Dclk1 (doublecortin-like kinase 1) - Rat Genome Database

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Gene: Dclk1 (doublecortin-like kinase 1) Rattus norvegicus
Analyze
Symbol: Dclk1
Name: doublecortin-like kinase 1
RGD ID: 68437
Description: Enables protein kinase activity. Predicted to be involved in several processes, including axon extension; regulation of postsynapse assembly; and response to virus. Predicted to act upstream of or within negative regulation of protein localization to nucleus and nervous system development. Located in growth cone. Orthologous to human DCLK1 (doublecortin like kinase 1); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: activity and neurotransmitter-induced early gene protein 4 (ania-4); Ania4; calcium/calmodulin-dependent protein kinase type I-like CPG16; Cpg16; Dcamkl1; double cortin and calcium/calmodulin-dependent protein kinase-like 1; doublecortin-like and CAM kinase-like 1; serine/threonine-protein kinase DCLK1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82141,567,215 - 141,861,088 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2141,571,983 - 141,861,090 (+)EnsemblGRCr8
mRatBN7.22139,417,234 - 139,710,956 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2139,417,163 - 139,710,956 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2146,207,364 - 146,283,054 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02144,318,813 - 144,394,500 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02138,951,229 - 139,026,915 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02144,646,255 - 144,939,389 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2144,646,308 - 144,936,927 (+)Ensemblrn6Rnor6.0
Rnor_5.02164,062,498 - 164,355,201 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42144,678,222 - 144,754,237 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2134,114,211 - 134,191,878 (+)NCBICelera
RGSC_v3.12144,628,184 - 144,704,200 (+)NCBI
Cytogenetic Map2q26NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (ISO)
allopurinol  (EXP)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
amosite asbestos  (ISO)
amphetamine  (EXP)
amphotericin B  (ISO)
antirheumatic drug  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-naphthoflavone  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bosentan  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (EXP,ISO)
C60 fullerene  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
chlorpyrifos  (EXP)
choline  (ISO)
clotrimazole  (EXP)
clozapine  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (EXP)
deoxycholic acid  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP,ISO)
Enterolactone  (ISO)
entinostat  (ISO)
ethanol  (ISO)
flavonoids  (EXP)
fluoxetine  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fructose  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glycidol  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
haloperidol  (EXP,ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
methylmercury chloride  (ISO)
Moniliformin  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Muraglitazar  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
okadaic acid  (ISO)
olanzapine  (ISO)
oxaliplatin  (EXP)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
pentanal  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
propanal  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
Sunset Yellow FCF  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
tributylstannane  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
troglitazone  (EXP)
urethane  (ISO)
valproic acid  (EXP,ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. A complex program of striatal gene expression induced by dopaminergic stimulation. Berke JD, etal., J Neurosci 1998 Jul 15;18(14):5301-10.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Hippocampal plasticity involves extensive gene induction and multiple cellular mechanisms. Hevroni D, etal., J Mol Neurosci 1998 Apr;10(2):75-98.
5. A novel role for doublecortin and doublecortin-like kinase in regulating growth cone microtubules. Jean DC, etal., Hum Mol Genet. 2012 Dec 15;21(26):5511-27. doi: 10.1093/hmg/dds395. Epub 2012 Sep 21.
6. DCAMKL1 encodes a protein kinase with homology to doublecortin that regulates microtubule polymerization. Lin PT, etal., J Neurosci 2000 Dec 15;20(24):9152-61.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Catalytic and regulatory domains of doublecortin kinase-1. Shang L, etal., Biochemistry 2003 Feb 25;42(7):2185-94.
13. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
14. Kainate-elicited seizures induce mRNA encoding a CaMK-related peptide: a putative modulator of kinase activity in rat hippocampus. Vreugdenhil E, etal., J Neurobiol 1999 Apr;39(1):41-50.
Additional References at PubMed
PMID:8889548   PMID:10550327   PMID:15277470   PMID:16387638   PMID:16387639   PMID:16548883   PMID:16684769   PMID:16869982   PMID:17114649   PMID:19844571   PMID:20236041   PMID:20418180  
PMID:22344266   PMID:23374535   PMID:26758546   PMID:27900578   PMID:29476059   PMID:30879761   PMID:33676985   PMID:35082322  


Genomics

Comparative Map Data
Dclk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82141,567,215 - 141,861,088 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2141,571,983 - 141,861,090 (+)EnsemblGRCr8
mRatBN7.22139,417,234 - 139,710,956 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2139,417,163 - 139,710,956 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2146,207,364 - 146,283,054 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02144,318,813 - 144,394,500 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02138,951,229 - 139,026,915 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02144,646,255 - 144,939,389 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2144,646,308 - 144,936,927 (+)Ensemblrn6Rnor6.0
Rnor_5.02164,062,498 - 164,355,201 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42144,678,222 - 144,754,237 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2134,114,211 - 134,191,878 (+)NCBICelera
RGSC_v3.12144,628,184 - 144,704,200 (+)NCBI
Cytogenetic Map2q26NCBI
DCLK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381335,768,652 - 36,131,939 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1335,768,652 - 36,132,164 (-)Ensemblhg38GRCh38
GRCh371336,342,789 - 36,706,076 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361335,243,478 - 35,603,443 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341335,243,477 - 35,603,443NCBI
Celera1317,410,025 - 17,772,331 (-)NCBICelera
Cytogenetic Map13q13.3NCBI
HuRef1317,497,886 - 17,517,445 (-)NCBIHuRef
HuRef1317,156,100 - 17,334,637 (-)NCBIHuRef
CHM1_11336,310,364 - 36,673,089 (-)NCBICHM1_1
T2T-CHM13v2.01334,986,929 - 35,351,445 (-)NCBIT2T-CHM13v2.0
Dclk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39355,149,724 - 55,446,489 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl355,149,785 - 55,446,489 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38355,242,303 - 55,539,068 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl355,242,364 - 55,539,068 (+)Ensemblmm10GRCm38
MGSCv37355,046,448 - 55,342,990 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36355,330,557 - 55,624,607 (+)NCBIMGSCv36mm8
Celera354,960,357 - 55,257,519 (+)NCBICelera
Cytogenetic Map3CNCBI
cM Map326.53NCBI
Dclk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554319,975,262 - 10,297,010 (+)Ensembl
ChiLan1.0NW_0049554319,975,629 - 10,302,605 (+)NCBIChiLan1.0ChiLan1.0
DCLK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21435,300,686 - 35,655,551 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11326,406,603 - 26,761,388 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01316,988,340 - 17,342,911 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11335,419,835 - 35,768,949 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1335,425,382 - 35,768,935 (-)EnsemblpanPan2panpan1.1
DCLK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1254,441,945 - 4,783,542 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl254,345,771 - 4,778,047 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha254,474,081 - 4,820,850 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0254,543,814 - 4,885,237 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl254,544,126 - 4,880,032 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1254,450,895 - 4,791,838 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0254,446,133 - 4,787,610 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0254,510,453 - 4,851,667 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Dclk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945165,664,364 - 165,993,443 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647229,964,218 - 30,287,841 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647229,958,716 - 30,287,798 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DCLK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1111,815,357 - 12,158,826 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11111,815,258 - 12,159,085 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21111,847,739 - 12,121,589 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DCLK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1314,358,997 - 14,713,621 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl314,362,301 - 14,536,027 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605729,580,519 - 29,932,214 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dclk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247761,301,762 - 1,676,835 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247761,299,691 - 1,679,888 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Dclk1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1398,908,664 - 99,197,469 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Dclk1
1833 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:2037
Count of miRNA genes:380
Interacting mature miRNAs:585
Transcripts:ENSRNOT00000019748, ENSRNOT00000072110
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)2105628029150628029Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1358360Sradr2Stress Responsive Adrenal Weight QTL 210.24adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)2124103798154505346Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2138595962205135428Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2124537199209621565Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2139067258192287892Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1582257Gluco21Glucose level QTL 213.10.0035blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2120039407159440891Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2100807373145807373Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2106869825151869825Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
5135226Leukc2Leukocyte quantity QTL 2eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)2120039407151869825Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)293602631145807373Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2139067258184067258Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
7488933Bp368Blood pressure QTL 3680.004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2104957381149957381Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
738007Anxrr7Anxiety related response QTL 74.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2120339555165339555Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979159440891Rat
1581552Pur12Proteinuria QTL 125.190.0009urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)2114032149150226270Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)2114440891159440891Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
1354594Despr10Despair related QTL 102e-06locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)2116804572161804572Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)261051541143746880Rat

Markers in Region
AA963194  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22139,638,475 - 139,638,694 (+)MAPPERmRatBN7.2
Rnor_6.02144,867,175 - 144,867,393NCBIRnor6.0
Rnor_5.02164,283,008 - 164,283,226UniSTSRnor5.0
RGSC_v3.42144,683,942 - 144,684,160UniSTSRGSC3.4
Celera2134,119,937 - 134,120,155UniSTS
RH 3.4 Map2861.4UniSTS
Cytogenetic Map2q26UniSTS
RH139488  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22139,710,646 - 139,710,851 (+)MAPPERmRatBN7.2
Rnor_6.02144,939,080 - 144,939,284NCBIRnor6.0
Rnor_5.02164,354,892 - 164,355,096UniSTSRnor5.0
RGSC_v3.42144,756,390 - 144,756,594UniSTSRGSC3.4
Celera2134,191,569 - 134,191,773UniSTS
RH 3.4 Map2861.5UniSTS
RH 3.4 Map2861.4UniSTS
Cytogenetic Map2q26UniSTS
BF387208  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22139,656,970 - 139,657,138 (+)MAPPERmRatBN7.2
Rnor_6.02144,885,440 - 144,885,607NCBIRnor6.0
Rnor_5.02164,301,252 - 164,301,419UniSTSRnor5.0
RGSC_v3.42144,702,544 - 144,702,711UniSTSRGSC3.4
Celera2134,137,859 - 134,138,026UniSTS
RH 3.4 Map2861.5UniSTS
Cytogenetic Map2q26UniSTS
BE106390  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22139,700,456 - 139,700,618 (+)MAPPERmRatBN7.2
Rnor_6.02144,928,890 - 144,929,051NCBIRnor6.0
Rnor_5.02164,344,702 - 164,344,863UniSTSRnor5.0
RGSC_v3.42144,746,200 - 144,746,361UniSTSRGSC3.4
Celera2134,181,379 - 134,181,540UniSTS
RH 3.4 Map2861.4UniSTS
Cytogenetic Map2q26UniSTS
AI836758  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22139,710,570 - 139,710,712 (+)MAPPERmRatBN7.2
Rnor_6.02144,939,004 - 144,939,145NCBIRnor6.0
Rnor_5.02164,354,816 - 164,354,957UniSTSRnor5.0
RGSC_v3.42144,756,314 - 144,756,455UniSTSRGSC3.4
Celera2134,191,493 - 134,191,634UniSTS
Cytogenetic Map2q26UniSTS
RH137977  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22139,695,387 - 139,695,572 (+)MAPPERmRatBN7.2
Rnor_6.02144,923,821 - 144,924,005NCBIRnor6.0
Rnor_5.02164,339,633 - 164,339,817UniSTSRnor5.0
RGSC_v3.42144,741,131 - 144,741,315UniSTSRGSC3.4
Celera2134,176,310 - 134,176,494UniSTS
RH 3.4 Map2861.5UniSTS
Cytogenetic Map2q26UniSTS
RH138275  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22139,672,956 - 139,673,108 (+)MAPPERmRatBN7.2
Rnor_6.02144,901,393 - 144,901,544NCBIRnor6.0
Rnor_5.02164,317,205 - 164,317,356UniSTSRnor5.0
RGSC_v3.42144,718,702 - 144,718,853UniSTSRGSC3.4
Celera2134,153,832 - 134,153,983UniSTS
RH 3.4 Map2860.3UniSTS
Cytogenetic Map2q26UniSTS
RH140320  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22139,710,677 - 139,710,852 (+)MAPPERmRatBN7.2
Rnor_6.02144,939,111 - 144,939,285NCBIRnor6.0
Rnor_5.02164,354,923 - 164,355,097UniSTSRnor5.0
RGSC_v3.42144,756,421 - 144,756,595UniSTSRGSC3.4
Celera2134,191,600 - 134,191,774UniSTS
Cytogenetic Map2q26UniSTS
RH141428  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22139,638,085 - 139,638,299 (+)MAPPERmRatBN7.2
Rnor_6.02144,866,785 - 144,866,998NCBIRnor6.0
Rnor_5.02164,282,618 - 164,282,831UniSTSRnor5.0
RGSC_v3.42144,683,552 - 144,683,765UniSTSRGSC3.4
Celera2134,119,547 - 134,119,760UniSTS
RH 3.4 Map2862.2UniSTS
Cytogenetic Map2q26UniSTS
ha2752  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera2134,147,669 - 134,148,365UniSTS
Cytogenetic Map2q26UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 87 86 55 79 55 6 339 179 11 151 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_021584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_053343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591138 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039103247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039103249 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039103250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039103252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039103253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039103254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039103255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039103256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039103257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039103258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039103260 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282639 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282640 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF030089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF045469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF407055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB586027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF978300 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211799 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC438344 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U78857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000019748   ⟹   ENSRNOP00000019748
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2141,782,914 - 141,861,085 (+)Ensembl
mRatBN7.2 Ensembl2139,632,744 - 139,710,956 (+)Ensembl
Rnor_6.0 Ensembl2144,861,455 - 144,936,927 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000072110   ⟹   ENSRNOP00000067781
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2139,417,163 - 139,641,880 (+)Ensembl
Rnor_6.0 Ensembl2144,861,459 - 144,870,582 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000078337   ⟹   ENSRNOP00000075702
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2141,571,983 - 141,797,116 (+)Ensembl
mRatBN7.2 Ensembl2139,417,423 - 139,647,677 (+)Ensembl
Rnor_6.0 Ensembl2144,646,308 - 144,934,025 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000093284   ⟹   ENSRNOP00000076110
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2141,800,052 - 141,861,090 (+)Ensembl
mRatBN7.2 Ensembl2139,649,914 - 139,710,956 (+)Ensembl
Rnor_6.0 Ensembl2144,861,455 - 144,936,807 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000093407   ⟹   ENSRNOP00000076341
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2141,787,464 - 141,861,090 (+)Ensembl
mRatBN7.2 Ensembl2139,417,163 - 139,708,357 (+)Ensembl
Rnor_6.0 Ensembl2144,646,429 - 144,936,803 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099182   ⟹   ENSRNOP00000090378
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2141,571,983 - 141,861,085 (+)Ensembl
mRatBN7.2 Ensembl2139,417,163 - 139,710,956 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107822   ⟹   ENSRNOP00000083313
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2141,571,983 - 141,861,090 (+)Ensembl
mRatBN7.2 Ensembl2139,417,163 - 139,710,956 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000145633   ⟹   ENSRNOP00000106599
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2141,786,888 - 141,861,090 (+)Ensembl
RefSeq Acc Id: NM_021584   ⟹   NP_067595
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82141,782,884 - 141,792,022 (+)NCBI
mRatBN7.22139,632,744 - 139,641,884 (+)NCBI
Rnor_6.02144,861,445 - 144,870,583 (+)NCBI
Rnor_5.02164,062,498 - 164,355,201 (+)NCBI
Celera2134,114,211 - 134,123,345 (+)NCBI
Sequence:
RefSeq Acc Id: NM_053343   ⟹   NP_445795
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82141,782,884 - 141,861,088 (+)NCBI
mRatBN7.22139,632,744 - 139,710,956 (+)NCBI
Rnor_6.02144,861,445 - 144,939,389 (+)NCBI
Rnor_5.02164,062,498 - 164,355,201 (+)NCBI
RGSC_v3.42144,678,222 - 144,754,237 (+)RGD
Celera2134,114,211 - 134,191,878 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008761005   ⟹   XP_008759227
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82141,782,691 - 141,858,627 (+)NCBI
mRatBN7.22139,632,574 - 139,710,956 (+)NCBI
Rnor_6.02144,860,554 - 144,933,928 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017591138   ⟹   XP_017446627
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82141,782,691 - 141,858,627 (+)NCBI
mRatBN7.22139,632,572 - 139,710,956 (+)NCBI
Rnor_6.02144,860,553 - 144,939,389 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017591139   ⟹   XP_017446628
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82141,567,215 - 141,858,627 (+)NCBI
mRatBN7.22139,417,245 - 139,710,956 (+)NCBI
Rnor_6.02144,646,255 - 144,933,928 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039103247   ⟹   XP_038959175
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82141,567,215 - 141,858,627 (+)NCBI
mRatBN7.22139,417,244 - 139,710,956 (+)NCBI
RefSeq Acc Id: XM_039103249   ⟹   XP_038959177
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82141,567,215 - 141,858,627 (+)NCBI
mRatBN7.22139,417,241 - 139,710,956 (+)NCBI
RefSeq Acc Id: XM_039103250   ⟹   XP_038959178
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82141,567,215 - 141,858,627 (+)NCBI
mRatBN7.22139,417,247 - 139,710,956 (+)NCBI
RefSeq Acc Id: XM_039103252   ⟹   XP_038959180
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82141,567,215 - 141,858,627 (+)NCBI
mRatBN7.22139,417,245 - 139,710,956 (+)NCBI
RefSeq Acc Id: XM_039103253   ⟹   XP_038959181
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82141,567,215 - 141,858,627 (+)NCBI
mRatBN7.22139,417,242 - 139,710,956 (+)NCBI
RefSeq Acc Id: XM_039103254   ⟹   XP_038959182
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82141,567,215 - 141,858,627 (+)NCBI
mRatBN7.22139,417,240 - 139,710,956 (+)NCBI
RefSeq Acc Id: XM_039103255   ⟹   XP_038959183
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82141,782,691 - 141,858,627 (+)NCBI
mRatBN7.22139,632,574 - 139,710,956 (+)NCBI
RefSeq Acc Id: XM_039103256   ⟹   XP_038959184
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82141,782,691 - 141,858,627 (+)NCBI
mRatBN7.22139,632,570 - 139,710,956 (+)NCBI
RefSeq Acc Id: XM_039103257   ⟹   XP_038959185
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82141,567,215 - 141,792,022 (+)NCBI
mRatBN7.22139,417,236 - 139,641,884 (+)NCBI
RefSeq Acc Id: XM_039103258   ⟹   XP_038959186
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82141,567,215 - 141,792,022 (+)NCBI
mRatBN7.22139,417,234 - 139,641,884 (+)NCBI
RefSeq Acc Id: XM_039103260   ⟹   XP_038959188
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82141,567,215 - 141,792,022 (+)NCBI
mRatBN7.22139,417,234 - 139,641,884 (+)NCBI
RefSeq Acc Id: XM_063282639   ⟹   XP_063138709
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82141,782,691 - 141,858,627 (+)NCBI
RefSeq Acc Id: XM_063282640   ⟹   XP_063138710
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82141,782,056 - 141,792,022 (+)NCBI
Protein Sequences
Protein RefSeqs NP_067595 (Get FASTA)   NCBI Sequence Viewer  
  NP_445795 (Get FASTA)   NCBI Sequence Viewer  
  XP_008759227 (Get FASTA)   NCBI Sequence Viewer  
  XP_017446627 (Get FASTA)   NCBI Sequence Viewer  
  XP_017446628 (Get FASTA)   NCBI Sequence Viewer  
  XP_038959175 (Get FASTA)   NCBI Sequence Viewer  
  XP_038959177 (Get FASTA)   NCBI Sequence Viewer  
  XP_038959178 (Get FASTA)   NCBI Sequence Viewer  
  XP_038959180 (Get FASTA)   NCBI Sequence Viewer  
  XP_038959181 (Get FASTA)   NCBI Sequence Viewer  
  XP_038959182 (Get FASTA)   NCBI Sequence Viewer  
  XP_038959183 (Get FASTA)   NCBI Sequence Viewer  
  XP_038959184 (Get FASTA)   NCBI Sequence Viewer  
  XP_038959185 (Get FASTA)   NCBI Sequence Viewer  
  XP_038959186 (Get FASTA)   NCBI Sequence Viewer  
  XP_038959188 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138709 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138710 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC99476 (Get FASTA)   NCBI Sequence Viewer  
  AAD43824 (Get FASTA)   NCBI Sequence Viewer  
  AAD51126 (Get FASTA)   NCBI Sequence Viewer  
  BBH55892 (Get FASTA)   NCBI Sequence Viewer  
  EDM14897 (Get FASTA)   NCBI Sequence Viewer  
  EDM14898 (Get FASTA)   NCBI Sequence Viewer  
  EDM14899 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000019748
  ENSRNOP00000075702
  ENSRNOP00000076341
  ENSRNOP00000083313
  ENSRNOP00000090378
GenBank Protein O08875 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_445795   ⟸   NM_053343
- Peptide Label: isoform 1
- UniProtKB: O08875 (UniProtKB/Swiss-Prot),   A6JVF3 (UniProtKB/TrEMBL),   A6JVF1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_067595   ⟸   NM_021584
- Peptide Label: isoform 2
- UniProtKB: Q9WVP7 (UniProtKB/TrEMBL),   Q9R1P9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008759227   ⟸   XM_008761005
- Peptide Label: isoform X11
- Sequence:
RefSeq Acc Id: XP_017446628   ⟸   XM_017591139
- Peptide Label: isoform X5
- UniProtKB: A0A1W2Q6Q2 (UniProtKB/TrEMBL),   A0A8I6AMY9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017446627   ⟸   XM_017591138
- Peptide Label: isoform X8
- UniProtKB: A0A8L2QB01 (UniProtKB/TrEMBL),   A6JVF1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000019748   ⟸   ENSRNOT00000019748
Ensembl Acc Id: ENSRNOP00000076341   ⟸   ENSRNOT00000093407
Ensembl Acc Id: ENSRNOP00000075702   ⟸   ENSRNOT00000078337
Ensembl Acc Id: ENSRNOP00000076110   ⟸   ENSRNOT00000093284
Ensembl Acc Id: ENSRNOP00000067781   ⟸   ENSRNOT00000072110
RefSeq Acc Id: XP_038959186   ⟸   XM_039103258
- Peptide Label: isoform X13
- UniProtKB: M0RDS3 (UniProtKB/TrEMBL),   A0A0G2KB92 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038959188   ⟸   XM_039103260
- Peptide Label: isoform X13
- UniProtKB: M0RDS3 (UniProtKB/TrEMBL),   A0A0G2KB92 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038959185   ⟸   XM_039103257
- Peptide Label: isoform X13
- UniProtKB: M0RDS3 (UniProtKB/TrEMBL),   A0A0G2KB92 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038959182   ⟸   XM_039103254
- Peptide Label: isoform X7
- UniProtKB: A0A8I6AMY9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038959177   ⟸   XM_039103249
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AMY9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038959181   ⟸   XM_039103253
- Peptide Label: isoform X6
- UniProtKB: A0A8I6AMY9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038959175   ⟸   XM_039103247
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZWQ8 (UniProtKB/TrEMBL),   A0A8I6AMY9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038959180   ⟸   XM_039103252
- Peptide Label: isoform X4
- UniProtKB: A0A8I6AMY9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038959178   ⟸   XM_039103250
- Peptide Label: isoform X3
- UniProtKB: A0A3Q9WS43 (UniProtKB/TrEMBL),   A0A8I6AMY9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038959184   ⟸   XM_039103256
- Peptide Label: isoform X12
RefSeq Acc Id: XP_038959183   ⟸   XM_039103255
- Peptide Label: isoform X10
- UniProtKB: A6JVF1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000090378   ⟸   ENSRNOT00000099182
Ensembl Acc Id: ENSRNOP00000083313   ⟸   ENSRNOT00000107822
RefSeq Acc Id: XP_063138710   ⟸   XM_063282640
- Peptide Label: isoform X14
- UniProtKB: Q9WVP7 (UniProtKB/TrEMBL),   Q9R1P9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138709   ⟸   XM_063282639
- Peptide Label: isoform X9
Ensembl Acc Id: ENSRNOP00000106599   ⟸   ENSRNOT00000145633
Protein Domains
Doublecortin   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O08875-F1-model_v2 AlphaFold O08875 1-433 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691347
Promoter ID:EPDNEW_R1858
Type:initiation region
Name:Dclk1_1
Description:doublecortin-like kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R1859  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02144,646,429 - 144,646,489EPDNEW
RGD ID:13691334
Promoter ID:EPDNEW_R1859
Type:multiple initiation site
Name:Dclk1_2
Description:doublecortin-like kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R1858  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02144,861,450 - 144,861,510EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68437 AgrOrtholog
BioCyc Gene G2FUF-53062 BioCyc
Ensembl Genes ENSRNOG00000032922 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000019748 ENTREZGENE
  ENSRNOT00000078337 ENTREZGENE
  ENSRNOT00000093407 ENTREZGENE
  ENSRNOT00000099182 ENTREZGENE
  ENSRNOT00000107822 ENTREZGENE
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report rno:83825 UniProtKB/Swiss-Prot
NCBI Gene 83825 ENTREZGENE
PANTHER SERINE/THREONINE-PROTEIN KINASE UniProtKB/Swiss-Prot
Pfam Pkinase UniProtKB/Swiss-Prot
PhenoGen Dclk1 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000032922 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
TIGR TC231457
UniProt A0A0G2KB92 ENTREZGENE, UniProtKB/TrEMBL
  A0A1W2Q632_RAT UniProtKB/TrEMBL
  A0A1W2Q6Q2 ENTREZGENE, UniProtKB/TrEMBL
  A0A3Q9WS43 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZWQ8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AMY9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QB01 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LLT8_RAT UniProtKB/TrEMBL
  A6JVF1 ENTREZGENE, UniProtKB/TrEMBL
  A6JVF3 ENTREZGENE, UniProtKB/TrEMBL
  DCLK1_RAT UniProtKB/Swiss-Prot
  M0RDS3 ENTREZGENE
  O08875 ENTREZGENE
  Q9R1P9 ENTREZGENE, UniProtKB/TrEMBL
  Q9WVP7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-04-17 Dclk1  doublecortin-like kinase 1  Ania4  activity and neurotransmitter-induced early gene protein 4 (ania-4)  Data merged from RGD:621187 737654 PROVISIONAL
2007-04-03 Dclk1  doublecortin-like kinase 1  Dcamkl1  double cortin and calcium/calmodulin-dependent protein kinase-like 1  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2002-08-07 Ania4  activity and neurotransmitter-induced early gene protein 4 (ania-4)      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Dcamkl1  double cortin and calcium/calmodulin-dependent protein kinase-like 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function has protein kinase activity 727578
gene_homology has similarity to calmodulin dependent protein kinases and to doublecortin 727578
gene_regulation expression is induced by kainate-elicited seizures in some regions of the hippocampus 631963