Mrgprx3 (MAS related GPR family member X3) - Rat Genome Database

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Gene: Mrgprx3 (MAS related GPR family member X3) Rattus norvegicus
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Symbol: Mrgprx3
Name: MAS related GPR family member X3
RGD ID: 632282
Description: Predicted to enable GTP binding activity; neuropeptide receptor activity; and pigment binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within response to cyclosporin A; response to peptide; and sensory perception of itch. Predicted to be active in plasma membrane. Orthologous to human MRGPRX3 (MAS related GPR family member X3); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: adenine receptor; G-protein coupled receptor; Mas-related G protein-coupled receptor g1; mas-related G-protein coupled receptor member A; MAS-related G-protein coupled receptor, member A; Mas-related gene A; MAS-related GPR, member X3; MGC108580; Mgrg1; MrgA; Mrga10; Mrgpra; nuclear receptor MrgA10 RF-amide G protein-coupled receptor; rc 56.1.3
RGD Orthologs
Human
Mouse
Bonobo
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81106,857,685 - 106,883,199 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1106,857,687 - 106,883,145 (-)EnsemblGRCr8
mRatBN7.2197,720,377 - 97,746,953 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl197,721,436 - 97,746,900 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1103,111,717 - 103,137,094 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01111,583,684 - 111,609,067 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01104,869,746 - 104,895,178 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01103,298,172 - 103,323,476 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1103,298,174 - 103,323,476 (-)Ensemblrn6Rnor6.0
Rnor_5.01104,361,322 - 104,387,707 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4197,729,771 - 97,757,150 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera191,966,982 - 91,992,534 (-)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA,ISO)
plasma membrane  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Characterization of an orphan G protein-coupled receptor localized in the dorsal root ganglia reveals adenine as a signaling molecule. Bender E, etal., Proc Natl Acad Sci U S A 2002 Jun 25;99(13):8573-8.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11551509   PMID:12477932   PMID:12909716   PMID:15604413   PMID:17728165   PMID:24583173   PMID:35770633  


Genomics

Comparative Map Data
Mrgprx3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81106,857,685 - 106,883,199 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1106,857,687 - 106,883,145 (-)EnsemblGRCr8
mRatBN7.2197,720,377 - 97,746,953 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl197,721,436 - 97,746,900 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1103,111,717 - 103,137,094 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01111,583,684 - 111,609,067 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01104,869,746 - 104,895,178 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01103,298,172 - 103,323,476 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1103,298,174 - 103,323,476 (-)Ensemblrn6Rnor6.0
Rnor_5.01104,361,322 - 104,387,707 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4197,729,771 - 97,757,150 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera191,966,982 - 91,992,534 (-)NCBICelera
Cytogenetic Map1q22NCBI
MRGPRX3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381118,120,955 - 18,138,488 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1118,120,955 - 18,138,488 (+)Ensemblhg38GRCh38
GRCh371118,142,502 - 18,160,035 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361118,099,078 - 18,116,603 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1118,274,798 - 18,292,323 (+)NCBICelera
Cytogenetic Map11p15.1NCBI
HuRef1117,825,399 - 17,842,923 (+)NCBIHuRef
CHM1_11118,142,072 - 18,159,631 (+)NCBICHM1_1
T2T-CHM13v2.01118,216,477 - 18,233,987 (+)NCBIT2T-CHM13v2.0
Mrgpra1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39746,984,623 - 47,003,988 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl746,984,623 - 47,003,988 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38747,334,875 - 47,354,240 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl747,334,875 - 47,354,240 (-)Ensemblmm10GRCm38
MGSCv37754,590,245 - 54,609,610 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36747,202,897 - 47,222,262 (-)NCBIMGSCv36mm8
Celera742,815,403 - 42,834,734 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map730.8NCBI
MRGPRX3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2920,462,269 - 20,468,183 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11120,422,671 - 20,428,585 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01118,183,247 - 18,189,153 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11117,865,453 - 17,871,337 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1117,870,060 - 17,871,028 (+)EnsemblpanPan2panpan1.1

Variants

.
Variants in Mrgprx3
101 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:46
Count of miRNA genes:44
Interacting mature miRNAs:46
Transcripts:ENSRNOT00000019051
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)192963855109494029Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1101228864146228864Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1102359314153680016Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)192683681137683681Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)192683681137683681Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)197582336142582336Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1101594089146594089Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1100345976145345976Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)196717367160111531Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 3 42 133 78 77 46 70 46 6 262 135 9 106 64 78 31 9 9

Sequence


Ensembl Acc Id: ENSRNOT00000019051   ⟹   ENSRNOP00000019051
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1106,857,687 - 106,883,145 (-)Ensembl
mRatBN7.2 Ensembl197,721,436 - 97,746,900 (-)Ensembl
Rnor_6.0 Ensembl1103,298,174 - 103,323,476 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000165152   ⟹   ENSRNOP00000107586
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1106,857,768 - 106,875,242 (-)Ensembl
RefSeq Acc Id: NM_145787   ⟹   NP_665730
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81106,857,685 - 106,883,145 (-)NCBI
mRatBN7.2197,721,434 - 97,746,900 (-)NCBI
Rnor_6.01103,298,172 - 103,323,476 (-)NCBI
Rnor_5.01104,361,322 - 104,387,707 (-)NCBI
RGSC_v3.4197,729,771 - 97,757,150 (-)RGD
Celera191,966,982 - 91,992,534 (-)RGD
Sequence:
RefSeq Acc Id: XM_039101537   ⟹   XP_038957465
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81106,857,685 - 106,883,199 (-)NCBI
mRatBN7.2197,720,377 - 97,746,953 (-)NCBI
RefSeq Acc Id: NP_665730   ⟸   NM_145787
- UniProtKB: Q91YB7 (UniProtKB/Swiss-Prot),   Q5FVU1 (UniProtKB/Swiss-Prot),   Q7TN49 (UniProtKB/Swiss-Prot),   A0A0H2UHL4 (UniProtKB/TrEMBL),   W8W3K1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000019051   ⟸   ENSRNOT00000019051
RefSeq Acc Id: XP_038957465   ⟸   XM_039101537
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000107586   ⟸   ENSRNOT00000165152
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q7TN49-F1-model_v2 AlphaFold Q7TN49 1-304 view protein structure
AF-A0A0H2UHL4-F1-model_v2 AlphaFold A0A0H2UHL4 1-331 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:632282 AgrOrtholog
BioCyc Gene G2FUF-59591 BioCyc
Ensembl Genes ENSRNOG00000014227 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000019051 ENTREZGENE
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7321342 IMAGE-MGC_LOAD
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  MRGPCRA UniProtKB/Swiss-Prot
  MRGPCRFAMILY UniProtKB/Swiss-Prot
KEGG Report rno:252960 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108580 IMAGE-MGC_LOAD
NCBI Gene 252960 ENTREZGENE
PANTHER PTHR11334 UniProtKB/Swiss-Prot
  PTHR11334:SF33 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Mrgprx3 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot
  MRGPCRA UniProtKB/Swiss-Prot
  MRGPCRFAMILY UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000014227 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt A0A0H2UHL4 ENTREZGENE, UniProtKB/TrEMBL
  MRGRA_RAT UniProtKB/Swiss-Prot
  Q5FVU1 ENTREZGENE
  Q7TN49 ENTREZGENE
  Q91YB7 ENTREZGENE
  W8W3K1 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q5FVU1 UniProtKB/Swiss-Prot
  Q91YB7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-02 Mrgprx3  MAS related GPR family member X3  Mrgprx3  MAS-related GPR, member X3  Name changed 629549 APPROVED
2010-04-23 Mrgprx3  MAS-related GPR, member X3  Mrga10  nuclear receptor MrgA10 RF-amide G protein-coupled receptor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-09-30 Mrga10        Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in brain cortex with highest expression level in the dorsal root ganglia and also moderately expressed in lung, hypothalamus, peripheral blood leukocytes, and ovaries 625441
gene_function binds adenine 625441
gene_process may have a role in nociception based on observed expression pattern 625441
gene_product belongs to the family of MAS-related gene (Mrg) receptors 625441