021,877 - 205,023,912 (-)NCBI
RGSC_v3.41185,770,310 - 185,772,313 (-)RGD
Celera1178,871,291 - 178,873,326 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_446063 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB94673 (Get FASTA)   NCBI Sequence Viewer  
  EDM17430 (Get FASTA)   NCBI Sequence Viewer  
  EDM17431 (Get FASTA)   NCBI Sequence Viewer  
  EDM17432 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000107734
GenBank Protein O54842 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446063   ⟸   NM_053611
- UniProtKB: O54842 (UniProtKB/Swiss-Prot),   A6I999 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000025988   ⟸   ENSRNOT00000025988

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O54842-F1-model_v2 AlphaFold O54842 1-80 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690384
Promoter ID:EPDNEW_R909
Type:single initiation site
Name:Nupr1_1
Description:nuclear protein 1, transcriptional regulator
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01194,769,481 - 194,769,541EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69363 AgrOrtholog
BioCyc Gene G2FUF-57436 BioCyc
Ensembl Genes ENSRNOG00000019206 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000025988 ENTREZGENE
InterPro NUPR1-like UniProtKB/Swiss-Prot
KEGG Report rno:100912108 UniProtKB/Swiss-Prot
NCBI Gene Nupr1 ENTREZGENE
PANTHER NUCLEAR PROTEIN 1 UniProtKB/Swiss-Prot
  PTHR17149 UniProtKB/Swiss-Prot
Pfam Phospho_p8 UniProtKB/Swiss-Prot
PhenoGen Nupr1 PhenoGen
RatGTEx ENSRNOG00000019206 RatGTEx
RNAcentral URS00022B7975 RNACentral
TIGR TC204889
UniProt A6I998_RAT UniProtKB/TrEMBL
  A6I999 ENTREZGENE
  A6I9A0_RAT UniProtKB/TrEMBL
  NUPR1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-30 Nupr1  nuclear protein 1, transcriptional regulator  Nupr1  nuclear protein, transcriptional regulator, 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-07-08 Nupr1  nuclear protein, transcriptional regulator, 1  LOC100912108  nuclear protein 1-like  Data merged from RGD:6488528 737654 APPROVED
2014-07-08 Nupr1  nuclear protein, transcriptional regulator, 1  Nupr1  nuclear protein, transcriptional regulator, 1  Type changed (type changed from [null] to [protein-coding]) 629549 APPROVED
2012-07-05 LOC100912108  nuclear protein 1-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2010-04-23 Nupr1  nuclear protein, transcriptional regulator, 1  Nupr1  nuclear protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Nupr1  nuclear protein 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression displays increased pancreatic acinar cell expression in pancreatitis, during development, and in response to cell injury and regeneration 68826