Symbol:
Sacm1l
Name:
SAC1 like phosphatidylinositide phosphatase
RGD ID:
69223
Description:
Enables phosphatidylinositol-3,5-bisphosphate phosphatase activity; phosphatidylinositol-3-phosphate phosphatase activity; and phosphatidylinositol-4-phosphate phosphatase activity. Involved in neurotransmitter receptor transport to postsynaptic membrane; phosphatidylinositol dephosphorylation; and vesicle-mediated transport in synapse. Located in endoplasmic reticulum membrane and endoplasmic reticulum-plasma membrane contact site. Is active in glutamatergic synapse. Orthologous to human SACM1L (SAC1 like phosphatidylinositide phosphatase); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride; bisphenol A.
Type:
protein-coding
RefSeq Status:
REVIEWED
Previously known as:
phosphatidylinositide phosphatase SAC1; phosphatidylinositol-3-phosphatase SAC1; phosphatidylinositol-4-phosphate phosphatase; Sac1; SAC1 (suppressor of actin mutations 1, homolog)-like (S. cerevisiae); SAC1 (supressor of actin mutations 1, homolog)-like; SAC1 (supressor of actin mutations 1, homolog)-like (S. cerevisiae); SAC1 suppressor of actin mutations 1-like; SAC1 suppressor of actin mutations 1-like (yeast); suppressor of actin 1; suppressor of actin mutations 1-like protein
RGD Orthologs
Alliance Orthologs
More Info
more info ...
More Info
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
SACM1L (SAC1 like phosphatidylinositide phosphatase) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Sacm1l (SAC1 suppressor of actin mutations 1-like (yeast)) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):
Sacm1l (SAC1 like phosphatidylinositide phosphatase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
SACM1L (SAC1 like phosphatidylinositide phosphatase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
SACM1L (SAC1 like phosphatidylinositide phosphatase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Sacm1l (SAC1 like phosphatidylinositide phosphatase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
SACM1L (SAC1 like phosphatidylinositide phosphatase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):
SACM1L (SAC1 like phosphatidylinositide phosphatase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Sacm1l (SAC1 like phosphatidylinositide phosphatase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
SACM1L (SAC1 like phosphatidylinositide phosphatase)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Mus musculus (house mouse):
Sacm1l (SAC1 suppressor of actin mutations 1-like (yeast))
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Danio rerio (zebrafish):
sacm1lb (SAC1 like phosphatidylinositide phosphatase b)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Danio rerio (zebrafish):
sacm1la (SAC1 like phosphatidylinositide phosphatase a)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):
SAC1
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Caenorhabditis elegans (roundworm):
sac-1
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Drosophila melanogaster (fruit fly):
Sac1
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):
sacm1l
Alliance
DIOPT (OMA|OrthoFinder|PhylomeDB)
Latest Assembly:
GRCr8 - GRCr8 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 8 132,053,465 - 132,109,857 (+) NCBI GRCr8 mRatBN7.2 8 123,176,017 - 123,232,413 (+) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 8 123,172,536 - 123,232,413 (+) Ensembl mRatBN7.2 Ensembl UTH_Rnor_SHR_Utx 8 128,765,500 - 128,828,247 (+) NCBI Rnor_SHR UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 8 126,964,469 - 127,027,208 (+) NCBI Rnor_SHRSP UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 8 124,793,995 - 124,856,731 (+) NCBI Rnor_WKY UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 8 132,607,166 - 132,663,502 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 8 132,607,166 - 132,663,502 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 8 131,759,866 - 131,816,202 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 8 128,302,927 - 128,359,950 (+) NCBI RGSC3.4 RGSC_v3.4 rn4 RGSC3.4 RGSC_v3.1 8 128,322,663 - 128,379,687 (+) NCBI Celera 8 122,286,384 - 122,342,572 (+) NCBI Celera Cytogenetic Map 8 q32 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Cellular Component
AMPA glutamate receptor complex (ISO) endoplasmic reticulum (IBA,IEA) endoplasmic reticulum membrane (IDA,IEA,ISO) endoplasmic reticulum-plasma membrane contact site (IDA,ISO) glutamatergic synapse (EXP,IDA,IEP,IMP,ISO) Golgi apparatus (IEA,ISO,ISS) Golgi membrane (IEA,ISO,ISS) membrane (IEA)
1.
Dynamic formation of ER-PM junctions presents a lipid phosphatase to regulate phosphoinositides.
Dickson EJ, etal., J Cell Biol. 2016 Apr 11;213(1):33-48. doi: 10.1083/jcb.201508106. Epub 2016 Apr 4.
2.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.
Rat ISS GO annotations from MGI mouse gene data--August 2006
MGD data from the GO Consortium
4.
Electronic Transfer of LocusLink and RefSeq Data
NCBI rat LocusLink and RefSeq merged data July 26, 2002
5.
Functional characterization of a mammalian Sac1 and mutants exhibiting substrate-specific defects in phosphoinositide phosphatase activity.
Nemoto Y, etal., J Biol Chem 2000 Nov 3;275(44):34293-305.
6.
Data Import for Chemical-Gene Interactions
RGD automated import pipeline for gene-chemical interactions
7.
Tentative Sequence Identification Numbers
Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
8.
JNK3 couples the neuronal stress response to inhibition of secretory trafficking.
Yang G, etal., Sci Signal. 2013 Jul 9;6(283):ra57. doi: 10.1126/scisignal.2003727.
Sacm1l Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 8 132,053,465 - 132,109,857 (+) NCBI GRCr8 mRatBN7.2 8 123,176,017 - 123,232,413 (+) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 8 123,172,536 - 123,232,413 (+) Ensembl mRatBN7.2 Ensembl UTH_Rnor_SHR_Utx 8 128,765,500 - 128,828,247 (+) NCBI Rnor_SHR UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 8 126,964,469 - 127,027,208 (+) NCBI Rnor_SHRSP UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 8 124,793,995 - 124,856,731 (+) NCBI Rnor_WKY UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 8 132,607,166 - 132,663,502 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 8 132,607,166 - 132,663,502 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 8 131,759,866 - 131,816,202 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 8 128,302,927 - 128,359,950 (+) NCBI RGSC3.4 RGSC_v3.4 rn4 RGSC3.4 RGSC_v3.1 8 128,322,663 - 128,379,687 (+) NCBI Celera 8 122,286,384 - 122,342,572 (+) NCBI Celera Cytogenetic Map 8 q32 NCBI
SACM1L Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 3 45,689,396 - 45,745,409 (+) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh38.p14 Ensembl 3 45,689,056 - 45,745,412 (+) Ensembl GRCh38 hg38 GRCh38 GRCh37 3 45,730,888 - 45,786,901 (+) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 3 45,705,947 - 45,761,905 (+) NCBI NCBI36 Build 36 hg18 NCBI36 Build 34 3 45,705,946 - 45,761,904 NCBI Celera 3 45,668,700 - 45,724,522 (+) NCBI Celera Cytogenetic Map 3 p21.31 NCBI HuRef 3 45,775,115 - 45,830,941 (+) NCBI HuRef CHM1_1 3 45,680,731 - 45,736,559 (+) NCBI CHM1_1 T2T-CHM13v2.0 3 45,705,375 - 45,761,083 (+) NCBI T2T-CHM13v2.0
Sacm1l Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm39 9 123,358,818 - 123,421,665 (+) NCBI GRCm39 GRCm39 mm39 GRCm39 Ensembl 9 123,358,824 - 123,421,665 (+) Ensembl GRCm39 Ensembl GRCm38 9 123,529,753 - 123,592,600 (+) NCBI GRCm38 GRCm38 mm10 GRCm38 GRCm38.p6 Ensembl 9 123,529,759 - 123,592,600 (+) Ensembl GRCm38 mm10 GRCm38 MGSCv37 9 123,439,000 - 123,501,716 (+) NCBI GRCm37 MGSCv37 mm9 NCBIm37 MGSCv36 9 123,378,580 - 123,441,296 (+) NCBI MGSCv36 mm8 Celera 9 123,982,316 - 124,047,496 (+) NCBI Celera Cytogenetic Map 9 F4 NCBI cM Map 9 74.08 NCBI
Sacm1l Chinchilla Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl ChiLan1.0 Ensembl NW_004955420 26,229,840 - 26,280,516 (-) Ensembl ChiLan1.0 ChiLan1.0 NW_004955420 26,231,597 - 26,280,516 (-) NCBI ChiLan1.0 ChiLan1.0
SACM1L Bonobo Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl NHGRI_mPanPan1-v2 2 45,653,967 - 45,709,677 (+) NCBI NHGRI_mPanPan1-v2 NHGRI_mPanPan1 3 45,658,749 - 45,714,444 (+) NCBI NHGRI_mPanPan1 Mhudiblu_PPA_v0 3 45,596,775 - 45,652,482 (+) NCBI Mhudiblu_PPA_v0 Mhudiblu_PPA_v0 panPan3 PanPan1.1 3 46,704,539 - 46,760,105 (+) NCBI panpan1.1 PanPan1.1 panPan2 PanPan1.1 Ensembl 3 46,704,565 - 46,760,104 (+) Ensembl panpan1.1 panPan2
SACM1L Dog Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl CanFam3.1 20 42,731,674 - 42,791,455 (-) NCBI CanFam3.1 CanFam3.1 canFam3 CanFam3.1 CanFam3.1 Ensembl 20 42,720,249 - 42,791,402 (-) Ensembl CanFam3.1 canFam3 CanFam3.1 Dog10K_Boxer_Tasha 20 42,648,744 - 42,708,307 (-) NCBI Dog10K_Boxer_Tasha ROS_Cfam_1.0 20 43,216,790 - 43,276,240 (-) NCBI ROS_Cfam_1.0 ROS_Cfam_1.0 Ensembl 20 43,216,794 - 43,276,251 (-) Ensembl ROS_Cfam_1.0 Ensembl UMICH_Zoey_3.1 20 42,457,062 - 42,516,486 (-) NCBI UMICH_Zoey_3.1 UNSW_CanFamBas_1.0 20 42,864,579 - 42,923,977 (-) NCBI UNSW_CanFamBas_1.0 UU_Cfam_GSD_1.0 20 43,139,544 - 43,199,143 (-) NCBI UU_Cfam_GSD_1.0
Sacm1l
SACM1L Pig Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Sscrofa11.1 Ensembl 13 28,817,132 - 28,891,685 (+) Ensembl Sscrofa11.1 susScr11 Sscrofa11.1 Sscrofa11.1 13 28,816,977 - 28,906,503 (+) NCBI Sscrofa11.1 Sscrofa11.1 susScr11 Sscrofa11.1 Sscrofa10.2 13 31,719,695 - 31,794,148 (-) NCBI Sscrofa10.2 Sscrofa10.2 susScr3
SACM1L Green Monkey Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl ChlSab1.1 22 7,159,701 - 7,214,368 (+) NCBI ChlSab1.1 ChlSab1.1 chlSab2 ChlSab1.1 Ensembl 22 7,159,809 - 7,214,555 (+) Ensembl ChlSab1.1 ChlSab1.1 Ensembl chlSab2 Vero_WHO_p1.0 NW_023666041 159,951,795 - 160,006,471 (-) NCBI Vero_WHO_p1.0 Vero_WHO_p1.0
Sacm1l
.
Predicted Target Of
Count of predictions: 444 Count of miRNA genes: 245 Interacting mature miRNAs: 302 Transcripts: ENSRNOT00000007223 Prediction methods: Microtar, Miranda, Targetscan Result types: miRGate_prediction
738011 Anxrr9 Anxiety related response QTL 9 6.1 exploratory behavior trait (VT:0010471) number of entries into a discrete space in an experimental apparatus (CMO:0000960) 8 93535351 123900184 Rat 1358903 Bp252 Blood pressure QTL 252 7 0.0001 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 8 93965141 123900184 Rat 738014 Anxrr15 Anxiety related response QTL 15 3.6 0.005 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) 8 95718998 123900184 Rat 2300182 Bmd56 Bone mineral density QTL 56 5.4 femur mineral mass (VT:0010011) volumetric bone mineral density (CMO:0001553) 8 95718998 123900184 Rat 1554321 Bmd3 Bone mineral density QTL 3 7.9 0.0001 femur mineral mass (VT:0010011) volumetric bone mineral density (CMO:0001553) 8 40952565 123900184 Rat 1358893 Bp263 Blood pressure QTL 263 5.01 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 8 93965141 123900184 Rat
D8Rat116
Rat Assembly Chr Position (strand) Source JBrowse mRatBN7.2 8 123,180,023 - 123,180,222 (+) MAPPER mRatBN7.2 Rnor_6.0 8 132,611,122 - 132,611,318 NCBI Rnor6.0 Rnor_5.0 8 131,763,822 - 131,764,018 UniSTS Rnor5.0 RGSC_v3.4 8 128,306,882 - 128,307,079 RGD RGSC3.4 RGSC_v3.4 8 128,306,883 - 128,307,079 UniSTS RGSC3.4 RGSC_v3.1 8 128,326,536 - 128,326,932 RGD Celera 8 122,290,340 - 122,290,536 UniSTS SHRSP x BN Map 8 84.17 RGD SHRSP x BN Map 8 84.17 UniSTS Cytogenetic Map 8 q32 UniSTS
Click on a value in the shaded box below the category label to view a detailed expression data table for that system.
alimentary part of gastrointestinal system
9
11
49
113
91
90
59
25
59
6
218
97
93
45
60
31
Too many to show, limit is 500. Download them if you would like to view them all.
Ensembl Acc Id:
ENSRNOT00000007223 ⟹ ENSRNOP00000007223
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl 8 123,186,796 - 123,232,413 (+) Ensembl Rnor_6.0 Ensembl 8 132,607,166 - 132,663,502 (+) Ensembl
Ensembl Acc Id:
ENSRNOT00000109426 ⟹ ENSRNOP00000080652
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl 8 123,172,536 - 123,232,413 (+) Ensembl
RefSeq Acc Id:
NM_001357497 ⟹ NP_001344426
RefSeq Status:
REVIEWED
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 8 132,053,465 - 132,109,857 (+) NCBI mRatBN7.2 8 123,176,017 - 123,232,413 (+) NCBI
RefSeq Acc Id:
NM_053798 ⟹ NP_446250
RefSeq Status:
REVIEWED
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 8 132,053,465 - 132,109,857 (+) NCBI mRatBN7.2 8 123,176,017 - 123,232,413 (+) NCBI Rnor_6.0 8 132,607,166 - 132,663,502 (+) NCBI Rnor_5.0 8 131,759,866 - 131,816,202 (+) NCBI RGSC_v3.4 8 128,302,927 - 128,359,950 (+) RGD Celera 8 122,286,384 - 122,342,572 (+) RGD
Sequence:
GGGGTACACTGCGGGTGGAGCGAAGCGGAGGAAGGTGCACGATGGCGGCCACAGCCTACGAGCATCTGAAGCTGCATATTACACCTGAAAAGTTTTATGTGGAAGCTTGTGATGATGGAGCAGATGAT
hide sequence
RefSeq Acc Id:
XM_063264777 ⟹ XP_063120847
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 8 132,068,271 - 132,109,857 (+) NCBI
RefSeq Acc Id:
NP_446250 ⟸ NM_053798
- Peptide Label:
isoform 1
- UniProtKB:
Q9ES21 (UniProtKB/Swiss-Prot), A6I4B9 (UniProtKB/TrEMBL), A0A8L2Q2L9 (UniProtKB/TrEMBL)
- Sequence:
MAATAYEHLKLHITPEKFYVEACDDGADDVLIIDRVSTEVTLAVKKDVPPSAVTRPIYGIMGTIHLVAGNYLVVITKKMKVGEFFNHVIWKATDFDVLSYKKTMLHLTDIQLQDNKTFLAMLNHVLST
hide sequence
Ensembl Acc Id:
ENSRNOP00000007223 ⟸ ENSRNOT00000007223
RefSeq Acc Id:
NP_001344426 ⟸ NM_001357497
- Peptide Label:
isoform 1x
- UniProtKB:
A0A8L2Q2L9 (UniProtKB/TrEMBL)
Ensembl Acc Id:
ENSRNOP00000080652 ⟸ ENSRNOT00000109426
RefSeq Acc Id:
XP_063120847 ⟸ XM_063264777
- Peptide Label:
isoform X1
RGD ID: 13696410 Promoter ID: EPDNEW_R6935 Type: initiation region Name: Sacm1l_1 Description: SAC1 like phosphatidylinositide phosphatase SO ACC ID: SO:0000170 Source: EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/ ) Experiment Methods: Single-end sequencing. Position: Rat Assembly Chr Position (strand) Source Rnor_6.0 8 132,607,110 - 132,607,170 EPDNEW
Date
Current Symbol
Current Name
Previous Symbol
Previous Name
Description
Reference
Status
2017-06-19
Sacm1l
SAC1 like phosphatidylinositide phosphatase
Sacm1l
SAC1 suppressor of actin mutations 1-like (yeast)
Nomenclature updated to reflect human and mouse nomenclature
1299863 APPROVED
2008-09-18
Sacm1l
SAC1 suppressor of actin mutations 1-like (yeast)
Sacm1l
SAC1 (suppressor of actin mutations 1, homolog)-like (S. cerevisiae)
Nomenclature updated to reflect human and mouse nomenclature
1299863 APPROVED
2002-06-10
Sacm1l
SAC1 (supressor of actin mutations 1, homolog)-like (S. cerevisiae)
Name updated
70584 APPROVED
Note Type
Note
Reference
gene_cellular_localization
localized to the endoplasmic reticulum
68842
gene_expression
expressed in cerebellar Purkinje cells
68842
