Ncs1 (neuronal calcium sensor 1) - Rat Genome Database

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Gene: Ncs1 (neuronal calcium sensor 1) Rattus norvegicus
Analyze
Symbol: Ncs1
Name: neuronal calcium sensor 1
RGD ID: 68417
Description: Enables metal ion binding activity; protein kinase binding activity; and voltage-gated calcium channel activity. Involved in several processes, including positive regulation of calcium-mediated signaling; regulation of exocytosis; and regulation of presynaptic cytosolic calcium ion concentration. Located in dense core granule. Is active in several cellular components, including calyx of Held; postsynaptic cytosol; and presynaptic cytosol. Orthologous to human NCS1 (neuronal calcium sensor 1); PARTICIPATES IN calcium/calcium-mediated signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 6-propyl-2-thiouracil; amitrole.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Freq; frequenin homolog; frequenin homolog (Drosophila); frequenin-like protein; frequenin-like ubiquitous protein; NCS-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8334,920,949 - 34,966,554 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl334,920,971 - 34,968,711 (+)EnsemblGRCr8
mRatBN7.2314,523,220 - 14,568,829 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl314,523,220 - 14,568,829 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx317,596,129 - 17,641,998 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0326,181,136 - 26,227,007 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0324,428,400 - 24,474,272 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0310,556,250 - 10,602,672 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl310,553,589 - 10,602,672 (-)Ensemblrn6Rnor6.0
Rnor_5.0315,911,972 - 15,960,622 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4310,305,202 - 10,354,149 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera39,278,946 - 9,324,605 (+)NCBICelera
RGSC_v3.1310,200,569 - 10,249,517 (+)NCBI
Cytogenetic Map3p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-hydroxypropanoic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
ATP  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
benzoates  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
Butylbenzyl phthalate  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
choline  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cocaine  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (ISO)
DDE  (ISO)
dibutyl phthalate  (EXP,ISO)
diethyl phthalate  (EXP,ISO)
diisobutyl phthalate  (EXP,ISO)
diisononyl phthalate  (EXP,ISO)
diquat  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
gentamycin  (EXP)
glycidyl methacrylate  (ISO)
ionomycin  (EXP)
ivermectin  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
menadione  (ISO)
methapyrilene  (ISO)
methylparaben  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
phenylarsine oxide  (EXP)
phosphatidylinositol 4-phosphate  (EXP)
pirinixic acid  (ISO)
propylparaben  (ISO)
rac-lactic acid  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
titanium dioxide  (ISO)
triticonazole  (EXP)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
wortmannin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Regulatory and structural EF-hand motifs of neuronal calcium sensor-1: Mg 2+ modulates Ca 2+ binding, Ca 2+ -induced conformational changes, and equilibrium unfolding transitions. Aravind P, etal., J Mol Biol. 2008 Feb 29;376(4):1100-15. doi: 10.1016/j.jmb.2007.12.033. Epub 2007 Dec 23.
2. Regulation of rhodopsin phosphorylation by a family of neuronal calcium sensors. De Castro E, etal., Biochem Biophys Res Commun 1995 Nov 2;216(1):133-40.
3. IL1-receptor accessory protein-like 1 (IL1RAPL1), a protein involved in cognitive functions, regulates N-type Ca2+-channel and neurite elongation. Gambino F, etal., Proc Natl Acad Sci U S A. 2007 May 22;104(21):9063-8. Epub 2007 May 14.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Analysis of the interacting partners of the neuronal calcium-binding proteins L-CaBP1, hippocalcin, NCS-1 and neurocalcin delta. Haynes LP, etal., Proteomics. 2006 Mar;6(6):1822-32.
6. Interaction with neuronal calcium sensor NCS-1 mediates desensitization of the D2 dopamine receptor. Kabbani N, etal., J Neurosci. 2002 Oct 1;22(19):8476-86.
7. Mechanisms underlying the neuronal calcium sensor-1-evoked enhancement of exocytosis in PC12 cells. Koizumi S, etal., J Biol Chem 2002 Aug 16;277(33):30315-24.
8. Intestinal inflammation modulates expression of the synaptic vesicle protein neuronal calcium sensor-1. Lourenssen S, etal., Am J Physiol Gastrointest Liver Physiol 2002 Jun;282(6):G1097-104.
9. The diversity of calcium sensor proteins in the regulation of neuronal function. McCue HV, etal., Cold Spring Harb Perspect Biol. 2010 Aug;2(8):a004085. doi: 10.1101/cshperspect.a004085. Epub 2010 Jul 28.
10. Neuronal Ca2+ sensor 1, the mammalian homologue of frequenin, is expressed in chromaffin and PC12 cells and regulates neurosecretion from dense-core granules. McFerran BW, etal., J Biol Chem. 1998 Aug 28;273(35):22768-72.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. GOA pipeline RGD automated data pipeline
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Neuronal calcium sensor-1 binds to regulated secretory organelles and functions in basal and stimulated exocytosis in PC12 cells. Scalettar BA, etal., J Cell Sci 2002 Jun 1;115(Pt 11):2399-412.
16. Acute changes in short-term plasticity at synapses with elevated levels of neuronal calcium sensor-1. Sippy T, etal., Nat Neurosci. 2003 Oct;6(10):1031-8. doi: 10.1038/nn1117. Epub 2003 Aug 31.
17. Neuronal calcium sensor 1 and phosphatidylinositol 4-OH kinase beta interact in neuronal cells and are translocated to membranes during nucleotide-evoked exocytosis. Taverna E, etal., J Cell Sci. 2002 Oct 15;115(Pt 20):3909-22.
18. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
19. Neuronal calcium sensor 1 and activity-dependent facilitation of P/Q-type calcium currents at presynaptic nerve terminals. Tsujimoto T, etal., Science. 2002 Mar 22;295(5563):2276-9. doi: 10.1126/science.1068278.
Additional References at PubMed
PMID:9030700   PMID:10514519   PMID:11825672   PMID:12471042   PMID:12717707   PMID:12783849   PMID:12928444   PMID:14607934   PMID:15336574   PMID:15659215   PMID:16088942   PMID:16469785  
PMID:16549499   PMID:16638749   PMID:16691292   PMID:16837555   PMID:17160505   PMID:19656467   PMID:19755107   PMID:20585375   PMID:20838877   PMID:21035569   PMID:22521426   PMID:23376485  
PMID:24978930   PMID:25979333   PMID:27796528  


Genomics

Comparative Map Data
Ncs1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8334,920,949 - 34,966,554 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl334,920,971 - 34,968,711 (+)EnsemblGRCr8
mRatBN7.2314,523,220 - 14,568,829 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl314,523,220 - 14,568,829 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx317,596,129 - 17,641,998 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0326,181,136 - 26,227,007 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0324,428,400 - 24,474,272 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0310,556,250 - 10,602,672 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl310,553,589 - 10,602,672 (-)Ensemblrn6Rnor6.0
Rnor_5.0315,911,972 - 15,960,622 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4310,305,202 - 10,354,149 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera39,278,946 - 9,324,605 (+)NCBICelera
RGSC_v3.1310,200,569 - 10,249,517 (+)NCBI
Cytogenetic Map3p12NCBI
NCS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389130,172,404 - 130,237,303 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9130,172,347 - 130,237,303 (+)Ensemblhg38GRCh38
GRCh379132,934,683 - 132,999,582 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369131,974,678 - 132,038,727 (+)NCBIBuild 36Build 36hg18NCBI36
Build 349130,014,410 - 130,078,457NCBI
Celera9103,585,939 - 103,651,680 (+)NCBICelera
Cytogenetic Map9q34.11NCBI
HuRef9102,534,885 - 102,599,998 (+)NCBIHuRef
CHM1_19133,083,844 - 133,148,450 (+)NCBICHM1_1
T2T-CHM13v2.09142,377,132 - 142,442,184 (+)NCBIT2T-CHM13v2.0
Ncs1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39231,135,766 - 31,186,001 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl231,135,835 - 31,186,001 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38231,245,708 - 31,295,989 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl231,245,823 - 31,295,989 (+)Ensemblmm10GRCm38
MGSCv37231,101,443 - 31,150,992 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36231,067,932 - 31,117,481 (+)NCBIMGSCv36mm8
MGSCv36231,588,257 - 31,638,499 (+)NCBIMGSCv36mm8
Celera230,984,573 - 30,999,665 (+)NCBICelera
Cytogenetic Map2BNCBI
cM Map221.81NCBI
Ncs1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955513269,046 - 283,418 (+)Ensembl
ChiLan1.0NW_004955513268,979 - 289,385 (+)NCBIChiLan1.0ChiLan1.0
NCS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2119,112,064 - 9,176,572 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan199,114,408 - 9,179,021 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09101,299,724 - 101,364,897 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19129,950,921 - 130,016,257 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9129,950,921 - 130,016,257 (+)EnsemblpanPan2panpan1.1
NCS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1953,661,361 - 53,676,925 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl953,672,910 - 53,676,910 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha952,857,022 - 52,906,752 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0954,558,680 - 54,608,458 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl954,561,828 - 54,607,982 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1953,334,722 - 53,385,113 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0953,656,911 - 53,706,612 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0953,749,027 - 53,798,770 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ncs1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947197,522,579 - 197,564,271 (+)NCBIHiC_Itri_2
NCS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1270,274,562 - 270,334,907 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11270,274,504 - 270,334,908 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21304,146,318 - 304,207,069 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NCS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1127,910,495 - 7,975,650 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660797,474,591 - 7,539,893 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ncs1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247605,376,634 - 5,410,473 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247605,374,211 - 5,410,550 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Ncs1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v154,337,681 - 4,387,763 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ncs1
355 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:224
Count of miRNA genes:156
Interacting mature miRNAs:174
Transcripts:ENSRNOT00000011648
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32905627547904329Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10450811Scl73Serum cholesterol level QTL 734.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat
10450808Scl72Serum cholesterol level QTL 724.40.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10450806Scl71Serum cholesterol level QTL 715.80.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)32862533967641995Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)3612543751125437Rat
8693641Alc30Alcohol consumption QTL 3020.739drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)33083238444921701Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3136721849Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3655634751556347Rat
1558657Cm43Cardiac mass QTL 436.63e-08heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31527234860272348Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)32905627547904329Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat

Markers in Region
D3Rat194  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2314,529,381 - 14,529,570 (-)MAPPERmRatBN7.2
Rnor_6.0310,596,322 - 10,596,510NCBIRnor6.0
Rnor_5.0315,954,272 - 15,954,460UniSTSRnor5.0
RGSC_v3.4310,311,364 - 10,311,552UniSTSRGSC3.4
RGSC_v3.4310,311,363 - 10,311,552RGDRGSC3.4
RGSC_v3.1310,206,696 - 10,207,022RGD
SHRSP x BN Map33.5299UniSTS
SHRSP x BN Map33.5299RGD
Cytogenetic Map3p12UniSTS
D3Rat232  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8334,927,094 - 34,927,317 (+)Marker Load Pipeline
mRatBN7.2314,529,365 - 14,529,588 (-)MAPPERmRatBN7.2
Rnor_6.0310,596,304 - 10,596,526NCBIRnor6.0
Rnor_5.0315,954,254 - 15,954,476UniSTSRnor5.0
RGSC_v3.4310,311,348 - 10,311,570UniSTSRGSC3.4
RGSC_v3.4310,311,347 - 10,311,570RGDRGSC3.4
Celera39,285,094 - 9,285,324UniSTS
RGSC_v3.1310,206,715 - 10,206,938RGD
SHRSP x BN Map33.4899UniSTS
SHRSP x BN Map33.4899RGD
Cytogenetic Map3p12UniSTS
AW531469  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2314,568,663 - 14,568,865 (-)MAPPERmRatBN7.2
Rnor_6.0310,556,214 - 10,556,415NCBIRnor6.0
Rnor_5.0315,914,587 - 15,914,788UniSTSRnor5.0
RGSC_v3.4310,353,984 - 10,354,185UniSTSRGSC3.4
Celera39,324,440 - 9,324,641UniSTS
RH 3.4 Map350.4UniSTS
Cytogenetic Map3p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 155 90 89 58 42 58 6 305 142 11 134 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000011648   ⟹   ENSRNOP00000011648
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl310,553,589 - 10,602,672 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111270   ⟹   ENSRNOP00000091251
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl334,920,971 - 34,968,711 (+)Ensembl
mRatBN7.2 Ensembl314,523,220 - 14,568,829 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000115862   ⟹   ENSRNOP00000095238
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl334,938,481 - 34,968,711 (+)Ensembl
mRatBN7.2 Ensembl314,556,304 - 14,568,829 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000116110   ⟹   ENSRNOP00000092268
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl334,933,545 - 34,968,711 (+)Ensembl
mRatBN7.2 Ensembl314,540,963 - 14,568,829 (+)Ensembl
RefSeq Acc Id: NM_024366   ⟹   NP_077342
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8334,920,949 - 34,966,554 (+)NCBI
mRatBN7.2314,523,220 - 14,568,829 (+)NCBI
Rnor_6.0310,556,250 - 10,602,672 (-)NCBI
Rnor_5.0315,911,972 - 15,960,622 (-)NCBI
RGSC_v3.4310,305,202 - 10,354,149 (+)RGD
Celera39,278,946 - 9,324,605 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_077342 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA88510 (Get FASTA)   NCBI Sequence Viewer  
  CAA57678 (Get FASTA)   NCBI Sequence Viewer  
  EDL93277 (Get FASTA)   NCBI Sequence Viewer  
  EDL93278 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000091251
  ENSRNOP00000091251.1
GenBank Protein P62168 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_077342   ⟸   NM_024366
- UniProtKB: P62168 (UniProtKB/Swiss-Prot),   A6JU20 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000011648   ⟸   ENSRNOT00000011648
Ensembl Acc Id: ENSRNOP00000091251   ⟸   ENSRNOT00000111270
Ensembl Acc Id: ENSRNOP00000092268   ⟸   ENSRNOT00000116110
Ensembl Acc Id: ENSRNOP00000095238   ⟸   ENSRNOT00000115862
Protein Domains
EF-hand

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P62168-F1-model_v2 AlphaFold P62168 1-190 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68417 AgrOrtholog
BioCyc Gene G2FUF-50180 BioCyc
Ensembl Genes ENSRNOG00000008761 Ensembl
  ENSRNOG00000064701 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000111270 ENTREZGENE
  ENSRNOT00000111270.1 UniProtKB/Swiss-Prot
Gene3D-CATH EF-hand UniProtKB/Swiss-Prot
InterPro EF-hand-dom_pair UniProtKB/Swiss-Prot
  EF_Hand_1_Ca_BS UniProtKB/Swiss-Prot
  EF_hand_dom UniProtKB/Swiss-Prot
  Recoverin UniProtKB/Swiss-Prot
KEGG Report rno:65153 UniProtKB/Swiss-Prot
NCBI Gene 65153 ENTREZGENE
PANTHER NEURONAL CALCIUM SENSOR 1 UniProtKB/Swiss-Prot
  PTHR23055 UniProtKB/Swiss-Prot
Pfam EF-hand_1 UniProtKB/Swiss-Prot
  EF-hand_7 UniProtKB/Swiss-Prot
PharmGKB FREQ RGD
PhenoGen Ncs1 PhenoGen
PRINTS RECOVERIN UniProtKB/Swiss-Prot
PROSITE EF_HAND_1 UniProtKB/Swiss-Prot
  EF_HAND_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000008761 RatGTEx
  ENSRNOG00000064701 RatGTEx
SMART EFh UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47473 UniProtKB/Swiss-Prot
TIGR TC205195
UniProt A0A8I6AM90_RAT UniProtKB/TrEMBL
  A0A8I6GJM4_RAT UniProtKB/TrEMBL
  A6JU20 ENTREZGENE, UniProtKB/TrEMBL
  NCS1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary P36610 UniProtKB/Swiss-Prot
  Q9UK26 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Ncs1  neuronal calcium sensor 1  Freq  frequenin homolog (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Freq  frequenin homolog (Drosophila)      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_product member of the EF-hand calcium binding protein superfamily 728740