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Gene: Abcd2 (ATP binding cassette subfamily D member 2) Rattus norvegicus

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Symbol:

Abcd2

Name:

ATP binding cassette subfamily D member 2

RGD ID:

69244

Description:

Enables protein heterodimerization activity and protein homodimerization activity. Involved in very long-chain fatty acid catabolic process. Located in peroxisomal membrane. Orthologous to human ABCD2 (ATP binding cassette subfamily D member 2); PARTICIPATES IN adrenoleukodystrophy pathway; carnitine-acylcarnitine translocase deficiency; fatty acid beta degradation pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

adrenoleukodystrophy-related protein; ALDR; ATP-binding cassette sub-family D member 2; ATP-binding cassette, sub-family D (ALD), member 2; ATP-binding cassette, subfamily D (ALD), member 2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ABCD2 (ATP binding cassette subfamily D member 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Abcd2 (ATP-binding cassette, sub-family D member 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Abcd2 (ATP binding cassette subfamily D member 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ABCD2 (ATP binding cassette subfamily D member 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ABCD2 (ATP binding cassette subfamily D member 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Abcd2 (ATP binding cassette subfamily D member 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ABCD2 (ATP binding cassette subfamily D member 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ABCD2 (ATP binding cassette subfamily D member 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Abcd2 (ATP binding cassette subfamily D member 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Abcd2 (ATP binding cassette subfamily D member 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	ABCD2 (ATP binding cassette subfamily D member 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Abcd2 (ATP-binding cassette, sub-family D member 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG2316	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	PXA1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	PXA1	Alliance	DIOPT (InParanoid\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	PXA2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	pmp-4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	abcd2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Is Marker For:

Strains: WIST/Nhg

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	124,142,597 - 124,191,202 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	7	124,142,595 - 124,191,202 (-)	Ensembl				GRCr8
mRatBN7.2	7	122,263,034 - 122,311,642 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	122,263,032 - 122,311,642 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	7	124,054,640 - 124,103,336 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	126,280,755 - 126,329,211 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	126,207,915 - 126,256,642 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	132,294,564 - 132,343,169 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	132,294,562 - 132,343,169 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	7	131,968,475 - 132,017,044 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	7	129,542,758 - 129,591,363 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	7	118,713,620 - 118,762,172 (-)	NCBI		Celera
RGSC_v3.1	7	129,577,902 - 129,626,508 (-)	NCBI
Cytogenetic Map	7	q35	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Colorectal Neoplasms (ISO)

hypothyroidism (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

17beta-estradiol (EXP,ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4,6-trinitrotoluene (EXP)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

3,4-methylenedioxymethamphetamine (ISO)

3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid (ISO)

3-chloropropane-1,2-diol (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

8-Br-cAMP (ISO)

acrylamide (EXP)

aflatoxin B1 (EXP,ISO)

aldehydo-D-glucose (ISO)

alpha-Zearalanol (EXP)

amitriptyline (EXP)

amitrole (EXP)

ammonium chloride (EXP)

amphetamine (EXP)

aspartame (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

Butylbenzyl phthalate (EXP)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

chlorpyrifos (ISO)

clofibrate (ISO)

clothianidin (ISO)

crocidolite asbestos (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

D-glucose (ISO)

delta-tocotrienol (ISO)

dexamethasone (ISO)

Diallyl sulfide (ISO)

dichloroacetic acid (ISO)

diethylstilbestrol (EXP)

endosulfan (EXP,ISO)

epoxiconazole (ISO)

ethylparaben (ISO)

fructose (ISO)

furan (EXP)

gentamycin (EXP)

glucose (ISO)

indole-3-methanol (EXP)

indometacin (ISO)

ketoconazole (EXP)

lipopolysaccharide (ISO)

maneb (ISO)

methimazole (EXP)

monosodium L-glutamate (ISO)

N-nitrosodiethylamine (EXP,ISO)

okadaic acid (ISO)

orphenadrine (EXP)

ozone (ISO)

paracetamol (EXP,ISO)

paraquat (EXP,ISO)

parathion (ISO)

perfluorooctanoic acid (EXP)

phenformin (EXP)

phenobarbital (ISO)

pirinixic acid (ISO)

quercetin (ISO)

resveratrol (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

Soman (EXP)

sulfadimethoxine (EXP)

Tesaglitazar (EXP)

testosterone (ISO)

tetrachloroethene (ISO)

tetrachloromethane (EXP,ISO)

tetracycline (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

tolcapone (EXP)

trichloroethene (EXP,ISO)

triphenyl phosphate (EXP,ISO)

Triptolide (ISO)

trovafloxacin (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

fatty acid beta-oxidation (IBA,IEA,ISO)

fatty acid biosynthetic process (IEA,ISO)

long-chain fatty acid import into peroxisome (IBA)

myelin maintenance (IEA,ISO,ISS)

negative regulation of cytokine production involved in inflammatory response (IEA,ISO,ISS)

negative regulation of reactive oxygen species biosynthetic process (IEA,ISO,ISS)

neuron projection maintenance (IEA,ISO,ISS)

peroxisome organization (IBA)

positive regulation of fatty acid beta-oxidation (IEA,ISO,ISS)

positive regulation of unsaturated fatty acid biosynthetic process (IEA,ISO,ISS)

response to bacterium (ISO)

transmembrane transport (IEA)

very long-chain fatty acid catabolic process (IBA,IEA,IMP,ISO,ISS)

very long-chain fatty acid metabolic process (IEA,IMP,ISO,ISS)

Cellular Component

membrane (IEA)

peroxisomal membrane (IBA,IDA,IEA,ISO)

peroxisome (IDA,IEA,ISO)

Molecular Function

ABC-type transporter activity (IEA)

ATP binding (IBA,IEA)

ATP hydrolysis activity (IEA,ISO)

ATPase-coupled transmembrane transporter activity (IBA,IEA,ISO,ISS)

fatty acyl-CoA hydrolase activity (IEA,ISO,ISS)

hydrolase activity (IEA)

long-chain fatty acid transmembrane transporter activity (IBA,IEA,ISO)

nucleotide binding (IEA)

protein binding (IPI,ISO)

protein heterodimerization activity (IDA)

protein homodimerization activity (IDA,IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

adrenoleukodystrophy pathway (ISO)

carnitine-acylcarnitine translocase deficiency (ISO)

fatty acid beta degradation pathway (ISO)

phytanic acid degradation pathway (ISO)

Refsum disease pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Rat adrenoleukodystrophy-related (ALDR) gene: full-length cDNA sequence and new insight in expression.	Albet S, etal., Biochim Biophys Acta 2001 Jan 26;1517(2):257-69.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Structure-function analysis of peroxisomal ATP-binding cassette transporters using chimeric dimers.	Geillon F, etal., J Biol Chem. 2014 Aug 29;289(35):24511-20. doi: 10.1074/jbc.M114.575506. Epub 2014 Jul 20.
4.	Peroxisomal ATP-binding cassette transporters form mainly tetramers.	Geillon F, etal., J Biol Chem. 2017 Apr 28;292(17):6965-6977. doi: 10.1074/jbc.M116.772806. Epub 2017 Mar 3.
5.	Substrate specificity overlap and interaction between adrenoleukodystrophy protein (ALDP/ABCD1) and adrenoleukodystrophy-related protein (ALDRP/ABCD2).	Genin EC, etal., J Biol Chem. 2011 Mar 11;286(10):8075-8084. doi: 10.1074/jbc.M110.211912. Epub 2011 Jan 5.
6.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
7.	A Thyroid Hormone-Based Strategy for Correcting the Biochemical Abnormality in X-Linked Adrenoleukodystrophy.	Hartley MD, etal., Endocrinology. 2017 May 1;158(5):1328-1338. doi: 10.1210/en.2016-1842.
8.	Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease.	Kikuchi M, etal., J Biol Chem. 2004 Jan 2;279(1):421-8. Epub 2003 Oct 15.
9.	A close relative of the adrenoleukodystrophy (ALD) gene codes for a peroxisomal protein with a specific expression pattern.	Lombard-Platet G, etal., Proc Natl Acad Sci U S A 1996 Feb 6;93(3):1265-9.
10.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
11.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
12.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
13.	GOA pipeline	RGD automated data pipeline
14.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
16.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data

Additional References at PubMed

PMID:10196381	PMID:10329405	PMID:15489218	PMID:16412981	PMID:16854843	PMID:17686565	PMID:18614015	PMID:18624909	PMID:18723473	PMID:18854420	PMID:21145416	PMID:23012479

Genomics

Comparative Map Data

Abcd2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	124,142,597 - 124,191,202 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	7	124,142,595 - 124,191,202 (-)	Ensembl				GRCr8
mRatBN7.2	7	122,263,034 - 122,311,642 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	122,263,032 - 122,311,642 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	7	124,054,640 - 124,103,336 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	126,280,755 - 126,329,211 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	126,207,915 - 126,256,642 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	132,294,564 - 132,343,169 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	132,294,562 - 132,343,169 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	7	131,968,475 - 132,017,044 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	7	129,542,758 - 129,591,363 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	7	118,713,620 - 118,762,172 (-)	NCBI		Celera
RGSC_v3.1	7	129,577,902 - 129,626,508 (-)	NCBI
Cytogenetic Map	7	q35	NCBI

ABCD2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	39,531,025 - 39,619,803 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	39,550,033 - 39,619,803 (-)	Ensembl			hg38	GRCh38
GRCh37	12	39,943,835 - 40,013,605 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	38,232,813 - 38,300,237 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	12	38,232,813 - 38,300,237	NCBI
Celera	12	38,749,047 - 38,818,059 (-)	NCBI		Celera
Cytogenetic Map	12	q12	ENTREZGENE
HuRef	12	36,971,383 - 37,040,198 (-)	NCBI		HuRef
CHM1_1	12	39,911,021 - 39,979,850 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	12	39,480,907 - 39,601,214 (-)	NCBI		T2T-CHM13v2.0

Abcd2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	91,029,874 - 91,076,013 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	91,030,074 - 91,076,002 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	15	91,145,871 - 91,192,007 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	91,145,871 - 91,191,799 (-)	Ensembl			mm10	GRCm38
MGSCv37	15	90,976,302 - 91,022,238 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	15	90,973,638 - 91,019,574 (-)	NCBI		MGSCv36	mm8
Celera	15	93,253,156 - 93,299,066 (-)	NCBI		Celera
Cytogenetic Map	15	E3	NCBI
cM Map	15	46.0	NCBI

Abcd2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955505	721,222 - 798,470 (+)	Ensembl
ChiLan1.0	NW_004955505	717,800 - 769,702 (+)	NCBI	ChiLan1.0	ChiLan1.0

ABCD2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	54,525,947 - 54,601,622 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	54,522,683 - 54,598,358 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	49,082,122 - 49,158,524 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	49,941,914 - 50,011,140 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	49,941,914 - 50,011,140 (+)	Ensembl			panPan2	panpan1.1

ABCD2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	27	14,015,093 - 14,084,362 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	27	14,015,091 - 14,163,312 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	27	32,351,661 - 32,426,133 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	27	14,182,734 - 14,251,081 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	27	14,187,982 - 14,251,183 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	27	13,992,155 - 14,060,013 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	27	14,030,140 - 14,098,038 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	27	32,500,349 - 32,568,488 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Abcd2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	74,459,561 - 74,544,026 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936607	1,292,888 - 1,343,334 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936607	1,292,964 - 1,345,671 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ABCD2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	71,122,325 - 71,180,723 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	5	71,123,187 - 71,180,758 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	73,679,380 - 73,746,350 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ABCD2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	35,818,451 - 35,884,696 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666037	210,906,997 - 210,973,843 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Abcd2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624778	847,879 - 909,727 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624778	854,297 - 912,498 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Abcd2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	1	264,139,947 - 264,186,092 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Abcd2
830 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	380
Count of miRNA genes:	221
Interacting mature miRNAs:	282
Transcripts:	ENSRNOT00000021064
Prediction methods:	Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631529	Tls2	T-lymphoma susceptibility QTL 2	0	0.001	thymus integrity trait (VT:0010555)	percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)	7	82111382	132099989	Rat
1354582	Stl11	Serum triglyceride level QTL 11	3.42		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	7	121393075	137014596	Rat
731176	Glom5	Glomerulus QTL 5	2.5	0.0035	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	7	98549867	137014596	Rat
1300112	Bp183	Blood pressure QTL 183	3.51		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	7	119280025	135560836	Rat
1331731	Bp216	Blood pressure QTL 216	2.851		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	104186212	135371468	Rat
631687	Hcas1	Hepatocarcinoma susceptibility QTL 1	3.9	0.001	liver integrity trait (VT:0010547)	liver tumorous lesion volume to total liver volume ratio (CMO:0001082)	7	93302009	131686183	Rat
1331748	Bp215	Blood pressure QTL 215	4.043		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	110725024	135371468	Rat
61428	Scl3	Serum cholesterol level QTL 3	3.2		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	7	100548246	137014596	Rat
61397	Bw17	Body weight QTL 17	6.3		body mass (VT:0001259)	body weight (CMO:0000012)	7	95485047	137014596	Rat
1331746	Kidm9	Kidney mass QTL 9	3.934		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	7	82111245	134948181	Rat
1358914	Bp266	Blood pressure QTL 266			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	115313999	136544683	Rat
2299163	Iddm34	Insulin dependent diabetes mellitus QTL 34	2.71		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	7	116269196	132020414	Rat
1582240	Sffal1	Serum free fatty acids level QTL 1	3.4	0.0021	blood free fatty acid amount (VT:0001553)	serum free fatty acids level (CMO:0000547)	7	118556868	125929417	Rat
631504	Cm27	Cardiac mass QTL 27	3.45		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	7	46307490	127866166	Rat
634322	Bw12	Body weight QTL 12	0		body mass (VT:0001259)	body weight (CMO:0000012)	7	85043242	130043242	Rat
70173	Niddm19	Non-insulin dependent diabetes mellitus QTL 19	4.33	0.00005	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	7	85497398	130497398	Rat
1549899	Stresp8	Stress response QTL 8	4.37	0.0008	stress-related behavior trait (VT:0010451)	defensive burying duration (CMO:0001961)	7	92362341	137014596	Rat
1358891	Bp265	Blood pressure QTL 265	2.21		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	71827901	136544683	Rat
2317052	Aia17	Adjuvant induced arthritis QTL 17	2.13		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	7	83626689	128626689	Rat

Markers in Region

D7Wox48

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	7	124,144,703 - 124,144,907 (+)	Marker Load Pipeline
mRatBN7.2	7	122,265,140 - 122,265,344 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	132,296,671 - 132,296,874	NCBI	Rnor6.0
Rnor_5.0	7	131,970,582 - 131,970,785	UniSTS	Rnor5.0
RGSC_v3.4	7	129,544,865 - 129,545,068	UniSTS	RGSC3.4
Celera	7	118,715,727 - 118,715,930	UniSTS
Cytogenetic Map	7	q35	UniSTS

BE109878

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	122,264,137 - 122,264,325 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	132,295,668 - 132,295,855	NCBI	Rnor6.0
Rnor_5.0	7	131,969,579 - 131,969,766	UniSTS	Rnor5.0
RGSC_v3.4	7	129,543,862 - 129,544,049	UniSTS	RGSC3.4
Celera	7	118,714,724 - 118,714,911	UniSTS
RH 3.4 Map	7	974.4	UniSTS
Cytogenetic Map	7	q35	UniSTS

RH144115

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	122,310,975 - 122,311,096 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	132,342,503 - 132,342,623	NCBI	Rnor6.0
Rnor_5.0	7	132,016,378 - 132,016,498	UniSTS	Rnor5.0
RGSC_v3.4	7	129,590,697 - 129,590,817	UniSTS	RGSC3.4
Celera	7	118,761,506 - 118,761,626	UniSTS
RH 3.4 Map	7	976.1	UniSTS
Cytogenetic Map	7	q35	UniSTS

BE116218

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	122,266,067 - 122,266,256 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	132,297,598 - 132,297,786	NCBI	Rnor6.0
Rnor_5.0	7	131,971,509 - 131,971,697	UniSTS	Rnor5.0
RGSC_v3.4	7	129,545,792 - 129,545,980	UniSTS	RGSC3.4
Celera	7	118,716,654 - 118,716,842	UniSTS
RH 3.4 Map	7	976.5	UniSTS
Cytogenetic Map	7	q35	UniSTS

Related Rat Strains

The following Strains have been annotated to Abcd2

WIST/Nhg

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
11	12	66	163	91	90	59	72	59	6	320	171	11	142	71	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_033352	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC120768	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF131293	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF131294	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474027	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ214887	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000021064 ⟹ ENSRNOP00000021064

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	124,142,595 - 124,191,202 (-)	Ensembl
mRatBN7.2 Ensembl	7	122,263,032 - 122,311,642 (-)	Ensembl
Rnor_6.0 Ensembl	7	132,294,562 - 132,343,169 (-)	Ensembl

RefSeq Acc Id:

NM_033352 ⟹ NP_203503

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	124,142,597 - 124,191,202 (-)	NCBI
mRatBN7.2	7	122,263,034 - 122,311,642 (-)	NCBI
Rnor_6.0	7	132,294,564 - 132,343,169 (-)	NCBI
Rnor_5.0	7	131,968,475 - 132,017,044 (-)	NCBI
RGSC_v3.4	7	129,542,758 - 129,591,363 (-)	RGD
Celera	7	118,713,620 - 118,762,172 (-)	RGD

Sequence:

show sequence

GAGGGACTCGCCCCCGGTGGATGCGGTGGAGTTTGAGCTTTTTGCTGCATCCGTCCCTGAAGAA
CAAAATAAGAGTAAGGGAGACAAGCTGCAGAGCATGGGAGGCTGTGGGGTTTTCTGAAACGTTT
GCTGGGCTCTCCGCGGAGCATGAGCTTTTAAAAGGAGTTCTTTGGAGAGAAATCCATTTGTGTT
AGCTGGAAAAATGATACACATGCTAAATGCAGCAGCCTATCGGGTGAAATGGACCAGATCCGGT
GCTGCTAAAAGGGCTGCCTGCCTGGTGGCTGCGGCATATGCTCTGAAAACCCTCTATCCCATCC
TTGGCAGGCGTTTAAAGCAGCCTGGCCACCGGAAGGCGAAAGCAGAAGATTACCCGCCTGCAGA
GAACAGAGAAAGACTGCATTGCACAGAGATCATCTGTAAAAAACCTGCGCCGGGACTAAATGCA
GATTTTTTCAAACAGCTACTAGAACTTCGGAAAATCCTCTTTCCAAAACTTGTGACCACTGAAA
CGGGGTGGCTCTGCCTCCACTCGGTGGCTCTAATCTCACGAACGTTTCTGTCTATCTACGTGGC
TGGTCTGGATGGGAAAATCGTGAAAAGCATCGTGGAAAAGAAGCCTCGGACTTTCATCATCAAA
CTAGTCAAGTGGCTTATGATTGCCGTCCCCGCTACCTTTGTCAACAGCGCTATCAGGTACCTGG
AGTGCAAACTGGCATTGGCCTTTAGAACTCGCTTAGTGGACCATGCCTATGAGACCTATTTTGC
AAATCAGACTTATTATAAGGTGATAAATATGGACGGGAGGCTGGCAAACCCTGACCAGTCTCTT
ACTGAAGACATTATGATGTTCTCGCAATCGGTGGCTCACCTGTATTCCAACCTTACCAAACCGA
TTTTAGATGTAATTCTAACCTCCTATACCCTCATCCGGACAGCTACATCCAGAGGAGCAAGCCC
CATCGGGCCCACCCTGTTAGCAGGGCTCGTGGTGTATGCCACTGCTAAAGTCCTGAAAGCTTGC
TCGCCCAAATTTGGTACTCTGGTGGCTGAAGAAGCTCATAGAAAGGGCTACTTGCGGTATGTTC
ACTCCAGAATCATAGCCAATGTGGAAGAAATTGCCTTCTACAGAGGACATAAGGTAGAAATGAA
GCAACTGCAGAAGTGTTACAAGGCTTTAGCTTACCAGATGAACCTTATTCTATCCAAACGTTTG
TGGTACATCATGATAGAACAGTTCCTGATGAAGTATGTGTGGAGCGGCTGTGGACTAATTATGG
TGGCCATACCTATCATCACTGCAACAGGCTTTGCAGATGGTGATCTGGAGGATGGCCCTAAGCA
GGCTATGGTTAGCGATCGGACAGAGGCCTTTACCACTGCTCGGAATTTACTGGCCTCTGGAGCT
GACGCGATTGAGAGGATTATGTCTTCATACAAAGAGATCACTGAACTAGCGGGTTATACTGCCA
GAGTGTACAACATGTTCTGGGTCTTCGATGAAGTGAAGAGAGGCATTTATAAGAGAACTGTCAC
TCAGGAGCCTGAAAACAATAGCAAGAGTGGAGGTGGCCTGGAGCTGCCCCTCAGTGACACCCTG
GCAATCAAAGGGACAGTCATTGACGTGGATCATGGAATCCTTTGTGAAAATGTTCCCATAATCA
CGCCGGCGGGAGAAGTGGTGGCTTCCAGTCTGAACTTCAAAGTAGAAGAAGGGATGCATCTTTT
GATAACCGGCCCCAATGGTTGTGGGAAAAGCTCTCTGTTCAGAATCTTAAGTGGGCTCTGGCCT
GTGTATGAAGGAGTCCTTTATAAACCACCTCCCCAACATATGTTCTATATTCCACAGAGGCCGT
ACATGTCTCTTGGAAGTCTTCGGGATCAAGTCATTTATCCTGACTCGGTGGATGACATGCATGA
GAAAGGTTATACAGACCGAGACCTAGAGCATATTCTGCACAGCGTCCACCTCTACCACATAGTC
CAAAGAGAAGGAGGATGGGATGCAGTCATGGATTGGAAAGATGTCCTTTCAGGAGGGGAGAAAC
AGAGAATGGGGATGGCACGGATGTTTTACCATAAACCGAAGTACGCATTGCTGGACGAGTGCAC
CAGTGCTGTGAGCATTGACGTGGAAGGAAAGATATTTCAGGCTGCTATCGGGGCTGGCATTTCC
TTACTGTCTATAACGCACAGGCCTTCTCTGTGGAAATACCACACCCACCTATTGCAATTTGATG
GCGAAGGAGGTTGGCGCTTTGAACAGTTGGACACTGCTATCCGCTTAACGTTAAGCGAGGAGAA
ACAGAAGTTGGAGTCGCAGCTCGCTGGAATTCCCAAAATGCAGCAGAGACTCAATGAACTGTGC
AAAATTTTGGGGGAAGACTCGGTGCTGAAAACGATCCAAACTGCAGAGGACACATCCTAACTGA
CCTTGACATGTTTTAAGTTAACTTCTAGGTGATGCCTCAGAGACTCTTTCTTTACTGCATGCAG
TATGTTAAGCTAAGTGAAGAGAAAGCAAGCCAGCAAAAAAAAAAAAAAAAGTATTTTGTATGAT
TTCAGCATCGAGGAAATATGATAACTTTTTCGAATGAAAAAAAAAGCGAACGAATTAGTTGCGG
TTAGTCATGACTCAGGTTAGTGCCCCGTGAGAGGCTAGCTCACCTGTAAAGTGGGTTTCTAGAT
TAGGAGAGTGTGTGTGGTTCTTCCTAGGAGAGAATGCCCCAAAACAAGACAGCAGGGGCACCAG
CTGGGCCGATGTCAGGAATTAGACCTTTGAGGGCTCTTTCAACCCAGGTAACGGGGACAATAGG
TGCAACACCTGGAATCTATAGTCAGCATTGCTAGGGGCCAACTCAAACTGTGTACAAAGTAGCA
GGCTGTTTGATACATAGTTTCAGTCTGAAAAGGGTGTATCCGAATGACAGTGGTTGAAAACAAG
CACGGCTAGACAAGTATAAAGTACTGTATTAAATTTTTTCATACCTTGAGCATCTTAATACAGA
TACAGAAATTAACATTAATAAAAATTGTGTGTATGTGTTTAAAAAAAAACCCTTTTATGTTTTA
AAAAGAGAATTGCCCATACAGAAGAGGACGGTCTGAACGATATTTGTTCTGGCTACCGCTTGAC
TCTGCAGTCCTATTTAGTACGGTTTCTGTCCAGAAATACTGTCTGTCTGGTGCCCAAAATGGCA
TTTTAGAAACTTGATTGCTGCCCTAAATATGGATCCTGGAAATCACAGTTATGTTCCTACATTC
ATTTTACCTTACTCCATCTTTTAAGACATACAAGTTTTTGTTCCTTTTTCTTCTGAAACGCGCG
CGCGCACACACACACACACACACACACACACACACACACACACACACACAGATTTACTTTAATC
ACATGATTTATTTTGGAAGAGCTGTAGCGATCATGAAGGTCTCCCTCCCCCACACACCAGACCC
AGTGCTGTCATCACTAATGGCCCTTAAATTTAACTGGGATATAATGTCAGTTTTAAAANGATGT
GGACCAGGCAGATGGCCAGAAATGGTTGTAGGCAAAGCAGGGCATAAGGGAAAAAATTAAAGCA
GATAAATAAATATTATTCAGGCATAGAAGAGTGACAGTTGCTTCTCTTGTAGGGGACCTGAGTT
CCATTGCCAACATCCACATGGTGGCTCAAACGTGTGTCTAATTCCAGCTCCAGGGGATCTGACA
TACATGTAGACTCCAGGGATCCTGCATACATGTAGTCCTCATACACACATACATGCAGACAAAA
CATTCATAGCATTAAAAATCAATAAATCTGAAAGATAGTAAGGATATTGAAAGCTGGCAATGTT
GATGTTACCATCACTTAATTACTGTTTGCGAGAAGTGAAAATTGAGTGAGAAATGCAATGGGCG
TTGGTCAACGCAGCTCGGCTGTGCACACCCACCTGATGCCGAAGTGTCTGCAGTGCCAGCGCTC
AGGAGGGCAGTACATTGCACTTCCGGTAAGCTTCACGCTGCTGAAGATGACAGAGACCCTCACA
TCATATGAAATACAGTGCATCTGGAGTACAAAACCACGACTAATGCTTTAATCTCATCCTCTCT
CAGACATGACGAGGTATGTGAAAACCCGAGATGAACAGTTTTAGGGGCTTAAGGTTTTGTTTCT
GTATTCAGACAGCGCTTTAGCAGACACTAACTCTCGATAACAGACGGTTTGGAAGACAGACCCC
CTAGAAGTCATTCACAATGATGGTCGTGAGAAATTGCAGCATTTCCACATTTTCAATTCCGCAA
AAATCTACACAATTTGAATTACCAATCACTGTGACCACCTTACACAAAACAATACAAGGTCATA
ATCAGTACCTTTGTATTTGTCTGTTACTGCTACTTCTTACTAATAATGTGGGACACTAATGAAA
TATTTGGTTTAGCAAAAGTATAAAACCAGAAATTGACACTGAATTAAAAAAAAAAACACACAAT
TCACTAATCTCTTAACAACCGTGCTAGCAGTTACCCAGGTTATAGTGCTAAAGGAGAATCATTT
GAAGCAAGGGTCTTATATTAGCTCTGACAAGCACAAGAGGAAAATTGAAAGTTCACATTTGAAA
TTATACCATTTCAGACTTAAAATAAACCATGTAAGACCTGATATCCTACGTTTTCAAGCTTTGC
GAAAGATGCCAACATCAATGCTACATTCGGAACTAGACCTTATTTAGTAGAGGTTACCAGCGAG
CTGGATCGAAATAAATAAGACTCGTTACACAGTGGATGGGGGTTCAACGATGTTTGGAATTCGG
TACTAAAACTCTAGTCACGAAATTTAAACGTTAAGGTTTCAGGACTAACTGTTTCCCAGTAGCC
TTTTGGTAACTACTGATTTAATGCTGGATATCTTTTTTTTTCTTTTTTTTCTTTTTTTTTCCAG
AGCTGGGGACCGAACCCAGGGCCTTGCGCTTCCTAGGCAAGCGCTCTACCACTGAGCTAAATCC
CCAACCCCACTACTGATTTTCTGAACTGCCTCTTCTGAGCCAGAGTACCCTCCGTCTTAGAGGG
AGAACCCGATGTGGATCTGTGTTGTGTATAATCTGACTCTTTCCAAAGTGCTCCCACGGGAGAC
CAGAGCTGATACTCTGACAGGCATACTTGTGAAAACACAAAGACCACTGAGACCTCTTCTTTGA
CTAGGACAAAGAATAATAAGGAAGACGAAGGATAGCTTCATCTGTCAAACTACTTTTTTTTTCC
TTAGAAAAGGCATAAATGTATGGAGTTCGATTATTTCGGGGAATAACTCAAAACCTGCATTGTG
ACATCCGATCTCTGGAGCATGCTATGGTATGCCAAGCACCCAAGCACACTGTGTTCACTCTTAC
AGACGAGATAATTGCTAAAATCCTCTTGAGTCACAAGGTCGGTGATCGTACTTGAAAACCAGCC
CAGTTCACCCTATGTTTACACGGGAAGAGTTTTCCTTTGATAGCAATTTGACTTTTGACCCAAA
TTTTGGCGTGTCAATAAAGGTATAAGC

hide sequence

Protein Sequences


Protein RefSeqs	NP_203503	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAF22142	(Get FASTA)	NCBI Sequence Viewer
	EDL76598	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000021064
	ENSRNOP00000021064.1
GenBank Protein	Q9QY44	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_203503 ⟸ NM_033352

- UniProtKB:

Q9QY44 (UniProtKB/Swiss-Prot), G3V7Z6 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MIHMLNAAAYRVKWTRSGAAKRAACLVAAAYALKTLYPILGRRLKQPGHRKAKAEDYPPAENRE
RLHCTEIICKKPAPGLNADFFKQLLELRKILFPKLVTTETGWLCLHSVALISRTFLSIYVAGLD
GKIVKSIVEKKPRTFIIKLVKWLMIAVPATFVNSAIRYLECKLALAFRTRLVDHAYETYFANQT
YYKVINMDGRLANPDQSLTEDIMMFSQSVAHLYSNLTKPILDVILTSYTLIRTATSRGASPIGP
TLLAGLVVYATAKVLKACSPKFGTLVAEEAHRKGYLRYVHSRIIANVEEIAFYRGHKVEMKQLQ
KCYKALAYQMNLILSKRLWYIMIEQFLMKYVWSGCGLIMVAIPIITATGFADGDLEDGPKQAMV
SDRTEAFTTARNLLASGADAIERIMSSYKEITELAGYTARVYNMFWVFDEVKRGIYKRTVTQEP
ENNSKSGGGLELPLSDTLAIKGTVIDVDHGILCENVPIITPAGEVVASSLNFKVEEGMHLLITG
PNGCGKSSLFRILSGLWPVYEGVLYKPPPQHMFYIPQRPYMSLGSLRDQVIYPDSVDDMHEKGY
TDRDLEHILHSVHLYHIVQREGGWDAVMDWKDVLSGGEKQRMGMARMFYHKPKYALLDECTSAV
SIDVEGKIFQAAIGAGISLLSITHRPSLWKYHTHLLQFDGEGGWRFEQLDTAIRLTLSEEKQKL
ESQLAGIPKMQQRLNELCKILGEDSVLKTIQTAEDTS

hide sequence

Ensembl Acc Id:

ENSRNOP00000021064 ⟸ ENSRNOT00000021064

Protein Domains

ABC transmembrane type-1 ABC transporter

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9QY44-F1-model_v2	AlphaFold	Q9QY44	1-741	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13695597

Promoter ID:

EPDNEW_R6121

Type:

single initiation site

Name:

Abcd2_1

Description:

ATP binding cassette subfamily D member 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	7	132,343,135 - 132,343,195	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:69244	AgrOrtholog
BioCyc Gene	G2FUF-32405	BioCyc
Ensembl Genes	ENSRNOG00000015538	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000021064	ENTREZGENE
	ENSRNOT00000021064.3	UniProtKB/Swiss-Prot
Gene3D-CATH	1.20.1560.10	UniProtKB/Swiss-Prot
	3.40.50.300	UniProtKB/Swiss-Prot
InterPro	AAA+_ATPase	UniProtKB/Swiss-Prot
	ABC1_TM_dom	UniProtKB/Swiss-Prot
	ABC1_TM_sf	UniProtKB/Swiss-Prot
	ABC_transporter-like	UniProtKB/Swiss-Prot
	ABC_transporter_CS	UniProtKB/Swiss-Prot
	ABC_transporter_sub-D	UniProtKB/Swiss-Prot
	P-loop_NTPase	UniProtKB/Swiss-Prot
KEGG Report	rno:84356	UniProtKB/Swiss-Prot
NCBI Gene	84356	ENTREZGENE
PANTHER	ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER	UniProtKB/Swiss-Prot
	PTHR11384:SF24	UniProtKB/Swiss-Prot
Pfam	ABC_membrane_2	UniProtKB/Swiss-Prot
	ABC_tran	UniProtKB/Swiss-Prot
PhenoGen	Abcd2	PhenoGen
PROSITE	ABC_TM1F	UniProtKB/Swiss-Prot
	ABC_TRANSPORTER_1	UniProtKB/Swiss-Prot
	ABC_TRANSPORTER_2	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000015538	RatGTEx
SMART	AAA	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF52540	UniProtKB/Swiss-Prot
	SSF90123	UniProtKB/Swiss-Prot
TIGR	TC216684
UniProt	ABCD2_RAT	UniProtKB/Swiss-Prot
	G3V7Z6	ENTREZGENE
	Q9QY44	ENTREZGENE
UniProt Secondary	G3V7Z6	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-12-09	Abcd2	ATP binding cassette subfamily D member 2	Abcd2	ATP-binding cassette, subfamily D (ALD), member 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2010-11-16	Abcd2	ATP-binding cassette, subfamily D (ALD), member 2	Abcd2	ATP-binding cassette, sub-family D (ALD), member 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-06-10	Abcd2	ATP-binding cassette, sub-family D (ALD), member 2			Name updated	70584	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_cellular_localization	localized to peroxisomal membrane	68735
gene_disease	associated with the development of X-linked adrenoleukodystrophy (X-ALD), an inherited demyelinating disorder	68735
gene_drugs	induced by fenofibrate in adult liver but is not induced in suckling rats
gene_expression	expressed in high levels in the brain and liver before the weaning stage and drops to low levels in the adult stage	68735
gene_expression	RNA levels increased gradually and reached a maximum level in the adult rat brain, expression levels higher in the liver for adult females	68735
gene_function	peroxisomal ABC half-transporter	68735
gene_homology	has 97% amino acid homology and 93% nucleotide identities to mouse orthologue	68735
gene_homology	has 92% for amino acids and 87% for nucleotide identities to human orthologue	68735
gene_process	responsible for peroxisomal B-oxidation impairement leading to accumulation of very long-chain fatty acids	68735
gene_product	member of the ATP-binding cassette (ABC) transporter superfamily	68735
gene_protein	741 amino acid	68735
gene_transcript	transcripts of 3.0 kb and 5.5 kb are detected
gene_transcript	5.5 kb	68735
gene_transcript	contains polyadenylation sites and alternative usage generates 3.0 and 5.5 kb transcripts and the 3 UTR contains two main functional consensus polyadenylation signals (AATAAA) at +2822 and +5315	68735

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

Imported Annotations - SMPDB

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Imported Disease Annotations - CTD

Imported Annotations - SMPDB