Nr5a2 (nuclear receptor subfamily 5, group A, member 2) - Rat Genome Database

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Gene: Nr5a2 (nuclear receptor subfamily 5, group A, member 2) Rattus norvegicus
Analyze
Symbol: Nr5a2
Name: nuclear receptor subfamily 5, group A, member 2
RGD ID: 68353
Description: Enables double-stranded DNA binding activity and nuclear receptor activity. Involved in calcineurin-mediated signaling. Predicted to be located in cytoplasm and nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Orthologous to human NR5A2 (nuclear receptor subfamily 5 group A member 2); PARTICIPATES IN maturity-onset diabetes of the young pathway; INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: fetoprotein transcription factor; Ftf; FTZ-F1 beta; FTZ-F1 beta2 protein; liver receptor homolog 1; Lrh-1; nuclear receptor subfamily 5 group A member 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81350,865,253 - 50,985,107 (-)NCBIGRCr8
mRatBN7.21348,313,634 - 48,433,494 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1348,316,301 - 48,433,326 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1350,924,322 - 51,041,371 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01352,212,210 - 52,329,237 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01349,479,256 - 49,596,284 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01353,750,470 - 53,870,288 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1353,750,473 - 53,870,428 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01358,791,496 - 58,910,967 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41349,931,592 - 50,048,756 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11349,945,671 - 50,062,836 (-)NCBI
Celera1348,623,262 - 48,740,634 (-)NCBICelera
Cytogenetic Map13q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,2-dilauroyl-sn-glycero-3-phosphocholine(1+)  (ISO)
1-O-oleoyl-sn-glycero-3-phosphocholine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-methoxyethanol  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
9-cis-retinoic acid  (ISO)
acetic acid  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
androst-4-ene-3,17-dione  (EXP)
arachidonic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
aztreonam  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromochloroacetic acid  (ISO)
bromocriptine  (EXP)
C60 fullerene  (EXP)
cadmium atom  (ISO)
carbon nanotube  (ISO)
cefalotin  (ISO)
cholesterol  (ISO)
choline  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP,ISO)
colforsin daropate hydrochloride  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dexamethasone  (EXP)
dextran sulfate  (ISO)
dibenz[a,h]anthracene  (ISO)
diethylstilbestrol  (ISO)
Diosbulbin B  (ISO)
dioxygen  (EXP)
endosulfan  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
gentamycin  (EXP)
imipenem hydrate  (ISO)
L-methionine  (ISO)
lead nitrate  (ISO)
linoleic acid  (ISO)
lipopolysaccharide  (ISO)
lithocholic acid  (EXP)
lysophosphatidylcholine  (ISO)
lysophosphatidylethanolamine  (ISO)
methapyrilene  (EXP,ISO)
methylmercury chloride  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
neomycin  (ISO)
nitrofen  (EXP)
obeticholic acid  (ISO)
ozone  (ISO)
p-toluidine  (EXP)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidylcholine  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
sulforaphane  (EXP)
sulpiride  (EXP)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP,ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The alpha1-fetoprotein locus is activated by a nuclear receptor of the Drosophila FTZ-F1 family. Galarneau L, etal., Mol Cell Biol 1996 Jul;16(7):3853-65.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Calcineurin and CRTC2 mediate FSH and TGFß1 upregulation of Cyp19a1 and Nr5a in ovary granulosa cells. Lai WA, etal., J Mol Endocrinol. 2014 Oct;53(2):259-70. doi: 10.1530/JME-14-0048. Epub 2014 Jul 23.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Liver receptor homolog-1 (NR5a2) regulates CD95/Fas ligand transcription and associated T-cell effector functions. Schwaderer J, etal., Cell Death Dis. 2017 Apr 13;8(4):e2745. doi: 10.1038/cddis.2017.173.
11. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:12456679   PMID:12672674   PMID:12865342   PMID:14736734   PMID:15014077   PMID:15143342   PMID:15205472   PMID:15684064   PMID:15723037   PMID:15798202   PMID:15831456   PMID:16289203  
PMID:16912278   PMID:17170099   PMID:17293441   PMID:17344471   PMID:19125815   PMID:19264593   PMID:19389484   PMID:19796622   PMID:20214950   PMID:20439489   PMID:20937355   PMID:21273442  
PMID:22977234   PMID:23637637   PMID:23689136   PMID:25063451   PMID:30555544   PMID:36857632  


Genomics

Comparative Map Data
Nr5a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81350,865,253 - 50,985,107 (-)NCBIGRCr8
mRatBN7.21348,313,634 - 48,433,494 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1348,316,301 - 48,433,326 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1350,924,322 - 51,041,371 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01352,212,210 - 52,329,237 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01349,479,256 - 49,596,284 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01353,750,470 - 53,870,288 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1353,750,473 - 53,870,428 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01358,791,496 - 58,910,967 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41349,931,592 - 50,048,756 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11349,945,671 - 50,062,836 (-)NCBI
Celera1348,623,262 - 48,740,634 (-)NCBICelera
Cytogenetic Map13q13NCBI
NR5A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381200,027,710 - 200,177,415 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1200,027,614 - 200,177,420 (+)EnsemblGRCh38hg38GRCh38
GRCh371199,996,838 - 200,146,543 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361198,263,393 - 198,413,175 (+)NCBINCBI36Build 36hg18NCBI36
Build 341196,728,426 - 196,878,205NCBI
Celera1173,119,461 - 173,269,192 (+)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1171,163,369 - 171,312,952 (+)NCBIHuRef
CHM1_11201,419,353 - 201,569,071 (+)NCBICHM1_1
T2T-CHM13v2.01199,284,725 - 199,434,351 (+)NCBIT2T-CHM13v2.0
Nr5a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391136,770,300 - 136,888,186 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1136,770,309 - 136,888,186 (-)EnsemblGRCm39 Ensembl
GRCm381136,842,562 - 136,960,448 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1136,842,571 - 136,960,448 (-)EnsemblGRCm38mm10GRCm38
MGSCv371138,740,161 - 138,857,025 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361138,660,687 - 138,776,859 (-)NCBIMGSCv36mm8
Celera1139,488,247 - 139,612,651 (-)NCBICelera
Cytogenetic Map1E4NCBI
cM Map159.98NCBI
Nr5a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540636,263,184 - 36,415,525 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540636,263,257 - 36,415,494 (+)NCBIChiLan1.0ChiLan1.0
NR5A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2149,206,752 - 49,357,599 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1149,168,065 - 49,318,860 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01175,625,140 - 175,775,955 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11179,934,573 - 180,083,607 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1179,934,573 - 180,083,607 (+)Ensemblpanpan1.1panPan2
NR5A2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.172,925,915 - 3,062,118 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl72,927,326 - 3,062,348 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha72,609,186 - 2,746,673 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.072,572,723 - 2,710,945 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl72,575,836 - 2,711,009 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.172,555,273 - 2,692,729 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.072,656,611 - 2,794,291 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.072,688,192 - 2,825,725 (-)NCBIUU_Cfam_GSD_1.0
Nr5a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934474,848,490 - 74,960,157 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365674,084,608 - 4,212,854 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365674,084,161 - 4,194,858 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NR5A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1022,715,735 - 22,865,364 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11022,727,865 - 22,866,905 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21027,281,190 - 27,424,774 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103230356
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12529,230,358 - 29,380,617 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2529,233,558 - 29,379,922 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605530,239,494 - 30,260,729 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nr5a2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624798356,953 - 494,877 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nr5a2
669 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:351
Count of miRNA genes:203
Interacting mature miRNAs:233
Transcripts:ENSRNOT00000000812
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133466346187525369Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)13931346554313465Rat
6893344Cm79Cardiac mass QTL 791.50.04heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)134372077062022792Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134619797684753113Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131491565559915655Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132320344868203448Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131769443653050594Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132369296968692969Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133228447177284471Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133124133158363171Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132369296968692969Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131515872260158722Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)13931346554313465Rat

Markers in Region
D13Rat154  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21348,414,651 - 48,414,900 (+)MAPPERmRatBN7.2
Rnor_6.01353,851,498 - 53,851,746NCBIRnor6.0
Rnor_5.01358,892,524 - 58,892,772UniSTSRnor5.0
RGSC_v3.41350,029,937 - 50,030,186RGDRGSC3.4
RGSC_v3.41350,029,938 - 50,030,186UniSTSRGSC3.4
RGSC_v3.11350,044,017 - 50,044,266RGD
Celera1348,722,170 - 48,722,418UniSTS
FHH x ACI Map1320.43RGD
FHH x ACI Map1320.43UniSTS
Cytogenetic Map13q13UniSTS
RH143570  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21348,422,566 - 48,422,735 (+)MAPPERmRatBN7.2
Rnor_6.01353,859,413 - 53,859,581NCBIRnor6.0
Rnor_5.01358,900,439 - 58,900,607UniSTSRnor5.0
RGSC_v3.41350,037,853 - 50,038,021UniSTSRGSC3.4
Celera1348,730,085 - 48,730,253UniSTS
RH 3.4 Map13148.8UniSTS
Cytogenetic Map13q13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 8 39 107 91 90 59 25 59 6 205 85 87 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000000812   ⟹   ENSRNOP00000000812
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1348,316,301 - 48,433,326 (-)Ensembl
Rnor_6.0 Ensembl1353,750,473 - 53,870,428 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097279   ⟹   ENSRNOP00000096873
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1348,316,301 - 48,433,326 (-)Ensembl
RefSeq Acc Id: NM_021742   ⟹   NP_068510
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81350,867,920 - 50,984,938 (-)NCBI
mRatBN7.21348,316,301 - 48,433,326 (-)NCBI
Rnor_6.01353,753,137 - 53,870,116 (-)NCBI
Rnor_5.01358,791,496 - 58,910,967 (-)NCBI
RGSC_v3.41349,931,592 - 50,048,756 (-)RGD
Celera1348,623,262 - 48,740,634 (-)RGD
Sequence:
RefSeq Acc Id: XM_006249928   ⟹   XP_006249990
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81350,865,253 - 50,985,107 (-)NCBI
mRatBN7.21348,313,634 - 48,433,494 (-)NCBI
Rnor_6.01353,750,470 - 53,870,288 (-)NCBI
Rnor_5.01358,791,496 - 58,910,967 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006249929   ⟹   XP_006249991
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81350,865,253 - 50,971,618 (-)NCBI
mRatBN7.21348,313,634 - 48,420,018 (-)NCBI
Rnor_6.01353,750,470 - 53,859,245 (-)NCBI
Rnor_5.01358,791,496 - 58,910,967 (-)NCBI
Sequence:
RefSeq Acc Id: NP_068510   ⟸   NM_021742
- UniProtKB: Q9QWM0 (UniProtKB/Swiss-Prot),   Q9QWM1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006249990   ⟸   XM_006249928
- Peptide Label: isoform X1
- UniProtKB: A6ICJ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006249991   ⟸   XM_006249929
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSRNOP00000000812   ⟸   ENSRNOT00000000812
Ensembl Acc Id: ENSRNOP00000096873   ⟸   ENSRNOT00000097279
Protein Domains
NR LBD   Nuclear receptor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QWM1-F1-model_v2 AlphaFold Q9QWM1 1-560 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68353 AgrOrtholog
BioCyc Gene G2FUF-18145 BioCyc
Ensembl Genes ENSRNOG00000000653 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055021307 UniProtKB/Swiss-Prot
  ENSRNOG00060017930 UniProtKB/Swiss-Prot
  ENSRNOG00065021414 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000000812.6 UniProtKB/Swiss-Prot
  ENSRNOT00000097279.1 UniProtKB/Swiss-Prot
  ENSRNOT00055036423 UniProtKB/Swiss-Prot
  ENSRNOT00060030772 UniProtKB/Swiss-Prot
  ENSRNOT00065036408 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.565.10 UniProtKB/Swiss-Prot
  3.30.50.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Retinoid X Receptor UniProtKB/TrEMBL
InterPro NHR-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NR5_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucl_hrmn_rcpt_lig-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nuclear_hrmn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_hrmn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_NHR/GATA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:60349 UniProtKB/Swiss-Prot
NCBI Gene 60349 ENTREZGENE
PANTHER NUCLEAR RECEPTOR SUBFAMILY 5 GROUP A UniProtKB/TrEMBL
  NUCLEAR RECEPTOR SUBFAMILY 5 GROUP A MEMBER 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24086 UniProtKB/Swiss-Prot
Pfam Hormone_recep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-C4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nr5a2 PhenoGen
PIRSF Nuc_orph_FTZ-F1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS STRDHORMONER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STROIDFINGER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NR_LBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000000653 RatGTEx
  ENSRNOG00055021307 RatGTEx
  ENSRNOG00060017930 RatGTEx
  ENSRNOG00065021414 RatGTEx
SMART HOLI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZnF_C4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nuclear receptor ligand-binding domain UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
TIGR TC222446
UniProt A6ICJ5 ENTREZGENE, UniProtKB/TrEMBL
  A6ICJ6_RAT UniProtKB/TrEMBL
  A6ICJ7_RAT UniProtKB/TrEMBL
  NR5A2_RAT UniProtKB/Swiss-Prot
  Q9QWM0 ENTREZGENE
  Q9QWM1 ENTREZGENE
UniProt Secondary Q9QWM0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Nr5a2  nuclear receptor subfamily 5, group A, member 2      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function may bind DNA as monomers and demonstrates no need for a specific ligand 68248
gene_transcript a single copy 5.2-kb transcript 68248