Clcnka (chloride voltage-gated channel Ka) - Rat Genome Database

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Gene: Clcnka (chloride voltage-gated channel Ka) Rattus norvegicus
Analyze
Symbol: Clcnka
Name: chloride voltage-gated channel Ka
RGD ID: 68435
Description: Enables chloride channel activity and voltage-gated monoatomic ion channel activity. Involved in several processes, including body fluid secretion; response to calcium ion; and response to pH. Located in apical plasma membrane and basolateral plasma membrane. Human ortholog(s) of this gene implicated in Bartter disease type 4b and sensorineural hearing loss. Orthologous to human CLCNKA (chloride voltage-gated channel Ka); PARTICIPATES IN amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; bumetanide pharmacodynamics pathway; INTERACTS WITH (4-chloro-2-methylphenoxy)acetic acid; 4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: chloride channel K1; chloride channel Ka; chloride channel protein ClC-Ka; chloride channel, voltage-sensitive Ka; clC-K1; Clcnk1; MGC93313
RGD Orthologs
Human
Mouse
Bonobo
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85158,974,190 - 158,989,275 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5158,974,193 - 158,989,128 (-)EnsemblGRCr8
mRatBN7.25153,691,208 - 153,706,295 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5153,691,209 - 153,706,148 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5156,378,149 - 156,393,093 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05158,151,434 - 158,166,379 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05158,140,613 - 158,155,555 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05159,931,497 - 159,946,483 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5159,931,511 - 159,946,446 (-)Ensemblrn6Rnor6.0
Rnor_5.05163,651,964 - 163,667,008 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45160,274,377 - 160,290,369 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5152,055,371 - 152,067,986 (-)NCBICelera
RGSC_v3.15160,284,564 - 160,300,557 (-)NCBI
Cytogenetic Map5q36NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Two highly homologous members of the ClC chloride channel family in both rat and human kidney. Kieferle S, etal., Proc Natl Acad Sci U S A 1994 Jul 19;91(15):6943-7.
4. Developmental expression of CLC-K1 in the postnatal rat kidney. Kobayashi K, etal., Histochem Cell Biol. 2001 Jul;116(1):49-56.
5. Overt nephrogenic diabetes insipidus in mice lacking the CLC-K1 chloride channel. Matsumura Y, etal., Nat Genet 1999 Jan;21(1):95-8.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Salt wasting and deafness resulting from mutations in two chloride channels. Schlingmann KP, etal., N Engl J Med 2004 Mar 25;350(13):1314-9.
14. Barttin modulates trafficking and function of ClC-K channels. Scholl U, etal., Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11411-6. Epub 2006 Jul 18.
15. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
16. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
17. Molecular cloning of a chloride channel that is regulated by dehydration and expressed predominantly in kidney medulla. Uchida S, etal., J Biol Chem 1993 Feb 25;268(6):3821-4.
18. Molecular cloning of a chloride channel that is regulated by dehydration and expressed predominantly in kidney medulla. Uchida S, etal., J Biol Chem 1994 Jul 22;269(29):19192.
19. Localization and functional characterization of rat kidney-specific chloride channel, ClC-K1. Uchida S, etal., J Clin Invest. 1995 Jan;95(1):104-13.
20. Barttin increases surface expression and changes current properties of ClC-K channels. Waldegger S, etal., Pflugers Arch 2002 Jun;444(3):411-8.
Additional References at PubMed
PMID:11133517   PMID:11423561   PMID:12759757   PMID:17562318   PMID:18945830  


Genomics

Comparative Map Data
Clcnka
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85158,974,190 - 158,989,275 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5158,974,193 - 158,989,128 (-)EnsemblGRCr8
mRatBN7.25153,691,208 - 153,706,295 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5153,691,209 - 153,706,148 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5156,378,149 - 156,393,093 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05158,151,434 - 158,166,379 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05158,140,613 - 158,155,555 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05159,931,497 - 159,946,483 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5159,931,511 - 159,946,446 (-)Ensemblrn6Rnor6.0
Rnor_5.05163,651,964 - 163,667,008 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45160,274,377 - 160,290,369 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5152,055,371 - 152,067,986 (-)NCBICelera
RGSC_v3.15160,284,564 - 160,300,557 (-)NCBI
Cytogenetic Map5q36NCBI
CLCNKA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38116,022,036 - 16,034,050 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl116,018,146 - 16,034,109 (+)Ensemblhg38GRCh38
GRCh37116,348,531 - 16,360,545 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36116,221,073 - 16,233,132 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34116,094,415 - 16,105,850NCBI
Celera114,828,391 - 14,840,450 (+)NCBICelera
Cytogenetic Map1p36.13NCBI
HuRef114,867,532 - 14,879,195 (+)NCBIHuRef
CHM1_1116,146,987 - 16,159,046 (+)NCBICHM1_1
T2T-CHM13v2.0115,463,347 - 15,475,360 (+)NCBIT2T-CHM13v2.0
Clcnka
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394141,111,922 - 141,126,017 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4141,111,921 - 141,126,035 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm384141,384,611 - 141,398,706 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4141,384,610 - 141,398,724 (-)Ensemblmm10GRCm38
MGSCv374140,940,526 - 140,954,621 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364139,138,024 - 139,141,158 (-)NCBIMGSCv36mm8
MGSCv364140,656,686 - 140,670,775 (-)NCBIMGSCv36mm8
Celera4143,203,482 - 143,215,208 (-)NCBICelera
Cytogenetic Map4D3NCBI
cM Map473.94NCBI
LOC100986591
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21210,887,107 - 210,901,016 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11210,135,593 - 210,147,698 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0115,159,362 - 15,171,376 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1116,152,022 - 16,163,777 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl116,152,022 - 16,163,777 (+)EnsemblpanPan2panpan1.1
Clcnka
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505837,766,062 - 37,777,337 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364743,591,106 - 3,602,045 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364743,591,134 - 3,601,562 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CLCNKA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366605419,795,813 - 19,801,977 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Clcnka
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247642,202,579 - 2,212,337 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247642,202,438 - 2,212,185 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Clcnka
33 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:68
Count of miRNA genes:60
Interacting mature miRNAs:65
Transcripts:ENSRNOT00000013103
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5130249266172190305Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5116702075161702075Rat
1354583Despr3Despair related QTL34.980.0002locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)5132930505172190305Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5141212838172190305Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5149642129171146538Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5133789363172190305Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5134369199172190305Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5136631198172190305Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5156396728172190305Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133081618172190305Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
631263Cm24Cardiac mass QTL 243.5heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)5149805999162987697Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5138002522170842766Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5133270647172190305Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)5141764300172190305Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5133789363172190305Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5148093485172129029Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5156396728167181764Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5131708216172190305Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5114131300159131300Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5149661912166600247Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5116702075161702075Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5116702075161702075Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5116702075161702075Rat
1298090Bp155Blood pressure QTL 1553.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)5156289283171137955Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5114131300159131300Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133081618172190305Rat

Markers in Region
C75963  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25153,691,291 - 153,691,539 (+)MAPPERmRatBN7.2
Rnor_6.05159,931,592 - 159,931,839NCBIRnor6.0
Rnor_5.05163,652,047 - 163,652,294UniSTSRnor5.0
Rnor_5.05163,648,170 - 163,648,417UniSTSRnor5.0
RGSC_v3.45160,274,460 - 160,274,707UniSTSRGSC3.4
Celera5152,055,454 - 152,055,701UniSTS
Cytogenetic Map5q36UniSTS
BE115105  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25153,691,207 - 153,691,360 (+)MAPPERmRatBN7.2
Rnor_6.05159,931,508 - 159,931,660NCBIRnor6.0
Rnor_5.05163,651,963 - 163,652,115UniSTSRnor5.0
Rnor_5.05163,648,086 - 163,648,238UniSTSRnor5.0
RGSC_v3.45160,274,376 - 160,274,528UniSTSRGSC3.4
Celera5152,055,370 - 152,055,522UniSTS
RH 3.4 Map51053.1UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
13 31 104 28 41 16 9 16 5 150 40 102 81 83 25 8 8

Sequence


Ensembl Acc Id: ENSRNOT00000089184   ⟹   ENSRNOP00000072591
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5158,974,193 - 158,989,128 (-)Ensembl
mRatBN7.2 Ensembl5153,691,211 - 153,706,148 (-)Ensembl
Rnor_6.0 Ensembl5159,931,511 - 159,946,446 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108320   ⟹   ENSRNOP00000097659
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5153,691,209 - 153,705,531 (-)Ensembl
RefSeq Acc Id: NM_053327   ⟹   NP_445779
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85158,974,191 - 158,989,148 (-)NCBI
mRatBN7.25153,691,209 - 153,706,168 (-)NCBI
Rnor_6.05159,931,509 - 159,946,466 (-)NCBI
Rnor_5.05163,651,964 - 163,667,008 (-)NCBI
RGSC_v3.45160,274,377 - 160,290,369 (-)RGD
Celera5152,055,371 - 152,067,986 (-)RGD
Sequence:
RefSeq Acc Id: XM_008764292   ⟹   XP_008762514
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85158,974,190 - 158,989,152 (-)NCBI
mRatBN7.25153,691,208 - 153,706,295 (-)NCBI
Rnor_6.05159,931,497 - 159,946,478 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063288464   ⟹   XP_063144534
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85158,974,190 - 158,989,275 (-)NCBI
RefSeq Acc Id: NP_445779   ⟸   NM_053327
- UniProtKB: Q06393 (UniProtKB/Swiss-Prot),   P97709 (UniProtKB/Swiss-Prot),   Q66HN9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008762514   ⟸   XM_008764292
- Peptide Label: isoform X1
- UniProtKB: Q06393 (UniProtKB/Swiss-Prot),   P97709 (UniProtKB/Swiss-Prot),   Q66HN9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072591   ⟸   ENSRNOT00000089184
Ensembl Acc Id: ENSRNOP00000097659   ⟸   ENSRNOT00000108320
RefSeq Acc Id: XP_063144534   ⟸   XM_063288464
- Peptide Label: isoform X1
- UniProtKB: Q06393 (UniProtKB/Swiss-Prot),   P97709 (UniProtKB/Swiss-Prot),   Q66HN9 (UniProtKB/TrEMBL)
Protein Domains
CBS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q06393-F1-model_v2 AlphaFold Q06393 1-687 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68435 AgrOrtholog
BioCyc Gene G2FUF-39351 BioCyc
Ensembl Genes ENSRNOG00000052368 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000089184 ENTREZGENE
Gene3D-CATH 3.10.580.10 UniProtKB/Swiss-Prot
  Clc chloride channel UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7108273 IMAGE-MGC_LOAD
InterPro CBS_dom UniProtKB/Swiss-Prot
  CBS_dom_sf UniProtKB/Swiss-Prot
  Cl-channel_core UniProtKB/Swiss-Prot
  Cl-channel_volt-gated UniProtKB/Swiss-Prot
  Cl_channel-K UniProtKB/Swiss-Prot
  Cl_channel_volt-gated UniProtKB/Swiss-Prot
KEGG Report rno:79425 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93313 IMAGE-MGC_LOAD
NCBI Gene 79425 ENTREZGENE
PANTHER CHLORIDE CHANNEL PROTEIN 2 UniProtKB/Swiss-Prot
  CHLORIDE CHANNEL PROTEIN CLC-KB UniProtKB/Swiss-Prot
Pfam CBS UniProtKB/Swiss-Prot
  Voltage_CLC UniProtKB/Swiss-Prot
PhenoGen Clcnka PhenoGen
PRINTS CLCHANNEL UniProtKB/Swiss-Prot
  CLCHANNELKDY UniProtKB/Swiss-Prot
PROSITE CBS UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000052368 RatGTEx
SMART CBS UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54631 UniProtKB/Swiss-Prot
  SSF81340 UniProtKB/Swiss-Prot
TIGR TC234636
UniProt CLCKA_RAT UniProtKB/Swiss-Prot
  P97709 ENTREZGENE
  Q06393 ENTREZGENE
  Q66HN9 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary P97709 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Clcnka  chloride voltage-gated channel Ka  Clcnka  chloride channel, voltage-sensitive Ka  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-16 Clcnka  chloride channel, voltage-sensitive Ka  Clcnka  chloride channel Ka  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-18 Clcnka  chloride channel Ka  Clcnk1  chloride channel K1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Clcnk1  chloride channel K1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mainly expressed in the thin ascending limb of henle's loop 68223
gene_regulation expression is upregulated by dehydration 68223