Fzd5 (frizzled class receptor 5) - Rat Genome Database

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Gene: Fzd5 (frizzled class receptor 5) Rattus norvegicus
Analyze
Symbol: Fzd5
Name: frizzled class receptor 5
RGD ID: 631406
Description: Enables Wnt-protein binding activity. Involved in presynapse assembly. Is active in glutamatergic synapse. Orthologous to human FZD5 (frizzled class receptor 5); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; Wnt signaling, non-canonical pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: frizzled family receptor 5; frizzled homolog 5; frizzled homolog 5 (Drosophila); frizzled-5; fz-5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8973,606,860 - 73,614,039 (-)NCBIGRCr8
mRatBN7.2966,113,096 - 66,120,276 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl966,113,112 - 66,121,457 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx974,637,916 - 74,639,673 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0979,767,933 - 79,769,690 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0978,172,390 - 78,174,147 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0971,443,784 - 71,445,541 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl971,443,588 - 71,445,739 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0971,120,245 - 71,122,004 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4963,386,990 - 63,388,747 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1963,533,971 - 63,535,729 (-)NCBI
Celera963,522,584 - 63,524,341 (-)NCBICelera
Cytogenetic Map9q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
acetamide  (EXP)
adenosine  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
arsenous acid  (ISO)
atrazine  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
chlorpyrifos  (EXP,ISO)
cobalt dichloride  (ISO)
cordycepin  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP,ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
diclofenac  (ISO)
diethylstilbestrol  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
etacrynic acid  (ISO)
Ethylenethiourea  (EXP,ISO)
etoposide  (ISO)
folic acid  (ISO)
genistein  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
isotretinoin  (ISO)
leflunomide  (ISO)
methyl methanesulfonate  (ISO)
nickel atom  (EXP)
niclosamide  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylmercury acetate  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
testosterone  (ISO)
Tetrachlorobisphenol A  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA,ISO)
anterior/posterior axis specification, embryo  (IEA,ISO)
apoptotic process involved in morphogenesis  (IEA,ISO)
biological_process  (ND)
branching involved in labyrinthine layer morphogenesis  (IEA,ISO)
canonical Wnt signaling pathway  (IBA,IEA,ISO,ISS)
cellular response to molecule of bacterial origin  (IEA,ISO)
chorionic trophoblast cell differentiation  (IEA,ISO)
embryonic axis specification  (ISO)
embryonic camera-type eye development  (ISO)
embryonic camera-type eye morphogenesis  (IEA,ISO)
eye development  (ISO,ISS)
G protein-coupled receptor signaling pathway  (IEA)
glandular epithelial cell maturation  (IEA,ISO)
intestinal epithelial cell maturation  (IEA,ISO)
labyrinthine layer blood vessel development  (IEA,ISO)
negative regulation of cell population proliferation  (IEA,ISO)
non-canonical Wnt signaling pathway  (IBA,IEA,ISO,ISS)
positive regulation of interleukin-1 beta production  (IEA,ISO)
positive regulation of JUN kinase activity  (ISO)
positive regulation of protein targeting to mitochondrion  (ISO)
positive regulation of T cell cytokine production  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of tumor necrosis factor production  (IEA,ISO)
positive regulation of type II interferon production  (IEA,ISO)
post-embryonic camera-type eye development  (IEA,ISO)
presynapse assembly  (EXP,IDA,IMP)
regulation of bicellular tight junction assembly  (IEA,ISO)
regulation of chorionic trophoblast cell proliferation  (IEA,ISO)
regulation of mitophagy  (ISO)
Spemann organizer formation  (IEA,ISO)
syncytiotrophoblast cell differentiation involved in labyrinthine layer development  (IEA,ISO)
T cell differentiation in thymus  (IEA,ISO)
vasculature development  (ISO)
Wnt signaling pathway  (ISO)

Cellular Component
axon  (IEA)
bicellular tight junction  (IEA,ISO)
cell surface  (IEA,ISO)
dendrite  (IEA)
early endosome  (IEA,ISO)
glutamatergic synapse  (EXP,IDA,IEP,IMP)
Golgi apparatus  (IEA,ISO)
Golgi membrane  (IEA)
perikaryon  (IEA)
perinuclear region of cytoplasm  (IEA,ISO)
plasma membrane  (IBA,IEA,ISO,ISS)
synapse  (IDA,IEP)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Functional characterization of WNT7A signaling in PC12 cells: interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins. Caricasole A, etal., J Biol Chem 2003 Sep 26;278(39):37024-31.
2. Secreted frizzled-related protein 4 regulates two Wnt7a signaling pathways and inhibits proliferation in endometrial cancer cells. Carmon KS and Loose DS, Mol Cancer Res. 2008 Jun;6(6):1017-28.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
11. The Wnt Homepage Roel Nusse - Howard Hughes Medical Institute and the Department of Developmental Biology at Stanford University, California, USA
12. Frizzled-5, a receptor for the synaptic organizer Wnt7a, regulates activity-mediated synaptogenesis. Sahores M, etal., Development. 2010 Jul;137(13):2215-25. doi: 10.1242/dev.046722.
Additional References at PubMed
PMID:9054360   PMID:10906785   PMID:11029007   PMID:11092808   PMID:11265645   PMID:11520064   PMID:12121999   PMID:12490564   PMID:15195140   PMID:15459103   PMID:15778706   PMID:16601243  
PMID:16890161   PMID:18174455   PMID:18234671   PMID:18606138   PMID:18791178   PMID:18832390   PMID:19643732   PMID:21857966   PMID:22575959   PMID:23610556   PMID:24080158   PMID:24205342  
PMID:24912190   PMID:28733458   PMID:29477872  


Genomics

Comparative Map Data
Fzd5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8973,606,860 - 73,614,039 (-)NCBIGRCr8
mRatBN7.2966,113,096 - 66,120,276 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl966,113,112 - 66,121,457 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx974,637,916 - 74,639,673 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0979,767,933 - 79,769,690 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0978,172,390 - 78,174,147 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0971,443,784 - 71,445,541 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl971,443,588 - 71,445,739 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0971,120,245 - 71,122,004 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4963,386,990 - 63,388,747 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1963,533,971 - 63,535,729 (-)NCBI
Celera963,522,584 - 63,524,341 (-)NCBICelera
Cytogenetic Map9q32NCBI
FZD5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382207,762,598 - 207,769,906 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2207,762,598 - 207,769,906 (-)EnsemblGRCh38hg38GRCh38
GRCh372208,627,322 - 208,634,630 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362208,335,555 - 208,342,388 (-)NCBINCBI36Build 36hg18NCBI36
Build 342208,456,793 - 208,459,624NCBI
Celera2202,389,191 - 202,396,022 (-)NCBICelera
Cytogenetic Map2q33.3NCBI
HuRef2200,469,499 - 200,476,330 (-)NCBIHuRef
CHM1_12208,633,224 - 208,640,055 (-)NCBICHM1_1
T2T-CHM13v2.02208,236,810 - 208,244,116 (-)NCBIT2T-CHM13v2.0
Fzd5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39164,769,717 - 64,776,907 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl164,769,717 - 64,776,910 (-)EnsemblGRCm39 Ensembl
GRCm38164,730,558 - 64,737,750 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl164,730,558 - 64,737,751 (-)EnsemblGRCm38mm10GRCm38
MGSCv37164,777,132 - 64,784,324 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36164,668,689 - 64,672,026 (-)NCBIMGSCv36mm8
Celera165,232,287 - 65,239,483 (-)NCBICelera
Cytogenetic Map1C2NCBI
cM Map132.74NCBI
Fzd5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554577,282,403 - 7,288,918 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554577,282,403 - 7,288,918 (+)NCBIChiLan1.0ChiLan1.0
FZD5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213110,381,340 - 110,384,119 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B110,396,317 - 110,398,448 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B95,003,246 - 95,010,577 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B213,128,615 - 213,135,569 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B213,133,017 - 213,134,774 (-)Ensemblpanpan1.1panPan2
FZD5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13716,123,788 - 16,126,634 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3716,123,798 - 16,125,567 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3717,009,102 - 17,009,792 (-)NCBIDog10K_Boxer_Tasha
Dog10K_Boxer_Tasha3717,007,183 - 17,008,981 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03716,058,764 - 16,060,560 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.03716,060,681 - 16,061,372 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3716,058,764 - 16,060,527 (-)EnsemblROS_Cfam_1.0 Ensembl
ROS_Cfam_1.0 Ensembl3716,058,764 - 16,060,527 (-)NCBIROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13716,006,509 - 16,007,199 (-)NCBIUMICH_Zoey_3.1
UMICH_Zoey_3.13716,004,586 - 16,006,388 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03715,977,646 - 15,979,448 (-)NCBIUNSW_CanFamBas_1.0
UNSW_CanFamBas_1.03715,979,569 - 15,980,242 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03715,988,871 - 15,989,561 (-)NCBIUU_Cfam_GSD_1.0
UU_Cfam_GSD_1.03715,986,945 - 15,988,741 (-)NCBIUU_Cfam_GSD_1.0
Fzd5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303164,270,066 - 164,280,869 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366313,911,693 - 3,915,560 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366313,909,046 - 3,915,939 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FZD5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15110,914,009 - 110,921,353 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115110,913,990 - 110,921,388 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215122,425,111 - 122,429,729 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FZD5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11093,545,792 - 93,553,092 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1093,550,189 - 93,551,946 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040105,817,194 - 105,824,526 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fzd5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247658,222,237 - 8,228,050 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247658,222,193 - 8,228,530 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fzd5
23 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:53
Count of miRNA genes:50
Interacting mature miRNAs:53
Transcripts:ENSRNOT00000019698
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92207120067071200Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
1598849Memor17Memory QTL 172.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)94996854671098346Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96207227596470995Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95584784177026453Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94249534379271511Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)93696235977814038Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94019418885194188Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)95662771378595166Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94019418885194188Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)92746863972468639Rat

Markers in Region
Fzd5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2966,119,076 - 66,120,205 (+)MAPPERmRatBN7.2
Rnor_6.0971,445,491 - 71,446,619NCBIRnor6.0
Rnor_5.0971,119,093 - 71,120,297UniSTSRnor5.0
RGSC_v3.4963,388,697 - 63,389,826UniSTSRGSC3.4
Celera963,524,291 - 63,525,400UniSTS
Cytogenetic Map9q32UniSTS
Fzd5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2966,117,859 - 66,118,056 (+)MAPPERmRatBN7.2
Rnor_6.0971,444,274 - 71,444,470NCBIRnor6.0
Rnor_5.0971,121,318 - 71,121,514UniSTSRnor5.0
RGSC_v3.4963,387,480 - 63,387,676UniSTSRGSC3.4
Celera963,523,074 - 63,523,270UniSTS
Cytogenetic Map9q32UniSTS
Fzd5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2966,118,143 - 66,118,310 (+)MAPPERmRatBN7.2
Rnor_6.0971,444,558 - 71,444,724NCBIRnor6.0
Rnor_5.0971,121,064 - 71,121,230UniSTSRnor5.0
RGSC_v3.4963,387,764 - 63,387,930UniSTSRGSC3.4
Celera963,523,358 - 63,523,524UniSTS
Cytogenetic Map9q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 10 49 113 91 90 59 25 59 6 217 96 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000019698   ⟹   ENSRNOP00000070441
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl966,113,112 - 66,121,457 (-)Ensembl
Rnor_6.0 Ensembl971,443,588 - 71,445,739 (-)Ensembl
RefSeq Acc Id: NM_173838   ⟹   NP_776210
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8973,606,860 - 73,614,039 (-)NCBI
mRatBN7.2966,113,096 - 66,120,276 (-)NCBI
Rnor_6.0971,443,784 - 71,445,541 (-)NCBI
Rnor_5.0971,120,245 - 71,122,004 (+)NCBI
RGSC_v3.4963,386,990 - 63,388,747 (-)RGD
Celera963,522,584 - 63,524,341 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_776210 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAC53980 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000070441.1
GenBank Protein Q8CHL0 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_776210   ⟸   NM_173838
- Peptide Label: precursor
- UniProtKB: A0A0G2JXX8 (UniProtKB/TrEMBL),   A6IPI5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070441   ⟸   ENSRNOT00000019698
Protein Domains
FZ   G-protein coupled receptors family 2 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8CHL0-F1-model_v2 AlphaFold Q8CHL0 1-585 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:631406 AgrOrtholog
BioCyc Gene G2FUF-27314 BioCyc
Ensembl Genes ENSRNOG00000014678 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019698.5 UniProtKB/TrEMBL
Gene3D-CATH 1.10.2000.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Frizzled/SFRP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Frizzled/Smoothened_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Frizzled_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Frizzled_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FZ5_CRD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:317674 UniProtKB/Swiss-Prot
NCBI Gene 317674 ENTREZGENE
PANTHER FRIZZLED-5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11309 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Frizzled UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF01392 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fzd5 PhenoGen
PRINTS FRIZZLED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F2_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50038 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014678 RatGTEx
SMART FRI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Frizzled UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF63501 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JXX8 ENTREZGENE, UniProtKB/TrEMBL
  A6IPI5 ENTREZGENE, UniProtKB/TrEMBL
  FZD5_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-02-06 Fzd5  frizzled class receptor 5  Fzd5  frizzled family receptor 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-02 Fzd5  frizzled family receptor 5  Fzd5  frizzled homolog 5 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-11 Fzd5  frizzled homolog 5 (Drosophila)      Symbol and Name status set to approved 625702 APPROVED