Cacna1h (calcium voltage-gated channel subunit alpha1 H) - Rat Genome Database

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Gene: Cacna1h (calcium voltage-gated channel subunit alpha1 H) Rattus norvegicus
Analyze
Symbol: Cacna1h
Name: calcium voltage-gated channel subunit alpha1 H
RGD ID: 68943
Description: Enables low voltage-gated calcium channel activity. Involved in calcium ion import; positive regulation of cardiac muscle cell contraction; and steroid hormone biosynthetic process. Located in dendrite and perikaryon. Biomarker of sciatic neuropathy. Human ortholog(s) of this gene implicated in childhood absence epilepsy and primary hyperaldosteronism. Orthologous to human CACNA1H (calcium voltage-gated channel subunit alpha1 H); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH (S)-nicotine; 1,3-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: calcium channel, voltage-dependent, T type, alpha 1H subunit; voltage-dependent T-type calcium channel subunit alpha-1H; voltage-gated calcium channel subunit alpha Cav3.2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Cacna1hem2Mcwi
Genetic Models: SS-Cacna1hem2Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81014,894,630 - 14,952,317 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1014,894,641 - 14,952,771 (-)EnsemblGRCr8
mRatBN7.21014,390,104 - 14,448,204 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1014,390,113 - 14,448,376 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1019,130,825 - 19,188,496 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01018,619,694 - 18,677,363 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01014,118,873 - 14,176,544 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01014,730,932 - 14,789,201 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1014,730,941 - 14,788,617 (-)Ensemblrn6Rnor6.0
Rnor_5.01014,547,456 - 14,605,627 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41014,621,372 - 14,679,051 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1014,061,778 - 14,119,454 (-)NCBICelera
RGSC_v3.11014,621,371 - 14,679,051 (-)NCBI
Cytogenetic Map10q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
17alpha-ethynylestradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP)
3-cyanoalanine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamiprid  (EXP)
actinomycin D  (EXP)
aflatoxin B1  (ISO)
amiloride  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP)
barium(0)  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
buta-1,3-diene  (ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (EXP)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
cefaloridine  (EXP)
cisplatin  (ISO)
cobalt dichloride  (EXP)
colforsin daropate hydrochloride  (EXP)
Cuprizon  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
desferrioxamine B  (EXP)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
diethylstilbestrol  (EXP)
dioxygen  (EXP)
doxorubicin  (ISO)
enzacamene  (EXP)
ethanol  (ISO)
fluoxetine  (EXP)
gentamycin  (EXP)
herbimycin  (ISO)
hexamethylene diisocyanate  (ISO)
imidacloprid  (EXP)
ketoconazole  (EXP)
KN-93  (ISO)
L-ascorbic acid  (ISO)
leflunomide  (ISO)
linsidomine  (EXP)
methapyrilene  (ISO)
methoxychlor  (EXP)
mevalonic acid  (EXP)
Mibefradil  (EXP,ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-1,4-benzoquinone imine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (EXP,ISO)
niclosamide  (ISO)
nicotine  (EXP)
Nor-9-carboxy-delta9-THC  (ISO)
okadaic acid  (ISO)
ozone  (EXP)
p-menthan-3-ol  (ISO)
paracetamol  (EXP)
perfluorooctanoic acid  (EXP)
phenethyl caffeate  (EXP)
phenylarsine oxide  (ISO)
potassium dichromate  (ISO)
raloxifene  (ISO)
rotenone  (ISO)
SB 203580  (EXP)
silicon dioxide  (EXP)
simvastatin  (EXP)
sodium arsenite  (EXP,ISO)
sunitinib  (ISO)
telmisartan  (EXP)
titanium dioxide  (ISO)
tributylstannane  (EXP)
trichloroethene  (EXP)
triclosan  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
valproic acid  (EXP,ISO)
verapamil  (EXP)
vincristine  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway   (ISO)
calcium transport pathway   (ISO)
calcium/calcium-mediated signaling pathway  (IEA,ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway   (ISO)
mitogen activated protein kinase signaling pathway  (IEA)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Voltage-gated calcium channels. Catterall WA Cold Spring Harb Perspect Biol. 2011 Aug 1;3(8):a003947. doi: 10.1101/cshperspect.a003947.
2. Association between genetic variation of CACNA1H and childhood absence epilepsy. Chen Y, etal., Ann Neurol 2003 Aug;54(2):239-43.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Temperature dependence of T-type calcium channel gating. Iftinca M, etal., Neuroscience. 2006 Nov 3;142(4):1031-42. Epub 2006 Aug 28.
6. Hyperalgesia induced by spinal and peripheral hydrogen sulfide: evidence for involvement of Cav3.2 T-type calcium channels. Maeda Y, etal., Pain. 2009 Mar;142(1-2):127-32. doi: 10.1016/j.pain.2008.12.021. Epub 2009 Jan 23.
7. Role of the T-type calcium channel CaV3.2 in the chronotropic action of corticosteroids in isolated rat ventricular myocytes. Maturana A, etal., Endocrinology. 2009 Aug;150(8):3726-34. doi: 10.1210/en.2008-1727. Epub 2009 May 14.
8. Molecular and functional characterization of a family of rat brain T-type calcium channels. McRory JE, etal., J Biol Chem 2001 Feb 9;276(6):3999-4011.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Regulation of aldosterone and cortisol production by the transcriptional repressor neuron restrictive silencer factor. Somekawa S, etal., Endocrinology. 2009 Jul;150(7):3110-7. Epub 2009 Apr 2.
17. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
18. Differential distribution of voltage-gated calcium channels in dopaminergic neurons of the rat retina. Witkovsky P, etal., J Comp Neurol. 2006 Jul 20;497(3):384-96.
19. Upregulation of T-type Ca2+ channels in primary sensory neurons in spinal nerve injury. Yue J, etal., Spine (Phila Pa 1976). 2013 Mar 15;38(6):463-70. doi: 10.1097/BRS.0b013e318272fbf8.
Additional References at PubMed
PMID:12530678   PMID:14729682   PMID:15616581   PMID:16567615   PMID:16644797   PMID:17690152   PMID:18759855   PMID:18765948   PMID:18832095   PMID:19641113   PMID:19666840   PMID:19940152  
PMID:20394732   PMID:20546998   PMID:21059758   PMID:21084288   PMID:21358644   PMID:21596106   PMID:21690417   PMID:21883220   PMID:22431737   PMID:22764245   PMID:23103495   PMID:23376589  
PMID:23508951   PMID:23669360   PMID:23813099   PMID:23867767   PMID:25099734   PMID:25377760   PMID:25931121   PMID:26331302   PMID:27149520   PMID:27902567   PMID:28912545   PMID:29468672  
PMID:29592785   PMID:29684385   PMID:31744861   PMID:32971090   PMID:37391087   PMID:38325845  


Genomics

Comparative Map Data
Cacna1h
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81014,894,630 - 14,952,317 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1014,894,641 - 14,952,771 (-)EnsemblGRCr8
mRatBN7.21014,390,104 - 14,448,204 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1014,390,113 - 14,448,376 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1019,130,825 - 19,188,496 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01018,619,694 - 18,677,363 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01014,118,873 - 14,176,544 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01014,730,932 - 14,789,201 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1014,730,941 - 14,788,617 (-)Ensemblrn6Rnor6.0
Rnor_5.01014,547,456 - 14,605,627 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41014,621,372 - 14,679,051 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1014,061,778 - 14,119,454 (-)NCBICelera
RGSC_v3.11014,621,371 - 14,679,051 (-)NCBI
Cytogenetic Map10q12NCBI
CACNA1H
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38161,153,106 - 1,221,768 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl161,153,103 - 1,224,169 (+)Ensemblhg38GRCh38
GRCh37161,203,106 - 1,271,768 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36161,143,242 - 1,211,773 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34161,143,241 - 1,211,772NCBI
Celera161,418,957 - 1,487,666 (+)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef161,111,743 - 1,204,831 (+)NCBIHuRef
CHM1_1161,179,129 - 1,271,446 (+)NCBICHM1_1
T2T-CHM13v2.0161,165,753 - 1,237,078 (+)NCBIT2T-CHM13v2.0
Cacna1h
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391725,593,259 - 25,655,308 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1725,593,259 - 25,652,759 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381725,374,285 - 25,436,334 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1725,374,285 - 25,433,783 (-)Ensemblmm10GRCm38
MGSCv371725,511,232 - 25,570,728 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361725,101,887 - 25,161,368 (-)NCBIMGSCv36mm8
Celera1725,902,087 - 25,961,468 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1712.53NCBI
Cacna1h
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544216,045,895 - 16,108,862 (-)Ensembl
ChiLan1.0NW_00495544216,047,965 - 16,108,862 (-)NCBIChiLan1.0ChiLan1.0
CACNA1H
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2181,406,005 - 1,477,547 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1165,187,949 - 5,257,891 (+)NCBINHGRI_mPanPan1
PanPan1.1161,195,991 - 1,222,917 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl161,195,364 - 1,222,917 (+)EnsemblpanPan2panpan1.1
CACNA1H
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1639,510,129 - 39,533,129 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl639,510,121 - 39,533,753 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha640,776,915 - 40,826,321 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0639,855,337 - 39,904,743 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl639,855,796 - 39,878,507 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1639,531,855 - 39,581,243 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0639,504,487 - 39,553,874 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0639,983,132 - 40,032,548 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cacna1h
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344103,984,951 - 104,007,239 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366942,702,964 - 2,724,416 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366942,702,224 - 2,724,574 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CACNA1H
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl340,637,427 - 40,695,177 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1340,637,420 - 40,694,616 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CACNA1H
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.151,039,709 - 1,106,212 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl51,078,973 - 1,106,507 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606829,985,587 - 30,052,739 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cacna1h
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249131,891,156 - 1,949,633 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046249131,926,405 - 1,952,426 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Cacna1h
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v192,638,294 - 2,696,463 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cacna1h
172 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:117
Count of miRNA genes:87
Interacting mature miRNAs:102
Transcripts:ENSRNOT00000043626
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10666111835509383Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135730538Rat
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10130004247Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10117749933Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138832698Rat

Markers in Region
RH128070  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21014,390,232 - 14,390,447 (+)MAPPERmRatBN7.2
Rnor_6.01014,731,061 - 14,731,275NCBIRnor6.0
Rnor_5.01014,547,585 - 14,547,799UniSTSRnor5.0
RGSC_v3.41014,621,492 - 14,621,706UniSTSRGSC3.4
Celera1014,061,898 - 14,062,112UniSTS
Cytogenetic Map10q12UniSTS
RH139078  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10q12UniSTS
Cacna1h  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21014,393,024 - 14,393,239 (+)MAPPERmRatBN7.2
Rnor_6.01014,733,853 - 14,734,067NCBIRnor6.0
Rnor_5.01014,550,377 - 14,550,591UniSTSRnor5.0
RGSC_v3.41014,624,285 - 14,624,499UniSTSRGSC3.4
Celera1014,064,690 - 14,064,904UniSTS
Cytogenetic Map10q12UniSTS
UniSTS:461910  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21014,401,237 - 14,402,395 (+)MAPPERmRatBN7.2
Rnor_6.01014,742,066 - 14,743,223NCBIRnor6.0
Rnor_5.01014,558,590 - 14,559,747UniSTSRnor5.0
RGSC_v3.41014,632,498 - 14,633,655UniSTSRGSC3.4
Celera1014,072,903 - 14,074,060UniSTS
Cytogenetic Map10q12UniSTS


Genetic Models
This gene Cacna1h is modified in the following models/strains:
SS-Cacna1hem2Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 159 88 87 56 71 56 6 329 171 10 138 78 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000043626   ⟹   ENSRNOP00000042239
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1014,894,641 - 14,952,771 (-)Ensembl
mRatBN7.2 Ensembl1014,390,113 - 14,448,376 (-)Ensembl
Rnor_6.0 Ensembl1014,730,941 - 14,788,617 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000110031   ⟹   ENSRNOP00000094098
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1014,417,421 - 14,448,376 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111325   ⟹   ENSRNOP00000097572
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1014,894,641 - 14,952,771 (-)Ensembl
mRatBN7.2 Ensembl1014,390,113 - 14,448,376 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117168   ⟹   ENSRNOP00000097334
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1014,894,641 - 14,952,771 (-)Ensembl
mRatBN7.2 Ensembl1014,390,113 - 14,448,376 (-)Ensembl
RefSeq Acc Id: NM_153814   ⟹   NP_722521
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,894,641 - 14,952,317 (-)NCBI
mRatBN7.21014,390,113 - 14,447,791 (-)NCBI
Rnor_6.01014,730,941 - 14,788,617 (-)NCBI
Rnor_5.01014,547,456 - 14,605,627 (-)NCBI
RGSC_v3.41014,621,372 - 14,679,051 (-)RGD
Celera1014,061,778 - 14,119,454 (-)RGD
Sequence:
RefSeq Acc Id: XM_063268284   ⟹   XP_063124354
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,894,630 - 14,923,341 (-)NCBI
RefSeq Acc Id: XM_063268285   ⟹   XP_063124355
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,894,630 - 14,923,336 (-)NCBI
RefSeq Acc Id: XM_063268286   ⟹   XP_063124356
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,894,630 - 14,923,338 (-)NCBI
RefSeq Acc Id: XM_063268287   ⟹   XP_063124357
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,894,630 - 14,913,428 (-)NCBI
RefSeq Acc Id: NP_722521   ⟸   NM_153814
- UniProtKB: Q9EQ60 (UniProtKB/Swiss-Prot),   A6HD26 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000042239   ⟸   ENSRNOT00000043626
Ensembl Acc Id: ENSRNOP00000097572   ⟸   ENSRNOT00000111325
Ensembl Acc Id: ENSRNOP00000094098   ⟸   ENSRNOT00000110031
Ensembl Acc Id: ENSRNOP00000097334   ⟸   ENSRNOT00000117168
RefSeq Acc Id: XP_063124354   ⟸   XM_063268284
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AUK1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063124356   ⟸   XM_063268286
- Peptide Label: isoform X3
- UniProtKB: G3V9C6 (UniProtKB/TrEMBL),   A6HD26 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063124355   ⟸   XM_063268285
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AUK1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063124357   ⟸   XM_063268287
- Peptide Label: isoform X4
- UniProtKB: A0A8I6AUK1 (UniProtKB/TrEMBL)
Protein Domains
Ion transport

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9EQ60-F1-model_v2 AlphaFold Q9EQ60 1-2359 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697052
Promoter ID:EPDNEW_R7575
Type:single initiation site
Name:Cacna1h_1
Description:calcium voltage-gated channel subunit alpha1 H
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01014,788,541 - 14,788,601EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68943 AgrOrtholog
BioCyc Gene G2FUF-25781 BioCyc
Ensembl Genes ENSRNOG00000033893 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000043626 ENTREZGENE
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot
  1.20.120.350 UniProtKB/Swiss-Prot
InterPro Ion_trans_dom UniProtKB/Swiss-Prot
  VDCC_alpha-1_subunit UniProtKB/Swiss-Prot
  VDCC_T_a1 UniProtKB/Swiss-Prot
  Volt_channel_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:114862 UniProtKB/Swiss-Prot
NCBI Gene 114862 ENTREZGENE
PANTHER VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1 UniProtKB/Swiss-Prot
  VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1H UniProtKB/Swiss-Prot
Pfam Ion_trans UniProtKB/Swiss-Prot
PharmGKB CACNA1H RGD
PhenoGen Cacna1h PhenoGen
PRINTS TVDCCALPHA1 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000033893 RatGTEx
Superfamily-SCOP Voltage-gated potassium channels UniProtKB/Swiss-Prot
TIGR TC205129
UniProt A0A8I6ASQ9_RAT UniProtKB/TrEMBL
  A0A8I6AUK1 ENTREZGENE, UniProtKB/TrEMBL
  A6HD26 ENTREZGENE, UniProtKB/TrEMBL
  CAC1H_RAT UniProtKB/Swiss-Prot
  G3V9C6 ENTREZGENE, UniProtKB/TrEMBL
  Q9EQ60 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Cacna1h  calcium channel, voltage-dependent, T type, alpha 1H subunit      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed throughout the newborn and juvenile brain 62421
gene_expression expressed throughout the newborn and juvenile brain 68748
gene_process mediates voltage-dependent entry of calcium into nerve, muscle, and endocrine cells 62421
gene_process mediates voltage-dependent entry of calcium into nerve, muscle, and endocrine cells 68748
gene_process responsible for central neuron rebound burst firing and implicated in slow wave sleep and epilepsy 62421
gene_process responsible for central neuron rebound burst firing and implicated in slow wave sleep and epilepsy 68748
gene_process may play a role in hormone secretion and smooth muscle excitability 62421
gene_process may play a role in hormone secretion and smooth muscle excitability 68748