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Gene: Serpinb5 (serpin family B member 5) Rattus norvegicus

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Symbol:

Serpinb5

Name:

serpin family B member 5

RGD ID:

69342

Description:

Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to act upstream of or within several processes, including extracellular matrix organization; prostate gland morphogenesis; and regulation of epithelial cell proliferation. Predicted to be located in sarcoplasm. Predicted to be active in cornified envelope and extracellular space. Orthologous to human SERPINB5 (serpin family B member 5); PARTICIPATES IN p53 signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; acrylamide; ammonium chloride.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

Maspin; Maspin, serine protease inhibitor; peptidase inhibitor 5; PI-5; Pi5; protease inhibitor 5; serine (or cysteine) peptidase inhibitor, clade B, member 5; serine (or cysteine) proteinase inhibitor clade B (ovalbumin) member 5; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5; serine (or cysteine) proteinase inhibitor, clade B, member 5; serpin B5; serpin peptidase inhibitor, clade B (ovalbumin), member 5

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SERPINB5 (serpin family B member 5)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Serpinb5 (serine (or cysteine) peptidase inhibitor, clade B, member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Serpinb5 (serpin family B member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SERPINB5 (serpin family B member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SERPINB5 (serpin family B member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Serpinb5 (serpin family B member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SERPINB5 (serpin family B member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SERPINB5 (serpin family B member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Serpinb5 (serpin family B member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	TCHP (trichoplein keratin filament binding)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	SERPINB5 (serpin family B member 5)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Serpinb5 (serine (or cysteine) peptidase inhibitor, clade B, member 5)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Spn27A	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	srp-6	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	srp-6	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|SonicParanoid)
Caenorhabditis elegans (roundworm):	srp-7	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	srp-7	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|SonicParanoid)
Caenorhabditis elegans (roundworm):	srp-8	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	srp-8	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Spn28Db	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Drosophila melanogaster (fruit fly):	Spn43Aa	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Spn47C	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Spn53F	Alliance	DIOPT (Ensembl Compara\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Spn55B	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Spn55B	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoInspector\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Spn88Ea	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Spn88Eb	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	nec	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Spn31A	Alliance	DIOPT (Ensembl Compara\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	serpinb5	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	23,500,203 - 23,520,401 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	23,500,198 - 23,520,400 (+)	Ensembl				GRCr8
mRatBN7.2	13	22,985,557 - 23,005,756 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	22,985,557 - 23,005,756 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	13	23,302,154 - 23,322,367 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	24,586,612 - 24,606,829 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	23,272,318 - 23,292,534 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	26,903,052 - 26,923,250 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	26,903,052 - 26,923,250 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	13	32,053,528 - 32,073,726 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	13	13,037,587 - 13,057,785 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	13	22,842,781 - 22,862,980 (+)	NCBI		Celera
RGSC_v3.1	13	13,037,586 - 13,057,785 (+)	NCBI
Cytogenetic Map	13	p11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Breast Neoplasms (ISO)

Colonic Neoplasms (ISO)

Colorectal Neoplasms (ISO)

hepatocellular carcinoma (ISO)

invasive ductal carcinoma (ISO)

Keloid (ISO)

Neoplasm Metastasis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (EXP,ISO)

17beta-estradiol (ISO)

17beta-hydroxy-17-methylestra-4,9,11-trien-3-one (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4,6-trinitrobenzenesulfonic acid (ISO)

2,6-dimethoxyphenol (ISO)

2-acetamidofluorene (ISO)

2-deoxy-D-glucose (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxynon-2-enal (ISO)

5-aza-2'-deoxycytidine (ISO)

5-fluorouracil (ISO)

acetylsalicylic acid (ISO)

acrylamide (EXP)

actinomycin D (ISO)

adefovir pivoxil (ISO)

ammonium chloride (EXP)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

beta-lapachone (ISO)

biphenyl-2-ol (ISO)

bis(2-chloroethyl) sulfide (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

butan-1-ol (ISO)

calcitriol (ISO)

camptothecin (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chloropicrin (ISO)

chrysene (ISO)

cidofovir anhydrous (ISO)

cisplatin (ISO)

cobalt atom (ISO)

copper atom (EXP,ISO)

copper(0) (EXP,ISO)

copper(II) chloride (ISO)

curcumin (ISO)

DDT (ISO)

deoxycholic acid (ISO)

diarsenic trioxide (ISO)

dichlorine (EXP)

diethyl phthalate (EXP)

diethylstilbestrol (ISO)

dioxygen (ISO)

doxazosin (ISO)

folic acid (ISO)

formaldehyde (ISO)

fulvestrant (ISO)

furan (EXP)

furfural (ISO)

furosemide (EXP)

genistein (ISO)

hydrogen peroxide (ISO)

irinotecan (ISO)

menadione (ISO)

methotrexate (ISO)

methylseleninic acid (ISO)

microcystin RR (ISO)

monosodium L-glutamate (ISO)

Muraglitazar (EXP)

N-nitrosodiethylamine (EXP)

Nutlin-3 (ISO)

okadaic acid (ISO)

ozone (EXP)

paracetamol (ISO)

pentane-2,3-dione (EXP)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (EXP)

perfluorooctanoic acid (EXP)

phenethyl caffeate (EXP)

PhIP (EXP)

procyanidin B2 (ISO)

progesterone (ISO)

quinoline (ISO)

resveratrol (ISO)

sodium arsenite (ISO)

sodium chloride (ISO)

sodium fluoride (ISO)

Soman (EXP)

succimer (ISO)

sulindac sulfide (ISO)

tamoxifen (ISO)

tanespimycin (ISO)

tert-butyl hydroperoxide (ISO)

Tesaglitazar (EXP)

Theaflavin 3,3'-digallate (ISO)

thiram (ISO)

trichostatin A (ISO)

troglitazone (EXP)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

extracellular matrix organization (ISO)

morphogenesis of an epithelium (ISO)

prostate gland morphogenesis (ISO)

regulation of epithelial cell proliferation (ISO)

Cellular Component

apical part of cell (IEA,ISO)

cell surface (IEA,ISO)

cornified envelope (IEA,ISO)

cytoplasm (IEA,ISO)

extracellular region (IEA)

extracellular space (IBA,IEA)

Molecular Function

protein binding (ISO)

serine-type endopeptidase inhibitor activity (IBA,IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

p53 signaling pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	miRNA-7/21/107 contribute to HBx-induced hepatocellular carcinoma progression through suppression of maspin.	Chen WS, etal., Oncotarget. 2015 Sep 22;6(28):25962-74. doi: 10.18632/oncotarget.4504.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
5.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
6.	GOA pipeline	RGD automated data pipeline
7.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	Localization of 54 rat genes, and definition of new synteny groups conserved in the human and the rat.	Szpirer C, etal., Mamm Genome 2000 Sep;11(9):729-35
10.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
11.	Rat and human maspins: structures, metastatic suppressor activity and mutation in prostate cancer cells.	Umekita Y, etal., Cancer Lett 1997 Feb 26;113(1-2):87-93.

Additional References at PubMed

PMID:16049006	PMID:17563239	PMID:17950367	PMID:18593913	PMID:21069375	PMID:23376485	PMID:32746986	PMID:34059749

Genomics

Comparative Map Data

Serpinb5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	23,500,203 - 23,520,401 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	23,500,198 - 23,520,400 (+)	Ensembl				GRCr8
mRatBN7.2	13	22,985,557 - 23,005,756 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	22,985,557 - 23,005,756 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	13	23,302,154 - 23,322,367 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	24,586,612 - 24,606,829 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	23,272,318 - 23,292,534 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	26,903,052 - 26,923,250 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	26,903,052 - 26,923,250 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	13	32,053,528 - 32,073,726 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	13	13,037,587 - 13,057,785 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	13	22,842,781 - 22,862,980 (+)	NCBI		Celera
RGSC_v3.1	13	13,037,586 - 13,057,785 (+)	NCBI
Cytogenetic Map	13	p11	NCBI

SERPINB5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	18	63,476,958 - 63,505,085 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	18	63,476,945 - 63,505,085 (+)	Ensembl			hg38	GRCh38
GRCh37	18	61,144,191 - 61,172,318 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	18	59,295,199 - 59,323,297 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	18	59,295,198 - 59,323,297	NCBI
Celera	18	57,864,608 - 57,892,790 (+)	NCBI		Celera
Cytogenetic Map	18	q21.33	NCBI
HuRef	18	57,843,583 - 57,871,802 (+)	NCBI		HuRef
CHM1_1	18	61,140,108 - 61,168,279 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	18	63,682,029 - 63,710,157 (+)	NCBI		T2T-CHM13v2.0

Serpinb5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	106,788,905 - 106,811,078 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	106,788,903 - 106,811,078 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	1	106,861,175 - 106,883,348 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	106,861,173 - 106,883,348 (+)	Ensembl			mm10	GRCm38
MGSCv37	1	108,757,757 - 108,779,925 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	1	108,688,727 - 108,710,895 (+)	NCBI		MGSCv36	mm8
Celera	1	109,710,530 - 109,732,695 (+)	NCBI		Celera
Cytogenetic Map	1	E2.1	NCBI
cM Map	1	50.34	NCBI

Serpinb5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955402	47,248,932 - 47,276,834 (+)	Ensembl
ChiLan1.0	NW_004955402	47,248,665 - 47,276,017 (+)	NCBI	ChiLan1.0	ChiLan1.0

SERPINB5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	17	80,987,697 - 81,017,301 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	18	66,680,457 - 66,708,595 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	18	56,836,403 - 56,864,533 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	18	60,148,552 - 60,176,624 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	18	60,148,552 - 60,176,624 (+)	Ensembl			panPan2	panpan1.1

SERPINB5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	13,566,982 - 13,638,839 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	13,568,376 - 13,638,781 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	14,528,333 - 14,605,043 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	13,422,906 - 13,500,501 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	13,424,300 - 13,500,439 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	13,461,241 - 13,538,649 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	13,390,278 - 13,467,916 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	13,639,169 - 13,716,725 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Serpinb5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404944	26,828,821 - 26,851,011 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936497	2,069,035 - 2,089,745 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936497	2,067,796 - 2,089,965 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SERPINB5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	158,167,646 - 158,195,796 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	1	158,167,756 - 158,195,896 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	175,646,842 - 175,666,862 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SERPINB5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	18	16,256,700 - 16,284,410 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	18	16,256,552 - 16,283,764 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666060	9,405,922 - 9,432,976 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Serpinb5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624792	9,198,657 - 9,221,264 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624792	9,196,932 - 9,220,147 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Variants

Variants in Serpinb5
137 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	105
Count of miRNA genes:	88
Interacting mature miRNAs:	94
Transcripts:	ENSRNOT00000003625
Prediction methods:	Miranda
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2317027	Aia22	Adjuvant induced arthritis QTL 22	2.29		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	13	1	34785618	Rat
2302275	Gluco37	Glucose level QTL 37	3.8		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	13	12448421	48744906	Rat
7207885	Glom27	Glomerulus QTL 27	3.9		kidney glomerulus integrity trait (VT:0010546)	kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)	13	21120177	109350286	Rat
9589141	Insul28	Insulin level QTL 28	10.82	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	13	11866254	56866254	Rat
1354621	Rf47	Renal function QTL 47	3.7		kidney renin amount (VT:0010559)	kidney renin level (CMO:0002166)	13	11081740	103588154	Rat
2317034	Aia9	Adjuvant induced arthritis QTL 9	4.62		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	12285517	34884386	Rat
1581554	Pur11	Proteinuria QTL 11			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	6002008	88706694	Rat
12879471	Bp398	Blood pressure QTL 398			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	3088755	48088755	Rat
1300163	Cardf1	Cardiac cell morphology QTL 1	4.18		aorta morphology trait (VT:0000272)	artery lesion measurement (CMO:0000975)	13	12448421	47969993	Rat
631672	Iddm12	Insulin dependent diabetes mellitus QTL 12	2.2	0.0032	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	13	6002008	37088115	Rat
2317040	Aia21	Adjuvant induced arthritis QTL 21	2.75		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	12384320	57384320	Rat
2303031	Bp326	Blood pressure QTL 326			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	12285517	23516549	Rat
631645	Bp121	Blood pressure QTL 121	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	17468282	62468282	Rat
2303030	Bp327	Blood pressure QTL 327			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	1	43736554	Rat
2317046	Aia8	Adjuvant induced arthritis QTL 8	3.9700000286102295		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	12384320	57384320	Rat
619615	Bp80	Blood pressure QTL 80		0.0354	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	7421791	87286911	Rat
2317044	Aia23	Adjuvant induced arthritis QTL 23	2.3		joint integrity trait (VT:0010548)	ankle joint diameter (CMO:0002148)	13	12285517	34884386	Rat
61339	Bp24	Blood pressure QTL 24		0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	6002008	47359539	Rat
1581573	Uae36	Urinary albumin excretion QTL 36			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	6002008	88706694	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	1	103588154	Rat
9589164	Gluco66	Glucose level QTL 66	6.67	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	13	17711336	62711336	Rat
738036	Lnnr4	Liver neoplastic nodule remodeling QTL 4	3.64		liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number (CMO:0001461)	13	1	34785618	Rat
7411662	Foco29	Food consumption QTL 29	20.8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	13	11866254	56866254	Rat

Markers in Region

D13Rat60

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	13	23,516,424 - 23,516,549 (+)	Marker Load Pipeline
mRatBN7.2	13	23,001,779 - 23,001,904 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	26,919,274 - 26,919,398	NCBI	Rnor6.0
Rnor_5.0	13	32,069,750 - 32,069,874	UniSTS	Rnor5.0
RGSC_v3.4	13	13,053,809 - 13,053,933	UniSTS	RGSC3.4
RGSC_v3.4	13	13,053,808 - 13,053,933	RGD	RGSC3.4
Celera	13	22,859,002 - 22,859,128	UniSTS
RGSC_v3.1	13	13,053,595 - 13,053,950	RGD
SHRSP x BN Map	13	3.3799	UniSTS
SHRSP x BN Map	13	3.3799	RGD
Cytogenetic Map	13	p13	UniSTS

RH134638

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	23,005,295 - 23,005,505 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	26,922,790 - 26,922,999	NCBI	Rnor6.0
Rnor_5.0	13	32,073,266 - 32,073,475	UniSTS	Rnor5.0
RGSC_v3.4	13	13,057,325 - 13,057,534	UniSTS	RGSC3.4
Celera	13	22,862,520 - 22,862,729	UniSTS
Cytogenetic Map	13	p13	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
16	5	10	29	51	56	30	14	30	6	151	30	19	70	86	26

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_057108	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAXUCZ010000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000003625 ⟹ ENSRNOP00000003625

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	23,500,198 - 23,520,400 (+)	Ensembl
mRatBN7.2 Ensembl	13	22,985,557 - 23,005,756 (+)	Ensembl
Rnor_6.0 Ensembl	13	26,903,052 - 26,923,250 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000110683 ⟹ ENSRNOP00000079975

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	22,993,345 - 23,005,756 (+)	Ensembl

RefSeq Acc Id:

NM_057108 ⟹ NP_476449

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	23,500,203 - 23,520,401 (+)	NCBI
mRatBN7.2	13	22,985,557 - 23,005,756 (+)	NCBI
Rnor_6.0	13	26,903,052 - 26,923,250 (+)	NCBI
Rnor_5.0	13	32,053,528 - 32,073,726 (+)	NCBI
RGSC_v3.4	13	13,037,587 - 13,057,785 (+)	RGD
Celera	13	22,842,781 - 22,862,980 (+)	RGD

Sequence:

show sequence

CTTCTCCCTAGGCCCGGAGAACACAGCTTTCACTGCCTCTGAGTTCTTTAGGCCTTTTTCCCTT
CTTGCAGCTCATTTGCTGGGATACCTGCAACTAAAGGCCCAGGATGGATGCCTTGAGACTGGCA
AATTCAGCTTTTGCTGTTGAATTGTTCAAACAACTATGTGAAAAGGAGCCAGCAGGAAACATTC
TCTTCTCTCCGATATGCCTCTCCACTTCTCTGTCCCTTGCTCAAGTAGGCGCCAAAGGTGACAC
GGCAAATGAAATTGGACAGGTCCTTCATTTTGAGAATGTTAAAGATGTACCCTTTGGTTTCAAA
CCAATCACTTCTGATGTTAATAAGCTCAGTTCCTTTTATTCGCTGAAACTAATCAAGCGACTAT
ACATTGACAAATCTCTGAACCTTTCTACAGAATTTATCAGTTCTACAAAAAGACCATATGCCAA
CGAATTGGAAACTGTTGACTTCAAAGATAAACTGGAAGAGACGAAAGGTCAAATTAACAGCTCC
ATTAAGGAACTCACAGACGGCCACTTTGAAGATATTTTGCCAGAGAACAGTATAAGTGACCAGA
CCAAAATCCTTGTGGTTAATGCTGCCTACTTTGTTGGAAAGTGGATGAAGAAATTTCCAGAATC
AGAAACAAAAGAATGTCCATTCAGAATCAACAAGACAGACACCAAACCAGTACAAATGATGAAT
CTTGAGGCTACCTTCTGCTTGGGTAACATTGATGACATCAACTGTAAGATCATAGAACTTCCTT
TCCAGAATAAGCATCTCAGTATGCTCATTGTGCTCCCTAAGGACGTGGAAGATGAATCCACAGG
CCTGGAGAAGATTGAAAAACAACTCAACCCAGAAACACTGTTACAGTGGACCAACCCCAGCACC
ATGGCCAATGCCAAAGTCAAGCTTTCCCTTCCAAAGTTTAAGGTAGAAAAGATGATTGACCCCA
AGGCTAGTCTGGAAAGCCTAGGGCTGAAAAGTCTCTTCAATGAAAGTACATCGGATTTCTCTGG
AATGTCAGAGACCAAGGGAGTGTCCGTATCAAATGTGATTCACAGAGTATGCCTAGAAATAACT
GAAGATGGTGGTGATTCCATCGAGGTGCCAGGGTCCCGGATCTTACAGCACAAGGATGAATTCA
AAGCTGACCATCCATTTCTTTTTATCGTTCGACACAACAAAACTCGAAACATCGTTTTCTTGGG
CAAATTCTCTTCTCCTTAGCTGGCAGGGCCTGGCCAACTCTCAGGTAACTTGTCTGTAGTTGCA
GGGCTCTGTAAACTTTGTATCCAGAATCACTTCTATACAATAAATTGTGAATGTTGCTGAATCA
GGAAGCACTCCATATTTGTCATATGTCACCTTCATACTAACAGACACTTCCCCCTAATTCCTCC
TTGTTTTCCTTTGTCAAAGGAAACAGAGGATACTTGTGAAAGGGAATCCCTTTAGAAAACATGT
GCTCTGCATTTGTCAAAGCATCCAGAGCGATGGGCAAAAATTCAGTCTTCAAGGGAGGAATTGC
TGTAGGGATGACGTGGGGACATTATTCTCAGGGCTTTGCTTTACTGAGATAATAAAGAATGTTC
TAGAAATCTTCACTCCTTTCAACCCTTAAAAAACAATAGTGTATAAGGCCCACAAAGTACCCTT
TTCAAGTGAATTTGTGTACATGTCACAATACTGTAGGTCCAGAAGACTTCATGTTAAACCTTAA
GAAACAGTTTTTTTTCAAGATACTAATTGGAGATTTTAGAAGAATGACATATTGTTAATACTAT
TTATCATGGAATACCACAAATAGTATCTGGAATATTACCCTATCAACCAATATCTTAATATTTC
TTCTATAAATATACACTATTTTCACAAAATGAGTATATAAAGATCGTTCATAAGTGATCAATTT
TTCTGAAAAATGAGTACATTATCAGCTCATAAAAACACTTTGAAGAACATTCTAGATCTTGGAG
TGTTGGATAAAGAATTCTGGGCCTATTTTAGCAGAAGATCAAGACCCCAAGGGAAAGCTCAGCT
TTTAAAAAAAAACTGGCTTTCATTTTCCCTAGCTCTCCCTCGTGATCATTTGGGTAATGCTGTA
TTGGCCAGGCTTCTAACCAGATCACAAGGTCCCTGACGTCTCCAGCATCAGCAACTTAAAATCT
ACAGGGATTCTCGTGATGATAAGAGTTTTGTGGCCATTAAAGGGACTTTCCTCTTTGCCTAATG
TGTCGGGGGTGGGGAGGTAAGGGATCCCAAACTCTCAGAAAATACAAGGAAAACTATTTAAGTA
CCCACAATGCTTTGGCATATATTTTTCTCAGTTTATAAATTTAGCTATTTCAGATAGCAGTTTG
TAGCCTACATAAATAATTTATAAAATGGTAAGTCAGTTATGTTGCAATCCAATTTTTAAATTCA
CCACCAAAAGGAAGTATTTGCTGCAGTTTTTCTTATGTGTCTTTCCTTATCCAATTTCTTACCA
TTTATGGCAAATAAGTTGTTCCAAGGGTTCAGTGGTGACTTCTTTTCTGTGCTATTTGACAATA
AAATATTATTGAATTA

hide sequence

Protein Sequences


Protein RefSeqs	NP_476449	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000003625
GenBank Protein	P70564	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_476449 ⟸ NM_057108

- UniProtKB:

P70564 (UniProtKB/Swiss-Prot), G3V6C1 (UniProtKB/TrEMBL), A6JSV3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDALRLANSAFAVELFKQLCEKEPAGNILFSPICLSTSLSLAQVGAKGDTANEIGQVLHFENVK
DVPFGFKPITSDVNKLSSFYSLKLIKRLYIDKSLNLSTEFISSTKRPYANELETVDFKDKLEET
KGQINSSIKELTDGHFEDILPENSISDQTKILVVNAAYFVGKWMKKFPESETKECPFRINKTDT
KPVQMMNLEATFCLGNIDDINCKIIELPFQNKHLSMLIVLPKDVEDESTGLEKIEKQLNPETLL
QWTNPSTMANAKVKLSLPKFKVEKMIDPKASLESLGLKSLFNESTSDFSGMSETKGVSVSNVIH
RVCLEITEDGGDSIEVPGSRILQHKDEFKADHPFLFIVRHNKTRNIVFLGKFSSP

hide sequence

Ensembl Acc Id:

ENSRNOP00000003625 ⟸ ENSRNOT00000003625

Ensembl Acc Id:

ENSRNOP00000079975 ⟸ ENSRNOT00000110683

Protein Domains

SERPIN

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P70564-F1-model_v2	AlphaFold	P70564	1-375	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698752

Promoter ID:

EPDNEW_R9277

Type:

initiation region

Name:

Serpinb5_1

Description:

serpin family B member 5

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	13	26,903,051 - 26,903,111	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:69342	AgrOrtholog
BioCyc Gene	G2FUF-18600	BioCyc
Ensembl Genes	ENSRNOG00000002640	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000003625	ENTREZGENE
Gene3D-CATH	2.30.39.10	UniProtKB/Swiss-Prot
	3.30.497.10	UniProtKB/Swiss-Prot
InterPro	Serpin_B9/Maspin	UniProtKB/Swiss-Prot
	Serpin_CS	UniProtKB/Swiss-Prot
	Serpin_dom	UniProtKB/Swiss-Prot
	Serpin_fam	UniProtKB/Swiss-Prot
	Serpin_sf	UniProtKB/Swiss-Prot
	Serpin_sf_1	UniProtKB/Swiss-Prot
	Serpin_sf_2	UniProtKB/Swiss-Prot
	SERPINB5_serpin_dom	UniProtKB/Swiss-Prot
KEGG Report	rno:116589	UniProtKB/Swiss-Prot
NCBI Gene	116589	ENTREZGENE
PANTHER	PTHR11461	UniProtKB/Swiss-Prot
	SERPIN B5	UniProtKB/Swiss-Prot
Pfam	Serpin	UniProtKB/Swiss-Prot
PhenoGen	Serpinb5	PhenoGen
PRINTS	MASPIN	UniProtKB/Swiss-Prot
PROSITE	SERPIN	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000002640	RatGTEx
SMART	SERPIN	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF56574	UniProtKB/Swiss-Prot
TIGR	TC217606
UniProt	A6JSV3	ENTREZGENE, UniProtKB/TrEMBL
	G3V6C1	ENTREZGENE, UniProtKB/TrEMBL
	P70564	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-04-13	Serpinb5	serpin family B member 5	Serpinb5	serpin peptidase inhibitor, clade B (ovalbumin), member 5	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2011-01-19	Serpinb5	serpin peptidase inhibitor, clade B (ovalbumin), member 5	Serpinb5	serine (or cysteine) peptidase inhibitor, clade B, member 5	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Serpinb5	serine (or cysteine) peptidase inhibitor, clade B, member 5		serine (or cysteine) proteinase inhibitor, clade B, member 5	Name updated	1299863	APPROVED
2002-06-10	Serpinb5	serine (or cysteine) proteinase inhibitor, clade B, member 5			Name updated	70584	APPROVED

RGD Curation Notes

Note Type	Note	Reference

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)