Retnla (resistin like alpha) - Rat Genome Database

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Gene: Retnla (resistin like alpha) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Retnla
Name: resistin like alpha
RGD ID: 68349
Description: Predicted to enable hormone activity. Predicted to be involved in signal transduction. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human RETNLB (resistin like beta); INTERACTS WITH 1,2-dimethylhydrazine; acrolein; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cysteine-rich secreted protein FIZZ1; Himf; hypoxia-induced mitogenic factor; RELMalpha; resistin-like alpha
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81165,424,685 - 65,426,484 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1165,424,687 - 65,426,398 (-)EnsemblGRCr8
mRatBN7.21151,961,726 - 51,963,527 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1151,961,730 - 51,963,441 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1160,724,799 - 60,726,298 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01153,386,583 - 53,388,082 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01152,491,370 - 52,492,868 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01154,543,727 - 54,545,493 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1154,543,731 - 54,545,230 (-)Ensemblrn6Rnor6.0
Rnor_5.01157,705,929 - 57,707,676 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41153,205,246 - 53,206,745 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1151,561,650 - 51,563,149 (-)NCBICelera
RGSC_v3.11153,262,834 - 53,264,334 (-)NCBI
Cytogenetic Map11q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. A family of tissue-specific resistin-like molecules. Steppan CM, etal., Proc Natl Acad Sci U S A 2001 Jan 16;98(2):502-6.
6. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:19136574   PMID:21426641   PMID:24040449   PMID:27492801   PMID:28348014  


Genomics

Variants

.
Variants in Retnla
4 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:61
Count of miRNA genes:51
Interacting mature miRNAs:54
Transcripts:ENSRNOT00000002676
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)112252474682951192Rat
1598841Memor7Memory QTL 7exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)113330600878306008Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)114644316891443168Rat
1598811Bp291Blood pressure QTL 2911.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113330600878306008Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)115892833699753367Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)113674945981749459Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113294306789836615Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)113191546976915469Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)113642841681428416Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)113461876079618760Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)115441539196071021Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)115893182292356038Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)115775483796071021Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112019354996351019Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)113674945981749459Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)113674945981749459Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)113674945981749459Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)115107102196071021Rat
631510Spl2Serum phospholipid level QTL 24.1blood phospholipid amount (VT:0006084)serum phospholipid level (CMO:0001171)112755668572556685Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
11 2 2 14 13 29 3 25 3 3 47 29 11 3 12 26

Sequence


Ensembl Acc Id: ENSRNOT00000002676   ⟹   ENSRNOP00000002676
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1165,424,687 - 65,426,398 (-)Ensembl
mRatBN7.2 Ensembl1151,961,730 - 51,963,441 (-)Ensembl
Rnor_6.0 Ensembl1154,543,731 - 54,545,230 (-)Ensembl
RefSeq Acc Id: NM_053333   ⟹   NP_445785
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81165,424,687 - 65,426,186 (-)NCBI
mRatBN7.21151,961,730 - 51,963,229 (-)NCBI
Rnor_6.01154,543,731 - 54,545,230 (-)NCBI
Rnor_5.01157,705,929 - 57,707,676 (-)NCBI
RGSC_v3.41153,205,246 - 53,206,745 (-)RGD
Celera1151,561,650 - 51,563,149 (-)RGD
Sequence:
RefSeq Acc Id: XM_006248283   ⟹   XP_006248345
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81165,424,685 - 65,426,484 (-)NCBI
mRatBN7.21151,961,726 - 51,963,527 (-)NCBI
Rnor_6.01154,543,727 - 54,545,493 (-)NCBI
Rnor_5.01157,705,929 - 57,707,676 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_445785 (Get FASTA)   NCBI Sequence Viewer  
  XP_006248345 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAG59828 (Get FASTA)   NCBI Sequence Viewer  
  EDM11109 (Get FASTA)   NCBI Sequence Viewer  
  Q99P85 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_445785   ⟸   NM_053333
- Peptide Label: precursor
- UniProtKB: Q99P85 (UniProtKB/Swiss-Prot),   A6IQV6 (UniProtKB/TrEMBL),   A0A8L2PZV1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248345   ⟸   XM_006248283
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000002676   ⟸   ENSRNOT00000002676

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q99P85-F1-model_v2 AlphaFold Q99P85 1-111 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68349 AgrOrtholog
BioCyc Gene G2FUF-21422 BioCyc
Ensembl Genes ENSRNOG00000001955 Ensembl
Gene3D-CATH 2.60.40.4230 UniProtKB/Swiss-Prot
InterPro Resistin UniProtKB/Swiss-Prot
  Resistin-like_sf UniProtKB/Swiss-Prot
KEGG Report rno:81712 UniProtKB/Swiss-Prot
NCBI Gene 81712 ENTREZGENE
PANTHER PTHR21101 UniProtKB/Swiss-Prot
  RESISTIN-LIKE ALPHA UniProtKB/Swiss-Prot
Pfam Resistin UniProtKB/Swiss-Prot
PhenoGen Retnla PhenoGen
RatGTEx ENSRNOG00000001955 RatGTEx
Superfamily-SCOP SSF111423 UniProtKB/Swiss-Prot
TIGR TC232551
UniProt A0A8L2PZV1 ENTREZGENE, UniProtKB/TrEMBL
  A6IQV6 ENTREZGENE, UniProtKB/TrEMBL
  Q99P85 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Retnla  resistin like alpha      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_homology has similarity to resistin, a hormone that is secreted by fat cells 68279