Shc3 (SHC adaptor protein 3) - Rat Genome Database

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Gene: Shc3 (SHC adaptor protein 3) Rattus norvegicus
Analyze
Symbol: Shc3
Name: SHC adaptor protein 3
RGD ID: 69348
Description: Predicted to enable phosphotyrosine residue binding activity and receptor tyrosine kinase binding activity. Predicted to be involved in cell surface receptor protein tyrosine kinase signaling pathway. Predicted to act upstream of or within glutamatergic synaptic transmission and learning or memory. Predicted to be located in cytosol. Predicted to be active in plasma membrane. Orthologous to human SHC3 (SHC adaptor protein 3); PARTICIPATES IN chemokine mediated signaling pathway; chronic myeloid leukemia pathway; epidermal growth factor/neuregulin signaling pathway; INTERACTS WITH 1,3-dinitrobenzene; 17alpha-ethynylestradiol; 3H-1,2-dithiole-3-thione.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: N-Shc; neuronal Shc; SH2 domain protein C3; SHC (Src homology 2 domain containing) transforming protein 3; SHC-transforming protein 3; SHC-transforming protein C; ShcC; src homology 2 domain-containing transforming; src homology 2 domain-containing transforming protein C3; src homology 2 domain-containing-transforming protein C3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81713,803,980 - 13,924,433 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1713,803,781 - 13,924,433 (+)EnsemblGRCr8
mRatBN7.21713,652,247 - 13,772,710 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1713,651,202 - 13,772,710 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1713,575,650 - 13,696,217 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01715,186,152 - 15,306,918 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01713,502,421 - 13,623,026 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01713,670,520 - 13,791,043 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1713,670,520 - 13,791,043 (+)Ensemblrn6Rnor6.0
Rnor_5.01715,743,125 - 15,862,911 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41719,520,861 - 19,649,482 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1713,401,154 - 13,520,906 (+)NCBICelera
RGSC_v3.11719,520,646 - 19,649,496 (+)NCBI
Cytogenetic Map17p14NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
Ependymomas  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,3-dinitrobenzene  (EXP)
17alpha-ethynylestradiol  (EXP)
2-palmitoylglycerol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP,ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (EXP)
carbamazepine  (ISO)
D-glucose  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
dimethylarsinic acid  (EXP)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
glucose  (ISO)
herbicide  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indometacin  (ISO)
lead(0)  (ISO)
manganese(II) chloride  (EXP)
mercury dibromide  (ISO)
methimazole  (EXP)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
nickel atom  (ISO)
okadaic acid  (ISO)
ouabain  (ISO)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
perfluorooctanoic acid  (EXP)
phenylmercury acetate  (ISO)
propiconazole  (EXP)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
temozolomide  (ISO)
tetraphene  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
valproic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (TAS)
nucleoplasm  (IEA,ISO)
plasma membrane  (IBA,TAS)
synapse  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Differential regulation of Shc adaptor proteins in skeletal muscle, spinal cord and forebrain of aged rats with sensorimotor impairment. Jiang X, etal., Aging Cell 2003 Feb;2(1):47-57.
3. EDG3 and SHC3 on chromosome 9q22 are co-amplified in human ependymomas. Magrassi L, etal., Cancer Lett. 2010 Apr 1;290(1):36-42. doi: 10.1016/j.canlet.2009.08.023. Epub 2009 Sep 12.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7970708   PMID:9507002   PMID:11812778   PMID:12111828   PMID:15716419   PMID:20624904   PMID:26058566  


Genomics

Comparative Map Data
Shc3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81713,803,980 - 13,924,433 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1713,803,781 - 13,924,433 (+)EnsemblGRCr8
mRatBN7.21713,652,247 - 13,772,710 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1713,651,202 - 13,772,710 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1713,575,650 - 13,696,217 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01715,186,152 - 15,306,918 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01713,502,421 - 13,623,026 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01713,670,520 - 13,791,043 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1713,670,520 - 13,791,043 (+)Ensemblrn6Rnor6.0
Rnor_5.01715,743,125 - 15,862,911 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41719,520,861 - 19,649,482 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1713,401,154 - 13,520,906 (+)NCBICelera
RGSC_v3.11719,520,646 - 19,649,496 (+)NCBI
Cytogenetic Map17p14NCBI
SHC3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38989,005,771 - 89,178,818 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl989,005,771 - 89,178,818 (-)Ensemblhg38GRCh38
GRCh37991,620,686 - 91,793,733 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36990,817,880 - 90,983,502 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34988,857,624 - 89,023,236NCBI
Celera962,203,335 - 62,375,878 (-)NCBICelera
Cytogenetic Map9q22.1NCBI
HuRef961,453,127 - 61,626,017 (-)NCBIHuRef
CHM1_1991,768,840 - 91,942,224 (-)NCBICHM1_1
T2T-CHM13v2.09101,168,260 - 101,341,598 (-)NCBIT2T-CHM13v2.0
Shc3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391351,577,422 - 51,724,909 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1351,585,077 - 51,723,523 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381351,423,389 - 51,569,451 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1351,431,041 - 51,569,487 (-)Ensemblmm10GRCm38
MGSCv371351,526,410 - 51,662,453 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361351,443,537 - 51,588,327 (-)NCBIMGSCv36mm8
Celera1352,503,726 - 52,639,942 (-)NCBICelera
Cytogenetic Map13A5NCBI
cM Map1326.12NCBI
Shc3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555152,860,230 - 3,016,467 (+)Ensembl
ChiLan1.0NW_0049555152,858,971 - 3,016,467 (+)NCBIChiLan1.0ChiLan1.0
SHC3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21150,150,180 - 50,456,193 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1950,152,573 - 50,458,581 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0960,095,067 - 60,269,949 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1988,140,761 - 88,313,139 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl988,148,449 - 88,311,146 (-)EnsemblpanPan2panpan1.1
SHC3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1197,019,545 - 97,100,905 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl197,019,928 - 97,094,844 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha197,456,055 - 97,564,767 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0197,605,053 - 97,713,762 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl197,605,068 - 97,706,768 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1197,232,817 - 97,341,513 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0196,951,908 - 97,060,586 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0197,710,375 - 97,819,108 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Shc3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494410,892,479 - 10,985,809 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049367807,885 - 130,002 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SHC3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14679,431 - 834,382 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.114672,439 - 836,090 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214903,959 - 912,925 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SHC3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11299,503,936 - 99,672,438 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1299,506,647 - 99,669,792 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603887,820,415 - 87,993,183 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Shc3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476523,486,712 - 23,653,778 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476523,486,707 - 23,659,951 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Shc3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11469,816,284 - 69,940,946 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Shc3
1254 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:135
Count of miRNA genes:111
Interacting mature miRNAs:116
Transcripts:ENSRNOT00000019442
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17143999106Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17926675540968173Rat
2293664Bmd28Bone mineral density QTL 285.10.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)17436005727233623Rat
8552966Pigfal18Plasma insulin-like growth factor 1 level QTL 188.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)171286094257860942Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17212084342054133Rat
1582224Epfw4Epididymal fat weight QTL 43.50.0058epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)17920650523859062Rat
1582225Bw67Body weight QTL 676.20.0001body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)17622199858177198Rat
1582226Bw64Body weight QTL 644.20.0017body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
9589151Insul30Insulin level QTL 308.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)171286094257860942Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131706603Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17473353449733534Rat
9589057Scfw6Subcutaneous fat weight QTL 68.620.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)171286094257860942Rat
1582208Kidm32Kidney mass QTL 323.90.0018kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17920650523859062Rat
9590154Scort9Serum corticosterone level QTL 923.570.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)171286094257860942Rat
9590088Insglur7Insulin/glucose ratio QTL 720.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)171286094257860942Rat
1549900Iddm20Insulin dependent diabetes mellitus QTL 203.7pancreas integrity trait (VT:0010560)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)17122181410Rat
2317053Aia25Adjuvant induced arthritis QTL 252.69joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)171060469455604694Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17136045694Rat
7411666Foco31Food consumption QTL 3111.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)171286094257860942Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)17121499218Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17473353449733534Rat
1581553Pur14Proteinuria QTL 145.30.0001urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)17798524316523460Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17857434232199534Rat
1582258Bw76Body weight QTL 764.60.0005body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17138037084Rat
1582199Insul5Insulin level QTL 53.40.0119blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)17920650523859062Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17143999106Rat
2293648Bmd31Bone mineral density QTL 314.50.0001femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)17436005727233623Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17143999106Rat
1641902Colcr7Colorectal carcinoma resistance QTL 73.350.0044intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)17212084322087569Rat
1582241Bw70Body weight QTL 704.60.0003body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
1582245Bw73Body weight QTL 734.60.0004body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122877318Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
12 10 57 147 50 45 22 15 22 6 199 104 9 126 54 91 23 15 15

Sequence


Ensembl Acc Id: ENSRNOT00000019442   ⟹   ENSRNOP00000019442
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1713,803,781 - 13,924,433 (+)Ensembl
mRatBN7.2 Ensembl1713,651,202 - 13,772,710 (+)Ensembl
Rnor_6.0 Ensembl1713,670,520 - 13,791,043 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110299   ⟹   ENSRNOP00000091901
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1713,803,781 - 13,924,147 (+)Ensembl
mRatBN7.2 Ensembl1713,651,202 - 13,772,424 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000118036   ⟹   ENSRNOP00000087909
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1713,803,781 - 13,924,433 (+)Ensembl
mRatBN7.2 Ensembl1713,651,202 - 13,772,710 (+)Ensembl
RefSeq Acc Id: NM_001105743   ⟹   NP_001099213
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81713,803,980 - 13,924,433 (+)NCBI
mRatBN7.21713,652,247 - 13,772,710 (+)NCBI
Rnor_6.01713,670,520 - 13,791,043 (+)NCBI
Rnor_5.01715,743,125 - 15,862,911 (+)NCBI
RGSC_v3.41719,520,861 - 19,649,482 (+)RGD
Celera1713,401,154 - 13,520,906 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001099213 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL98091 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000019442
GenBank Protein O70143 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001099213   ⟸   NM_001105743
- UniProtKB: O70143 (UniProtKB/Swiss-Prot),   G3V7V0 (UniProtKB/TrEMBL),   A6J6U1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000019442   ⟸   ENSRNOT00000019442
Ensembl Acc Id: ENSRNOP00000091901   ⟸   ENSRNOT00000110299
Ensembl Acc Id: ENSRNOP00000087909   ⟸   ENSRNOT00000118036
Protein Domains
PID   SH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O70143-F1-model_v2 AlphaFold O70143 1-594 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69348 AgrOrtholog
BioCyc Gene G2FUF-10070 BioCyc
Ensembl Genes ENSRNOG00000014366 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000019442 ENTREZGENE
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot
  3.30.505.10 UniProtKB/Swiss-Prot
InterPro CEP152/SHC-Transforming UniProtKB/Swiss-Prot
  PH-like_dom_sf UniProtKB/Swiss-Prot
  PID_Shc-like UniProtKB/Swiss-Prot
  PTB/PI_dom UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
  SH2_dom_sf UniProtKB/Swiss-Prot
  SHC_SH2 UniProtKB/Swiss-Prot
NCBI Gene 114858 ENTREZGENE
PANTHER PTHR10337:SF4 UniProtKB/Swiss-Prot
  SHC TRANSFORMING PROTEIN UniProtKB/Swiss-Prot
Pfam PID UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
PhenoGen Shc3 PhenoGen
PRINTS SH2DOMAIN UniProtKB/Swiss-Prot
  SHCPIDOMAIN UniProtKB/Swiss-Prot
PROSITE PID UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000014366 RatGTEx
SMART PTB UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot
  SSF55550 UniProtKB/Swiss-Prot
UniProt A0A8I6A6R6_RAT UniProtKB/TrEMBL
  A0A8I6AFF3_RAT UniProtKB/TrEMBL
  A6J6U1 ENTREZGENE, UniProtKB/TrEMBL
  G3V7V0 ENTREZGENE, UniProtKB/TrEMBL
  O70143 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-20 Shc3  SHC adaptor protein 3  Shc3  SHC (Src homology 2 domain containing) transforming protein 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-04 Shc3  SHC (Src homology 2 domain containing) transforming protein 3  Shc3  src homology 2 domain-containing transforming protein C3   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Shc3  src homology 2 domain-containing transforming protein C3       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference