Nr5a2 (nuclear receptor subfamily 5, group A, member 2) - Rat Genome Database

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Gene: Nr5a2 (nuclear receptor subfamily 5, group A, member 2) Mus musculus
Analyze
Symbol: Nr5a2
Name: nuclear receptor subfamily 5, group A, member 2
RGD ID: 68500
MGI Page MGI
Description: Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; cholesterol homeostasis; and pancreas morphogenesis. Located in nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; ear; early conceptus; and gonad. Orthologous to human NR5A2 (nuclear receptor subfamily 5 group A member 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AU020803; D1Ertd308; D1Ertd308e; fetoprotein transcription factor; Ftf; liver receptor homolog 1; LRH; LRH-1; nuclear receptor subfamily 5 group A member 2; UF2-H3B
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm17743   Gm18981  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391136,770,300 - 136,888,186 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1136,770,309 - 136,888,186 (-)EnsemblGRCm39 Ensembl
GRCm381136,842,562 - 136,960,448 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1136,842,571 - 136,960,448 (-)EnsemblGRCm38mm10GRCm38
MGSCv371138,740,161 - 138,857,025 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361138,660,687 - 138,776,859 (-)NCBIMGSCv36mm8
Celera1139,488,247 - 139,612,651 (-)NCBICelera
Cytogenetic Map1E4NCBI
cM Map159.98NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (EXP)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,2-dilauroyl-sn-glycero-3-phosphocholine(1+)  (EXP)
1-O-oleoyl-sn-glycero-3-phosphocholine  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-methoxyethanol  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (EXP)
9-cis-retinoic acid  (ISO)
acetic acid  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
androst-4-ene-3,17-dione  (ISO)
arachidonic acid  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
aztreonam  (EXP)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bromochloroacetic acid  (EXP)
bromocriptine  (ISO)
C60 fullerene  (ISO)
cadmium atom  (ISO)
carbon nanotube  (EXP)
cefalotin  (EXP)
cholesterol  (EXP)
choline  (EXP)
cisplatin  (ISO)
clofibrate  (EXP)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dextran sulfate  (EXP)
dibenz[a,h]anthracene  (EXP)
diethylstilbestrol  (EXP)
Diosbulbin B  (EXP)
dioxygen  (ISO)
endosulfan  (ISO)
flutamide  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
fulvestrant  (ISO)
genistein  (EXP)
gentamycin  (ISO)
imipenem hydrate  (EXP)
L-methionine  (EXP)
lead nitrate  (EXP)
linoleic acid  (EXP)
lipopolysaccharide  (ISO)
lithocholic acid  (ISO)
lysophosphatidylcholine  (EXP)
lysophosphatidylethanolamine  (EXP)
methapyrilene  (ISO)
methylmercury chloride  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
neomycin  (EXP)
nitrofen  (ISO)
obeticholic acid  (ISO)
ozone  (EXP)
p-toluidine  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenobarbital  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidylcholine  (EXP)
pirinixic acid  (EXP)
potassium dichromate  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sodium arsenite  (ISO)
succimer  (EXP)
sulforaphane  (ISO)
sulpiride  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
trichloroethene  (EXP,ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (ISO)
vancomycin  (EXP)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal amniotic cavity morphology  (IAGP)
abnormal bile composition  (IAGP)
abnormal bile salt homeostasis  (IAGP)
abnormal bile salt level  (IAGP)
abnormal bile secretion  (IAGP)
abnormal cholesterol homeostasis  (IAGP)
abnormal colon morphology  (IAGP)
abnormal crypts of Lieberkuhn morphology  (IAGP)
abnormal ectoderm development  (IAGP)
abnormal embryo development  (IAGP)
abnormal feces composition  (IAGP)
abnormal germ layer development  (IAGP)
abnormal intestinal lipid absorption  (IAGP)
abnormal mesoderm development  (IAGP)
abnormal pregnancy  (IAGP)
abnormal proamniotic cavity morphology  (IAGP)
abnormal sterol level  (IAGP)
abnormal visceral endoderm morphology  (IAGP)
absent amniotic cavity  (IAGP)
colonic necrosis  (IAGP)
decreased cholesterol level  (IAGP)
decreased circulating aspartate transaminase level  (IAGP)
decreased circulating cholesterol level  (IAGP)
decreased circulating LDL cholesterol level  (IAGP)
decreased circulating progesterone level  (IAGP)
decreased circulating testosterone level  (IAGP)
decreased circulating triglyceride level  (IAGP)
decreased embryo size  (IAGP)
decreased epididymis weight  (IAGP)
decreased seminal vesicle weight  (IAGP)
decreased susceptibility to atherosclerosis  (IAGP)
edema  (IAGP)
embryonic lethality between implantation and somite formation, complete penetrance  (IAGP)
embryonic lethality between implantation and somite formation, incomplete penetrance  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
increased bile salt level  (IAGP)
increased liver cholesterol level  (IAGP)
increased susceptibility to induced colitis  (IAGP)
increased uterus weight  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
reduced female fertility  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. The alpha1-fetoprotein locus is activated by a nuclear receptor of the Drosophila FTZ-F1 family. Galarneau L, etal., Mol Cell Biol 1996 Jul;16(7):3853-65.
2. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, etal., Science 2004 Dec 24;306(5705):2255-7.
3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
4. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
5. MGDs mouse GO annotations MGD data from the GO Consortium
6. MGD IEA MGD IEA
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. Mouse MP Annotation Import Pipeline RGD automated import pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Liver receptor homolog-1 (NR5a2) regulates CD95/Fas ligand transcription and associated T-cell effector functions. Schwaderer J, etal., Cell Death Dis. 2017 Apr 13;8(4):e2745. doi: 10.1038/cddis.2017.173.
Additional References at PubMed
PMID:10349636   PMID:10559496   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11145965   PMID:11217851   PMID:12456679   PMID:12466851   PMID:12477932   PMID:12482977   PMID:12520002  
PMID:12672674   PMID:12820970   PMID:12837754   PMID:12865342   PMID:12972182   PMID:12972592   PMID:14610273   PMID:14681479   PMID:14701919   PMID:14726490   PMID:14766742   PMID:15014077  
PMID:15327767   PMID:15684064   PMID:15707893   PMID:15721253   PMID:15798202   PMID:15831456   PMID:15976031   PMID:16003771   PMID:16141072   PMID:16141073   PMID:16264403   PMID:16282330  
PMID:16325481   PMID:16469397   PMID:16500646   PMID:16702404   PMID:16893604   PMID:16912278   PMID:16919269   PMID:16923850   PMID:16943422   PMID:16971476   PMID:16973757   PMID:17075876  
PMID:17205580   PMID:17289919   PMID:17293441   PMID:17409375   PMID:17522048   PMID:17609113   PMID:17670946   PMID:17908794   PMID:17967808   PMID:18287559   PMID:18323469   PMID:18385139  
PMID:18628394   PMID:18722179   PMID:18799693   PMID:19389484   PMID:19538736   PMID:19796622   PMID:20044028   PMID:20056718   PMID:20059953   PMID:20096661   PMID:20159957   PMID:20211142  
PMID:20375256   PMID:20412781   PMID:20439489   PMID:20483916   PMID:20734354   PMID:20823062   PMID:20853131   PMID:20932939   PMID:20937355   PMID:20943815   PMID:21129436   PMID:21203589  
PMID:21267068   PMID:21391220   PMID:21536586   PMID:21614002   PMID:21731673   PMID:21852532   PMID:21873635   PMID:21990348   PMID:22232429   PMID:22296850   PMID:22772466   PMID:22977234  
PMID:22988430   PMID:23038264   PMID:23425349   PMID:23454691   PMID:23504956   PMID:23536856   PMID:23637637   PMID:23645620   PMID:23737522   PMID:23747249   PMID:23817023   PMID:24449835  
PMID:24459144   PMID:24531913   PMID:24552399   PMID:24564400   PMID:24632207   PMID:24705138   PMID:24735206   PMID:24737860   PMID:24952961   PMID:25063451   PMID:25176150   PMID:25449416  
PMID:25873311   PMID:26241054   PMID:26268559   PMID:26657766   PMID:27298334   PMID:27345266   PMID:27447294   PMID:27995969   PMID:28094767   PMID:28520915   PMID:28552526   PMID:29443959  
PMID:29515023   PMID:29662071   PMID:30305617   PMID:30327475   PMID:30529950   PMID:30555544   PMID:31061415   PMID:31323030   PMID:31328159   PMID:31355949   PMID:31461657   PMID:33079429  
PMID:33411242   PMID:33441767   PMID:33527355   PMID:33951437   PMID:34397088   PMID:34488925   PMID:35192609   PMID:35602948   PMID:36045707   PMID:36173805   PMID:36423263   PMID:36765131  
PMID:36861295   PMID:36905926   PMID:37053002   PMID:37057309   PMID:37353485   PMID:37494420   PMID:37524711   PMID:37935903   PMID:38031019   PMID:38160393  


Genomics

Comparative Map Data
Nr5a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391136,770,300 - 136,888,186 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1136,770,309 - 136,888,186 (-)EnsemblGRCm39 Ensembl
GRCm381136,842,562 - 136,960,448 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1136,842,571 - 136,960,448 (-)EnsemblGRCm38mm10GRCm38
MGSCv371138,740,161 - 138,857,025 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361138,660,687 - 138,776,859 (-)NCBIMGSCv36mm8
Celera1139,488,247 - 139,612,651 (-)NCBICelera
Cytogenetic Map1E4NCBI
cM Map159.98NCBI
NR5A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381200,027,710 - 200,177,415 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1200,027,614 - 200,177,420 (+)EnsemblGRCh38hg38GRCh38
GRCh371199,996,838 - 200,146,543 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361198,263,393 - 198,413,175 (+)NCBINCBI36Build 36hg18NCBI36
Build 341196,728,426 - 196,878,205NCBI
Celera1173,119,461 - 173,269,192 (+)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1171,163,369 - 171,312,952 (+)NCBIHuRef
CHM1_11201,419,353 - 201,569,071 (+)NCBICHM1_1
T2T-CHM13v2.01199,284,725 - 199,434,351 (+)NCBIT2T-CHM13v2.0
Nr5a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81350,865,253 - 50,985,107 (-)NCBIGRCr8
mRatBN7.21348,313,634 - 48,433,494 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1348,316,301 - 48,433,326 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1350,924,322 - 51,041,371 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01352,212,210 - 52,329,237 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01349,479,256 - 49,596,284 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01353,750,470 - 53,870,288 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1353,750,473 - 53,870,428 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01358,791,496 - 58,910,967 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41349,931,592 - 50,048,756 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11349,945,671 - 50,062,836 (-)NCBI
Celera1348,623,262 - 48,740,634 (-)NCBICelera
Cytogenetic Map13q13NCBI
Nr5a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540636,263,184 - 36,415,525 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540636,263,257 - 36,415,494 (+)NCBIChiLan1.0ChiLan1.0
NR5A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2149,206,752 - 49,357,599 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1149,168,065 - 49,318,860 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01175,625,140 - 175,775,955 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11179,934,573 - 180,083,607 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1179,934,573 - 180,083,607 (+)Ensemblpanpan1.1panPan2
NR5A2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.172,925,915 - 3,062,118 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl72,927,326 - 3,062,348 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha72,609,186 - 2,746,673 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.072,572,723 - 2,710,945 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl72,575,836 - 2,711,009 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.172,555,273 - 2,692,729 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.072,656,611 - 2,794,291 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.072,688,192 - 2,825,725 (-)NCBIUU_Cfam_GSD_1.0
Nr5a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934474,848,490 - 74,960,157 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365674,084,608 - 4,212,854 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365674,084,161 - 4,194,858 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NR5A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1022,715,735 - 22,865,364 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11022,727,865 - 22,866,905 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21027,281,190 - 27,424,774 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103230356
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12529,230,358 - 29,380,617 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2529,233,558 - 29,379,922 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605530,239,494 - 30,260,729 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nr5a2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624798356,953 - 494,877 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nr5a2
4176 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1217
Count of miRNA genes:411
Interacting mature miRNAs:505
Transcripts:ENSMUST00000027649, ENSMUST00000168126
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
1357753Kidq2_mkidney weight QTL 2 (mouse)Not determined134760138150193871Mouse
1357488Splq3_mspleen weight QTL 3 (mouse)Not determined134760138150193871Mouse
1558860W10q7_mweight 10 weeks QTL 7 (mouse)Not determined134760138150193871Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145783900189303617Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52457737182250592Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163854690189303617Mouse
1300841Ssial1_msusceptibility to sialadenitis 1 (mouse)Not determined163920002153557562Mouse
1300989Lrdg1_mlight induced retinal degeneration 1 (mouse)Not determined173755175147125370Mouse
4141914Gcsfis_mG-CSF induced splenomegaly (mouse)Not determined74516235148715579Mouse
27095928Pglq6_mpelvic girdle length QTL 6, 10 week (mouse)175976637148775742Mouse
26884448Sklq1_mskull length QTL 1, 5 week (mouse)175976637181327565Mouse
1301350Nidd4k_mNidd4 on KK-A (mouse)Not determined782291982147125370Mouse
27095913Scvln2_msacral vertebrae length 2, 5 week (mouse)194127725148775742Mouse
27095901Scvln8_msacral vertebrae length 2, 10 week (mouse)194127725172027567Mouse
27226779Tibl1_mtibia length 1, 5 week (mouse)195527725162027569Mouse
1301193Lxw3_mlupus BXSB x NZW 3 (mouse)Not determined1102968534136968667Mouse
10412162Nobq3_mNew Zealand obese QTL 3 (mouse)Not determined1103933405191225397Mouse
12790994Aaaq1_maortic arch angle QTL 1 (mouse)1109495943143495943Mouse
1301979Melm1_mmelanoma modifier 1 (mouse)Not determined1109638262143638479Mouse
1357600Obq17_mobesity QTL 17 (mouse)Not determined1110553179144553298Mouse
10401248Bglu12_mblood glucose level 12 (mouse)Not determined1110553179144553298Mouse
1301149Lrnx12_mlearning-contextual 12 (mouse)Not determined1112008822168186402Mouse
1302098Eila1_methanol induced locomotor activity 1 (mouse)Not determined1112008822175468938Mouse
1301249Sbw1_msplenomegaly-NZB x NZW 1 (mouse)Not determined1112131005146131085Mouse
10045640Jckm4_mjuvenile cystic kidney modifier 4 (mouse)Not determined1116290836150290937Mouse
27095915Scvln13_msacral vertebrae length 2, 16 week (mouse)1117527730179827565Mouse
1302161Exq2_mexploratory and excitability QTL 2 (mouse)Not determined1118099720152099816Mouse
27226714Metcl1_mmetatarsal-calcaneal length 1, 5 week (mouse)1121727729139727738Mouse
27226740Metcl13_mmetatarsal-calcaneal length 13, 16 week (mouse)1121727729153775746Mouse
27226743Metcl7_mmetatarsal-calcaneal length 7, 10 week (mouse)1121727729153875746Mouse
27226767Tibl10_mtibia length 10, 10 week (mouse)1121727729164827569Mouse
27226799Feml5_mfemur length 5, 5 week (mouse)1122027729164827569Mouse
12880408V125Dq3_mvitamin D active form serum level QTL 3 (mouse)1122927738156927738Mouse
27095935Ulnl5_mulna length 5, 10 week (mouse)1128727737181327565Mouse
1301608Emo3_memotionality 3 (mouse)Not determined1129130858163130993Mouse
1302128Ity3_mimmunity to S. typhimurium 3 (mouse)Not determined11131156308165139464Mouse
14746980Manh50_mmandible shape 50 (mouse)1134131564168131564Mouse
13504831Bacszq1_mbaculum size QTL 1 (mouse)1134331161148128608Mouse
1301458Skts8_mskin tumor susceptibility 8 (mouse)Not determined1135794822169795012Mouse
1301408Lore8_mloss of righting induced by ethanol 8 (mouse)Not determined1135877901169878015Mouse
1357434Obsty1_mobesity 1 (mouse)Not determined1136209950170210094Mouse

Markers in Region
RH136280  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381136,921,472 - 136,921,671UniSTSGRCm38
MGSCv371138,818,049 - 138,818,248UniSTSGRCm37
Celera1139,573,451 - 139,573,650UniSTS
Cytogenetic Map1E4UniSTS
cM Map178.0UniSTS
25.MHAa58c1.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381136,855,924 - 136,856,097UniSTSGRCm38
MGSCv371138,752,501 - 138,752,674UniSTSGRCm37
Celera1139,500,651 - 139,500,824UniSTS
Cytogenetic Map1E4UniSTS
cM Map178.0UniSTS
Whitehead/MRC_RH19569.59UniSTS
Nr5a2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1E4UniSTS
cM Map178.0UniSTS
RH126840  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381136,843,890 - 136,844,089UniSTSGRCm38
MGSCv371138,740,467 - 138,740,666UniSTSGRCm37
Celera1139,488,553 - 139,488,752UniSTS
Cytogenetic Map1E4UniSTS
cM Map178.0UniSTS
Whitehead/MRC_RH11936.07UniSTS
D1Ertd811e  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381136,921,330 - 136,921,570UniSTSGRCm38
MGSCv371138,817,907 - 138,818,147UniSTSGRCm37
Celera1139,573,309 - 139,573,549UniSTS
Cytogenetic Map1E4UniSTS
cM Map178.8UniSTS
PMC193920P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381136,960,705 - 136,961,061UniSTSGRCm38
MGSCv371138,857,282 - 138,857,638UniSTSGRCm37
Celera1139,612,908 - 139,613,264UniSTS
Cytogenetic Map1E4UniSTS
cM Map178.0UniSTS
Nr5a2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1E4UniSTS
Nr5a2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1E4UniSTS
Nr5a2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1E4UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000027649   ⟹   ENSMUSP00000027649
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1136,770,309 - 136,888,186 (-)Ensembl
GRCm38.p6 Ensembl1136,842,571 - 136,960,448 (-)Ensembl
RefSeq Acc Id: ENSMUST00000168126   ⟹   ENSMUSP00000129071
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1136,772,014 - 136,877,300 (-)Ensembl
GRCm38.p6 Ensembl1136,844,276 - 136,949,562 (-)Ensembl
RefSeq Acc Id: ENSMUST00000192357   ⟹   ENSMUSP00000142219
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1136,773,052 - 136,888,118 (-)Ensembl
GRCm38.p6 Ensembl1136,845,314 - 136,960,380 (-)Ensembl
RefSeq Acc Id: ENSMUST00000192587
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1136,818,095 - 136,868,321 (-)Ensembl
GRCm38.p6 Ensembl1136,890,357 - 136,940,583 (-)Ensembl
RefSeq Acc Id: ENSMUST00000192929   ⟹   ENSMUSP00000141495
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1136,773,201 - 136,881,368 (-)Ensembl
GRCm38.p6 Ensembl1136,845,463 - 136,953,630 (-)Ensembl
RefSeq Acc Id: ENSMUST00000195428   ⟹   ENSMUSP00000141645
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1136,868,723 - 136,876,911 (-)Ensembl
GRCm38.p6 Ensembl1136,940,985 - 136,949,173 (-)Ensembl
RefSeq Acc Id: NM_001159769   ⟹   NP_001153241
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391136,771,322 - 136,881,368 (-)NCBI
GRCm381136,843,584 - 136,953,630 (-)NCBI
MGSCv371138,740,161 - 138,857,025 (-)RGD
Celera1139,488,247 - 139,612,651 (-)RGD
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_030676   ⟹   NP_109601
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391136,771,322 - 136,888,186 (-)NCBI
GRCm381136,843,584 - 136,960,448 (-)NCBI
MGSCv371138,740,161 - 138,857,025 (-)RGD
Celera1139,488,247 - 139,612,651 (-)RGD
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006529621   ⟹   XP_006529684
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391136,770,300 - 136,888,116 (-)NCBI
GRCm381136,842,562 - 136,960,378 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006529622   ⟹   XP_006529685
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391136,770,300 - 136,877,315 (-)NCBI
GRCm381136,842,562 - 136,949,577 (-)NCBI
Sequence:
RefSeq Acc Id: NP_109601   ⟸   NM_030676
- Peptide Label: isoform 1
- UniProtKB: B9EHF9 (UniProtKB/Swiss-Prot),   P45448 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001153241   ⟸   NM_001159769
- Peptide Label: isoform 2
- UniProtKB: Q1WLP7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006529684   ⟸   XM_006529621
- Peptide Label: isoform X1
- UniProtKB: A0A0A6YY04 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006529685   ⟸   XM_006529622
- Peptide Label: isoform X2
- UniProtKB: Q1WLP7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000027649   ⟸   ENSMUST00000027649
RefSeq Acc Id: ENSMUSP00000129071   ⟸   ENSMUST00000168126
RefSeq Acc Id: ENSMUSP00000142219   ⟸   ENSMUST00000192357
RefSeq Acc Id: ENSMUSP00000141495   ⟸   ENSMUST00000192929
RefSeq Acc Id: ENSMUSP00000141645   ⟸   ENSMUST00000195428
Protein Domains
NR LBD   Nuclear receptor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P45448-F1-model_v2 AlphaFold P45448 1-560 view protein structure

Promoters
RGD ID:6875120
Promoter ID:EPDNEW_M1011
Type:initiation region
Name:Nr5a2_2
Description:Mus musculus nuclear receptor subfamily 5, group A, member 2, transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M1012  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381136,949,488 - 136,949,548EPDNEW
RGD ID:6875122
Promoter ID:EPDNEW_M1012
Type:single initiation site
Name:Nr5a2_1
Description:Mus musculus nuclear receptor subfamily 5, group A, member 2, transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M1011  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381136,953,604 - 136,953,664EPDNEW
RGD ID:6818185
Promoter ID:MM_KWN:2265
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:UC007CVA.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361138,845,646 - 138,846,146 (-)MPROMDB
RGD ID:6818183
Promoter ID:MM_KWN:2266
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell
Transcripts:NM_001159769
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361138,849,621 - 138,850,121 (-)MPROMDB
RGD ID:6818184
Promoter ID:MM_KWN:2267
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:NM_030676
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361138,856,796 - 138,857,296 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1346834 AgrOrtholog
Ensembl Genes ENSMUSG00000026398 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000027649 ENTREZGENE
  ENSMUST00000027649.14 UniProtKB/Swiss-Prot
  ENSMUST00000168126 ENTREZGENE
  ENSMUST00000168126.7 UniProtKB/TrEMBL
  ENSMUST00000192357 ENTREZGENE
  ENSMUST00000192357.6 UniProtKB/TrEMBL
  ENSMUST00000192929 ENTREZGENE
  ENSMUST00000192929.6 UniProtKB/TrEMBL
  ENSMUST00000195428.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.565.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.50.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro NHR-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NR5_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucl_hrmn_rcpt_lig-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nuclear_hrmn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_hrmn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_NHR/GATA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:26424 UniProtKB/Swiss-Prot
MGD MGI:1346834 ENTREZGENE
NCBI Gene 26424 ENTREZGENE
PANTHER NUCLEAR RECEPTOR SUBFAMILY 5 GROUP A MEMBER 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24086 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Hormone_recep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-C4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nr5a2 PhenoGen
PIRSF Nuc_orph_FTZ-F1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS STRDHORMONER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STROIDFINGER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NR_LBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HOLI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZnF_C4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48508 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0A6YWQ4_MOUSE UniProtKB/TrEMBL
  A0A0A6YY04 ENTREZGENE, UniProtKB/TrEMBL
  B9EHF9 ENTREZGENE
  NR5A2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q1WLP7 ENTREZGENE, UniProtKB/TrEMBL
  Q61807_MOUSE UniProtKB/TrEMBL
UniProt Secondary B9EHF9 UniProtKB/Swiss-Prot