Cacna1i (calcium voltage-gated channel subunit alpha1 I) - Rat Genome Database

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Gene: Cacna1i (calcium voltage-gated channel subunit alpha1 I) Rattus norvegicus
Analyze
Symbol: Cacna1i
Name: calcium voltage-gated channel subunit alpha1 I
RGD ID: 68944
Description: Enables low voltage-gated calcium channel activity. Involved in calcium ion import and calcium ion transport into cytosol. Acts upstream of or within calcium ion transport and regulation of membrane potential. Predicted to be located in membrane. Predicted to be part of voltage-gated sodium channel complex. Predicted to be active in neuron projection. Biomarker of sciatic neuropathy. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human CACNA1I (calcium voltage-gated channel subunit alpha1 I); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH 3-isobutyl-1-methyl-7H-xanthine; 6-propyl-2-thiouracil; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: calcium channel, voltage-dependent, alpha 1I subunit; calcium channel, voltage-dependent, T type, alpha 1I subunit; caVT.3; hypothetical gene supported by NM_020084; LOC497824; low voltage-activated T-type calcium channel alpha-1 subunit (CACNA1I); voltage-dependent calcium channel; voltage-dependent T-type calcium channel subunit alpha-1I; voltage-gated calcium channel subunit alpha Cav3.3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87113,716,266 - 113,827,670 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7113,716,266 - 113,827,670 (+)EnsemblGRCr8
mRatBN7.27111,835,996 - 111,947,418 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7111,836,012 - 111,944,688 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7113,591,130 - 113,702,387 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07115,814,660 - 115,925,924 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07115,784,029 - 115,895,287 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07121,521,787 - 121,619,300 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7121,511,097 - 121,619,283 (+)Ensemblrn6Rnor6.0
Rnor_5.07121,509,362 - 121,609,542 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47118,582,279 - 118,681,537 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7108,173,442 - 108,270,677 (+)NCBICelera
RGSC_v3.17118,604,777 - 118,715,750 (+)NCBI
Cytogenetic Map7q34NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
androgen antagonist  (EXP)
aspartame  (ISO)
atrazine  (EXP)
barium(0)  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
Butylparaben  (EXP)
C60 fullerene  (EXP)
calcium atom  (EXP)
calcium(0)  (EXP)
cannabidiol  (EXP)
colforsin daropate hydrochloride  (EXP)
DDE  (EXP)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
diethylstilbestrol  (EXP)
dimethylarsinic acid  (ISO)
dioxygen  (EXP)
enflurane  (EXP)
enzacamene  (EXP)
epoxiconazole  (EXP)
erythromycin estolate  (EXP)
ethanol  (ISO)
etomidate  (EXP)
folic acid  (ISO)
genistein  (ISO)
irinotecan  (ISO)
isoflurane  (EXP)
ketoconazole  (EXP)
linuron  (EXP)
methapyrilene  (ISO)
methylarsonic acid  (ISO)
Mibefradil  (EXP)
monosodium L-glutamate  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
nickel atom  (EXP)
nickel sulfate  (EXP)
nitrates  (ISO)
Nor-9-carboxy-delta9-THC  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP)
pentobarbital  (EXP)
phenobarbital  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
prochloraz  (EXP)
procymidone  (EXP)
propanal  (ISO)
propofol  (EXP)
raloxifene  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
tetraphene  (ISO)
thiopental  (EXP)
titanium dioxide  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Voltage-gated calcium channels. Catterall WA Cold Spring Harb Perspect Biol. 2011 Aug 1;3(8):a003947. doi: 10.1101/cshperspect.a003947.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Methamphetamine blunts Ca(2+) currents and excitatory synaptic transmission through D1/5 receptor-mediated mechanisms in the mouse medial prefrontal cortex. González B, etal., Addict Biol. 2016 May;21(3):589-602. doi: 10.1111/adb.12249. Epub 2015 Apr 14.
5. Temperature dependence of T-type calcium channel gating. Iftinca M, etal., Neuroscience. 2006 Nov 3;142(4):1031-42. Epub 2006 Aug 28.
6. Distinct contributions of different structural regions to the current kinetics of the Cav3.3 T-type Ca2+ channel. Kang HW, etal., Biochim Biophys Acta. 2008 Dec;1778(12):2740-8. Epub 2008 Aug 9.
7. Identification of T-type alpha1H Ca2+ channels (Ca(v)3.2) in major pelvic ganglion neurons. Lee JH, etal., J Neurophysiol 2002 Jun;87(6):2844-50.
8. Cloning and expression of a novel member of the low voltage-activated T-type calcium channel family. Lee JH, etal., J Neurosci 1999 Mar 15;19(6):1912-21.
9. Spontaneous regenerative activity in mammalian retinal bipolar cells: roles of multiple subtypes of voltage-dependent Ca2+ channels. Ma YP and Pan ZH, Vis Neurosci 2003 Mar-Apr;20(2):131-9.
10. Molecular and functional characterization of a family of rat brain T-type calcium channels. McRory JE, etal., J Biol Chem 2001 Feb 9;276(6):3999-4011.
11. Alternative splicing of the rat Ca(v)3.3 T-type calcium channel gene produces variants with distinct functional properties(1). Murbartian J, etal., FEBS Lett 2002 Sep 25;528(1-3):272-8.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
17. Intrathecal administration of Cav3.2 and Cav3.3 antisense oligonucleotide reverses tactile allodynia and thermal hyperalgesia in rats following chronic compression of dorsal root of ganglion. Wen XJ, etal., Acta Pharmacol Sin. 2006 Dec;27(12):1547-52. doi: 10.1111/j.1745-7254.2006.00461.x.
18. Further evidence for the genetic association between CACNA1I and schizophrenia. Xie Y, etal., Hereditas. 2018 Jan 2;155:16. doi: 10.1186/s41065-017-0054-0. eCollection 2018.
19. Genetic risk between the CACNA1I gene and schizophrenia in Chinese Uygur population. Xu W, etal., Hereditas. 2017 Jul 17;155:5. doi: 10.1186/s41065-017-0037-1. eCollection 2018.
20. Upregulation of T-type Ca2+ channels in primary sensory neurons in spinal nerve injury. Yue J, etal., Spine (Phila Pa 1976). 2013 Mar 15;38(6):463-70. doi: 10.1097/BRS.0b013e318272fbf8.
Additional References at PubMed
PMID:16505194   PMID:16567615   PMID:21808016   PMID:25454347   PMID:28974111   PMID:31666636  


Genomics

Comparative Map Data
Cacna1i
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87113,716,266 - 113,827,670 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7113,716,266 - 113,827,670 (+)EnsemblGRCr8
mRatBN7.27111,835,996 - 111,947,418 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7111,836,012 - 111,944,688 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7113,591,130 - 113,702,387 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07115,814,660 - 115,925,924 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07115,784,029 - 115,895,287 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07121,521,787 - 121,619,300 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7121,511,097 - 121,619,283 (+)Ensemblrn6Rnor6.0
Rnor_5.07121,509,362 - 121,609,542 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47118,582,279 - 118,681,537 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7108,173,442 - 108,270,677 (+)NCBICelera
RGSC_v3.17118,604,777 - 118,715,750 (+)NCBI
Cytogenetic Map7q34NCBI
CACNA1I
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382239,570,753 - 39,689,735 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2239,570,753 - 39,689,735 (+)Ensemblhg38GRCh38
GRCh372239,966,758 - 40,085,740 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362238,296,704 - 38,415,686 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342238,291,257 - 38,410,238NCBI
Celera2223,768,830 - 23,887,794 (+)NCBICelera
Cytogenetic Map22q13.1NCBI
HuRef2222,931,166 - 23,048,848 (+)NCBIHuRef
CHM1_12239,925,499 - 40,044,841 (+)NCBICHM1_1
T2T-CHM13v2.02240,041,540 - 40,160,675 (+)NCBIT2T-CHM13v2.0
Cacna1i
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391580,171,439 - 80,282,493 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1580,171,439 - 80,282,480 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381580,287,238 - 80,398,292 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1580,287,238 - 80,398,279 (+)Ensemblmm10GRCm38
MGSCv371580,117,668 - 80,228,722 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361580,114,300 - 80,225,547 (+)NCBIMGSCv36mm8
Celera1582,404,367 - 82,516,148 (+)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1537.85NCBI
Cacna1i
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541325,453,703 - 25,535,530 (+)Ensembl
ChiLan1.0NW_00495541325,440,533 - 25,538,367 (+)NCBIChiLan1.0ChiLan1.0
CACNA1I
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22349,404,522 - 49,536,330 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12252,095,860 - 52,227,638 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02220,463,511 - 20,595,253 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12238,325,411 - 38,412,923 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2238,296,436 - 38,414,963 (+)EnsemblpanPan2panpan1.1
CACNA1I
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11025,381,446 - 25,493,680 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1025,380,943 - 25,482,852 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1025,317,909 - 25,429,936 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01026,133,456 - 26,245,748 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1026,134,925 - 26,234,803 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11025,845,366 - 25,946,629 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01026,167,842 - 26,279,957 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01026,337,549 - 26,455,352 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cacna1i
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049458,980,016 - 9,035,382 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364921,998,793 - 2,075,257 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364921,990,430 - 2,030,744 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CACNA1I
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl58,595,909 - 8,701,367 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.158,593,014 - 8,702,734 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.255,894,595 - 6,011,363 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CACNA1I
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11922,129,795 - 22,264,485 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1922,143,980 - 22,261,098 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666045103,346,665 - 103,503,501 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cacna1i
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247528,705,149 - 8,785,272 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247528,702,320 - 8,795,192 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Cacna1i
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11250,055,465 - 250,165,515 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cacna1i
757 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:93
Count of miRNA genes:75
Interacting mature miRNAs:80
Transcripts:ENSRNOT00000048790
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)792388565119280177Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)782111245123048330Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7104186212135371468Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)773618702118618702Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)793302009131686183Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)771621154114982716Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)785043242130043242Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)785497398130497398Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)783626689128626689Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)782111382132099989Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
631201Panci1Pancreas inflammation QTL 100.001pancreas integrity trait (VT:0010560)percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)773557047118557047Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)782111245123048330Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)796700404118618702Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7110725024135371468Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)749682832115766396Rat
10450862Kidm55Kidney mass QTL 554.9kidney mass (VT:0002707)kidney weight (CMO:0000081)772725037117725037Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)7100548246137014596Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
10450856Livw4Liver weight QTL 43.8liver mass (VT:0003402)liver weight (CMO:0000092)772725037117725037Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)749682832115766396Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)778682549123682549Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)749682832115766396Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)771621154119349044Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat

Markers in Region
D7Hmgc1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr87113,742,952 - 113,743,158 (+)Marker Load Pipeline
mRatBN7.27111,862,692 - 111,862,898 (+)MAPPERmRatBN7.2
Rnor_6.07121,536,547 - 121,536,752NCBIRnor6.0
Rnor_5.07121,524,620 - 121,524,825UniSTSRnor5.0
RGSC_v3.47118,596,769 - 118,596,974UniSTSRGSC3.4
RGSC_v3.47118,596,768 - 118,596,974RGDRGSC3.4
Celera7108,189,147 - 108,189,352UniSTS
RH 3.4 Map7860.8UniSTS
RH 3.4 Map7860.8RGD
Cytogenetic Map7q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 8 29 142 51 51 24 49 24 6 189 103 9 124 47 91 27 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000084352
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7113,726,999 - 113,827,670 (+)Ensembl
mRatBN7.2 Ensembl7111,846,738 - 111,944,688 (+)Ensembl
Rnor_6.0 Ensembl7121,521,787 - 121,619,194 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000086192
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl7121,511,097 - 121,614,469 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000092608
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7113,716,266 - 113,827,670 (+)Ensembl
mRatBN7.2 Ensembl7111,836,012 - 111,944,688 (+)Ensembl
Rnor_6.0 Ensembl7121,511,097 - 121,619,283 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000144089   ⟹   ENSRNOP00000104426
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7113,781,771 - 113,827,670 (+)Ensembl
RefSeq Acc Id: NM_020084   ⟹   NP_064469
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87113,716,266 - 113,827,670 (+)NCBI
mRatBN7.27111,835,997 - 111,947,418 (+)NCBI
Rnor_6.07121,521,787 - 121,619,300 (+)NCBI
Rnor_5.07121,509,362 - 121,609,542 (+)NCBI
RGSC_v3.47118,582,279 - 118,681,537 (+)RGD
Celera7108,173,442 - 108,270,677 (+)RGD
Sequence:
RefSeq Acc Id: XM_063264167   ⟹   XP_063120237
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87113,716,304 - 113,827,670 (+)NCBI
RefSeq Acc Id: XM_063264168   ⟹   XP_063120238
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87113,716,304 - 113,827,670 (+)NCBI
RefSeq Acc Id: XM_063264169   ⟹   XP_063120239
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87113,716,304 - 113,827,670 (+)NCBI
RefSeq Acc Id: XM_063264170   ⟹   XP_063120240
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87113,716,304 - 113,827,670 (+)NCBI
RefSeq Acc Id: NP_064469   ⟸   NM_020084
- UniProtKB: A0A8I5ZQK3 (UniProtKB/TrEMBL),   A0A8I6APG9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_063120240   ⟸   XM_063264170
- Peptide Label: isoform X4
- UniProtKB: A0A8I6APG9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063120238   ⟸   XM_063264168
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZQK3 (UniProtKB/TrEMBL),   A0A8I6APG9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063120237   ⟸   XM_063264167
- Peptide Label: isoform X1
- UniProtKB: A0A8I6APG9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063120239   ⟸   XM_063264169
- Peptide Label: isoform X3
- UniProtKB: A0A8I6APG9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000104426   ⟸   ENSRNOT00000144089
Protein Domains
Ion transport

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z0Y8-F1-model_v2 AlphaFold Q9Z0Y8 1-2201 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68944 AgrOrtholog
BioCyc Gene G2FUF-32703 BioCyc
Ensembl Genes ENSRNOG00000060407 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000084352 ENTREZGENE
  ENSRNOT00000092608 ENTREZGENE
  ENSRNOT00000144089 ENTREZGENE
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot
  1.20.120.350 UniProtKB/Swiss-Prot
InterPro Ion_trans_dom UniProtKB/Swiss-Prot
  VDCC_alpha-1_subunit UniProtKB/Swiss-Prot
  VDCC_T_a1 UniProtKB/Swiss-Prot
  VDCCAlpha1 UniProtKB/Swiss-Prot
  Volt_channel_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:56827 UniProtKB/Swiss-Prot
NCBI Gene 56827 ENTREZGENE
PANTHER VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1 UniProtKB/Swiss-Prot
  VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1I UniProtKB/Swiss-Prot
Pfam Ion_trans UniProtKB/Swiss-Prot
PhenoGen Cacna1i PhenoGen
PRINTS CACHANNEL UniProtKB/Swiss-Prot
  TVDCCALPHA1 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000060407 RatGTEx
Superfamily-SCOP Voltage-gated potassium channels UniProtKB/Swiss-Prot
TIGR TC209367
UniProt A0A8I5ZQK3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6APG9 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L4F6_RAT UniProtKB/TrEMBL
  CAC1I_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q9EQ59 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Cacna1i  calcium voltage-gated channel subunit alpha1 I  Cacna1i  calcium channel, voltage-dependent, T type, alpha 1I subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-04-17 Cacna1i  calcium channel, voltage-dependent, T type, alpha 1I subunit  LOC497824  hypothetical gene supported by NM_020084  Data merged from RGD:1583748 737654 PROVISIONAL
2008-09-29 Cacna1i  calcium channel, voltage-dependent, T type, alpha 1I subunit  Cacna1i  calcium channel, voltage-dependent, alpha 1I subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC497824  hypothetical gene supported by NM_020084      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-09-10 Cacna1i  calcium channel, voltage-dependent, alpha 1I subunit    calcium channel, voltage-dependent, T type, alpha 1I subunit  Name updated 1299863 APPROVED
2002-06-10 Cacna1i  calcium channel, voltage-dependent, T type, alpha 1I subunit      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed throughout the newborn and juvenile brain 62421
gene_expression mRNA expression is restricted to the striatum 68748
gene_process mediates voltage-dependent entry of calcium into nerve, muscle, and endocrine cells 68748
gene_process responsible for central neuron rebound burst firing and implicated in slow wave sleep and epilepsy 68748
gene_process may play a role in hormone secretion and smooth muscle excitability 68748