Cd82 (Cd82 molecule) - Rat Genome Database

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Gene: Cd82 (Cd82 molecule) Rattus norvegicus
Analyze
Symbol: Cd82
Name: Cd82 molecule
RGD ID: 69070
Description: Predicted to be located in membrane. Predicted to be active in plasma membrane. Biomarker of hypertension and ovarian cancer. Orthologous to human CD82 (CD82 molecule); PARTICIPATES IN p53 signaling pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CD82 antigen; CD82 antigen (R2 leukocyte antigen antigen detected by monoclonal and antibody IA4)); CD82 antigen (R2 leukocyte antigen, antigen detected by monoclonal and antibody IA4)); Kai1; kangai 1; Kangai 1 (suppression of tumerigenicity 6 prostate) CD82 antigen; Kangai 1 (suppression of tumerigenicity 6, prostate) CD82 antigen; kangai 1 (suppression of tumorigenicity 6) prostate; kangai 1 (suppression of tumorigenicity 6), prostate; Kangai 1 (suppression of tumorigenicity 6, prostate, CD82 antigen (R2 leukocyte antigen, antigen detected by monoclonal and antibody IA4)); metastasis suppressor Kangai-1 homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8399,842,748 - 99,887,298 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl399,842,757 - 99,886,744 (-)EnsemblGRCr8
mRatBN7.2379,387,361 - 79,431,847 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl379,385,887 - 79,431,809 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx382,861,325 - 82,905,239 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0391,460,386 - 91,504,299 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0389,311,775 - 89,356,142 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0382,324,344 - 82,368,846 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl382,324,354 - 82,368,357 (-)Ensemblrn6Rnor6.0
Rnor_5.0389,026,114 - 89,070,616 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4377,831,771 - 77,875,764 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera378,589,536 - 78,633,414 (-)NCBICelera
RGSC_v3.1377,728,200 - 77,772,102 (-)NCBI
Cytogenetic Map3q31NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2,4-trimethylbenzene  (EXP)
1,2-dichloroethane  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dimethoxyphenol  (ISO)
2-palmitoylglycerol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitrophenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
actinomycin D  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (EXP,ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
Bufotalin  (ISO)
butanal  (ISO)
calcitriol  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
Cuprizon  (EXP)
dibutyl phthalate  (ISO)
diquat  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
fenthion  (ISO)
flutamide  (EXP)
formaldehyde  (ISO)
furfural  (ISO)
genistein  (ISO)
L-ascorbic acid  (EXP)
lead(0)  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercury dibromide  (ISO)
methapyrilene  (ISO)
methidathion  (ISO)
methylmercury chloride  (ISO)
nefazodone  (EXP)
nickel sulfate  (ISO)
nimesulide  (EXP)
Nutlin-3  (ISO)
oxaliplatin  (EXP)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP)
pentachlorophenol  (ISO)
pentanal  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
phenethyl isothiocyanate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propanal  (ISO)
S-nitrosoglutathione  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
Soman  (EXP)
sotorasib  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
temozolomide  (ISO)
Terfenadine  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
topotecan  (EXP)
trametinib  (ISO)
triphenyl phosphate  (ISO)
undecane  (EXP)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)
plasma membrane  (IBA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Expression of KAI1/CD82 and MRP-1/CD9 in transitional cell carcinoma of bladder. Ai X, etal., J Huazhong Univ Sci Technolog Med Sci. 2007 Feb;27(1):79-82.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Frequent loss of KAI1 expression in squamous and lymphoid neoplasms. An immunohistochemical study of archival tissues. Geradts J, etal., Am J Pathol 1999 Jun;154(6):1665-71.
4. Loss of expression and altered localization of KAI1 and CD9 protein are associated with epithelial ovarian cancer progression. Houle CD, etal., Gynecol Oncol. 2002 Jul;86(1):69-78.
5. Aberrant expression of novel and previously described cell membrane markers in human breast cancer cell lines and tumors. Huang H, etal., Clin Cancer Res. 2005 Jun 15;11(12):4357-64.
6. Downregulation of KAI1 mRNA in localised prostate cancer and its bony metastases does not correlate with p53 overexpression. Jackson P, etal., Prostate Cancer Prostatic Dis. 2003;6(2):174-81.
7. Location of KAI1 on the short arm of human chromosome 11 and frequency of allelic loss in advanced human prostate cancer. Kawana Y, etal., Prostate. 1997 Aug 1;32(3):205-13.
8. KAI1 metastasis suppressor protein is down-regulated during the progression of human endometrial cancer. Liu FS, etal., Clin Cancer Res. 2003 Apr;9(4):1393-8.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. Establishment of rat hepatocellular carcinoma cell lines with differing metastatic potential in nude mice. Ogawa K, etal., Int J Cancer. 2001 Mar 15;91(6):797-802.
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Comprehensive gene review and curation RGD comprehensive gene curation
18. Protein networking in bladder cancer: immunoreactivity for FGFR3, EGFR, ERBB2, KAI1, PTEN, and RAS in normal and malignant urothelium. Rotterud R, etal., Histol Histopathol. 2007 Apr;22(4):349-63.
19. Reduced metastasis-suppressor gene mRNA-expression in breast cancer brain metastases. Stark AM, etal., J Cancer Res Clin Oncol. 2005 Mar;131(3):191-8. Epub 2004 Dec 8.
20. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
21. Decreased expression of KAI1 metastasis suppressor gene is a recurrence predictor in primary pTa and pT1 urothelial bladder carcinoma. Su JS, etal., Int J Urol. 2004 Feb;11(2):74-82.
22. Identification of the rat homologue of KAI1 and its expression in Dunning rat prostate cancers. Suzuki H, etal., Prostate 1998 Dec 1;37(4):253-60.
23. Localization of 54 rat genes, and definition of new synteny groups conserved in the human and the rat. Szpirer C, etal., Mamm Genome 2000 Sep;11(9):729-35
24. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
25. KAI1 expression can be a predictor of stage A prostate cancer progression. Tozawa K, etal., Prostate Cancer Prostatic Dis. 2001;4(3):150-153.
26. Temporal changes in gene expression after injury in the rat retina. Vazquez-Chona F, etal., Invest Ophthalmol Vis Sci. 2004 Aug;45(8):2737-46.
27. [Expression of metastasis suppressor gene KAI1/CD82 in cervical squamous cell carcinoma and its clinical significance.] Xiong Y, etal., Ai Zheng. 2005 Jan;24(1):110-5.
28. Identification of upregulated genes in the thymus of spontaneously hypertensive rats by cDNA representational difference analysis. Zhao XS, etal., Blood Press. 1998 Nov;7(5-6):316-23.
Additional References at PubMed
PMID:19199708   PMID:19741124   PMID:20458337   PMID:30463011  


Genomics

Comparative Map Data
Cd82
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8399,842,748 - 99,887,298 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl399,842,757 - 99,886,744 (-)EnsemblGRCr8
mRatBN7.2379,387,361 - 79,431,847 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl379,385,887 - 79,431,809 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx382,861,325 - 82,905,239 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0391,460,386 - 91,504,299 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0389,311,775 - 89,356,142 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0382,324,344 - 82,368,846 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl382,324,354 - 82,368,357 (-)Ensemblrn6Rnor6.0
Rnor_5.0389,026,114 - 89,070,616 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4377,831,771 - 77,875,764 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera378,589,536 - 78,633,414 (-)NCBICelera
RGSC_v3.1377,728,200 - 77,772,102 (-)NCBI
Cytogenetic Map3q31NCBI
CD82
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381144,564,409 - 44,620,358 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1144,564,414 - 44,620,924 (+)Ensemblhg38GRCh38
GRCh371144,587,213 - 44,641,908 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361144,543,717 - 44,597,915 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1144,734,291 - 44,788,479 (+)NCBICelera
Cytogenetic Map11p11.2NCBI
HuRef1144,296,423 - 44,350,592 (+)NCBIHuRef
CHM1_11144,585,957 - 44,640,111 (+)NCBICHM1_1
T2T-CHM13v2.01144,720,425 - 44,776,379 (+)NCBIT2T-CHM13v2.0
Cd82
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39293,249,447 - 93,293,295 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl293,249,456 - 93,293,485 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38293,419,102 - 93,462,950 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl293,419,111 - 93,463,140 (-)Ensemblmm10GRCm38
MGSCv37293,259,269 - 93,303,103 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36293,219,951 - 93,263,335 (-)NCBIMGSCv36mm8
Celera294,814,780 - 94,859,821 (-)NCBICelera
Cytogenetic Map2E1NCBI
cM Map251.62NCBI
Cd82
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554223,033,133 - 3,052,153 (-)Ensembl
ChiLan1.0NW_0049554223,035,887 - 3,069,298 (-)NCBIChiLan1.0ChiLan1.0
CD82
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2946,780,583 - 46,836,160 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11146,786,918 - 46,842,472 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01144,526,010 - 44,581,560 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11145,020,362 - 45,075,876 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1145,020,319 - 45,075,876 (+)EnsemblpanPan2panpan1.1
CD82
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11844,658,414 - 44,707,897 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1844,659,180 - 44,706,768 (-)EnsemblcanFam3CanFam3.1
ROS_Cfam_1.01845,317,202 - 45,369,506 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1845,317,220 - 45,368,392 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11844,800,179 - 44,851,496 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01844,353,829 - 44,406,031 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01845,086,983 - 45,139,553 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cd82
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494721,960,790 - 21,973,529 (-)NCBIHiC_Itri_2
CD82
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl217,750,660 - 17,803,126 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1217,751,153 - 17,803,172 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2219,249,749 - 19,264,391 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CD82
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1120,736,216 - 20,793,943 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl120,735,287 - 20,763,160 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666038117,969,772 - 118,024,761 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cd82
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247673,556,128 - 3,589,956 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Cd82
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1567,590,431 - 67,634,184 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cd82
156 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:393
Count of miRNA genes:215
Interacting mature miRNAs:252
Transcripts:ENSRNOT00000000052
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)351490129111359995Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)373592611110333156Rat
1358293Bw38Body weight QTL 3860.0000031body mass (VT:0001259)body weight (CMO:0000012)374364268119364268Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)396509147141509147Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)373592512136118980Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)385062224136118980Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)385062224136118980Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)393829559138829559Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)396509147141509147Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)358925062103925062Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)370311536115311536Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)381541464126563126Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)390755164141509147Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)336721849110333156Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)342158111124558371Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)342158111124558371Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat

Markers in Region
RH127894  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2379,387,524 - 79,387,715 (+)MAPPERmRatBN7.2
Rnor_6.0382,324,509 - 82,324,699NCBIRnor6.0
Rnor_5.0389,026,279 - 89,026,469UniSTSRnor5.0
RGSC_v3.4377,831,931 - 77,832,121UniSTSRGSC3.4
Celera378,589,696 - 78,589,886UniSTS
RH 3.4 Map3685.5UniSTS
Cytogenetic Map3q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000000052   ⟹   ENSRNOP00000000052
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl399,842,757 - 99,886,744 (-)Ensembl
mRatBN7.2 Ensembl379,387,361 - 79,431,782 (-)Ensembl
Rnor_6.0 Ensembl382,324,354 - 82,368,357 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097921   ⟹   ENSRNOP00000078723
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl399,842,757 - 99,857,339 (-)Ensembl
mRatBN7.2 Ensembl379,387,367 - 79,431,310 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100406   ⟹   ENSRNOP00000084636
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl399,843,026 - 99,886,744 (-)Ensembl
mRatBN7.2 Ensembl379,387,367 - 79,431,311 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000119233   ⟹   ENSRNOP00000091451
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl379,385,887 - 79,431,809 (-)Ensembl
RefSeq Acc Id: NM_031797   ⟹   NP_113985
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8399,842,752 - 99,886,744 (-)NCBI
mRatBN7.2379,387,365 - 79,431,358 (-)NCBI
Rnor_6.0382,324,349 - 82,368,357 (-)NCBI
Rnor_5.0389,026,114 - 89,070,616 (-)NCBI
RGSC_v3.4377,831,771 - 77,875,764 (-)RGD
Celera378,589,536 - 78,633,414 (-)RGD
Sequence:
RefSeq Acc Id: XM_006234597   ⟹   XP_006234659
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8399,842,748 - 99,887,208 (-)NCBI
mRatBN7.2379,387,370 - 79,431,805 (-)NCBI
Rnor_6.0382,324,344 - 82,368,794 (-)NCBI
Rnor_5.0389,026,114 - 89,070,616 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006234598   ⟹   XP_006234660
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8399,842,748 - 99,887,298 (-)NCBI
mRatBN7.2379,387,370 - 79,431,847 (-)NCBI
Rnor_6.0382,324,344 - 82,368,846 (-)NCBI
Rnor_5.0389,026,114 - 89,070,616 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039105948   ⟹   XP_038961876
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8399,842,748 - 99,861,087 (-)NCBI
mRatBN7.2379,387,370 - 79,405,697 (-)NCBI
RefSeq Acc Id: XM_039105951   ⟹   XP_038961879
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8399,842,748 - 99,850,372 (-)NCBI
mRatBN7.2379,387,361 - 79,394,473 (-)NCBI
RefSeq Acc Id: XM_039105953   ⟹   XP_038961881
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8399,842,748 - 99,849,601 (-)NCBI
mRatBN7.2379,387,361 - 79,394,209 (-)NCBI
RefSeq Acc Id: NP_113985   ⟸   NM_031797
- UniProtKB: O70352 (UniProtKB/Swiss-Prot),   Q6IN14 (UniProtKB/TrEMBL),   A6HNI9 (UniProtKB/TrEMBL),   F7EV99 (UniProtKB/TrEMBL),   A0A8I5ZZR7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234660   ⟸   XM_006234598
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006234659   ⟸   XM_006234597
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000000052   ⟸   ENSRNOT00000000052
RefSeq Acc Id: XP_038961879   ⟸   XM_039105951
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038961881   ⟸   XM_039105953
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038961876   ⟸   XM_039105948
- Peptide Label: isoform X2
- UniProtKB: A6HNJ0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000078723   ⟸   ENSRNOT00000097921
Ensembl Acc Id: ENSRNOP00000084636   ⟸   ENSRNOT00000100406
Ensembl Acc Id: ENSRNOP00000091451   ⟸   ENSRNOT00000119233

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O70352-F1-model_v2 AlphaFold O70352 1-266 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692232
Promoter ID:EPDNEW_R2756
Type:initiation region
Name:Cd82_1
Description:Cd82 molecule
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0382,368,340 - 82,368,400EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69070 AgrOrtholog
BioCyc Gene G2FUF-48668 BioCyc
Ensembl Genes ENSRNOG00000000047 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000000052 ENTREZGENE
  ENSRNOT00000097921 ENTREZGENE
Gene3D-CATH 1.10.1450.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7096826 IMAGE-MGC_LOAD
InterPro Tetraspanin UniProtKB/Swiss-Prot
  Tetraspanin/Peripherin UniProtKB/Swiss-Prot
  Tetraspanin_CS UniProtKB/Swiss-Prot
  Tetraspanin_EC2_sf UniProtKB/Swiss-Prot
MGC_CLONE MGC:91618 IMAGE-MGC_LOAD
NCBI Gene 83628 ENTREZGENE
PANTHER CD82 ANTIGEN UniProtKB/Swiss-Prot
  PTHR19282 UniProtKB/Swiss-Prot
Pfam Tetraspanin UniProtKB/Swiss-Prot
PhenoGen Cd82 PhenoGen
PIRSF Tetraspanin UniProtKB/Swiss-Prot
PRINTS TMFOUR UniProtKB/Swiss-Prot
PROSITE TM4_1 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000000047 RatGTEx
Superfamily-SCOP SSF48652 UniProtKB/Swiss-Prot
TIGR TC229731
UniProt A0A8I5ZP15_RAT UniProtKB/TrEMBL
  A0A8I5ZZR7 ENTREZGENE, UniProtKB/TrEMBL
  A0ABZ3NN84_RAT UniProtKB/TrEMBL
  A6HNI9 ENTREZGENE, UniProtKB/TrEMBL
  A6HNJ0 ENTREZGENE, UniProtKB/TrEMBL
  CD82_RAT UniProtKB/Swiss-Prot
  F7EV99 ENTREZGENE
  O70352 ENTREZGENE
  Q6IN14 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-29 Cd82  Cd82 molecule  Cd82  CD82 antigen  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Cd82  CD82 antigen  Kai1  kangai 1  Symbol and Name updated 1299863 APPROVED
2004-12-14 Kai1  kangai 1      Symbol and Name status set to approved 1299863 APPROVED
2002-06-10 Kai1  kangai 1      Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease down-regulated in squamous cell carcinomas 68869
gene_disease down-regulated in squamous cell carcinomas 70284
gene_disease 2.0-kb mRNA is associated with high metastatic ability by prostate cancer cells; 1.8-kb transcript is upregulated but not associated with metastasis 68869
gene_disease 2.0-kb mRNA is associated with high metastatic ability by prostate cancer cells; 1.8-kb transcript is upregulated but not associated with metastasis 70284
gene_disease expression not found in some low-grade and high-grade lymphomas 68869
gene_disease expression not found in some low-grade and high-grade lymphomas 70284
gene_expression expressed in squamous cell carcinomas 68869
gene_expression expressed in squamous cell carcinomas 70284
gene_process suppresses the metastatic potential of prostate cancer cells 68869
gene_process suppresses the metastatic potential of prostate cancer cells 70284
gene_product glycoprotein that belongs to the transmembrane 4 superfamily (TM4SF) 68869
gene_product glycoprotein that belongs to the transmembrane 4 superfamily (TM4SF) 70284
gene_transcript expresses a predominant 2.0-kb and a minor 1.8-kb-sized RNA 70284