RGD Reference Report - Hippocampal plasticity involves extensive gene induction and multiple cellular mechanisms. - Rat Genome Database

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Hippocampal plasticity involves extensive gene induction and multiple cellular mechanisms.

Authors: Hevroni, D  Rattner, A  Bundman, M  Lederfein, D  Gabarah, A  Mangelus, M  Silverman, MA  Kedar, H  Naor, C  Kornuc, M  Hanoch, T  Seger, R  Theill, LE  Nedivi, E  Richter-Levin, G  Citri, Y 
Citation: Hevroni D, etal., J Mol Neurosci 1998 Apr;10(2):75-98.
RGD ID: 68228
Pubmed: PMID:9699150   (View Abstract at PubMed)
DOI: DOI:10.1007/BF02737120   (Journal Full-text)

Long-term plasticity of the central nervous system (CNS) involves induction of a set of genes whose identity is incompletely characterized. To identify candidate plasticity-related genes (CPGs), we conducted an exhaustive screen for genes that undergo induction or downregulation in the hippocampus dentate gyrus (DG) following animal treatment with the potent glutamate analog, kainate. The screen yielded 362 upregulated CPGs and 41 downregulated transcripts (dCPGs). Of these, 66 CPGs and 5 dCPGs are known genes that encode for a variety of signal transduction proteins, transcription factors, and structural proteins. Seven novel CPGs predict the following putative functions: cpg2--a dystrophin-like cytoskeletal protein; cpg4--a heat-shock protein: cpg16--a protein kinase; cpg20--a transcription factor; cpg21--a dual-specificity MAP-kinase phosphatase; and cpg30 and cpg38--two new seven-transmembrane domain receptors. Experiments performed in vitro and with cultured hippocampal cells confirmed the ability of the cpg-21 product to inactivate the MAP-kinase. To test relevance to neural plasticity, 66 CPGs were tested for induction by stimuli producing long-term potentiation (LTP). Approximately one-fourth of the genes examined were upregulated by LTP. These results indicate that an extensive genetic response is induced in mammalian brain after glutamate receptor activation, and imply that a significant proportion of this activity is coinduced by LTP. Based on the identified CPGs, it is conceivable that multiple cellular mechanisms underlie long-term plasticity of the nervous system.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
negative regulation of DNA-templated transcription  IDA 68228 RGD 

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
MAP kinase tyrosine/serine/threonine phosphatase activity  IDA 68228 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Dusp5  (dual specificity phosphatase 5)

Objects referenced in this article
Gene Dclk1 doublecortin-like kinase 1 Rattus norvegicus
Gene Klf10 KLF transcription factor 10 Rattus norvegicus

Additional Information