Nr5a2 (nuclear receptor subfamily 5, group A, member 2) - Rat Genome Database

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Gene: Nr5a2 (nuclear receptor subfamily 5, group A, member 2) Rattus norvegicus
Analyze
Symbol: Nr5a2
Name: nuclear receptor subfamily 5, group A, member 2
RGD ID: 68353
Description: Enables double-stranded DNA binding activity and nuclear receptor activity. Involved in calcineurin-mediated signaling. Predicted to be located in cytoplasm. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in nucleus. Orthologous to human NR5A2 (nuclear receptor subfamily 5 group A member 2); PARTICIPATES IN maturity-onset diabetes of the young pathway; INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: fetoprotein transcription factor; Ftf; FTZ-F1 beta; FTZ-F1 beta2 protein; liver receptor homolog 1; Lrh-1; nuclear receptor subfamily 5 group A member 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81350,865,253 - 50,985,107 (-)NCBIGRCr8
mRatBN7.21348,313,634 - 48,433,494 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1348,316,301 - 48,433,326 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1350,924,322 - 51,041,371 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01352,212,210 - 52,329,237 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01349,479,256 - 49,596,284 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01353,750,470 - 53,870,288 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1353,750,473 - 53,870,428 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01358,791,496 - 58,910,967 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41349,931,592 - 50,048,756 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11349,945,671 - 50,062,836 (-)NCBI
Celera1348,623,262 - 48,740,634 (-)NCBICelera
Cytogenetic Map13q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
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Original Reference(s)
Nr5a2Ratcolon cancer  ISONR5A2 (Homo sapiens)9068941RNA:increased expression:colon (human)RGDPMID:28710032 and REF_RGD_ID:153344627
Nr5a2Rathepatitis treatmentISONr5a2 (Mus musculus)14401591 RGD 
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Nr5a2Ratgastrointestinal stromal tumor  ISONR5A2 (Homo sapiens)8554872ClinVar Annotator: match by term: Gastrointestinal stromal tumorClinVarPMID:28492532
Nr5a2Ratlong QT syndrome  ISONR5A2 (Homo sapiens)8554872ClinVar Annotator: match by term: Long QT syndromeClinVarPMID:26132555
Nr5a2Ratparathyroid carcinoma  ISONR5A2 (Homo sapiens)8554872ClinVar Annotator: match by term: Parathyroid carcinomaClinVarPMID:28492532
Nr5a2Ratprimary ovarian insufficiency  ISONR5A2 (Homo sapiens)8554872ClinVar Annotator: match by term: Premature ovarian failureClinVarPMID:25741868
Nr5a2Ratsyndromic microphthalmia 5  ISONR5A2 (Homo sapiens)8554872ClinVar Annotator: match by term: Anophthalmia-microphthalmia syndromeClinVarPMID:26893459
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Original Reference(s)
Nr5a2Ratanovulation  ISONR5A2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18628394
Nr5a2RatChemical and Drug Induced Liver Injury  ISONR5A2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:29515023
Nr5a2RatDyslipidemias  ISONR5A2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:29515023
Nr5a2RatFemale Infertility  ISONR5A2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17409375
Nr5a2Ratglucose intolerance  ISONR5A2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:29515023
Nr5a2RatHepatomegaly  ISONR5A2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:29515023
Nr5a2Ratmetabolic dysfunction-associated steatotic liver disease  ISONR5A2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:29515023
Nr5a2Ratpancreatic cancer  ISONR5A2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20101243 and PMID:26098869

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Nr5a2Rat(-)-demecolcine increases expressionISONR5A2 (Homo sapiens)6480464Demecolcine results in increased expression of NR5A2 mRNACTDPMID:23649840
Nr5a2Rat(1->4)-beta-D-glucan multiple interactionsISONr5a2 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of NR5A2 mRNACTDPMID:36331819
Nr5a2Rat1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane multiple interactionsEXP 64804642 more ...CTDPMID:19414516
Nr5a2Rat1,2-dilauroyl-sn-glycero-3-phosphocholine(1+) increases expressionISONr5a2 (Mus musculus)64804641 and 2-dilauroylphosphatidylcholine results in increased expression of NR5A2CTDPMID:24459144
Nr5a2Rat1-O-oleoyl-sn-glycero-3-phosphocholine multiple interactionsISONr5a2 (Mus musculus)6480464[NR5A2 gene mutant form results in increased susceptibility to Dietary Fats] which results in increased abundance of 1-oleoyl lysophosphatidylcholineCTDPMID:29515023
Nr5a2Rat17alpha-ethynylestradiol increases expressionISONr5a2 (Mus musculus)6480464Ethinyl Estradiol results in increased expression of NR5A2 mRNACTDPMID:17942748
Nr5a2Rat17alpha-ethynylestradiol multiple interactionsISONr5a2 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NR5A2 mRNACTDPMID:17942748
Nr5a2Rat17alpha-ethynylestradiol decreases expressionEXP 6480464Ethinyl Estradiol results in decreased expression of NR5A2 mRNACTDPMID:15834898
Nr5a2Rat17beta-estradiol increases expressionISONR5A2 (Homo sapiens)6480464Estradiol results in increased expression of NR5A2 mRNACTDPMID:20607599 more ...
Nr5a2Rat17beta-estradiol multiple interactionsEXP 6480464[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of NR5A2 mRNACTDPMID:32741896
Nr5a2Rat17beta-estradiol affects expressionEXP 6480464Estradiol affects the expression of NR5A2 mRNACTDPMID:32145629
Nr5a2Rat17beta-estradiol decreases abundanceISONr5a2 (Mus musculus)6480464NR5A2 protein results in decreased abundance of EstradiolCTDPMID:18628394
Nr5a2Rat17beta-estradiol multiple interactionsISONr5a2 (Mus musculus)6480464[[NR5A2 protein results in increased phosphorylation of and results in increased activity of NOS3 protein] which results in decreased activity of CYP19A1 protein] which results in decreased chemical synthesis of Estradiol and [NR5A2 results in increased expression of NOS3 mRNA] which results in decreased abundance of EstradiolCTDPMID:18628394
Nr5a2Rat17beta-estradiol decreases expressionISONR5A2 (Homo sapiens)6480464Estradiol results in decreased expression of NR5A2 mRNA and Estradiol results in decreased expression of NR5A2 proteinCTDPMID:20106945 and PMID:33181973
Nr5a2Rat17beta-estradiol 3-benzoate multiple interactionsEXP 6480464[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of NR5A2 mRNACTDPMID:32741896
Nr5a2Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISONr5a2 (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of NR5A2 mRNACTDPMID:24058054
Nr5a2Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of NR5A2 mRNACTDPMID:33387578
Nr5a2Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of NR5A2 mRNACTDPMID:32109520
Nr5a2Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISONR5A2 (Homo sapiens)64804642-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide affects the reaction [Tetrachlorodibenzodioxin results in increased expression of NR5A2 mRNA]CTDPMID:29704546
Nr5a2Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISONr5a2 (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of NR5A2 mRNACTDPMID:29452137 and PMID:37172768

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Biological Process
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Nr5a2Ratacinar cell differentiation acts_upstream_of_or_withinISONr5a2 (Mus musculus)1624291 PMID:25063451RGDPMID:25063451
Nr5a2Ratacinar cell differentiation acts_upstream_of_or_withinIEAUniProtKB:P45448 and ensembl:ENSMUSP000000276491600115GO_REF:0000107EnsemblGO_REF:0000107
Nr5a2Ratbile acid metabolic process acts_upstream_ofIEAUniProtKB:O00482 and ensembl:ENSP000003563311600115GO_REF:0000107EnsemblGO_REF:0000107
Nr5a2Ratbile acid metabolic process acts_upstream_ofIEAUniProtKB:P45448 and ensembl:ENSMUSP000000276491600115GO_REF:0000107EnsemblGO_REF:0000107
Nr5a2Ratbile acid metabolic process acts_upstream_of_or_withinISONr5a2 (Mus musculus)1624291MGI:3050234 PMID:15014077RGDPMID:15014077
Nr5a2Ratbile acid metabolic process acts_upstream_ofISONR5A2 (Homo sapiens)1624291 PMID:21614002RGDPMID:21614002
Nr5a2Ratbile acid metabolic process acts_upstream_ofISONr5a2 (Mus musculus)1624291 PMID:14766742 and PMID:21614002RGDPMID:14766742 and PMID:21614002
Nr5a2Ratcalcineurin-mediated signaling  IMP 12904895 RGD 
Nr5a2Ratcartilage development involved_inISONr5a2 (Mus musculus)1624291 PMID:36905926RGDPMID:36905926
Nr5a2Ratcartilage development involved_inIEAUniProtKB:P45448 and ensembl:ENSMUSP000000276491600115GO_REF:0000107EnsemblGO_REF:0000107
Nr5a2Ratcellular response to leukemia inhibitory factor acts_upstream_of_or_withinISONr5a2 (Mus musculus)1624291 PMID:20439489RGDPMID:20439489
Nr5a2Ratcellular response to leukemia inhibitory factor acts_upstream_of_or_withinIEAUniProtKB:P45448 and ensembl:ENSMUSP000000276491600115GO_REF:0000107EnsemblGO_REF:0000107
Nr5a2Ratcholesterol homeostasis acts_upstream_of_or_withinISONr5a2 (Mus musculus)1624291MGI:3050234 PMID:15014077RGDPMID:15014077
Nr5a2Ratcholesterol homeostasis acts_upstream_of_or_withinIEAUniProtKB:P45448 and ensembl:ENSMUSP000000276491600115GO_REF:0000107EnsemblGO_REF:0000107
Nr5a2Ratchromatin remodeling involved_inISONr5a2 (Mus musculus)1624291 PMID:37935903 more ...RGDPMID:37935903 more ...
Nr5a2Ratchromatin remodeling involved_inISONR5A2 (Homo sapiens)1624291 PMID:38409506RGDPMID:38409506
Nr5a2Ratchromatin remodeling involved_inISSUniProtKB:P454481600115GO_REF:0000024UniProtGO_REF:0000024
Nr5a2Ratchromatin remodeling involved_inIEAUniProtKB:O00482 and ensembl:ENSP000003563311600115GO_REF:0000107EnsemblGO_REF:0000107
Nr5a2Ratchromatin remodeling involved_inIEAUniProtKB:P45448 and ensembl:ENSMUSP000000276491600115GO_REF:0000107EnsemblGO_REF:0000107
Nr5a2Ratembryonic cleavage involved_inISONr5a2 (Mus musculus)1624291 PMID:15831456RGDPMID:15831456
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Cellular Component
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Original Reference(s)
Nr5a2Ratchromosome located_inIEAUniProtKB-KW:KW-01581600115GO_REF:0000043UniProtGO_REF:0000043
Nr5a2Ratchromosome located_inIEAUniProtKB-SubCell:SL-04681600115GO_REF:0000044UniProtGO_REF:0000044
Nr5a2Ratcytoplasm located_inISONR5A2 (Homo sapiens)1624291 PMID:15205472RGDPMID:15205472
Nr5a2Ratcytoplasm located_inIEAUniProtKB:O00482 and ensembl:ENSP000003563311600115GO_REF:0000107EnsemblGO_REF:0000107
Nr5a2Ratnucleus located_inISONR5A2 (Homo sapiens)1624291 PMID:15143342 and PMID:15205472RGDPMID:15143342 and PMID:15205472
Nr5a2Ratnucleus located_inIEAUniProtKB:P45448 and ensembl:ENSMUSP000000276491600115GO_REF:0000107EnsemblGO_REF:0000107
Nr5a2Ratnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
Nr5a2Ratnucleus located_inIEAUniProtKB:O00482 and ensembl:ENSP000003563311600115GO_REF:0000107EnsemblGO_REF:0000107
Nr5a2Ratnucleus is_active_inISONR5A2 (Homo sapiens)1624291 PMID:28642062RGDPMID:28642062
Nr5a2Ratnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
Nr5a2Ratnucleus is_active_inISONr5a2 (Mus musculus)1624291 PMID:33441767 and PMID:36423263RGDPMID:33441767 and PMID:36423263
Nr5a2Ratnucleus located_inISONr5a2 (Mus musculus)1624291 PMID:19796622RGDPMID:19796622
Nr5a2RatRNA polymerase II transcription regulator complex part_ofISONr5a2 (Mus musculus)1624291 PMID:19389484RGDPMID:19389484
Nr5a2RatRNA polymerase II transcription regulator complex part_ofIEAUniProtKB:P45448 and ensembl:ENSMUSP000000276491600115GO_REF:0000107EnsemblGO_REF:0000107
Nr5a2RatRNA polymerase II transcription regulator complex part_ofIBAMGI:1346833 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
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Molecular Function
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Nr5a2Ratchromatin binding enablesISONr5a2 (Mus musculus)1624291 PMID:19389484RGDPMID:19389484
Nr5a2Ratchromatin binding enablesIEAUniProtKB:P45448 and ensembl:ENSMUSP000000276491600115GO_REF:0000107EnsemblGO_REF:0000107
Nr5a2RatDNA binding enablesISSUniProtKB:O004821600115GO_REF:0000024UniProtGO_REF:0000024
Nr5a2RatDNA binding enablesIEAUniProtKB-KW:KW-02381600115GO_REF:0000043UniProtGO_REF:0000043
Nr5a2RatDNA binding enablesIEAUniProtKB:O00482 and ensembl:ENSP000003563311600115GO_REF:0000107EnsemblGO_REF:0000107
Nr5a2RatDNA binding enablesIEAUniProtKB:P45448 and ensembl:ENSMUSP000000276491600115GO_REF:0000107EnsemblGO_REF:0000107
Nr5a2RatDNA binding enablesIEAARBA:ARBA000292241600115GO_REF:0000117UniProtGO_REF:0000117
Nr5a2RatDNA binding enablesIEAInterPro:IPR0163551600115GO_REF:0000002InterProGO_REF:0000002
Nr5a2RatDNA binding enablesISONr5a2 (Mus musculus)1624291 PMID:15014077 and PMID:16912278RGDPMID:15014077 and PMID:16912278
Nr5a2RatDNA binding enablesISONR5A2 (Homo sapiens)1624291 PMID:16289203RGDPMID:16289203
Nr5a2RatDNA-binding transcription activator activity, RNA polymerase II-specific enablesISONr5a2 (Mus musculus)1624291 PMID:12456679RGDPMID:12456679
Nr5a2RatDNA-binding transcription activator activity, RNA polymerase II-specific enablesIEAUniProtKB:P45448 and ensembl:ENSMUSP000000276491600115GO_REF:0000107EnsemblGO_REF:0000107
Nr5a2RatDNA-binding transcription factor activity enablesISONR5A2 (Homo sapiens)1624291 PMID:15205472 more ...RGDPMID:15205472 more ...
Nr5a2RatDNA-binding transcription factor activity enablesIEAInterPro:IPR0016281600115GO_REF:0000002InterProGO_REF:0000002
Nr5a2RatDNA-binding transcription factor activity enablesIEAUniProtKB:O00482 and ensembl:ENSP000003563311600115GO_REF:0000107EnsemblGO_REF:0000107
Nr5a2RatDNA-binding transcription factor activity enablesISSUniProtKB:O004821600115GO_REF:0000024UniProtGO_REF:0000024
Nr5a2Ratdouble-stranded DNA binding  IDA 68248 RGD 
Nr5a2Ratlipid binding enablesIEAUniProtKB-KW:KW-04461600115GO_REF:0000043UniProtGO_REF:0000043
Nr5a2Ratmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Nr5a2Ratnuclear receptor activity  IDA 68248 RGD 
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Imported Annotations - KEGG (archival)

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Original Reference(s)
Nr5a2Ratmaturity-onset diabetes of the young pathway  IEA 6907045 KEGGrno:04950

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Reference Title
Reference Citation
1. The alpha1-fetoprotein locus is activated by a nuclear receptor of the Drosophila FTZ-F1 family. Galarneau L, etal., Mol Cell Biol 1996 Jul;16(7):3853-65.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Calcineurin and CRTC2 mediate FSH and TGFß1 upregulation of Cyp19a1 and Nr5a in ovary granulosa cells. Lai WA, etal., J Mol Endocrinol. 2014 Oct;53(2):259-70. doi: 10.1530/JME-14-0048. Epub 2014 Jul 23.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Liver receptor homolog-1 (NR5a2) regulates CD95/Fas ligand transcription and associated T-cell effector functions. Schwaderer J, etal., Cell Death Dis. 2017 Apr 13;8(4):e2745. doi: 10.1038/cddis.2017.173.
11. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
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PMID:12456679   PMID:12672674   PMID:12865342   PMID:14736734   PMID:15014077   PMID:15143342   PMID:15205472   PMID:15684064   PMID:15723037   PMID:15798202   PMID:15831456   PMID:16289203  
PMID:16912278   PMID:17170099   PMID:17293441   PMID:17344471   PMID:19125815   PMID:19264593   PMID:19389484   PMID:19796622   PMID:20214950   PMID:20439489   PMID:20937355   PMID:21273442  
PMID:22977234   PMID:23637637   PMID:23689136   PMID:25063451   PMID:30555544   PMID:36857632  



Nr5a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81350,865,253 - 50,985,107 (-)NCBIGRCr8
mRatBN7.21348,313,634 - 48,433,494 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1348,316,301 - 48,433,326 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1350,924,322 - 51,041,371 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01352,212,210 - 52,329,237 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01349,479,256 - 49,596,284 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01353,750,470 - 53,870,288 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1353,750,473 - 53,870,428 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01358,791,496 - 58,910,967 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41349,931,592 - 50,048,756 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11349,945,671 - 50,062,836 (-)NCBI
Celera1348,623,262 - 48,740,634 (-)NCBICelera
Cytogenetic Map13q13NCBI
NR5A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381200,027,710 - 200,177,415 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1200,027,614 - 200,177,420 (+)EnsemblGRCh38hg38GRCh38
GRCh371199,996,838 - 200,146,543 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361198,263,393 - 198,413,175 (+)NCBINCBI36Build 36hg18NCBI36
Build 341196,728,426 - 196,878,205NCBI
Celera1173,119,461 - 173,269,192 (+)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1171,163,369 - 171,312,952 (+)NCBIHuRef
CHM1_11201,419,353 - 201,569,071 (+)NCBICHM1_1
T2T-CHM13v2.01199,284,725 - 199,434,351 (+)NCBIT2T-CHM13v2.0
Nr5a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391136,770,300 - 136,888,186 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1136,770,309 - 136,888,186 (-)EnsemblGRCm39 Ensembl
GRCm381136,842,562 - 136,960,448 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1136,842,571 - 136,960,448 (-)EnsemblGRCm38mm10GRCm38
MGSCv371138,740,161 - 138,857,025 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361138,660,687 - 138,776,859 (-)NCBIMGSCv36mm8
Celera1139,488,247 - 139,612,651 (-)NCBICelera
Cytogenetic Map1E4NCBI
cM Map159.98NCBI
Nr5a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540636,263,184 - 36,415,525 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540636,263,257 - 36,415,494 (+)NCBIChiLan1.0ChiLan1.0
NR5A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2149,206,752 - 49,357,599 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1149,168,065 - 49,318,860 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01175,625,140 - 175,775,955 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11179,934,573 - 180,083,607 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1179,934,573 - 180,083,607 (+)Ensemblpanpan1.1panPan2
NR5A2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.172,925,915 - 3,062,118 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl72,927,326 - 3,062,348 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha72,609,186 - 2,746,673 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.072,572,723 - 2,710,945 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl72,575,836 - 2,711,009 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.172,555,273 - 2,692,729 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.072,656,611 - 2,794,291 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.072,688,192 - 2,825,725 (-)NCBIUU_Cfam_GSD_1.0
Nr5a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934474,848,490 - 74,960,157 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365674,084,608 - 4,212,854 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365674,084,161 - 4,194,858 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NR5A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1022,715,735 - 22,865,364 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11022,727,865 - 22,866,905 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21027,281,190 - 27,424,774 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103230356
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12529,230,358 - 29,380,617 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2529,233,558 - 29,379,922 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605530,239,494 - 30,260,729 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nr5a2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624798356,953 - 494,877 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Nr5a2
669 total Variants

Predicted Target Of
Summary Value
Count of predictions:351
Count of miRNA genes:203
Interacting mature miRNAs:233
Transcripts:ENSRNOT00000000812
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 33 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133466346187525369Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)13931346554313465Rat
6893344Cm79Cardiac mass QTL 791.50.04heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)134372077062022792Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134619797684753113Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131491565559915655Rat

1 to 10 of 33 rows
D13Rat154  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21348,414,651 - 48,414,900 (+)MAPPERmRatBN7.2
Rnor_6.01353,851,498 - 53,851,746NCBIRnor6.0
Rnor_5.01358,892,524 - 58,892,772UniSTSRnor5.0
RGSC_v3.41350,029,937 - 50,030,186RGDRGSC3.4
RGSC_v3.41350,029,938 - 50,030,186UniSTSRGSC3.4
RGSC_v3.11350,044,017 - 50,044,266RGD
Celera1348,722,170 - 48,722,418UniSTS
FHH x ACI Map1320.43RGD
FHH x ACI Map1320.43UniSTS
Cytogenetic Map13q13UniSTS
RH143570  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21348,422,566 - 48,422,735 (+)MAPPERmRatBN7.2
Rnor_6.01353,859,413 - 53,859,581NCBIRnor6.0
Rnor_5.01358,900,439 - 58,900,607UniSTSRnor5.0
RGSC_v3.41350,037,853 - 50,038,021UniSTSRGSC3.4
Celera1348,730,085 - 48,730,253UniSTS
RH 3.4 Map13148.8UniSTS
Cytogenetic Map13q13UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 8 39 107 91 90 59 25 59 6 205 85 87 45 60 31



Ensembl Acc Id: ENSRNOT00000000812   ⟹   ENSRNOP00000000812
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1348,316,301 - 48,433,326 (-)Ensembl
Rnor_6.0 Ensembl1353,750,473 - 53,870,428 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097279   ⟹   ENSRNOP00000096873
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1348,316,301 - 48,433,326 (-)Ensembl
RefSeq Acc Id: NM_021742   ⟹   NP_068510
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81350,867,920 - 50,984,938 (-)NCBI
mRatBN7.21348,316,301 - 48,433,326 (-)NCBI
Rnor_6.01353,753,137 - 53,870,116 (-)NCBI
Rnor_5.01358,791,496 - 58,910,967 (-)NCBI
RGSC_v3.41349,931,592 - 50,048,756 (-)RGD
Celera1348,623,262 - 48,740,634 (-)RGD
Sequence:
RefSeq Acc Id: XM_006249928   ⟹   XP_006249990
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81350,865,253 - 50,985,107 (-)NCBI
mRatBN7.21348,313,634 - 48,433,494 (-)NCBI
Rnor_6.01353,750,470 - 53,870,288 (-)NCBI
Rnor_5.01358,791,496 - 58,910,967 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006249929   ⟹   XP_006249991
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81350,865,253 - 50,971,618 (-)NCBI
mRatBN7.21348,313,634 - 48,420,018 (-)NCBI
Rnor_6.01353,750,470 - 53,859,245 (-)NCBI
Rnor_5.01358,791,496 - 58,910,967 (-)NCBI
Sequence:
RefSeq Acc Id: NP_068510   ⟸   NM_021742
- UniProtKB: Q9QWM0 (UniProtKB/Swiss-Prot),   Q9QWM1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006249990   ⟸   XM_006249928
- Peptide Label: isoform X1
- UniProtKB: A6ICJ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006249991   ⟸   XM_006249929
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSRNOP00000000812   ⟸   ENSRNOT00000000812
Ensembl Acc Id: ENSRNOP00000096873   ⟸   ENSRNOT00000097279
NR LBD   Nuclear receptor

Name Modeler Protein Id AA Range Protein Structure
AF-Q9QWM1-F1-model_v2 AlphaFold Q9QWM1 1-560 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 40 of 40 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-18145 BioCyc
Ensembl Genes ENSRNOG00000000653 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000000812 ENTREZGENE
  ENSRNOT00000000812.6 UniProtKB/Swiss-Prot
  ENSRNOT00000097279 ENTREZGENE
  ENSRNOT00000097279.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.565.10 UniProtKB/Swiss-Prot
  3.30.50.10 UniProtKB/Swiss-Prot
InterPro NHR-like_dom_sf UniProtKB/Swiss-Prot
  NR5_fam UniProtKB/Swiss-Prot
  Nucl_hrmn_rcpt_lig-bd UniProtKB/Swiss-Prot
  Nuclear_hrmn_rcpt UniProtKB/Swiss-Prot
  Znf_hrmn_rcpt UniProtKB/Swiss-Prot
  Znf_NHR/GATA UniProtKB/Swiss-Prot
KEGG Report rno:60349 UniProtKB/Swiss-Prot
NCBI Gene 60349 ENTREZGENE
PANTHER NUCLEAR RECEPTOR SUBFAMILY 5 GROUP A MEMBER 2 UniProtKB/Swiss-Prot
  PTHR24086 UniProtKB/Swiss-Prot
Pfam Hormone_recep UniProtKB/Swiss-Prot
  zf-C4 UniProtKB/Swiss-Prot
PhenoGen Nr5a2 PhenoGen
PIRSF Nuc_orph_FTZ-F1 UniProtKB/Swiss-Prot
PRINTS STRDHORMONER UniProtKB/Swiss-Prot
  STROIDFINGER UniProtKB/Swiss-Prot
PROSITE NR_LBD UniProtKB/Swiss-Prot
  NUCLEAR_REC_DBD_1 UniProtKB/Swiss-Prot
  NUCLEAR_REC_DBD_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000000653 RatGTEx
SMART HOLI UniProtKB/Swiss-Prot
  ZnF_C4 UniProtKB/Swiss-Prot
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot
  SSF48508 UniProtKB/Swiss-Prot
TIGR TC222446
UniProt A6ICJ5 ENTREZGENE, UniProtKB/TrEMBL
  A6ICJ6_RAT UniProtKB/TrEMBL
  A6ICJ7_RAT UniProtKB/TrEMBL
  NR5A2_RAT UniProtKB/Swiss-Prot
  Q9QWM0 ENTREZGENE
  Q9QWM1 ENTREZGENE
UniProt Secondary Q9QWM0 UniProtKB/Swiss-Prot
1 to 40 of 40 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Nr5a2  nuclear receptor subfamily 5, group A, member 2      Name updated 70584 APPROVED

Note Type Note Reference
gene_function may bind DNA as monomers and demonstrates no need for a specific ligand 68248
gene_transcript a single copy 5.2-kb transcript 68248