Mtus1 (microtubule associated scaffold protein 1) - Rat Genome Database

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Gene: Mtus1 (microtubule associated scaffold protein 1) Rattus norvegicus
Analyze
Symbol: Mtus1
Name: microtubule associated scaffold protein 1
RGD ID: 631381
Description: Predicted to enable microtubule binding activity. Involved in cellular response to angiotensin. Predicted to be located in Golgi apparatus; mitochondrion; and plasma membrane. Predicted to be active in nucleus. Predicted to colocalize with cytoplasm. Orthologous to human MTUS1 (microtubule associated scaffold protein 1); PARTICIPATES IN angiotensin II signaling pathway via AT2 receptor; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: angiotensin-II type 2 receptor-interacting protein; Atip3b; ATIP4; growth factor inhibitor; LOC100911065; microtubule associated tumor suppressor 1; microtubule-associated tumor suppressor 1 homolog; mitochondrial tumor suppressor 1; mitochondrial tumor suppressor 1 homolog; mitochondrial tumor suppressor gene 1; Mtsg1; transcription factor MTSG1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81657,905,991 - 58,051,466 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1657,906,128 - 58,051,474 (+)EnsemblGRCr8
mRatBN7.21651,202,497 - 51,347,794 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1651,253,562 - 51,347,793 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1656,523,752 - 56,667,067 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01659,921,798 - 60,066,935 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01655,157,687 - 55,301,013 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01654,240,892 - 54,386,131 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1654,291,251 - 54,386,129 (+)Ensemblrn6Rnor6.0
Rnor_5.01653,953,029 - 54,098,281 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41654,611,502 - 54,664,075 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1649,189,574 - 49,242,085 (+)NCBICelera
RGSC_v3.11654,611,808 - 54,661,662 (+)NCBI
Cytogenetic Map16q12.1NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
astemizole  (EXP)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
celecoxib  (ISO)
CGP 52608  (ISO)
chloroprene  (EXP)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cytarabine  (ISO)
dexamethasone  (EXP)
diarsenic trioxide  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP,ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
entinostat  (ISO)
ethanol  (ISO)
etoposide  (ISO)
FR900359  (ISO)
fructose  (ISO)
furan  (EXP)
gentamycin  (EXP)
glycidol  (EXP)
hydroquinone  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
methapyrilene  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
PD123319  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenethyl caffeate  (EXP)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
progesterone  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
senecionine  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
testosterone  (EXP)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP,ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
valsartan  (EXP)
vinclozolin  (EXP)
vorinostat  (ISO)
zinc atom  (EXP,ISO)
zinc sulfate  (EXP)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,ISO)
Golgi apparatus  (IEA)
microtubule cytoskeleton  (IEA,ISO)
mitochondrion  (IEA)
nucleolus  (IEA,ISO)
nucleus  (IBA,IEA)
plasma membrane  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Down-regulation of tumor suppressor MTUS1/ATIP is associated with enhanced proliferation, poor differentiation and poor prognosis in oral tongue squamous cell carcinoma. Ding X, etal., Mol Oncol. 2012 Feb;6(1):73-80. doi: 10.1016/j.molonc.2011.11.002. Epub 2011 Nov 18.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Angiotensin II-induced neural differentiation via angiotensin II type 2 (AT2) receptor-MMS2 cascade involving interaction between AT2 receptor-interacting protein and Src homology 2 domain-containing protein-tyrosine phosphatase 1. Li JM, etal., Mol Endocrinol. 2007 Feb;21(2):499-511. doi: 10.1210/me.2006-0005. Epub 2006 Oct 26.
4. Five genes from chromosomal band 8p22 are significantly down-regulated in ovarian carcinoma: N33 and EFA6R have a potential impact on overall survival. Pils D, etal., Cancer. 2005 Dec 1;104(11):2417-29.
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
8. An ATIPical family of angiotensin II AT2 receptor-interacting proteins. Rodrigues-Ferreira S and Nahmias C, Trends Endocrinol Metab. 2010 Nov;21(11):684-90.
9. 8p22 MTUS1 gene product ATIP3 is a novel anti-mitotic protein underexpressed in invasive breast carcinoma of poor prognosis. Rodrigues-Ferreira S, etal., PLoS One. 2009 Oct 1;4(10):e7239.
10. Identification of a new tumor suppressor gene located at chromosome 8p21.3-22. Seibold S, etal., FASEB J 2003 Jun;17(9):1180-2.
11. Loss of MTUS1 Expression Is Associated With Poor Prognosis in Patients With Gallbladder Carcinoma. Sim J, etal., In Vivo. 2020 Jan-Feb;34(1):125-132. doi: 10.21873/invivo.11753.
12. Regulation of transport of the angiotensin AT2 receptor by a novel membrane-associated Golgi protein. Wruck CJ, etal., Arterioscler Thromb Vasc Biol. 2005 Jan;25(1):57-64. Epub 2004 Nov 11.
13. MTUS1/ATIP3a down-regulation is associated with enhanced migration, invasion and poor prognosis in salivary adenoid cystic carcinoma. Zhao T, etal., BMC Cancer. 2015 Mar 31;15:203. doi: 10.1186/s12885-015-1209-x.
14. Down-regulation of MTUS1 in human colon tumors. Zuern C, etal., Oncol Rep. 2010 Jan;23(1):183-9.
Additional References at PubMed
PMID:12477932   PMID:21389599   PMID:22200760   PMID:22664934   PMID:23559668   PMID:23565185  


Genomics

Comparative Map Data
Mtus1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81657,905,991 - 58,051,466 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1657,906,128 - 58,051,474 (+)EnsemblGRCr8
mRatBN7.21651,202,497 - 51,347,794 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1651,253,562 - 51,347,793 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1656,523,752 - 56,667,067 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01659,921,798 - 60,066,935 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01655,157,687 - 55,301,013 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01654,240,892 - 54,386,131 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1654,291,251 - 54,386,129 (+)Ensemblrn6Rnor6.0
Rnor_5.01653,953,029 - 54,098,281 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41654,611,502 - 54,664,075 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1649,189,574 - 49,242,085 (+)NCBICelera
RGSC_v3.11654,611,808 - 54,661,662 (+)NCBI
Cytogenetic Map16q12.1NCBI
MTUS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38817,643,802 - 17,801,521 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl817,643,794 - 17,801,545 (-)Ensemblhg38GRCh38
GRCh37817,501,311 - 17,659,030 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36817,545,583 - 17,702,666 (-)NCBIBuild 36Build 36hg18NCBI36
Celera816,466,963 - 16,624,476 (-)NCBICelera
Cytogenetic Map8p22NCBI
HuRef816,045,792 - 16,202,703 (-)NCBIHuRef
CHM1_1817,702,752 - 17,859,884 (-)NCBICHM1_1
T2T-CHM13v2.0817,910,954 - 18,069,106 (-)NCBIT2T-CHM13v2.0
Mtus1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39841,443,949 - 41,587,318 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl841,443,951 - 41,586,763 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38840,990,912 - 41,133,983 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl840,990,914 - 41,133,726 (-)Ensemblmm10GRCm38
MGSCv37842,076,266 - 42,219,080 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36842,483,630 - 42,583,725 (-)NCBIMGSCv36mm8
Celera843,620,541 - 43,768,183 (-)NCBICelera
Cytogenetic Map8A4NCBI
cM Map823.89NCBI
Mtus1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555521,924,922 - 2,040,653 (+)Ensembl
ChiLan1.0NW_0049555521,867,477 - 2,040,659 (+)NCBIChiLan1.0ChiLan1.0
MTUS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2736,118,477 - 36,230,400 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1811,844,568 - 12,002,800 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0816,863,307 - 17,020,684 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1813,815,404 - 13,973,111 (-)NCBIPanPan1.1PanPan1.1panPan2
MTUS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11640,955,619 - 41,118,601 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1640,957,574 - 41,068,967 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1641,462,449 - 41,627,707 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01643,011,175 - 43,176,981 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1643,009,798 - 43,177,320 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11641,104,451 - 41,220,245 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01641,648,152 - 41,813,671 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01641,842,816 - 42,008,328 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mtus1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494338,219,444 - 38,364,919 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936614240,113 - 387,730 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936614242,710 - 387,541 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MTUS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl175,329,750 - 5,507,119 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1175,331,668 - 5,507,212 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2175,869,064 - 5,914,352 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MTUS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1815,739,220 - 15,899,834 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl815,741,294 - 15,853,293 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605226,376,799 - 26,538,425 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mtus1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476921,399,747 - 21,617,753 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Mtus1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11346,426,325 - 46,571,602 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Mtus1
995 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1003
Count of miRNA genes:286
Interacting mature miRNAs:378
Transcripts:ENSRNOT00000037685, ENSRNOT00000047314
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)164445512389455123Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)163692878281928782Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)164199206486992064Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16423421266955197Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162846870173468701Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164909919691442908Rat
1357403Slep4Serum leptin concentration QTL 43.91blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)163236104377361043Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)163105803976058039Rat
1298529Arunc1Aerobic running capacity QTL 14exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)163439829479398294Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683908666195506Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683908666195506Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)163188527176885271Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)164445512389455123Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683908666195506Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161773081872536785Rat
2301406Kidm39Kidney mass QTL 390.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)161590580260905802Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683908666195506Rat

Markers in Region
BE112380  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21651,346,957 - 51,347,104 (+)MAPPERmRatBN7.2
Rnor_6.01654,385,298 - 54,385,444NCBIRnor6.0
Rnor_5.01654,097,448 - 54,097,594UniSTSRnor5.0
RGSC_v3.41654,663,242 - 54,663,388UniSTSRGSC3.4
Celera1649,241,252 - 49,241,398UniSTS
RH 3.4 Map16522.6UniSTS
Cytogenetic Map16q12.1UniSTS
AV013190  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21651,348,094 - 51,348,177 (+)MAPPERmRatBN7.2
Rnor_6.01654,386,435 - 54,386,517NCBIRnor6.0
Rnor_5.01654,098,585 - 54,098,667UniSTSRnor5.0
RGSC_v3.41654,664,379 - 54,664,461UniSTSRGSC3.4
Celera1649,242,389 - 49,242,471UniSTS
Cytogenetic Map16q12.1UniSTS
AI481402  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21651,345,509 - 51,345,597 (+)MAPPERmRatBN7.2
Rnor_6.01654,383,850 - 54,383,937NCBIRnor6.0
Rnor_5.01654,096,000 - 54,096,087UniSTSRnor5.0
RGSC_v3.41654,661,794 - 54,661,881UniSTSRGSC3.4
Celera1649,239,804 - 49,239,891UniSTS
Cytogenetic Map16q12.1UniSTS
RH142940  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21651,297,859 - 51,297,980 (+)MAPPERmRatBN7.2
Rnor_6.01654,335,478 - 54,335,598NCBIRnor6.0
Rnor_5.01654,047,608 - 54,047,728UniSTSRnor5.0
RGSC_v3.41654,614,125 - 54,614,245UniSTSRGSC3.4
RGSC_v3.41654,614,125 - 54,615,816UniSTSRGSC3.4
Celera1649,192,196 - 49,192,316UniSTS
Celera1649,192,196 - 49,193,887UniSTS
RH 3.4 Map16522.1UniSTS
Cytogenetic Map16q12.1UniSTS
RH144607  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21651,304,227 - 51,304,411 (+)MAPPERmRatBN7.2
Rnor_6.01654,342,202 - 54,342,385NCBIRnor6.0
Rnor_5.01654,054,332 - 54,054,515UniSTSRnor5.0
RGSC_v3.41654,620,495 - 54,620,678UniSTSRGSC3.4
Celera1649,198,566 - 49,198,749UniSTS
RH 3.4 Map16519.01UniSTS
Cytogenetic Map16q12.1UniSTS
BE115024  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81658,049,403 - 58,049,581 (+)Marker Load Pipeline
mRatBN7.21651,345,911 - 51,346,089 (+)MAPPERmRatBN7.2
Rnor_6.01654,384,252 - 54,384,429NCBIRnor6.0
Rnor_5.01654,096,402 - 54,096,579UniSTSRnor5.0
RGSC_v3.41654,662,196 - 54,662,373UniSTSRGSC3.4
Celera1649,240,206 - 49,240,383UniSTS
RH 3.4 Map16522.9UniSTS
Cytogenetic Map16q12.1UniSTS
RH141185  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21651,347,421 - 51,347,641 (+)MAPPERmRatBN7.2
Rnor_6.01654,385,762 - 54,385,981NCBIRnor6.0
Rnor_5.01654,097,912 - 54,098,131UniSTSRnor5.0
RGSC_v3.41654,663,706 - 54,663,925UniSTSRGSC3.4
Celera1649,241,716 - 49,241,935UniSTS
RH 3.4 Map16522.9UniSTS
Cytogenetic Map16q12.1UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001395000 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_178093 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275428 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010058295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB190507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY208915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY208916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC072537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC166591 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU417559 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU245886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000037685   ⟹   ENSRNOP00000030995
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1657,998,632 - 58,051,474 (+)Ensembl
mRatBN7.2 Ensembl1651,295,188 - 51,347,793 (+)Ensembl
Rnor_6.0 Ensembl1654,332,660 - 54,386,129 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000047314   ⟹   ENSRNOP00000042990
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1657,998,765 - 58,051,426 (+)Ensembl
mRatBN7.2 Ensembl1651,296,102 - 51,347,793 (+)Ensembl
Rnor_6.0 Ensembl1654,358,471 - 54,383,643 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000079006   ⟹   ENSRNOP00000069962
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1657,906,128 - 58,051,473 (+)Ensembl
mRatBN7.2 Ensembl1651,253,562 - 51,347,793 (+)Ensembl
Rnor_6.0 Ensembl1654,291,251 - 54,383,643 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000090266   ⟹   ENSRNOP00000070944
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1657,985,397 - 58,051,473 (+)Ensembl
mRatBN7.2 Ensembl1651,281,905 - 51,347,793 (+)Ensembl
Rnor_6.0 Ensembl1654,319,377 - 54,383,643 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102597   ⟹   ENSRNOP00000084500
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1658,023,603 - 58,051,463 (+)Ensembl
mRatBN7.2 Ensembl1651,272,197 - 51,347,793 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000153250   ⟹   ENSRNOP00000102205
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1657,975,704 - 58,049,152 (+)Ensembl
RefSeq Acc Id: NM_001395000   ⟹   NP_001381929
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81657,906,291 - 58,051,286 (+)NCBI
mRatBN7.21651,202,795 - 51,347,794 (+)NCBI
RefSeq Acc Id: NM_178093   ⟹   NP_835194
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81657,998,732 - 58,051,283 (+)NCBI
mRatBN7.21651,295,237 - 51,347,791 (+)NCBI
Rnor_6.01654,332,709 - 54,386,131 (+)NCBI
Rnor_5.01653,953,029 - 54,098,281 (+)NCBI
RGSC_v3.41654,611,502 - 54,664,075 (+)RGD
Celera1649,189,574 - 49,242,085 (+)RGD
Sequence:
RefSeq Acc Id: XM_006253181   ⟹   XP_006253243
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81657,905,991 - 58,051,466 (+)NCBI
mRatBN7.21651,202,497 - 51,346,143 (+)NCBI
Rnor_6.01654,240,892 - 54,384,483 (+)NCBI
Rnor_5.01653,953,029 - 54,098,281 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006253182   ⟹   XP_006253244
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81657,985,322 - 58,051,429 (+)NCBI
mRatBN7.21651,281,890 - 51,346,143 (+)NCBI
Rnor_6.01654,318,452 - 54,384,483 (+)NCBI
Rnor_5.01653,953,029 - 54,098,281 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600120   ⟹   XP_017455609
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81657,975,681 - 58,051,429 (+)NCBI
mRatBN7.21651,272,237 - 51,346,143 (+)NCBI
Rnor_6.01654,308,937 - 54,384,483 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600121   ⟹   XP_017455610
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81657,986,813 - 58,051,429 (+)NCBI
mRatBN7.21651,283,323 - 51,346,143 (+)NCBI
Rnor_6.01654,320,659 - 54,384,483 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600122   ⟹   XP_017455611
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81657,999,339 - 58,051,429 (+)NCBI
mRatBN7.21651,295,853 - 51,346,143 (+)NCBI
Rnor_6.01654,333,705 - 54,384,483 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039094527   ⟹   XP_038950455
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81658,022,739 - 58,051,429 (+)NCBI
mRatBN7.21651,320,110 - 51,346,143 (+)NCBI
RefSeq Acc Id: XM_063275428   ⟹   XP_063131498
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81657,937,702 - 58,051,466 (+)NCBI
RefSeq Acc Id: XR_010058295
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81657,906,250 - 58,001,554 (+)NCBI
RefSeq Acc Id: NP_835194   ⟸   NM_178093
- Peptide Label: isoform 2
- UniProtKB: Q6XUU5 (UniProtKB/Swiss-Prot),   Q80Z99 (UniProtKB/Swiss-Prot),   Q6IMY1 (UniProtKB/Swiss-Prot),   A6JPU4 (UniProtKB/TrEMBL),   I7GGY1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253243   ⟸   XM_006253181
- Peptide Label: isoform X1
- UniProtKB: B1A2U8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253244   ⟸   XM_006253182
- Peptide Label: isoform X2
- UniProtKB: D2XRB8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455609   ⟸   XM_017600120
- Peptide Label: isoform X3
- UniProtKB: A0A8I5ZY91 (UniProtKB/TrEMBL),   I7GGY1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455610   ⟸   XM_017600121
- Peptide Label: isoform X4
- UniProtKB: I7GGY1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455611   ⟸   XM_017600122
- Peptide Label: isoform X5
- UniProtKB: A0A8L2QL23 (UniProtKB/TrEMBL),   I7GGY1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069962   ⟸   ENSRNOT00000079006
Ensembl Acc Id: ENSRNOP00000070944   ⟸   ENSRNOT00000090266
Ensembl Acc Id: ENSRNOP00000042990   ⟸   ENSRNOT00000047314
Ensembl Acc Id: ENSRNOP00000030995   ⟸   ENSRNOT00000037685
RefSeq Acc Id: XP_038950455   ⟸   XM_039094527
- Peptide Label: isoform X6
Ensembl Acc Id: ENSRNOP00000084500   ⟸   ENSRNOT00000102597
RefSeq Acc Id: NP_001381929   ⟸   NM_001395000
- Peptide Label: isoform 1
- UniProtKB: B1A2U8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131498   ⟸   XM_063275428
- Peptide Label: isoform X1
- UniProtKB: B1A2U8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000102205   ⟸   ENSRNOT00000153250

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6IMY1-F1-model_v2 AlphaFold Q6IMY1 1-440 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700119
Promoter ID:EPDNEW_R10642
Type:initiation region
Name:Mtus1_1
Description:microtubule associated scaffold protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R10643  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01654,332,712 - 54,332,772EPDNEW
RGD ID:13700133
Promoter ID:EPDNEW_R10643
Type:multiple initiation site
Name:Mtus1_2
Description:microtubule associated scaffold protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R10642  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01654,358,455 - 54,358,515EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:631381 AgrOrtholog
BioCyc Gene G2FUF-11257 BioCyc
Ensembl Genes ENSRNOG00000010748 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000037685 ENTREZGENE
  ENSRNOT00000037685.6 UniProtKB/Swiss-Prot
  ENSRNOT00000079006 ENTREZGENE
  ENSRNOT00000090266 ENTREZGENE
  ENSRNOT00000102597 ENTREZGENE
  ENSRNOT00000153250 ENTREZGENE
IMAGE_CLONE IMAGE:7938925 IMAGE-MGC_LOAD
InterPro MTUS1/CCDC69 UniProtKB/Swiss-Prot
KEGG Report rno:306487 UniProtKB/Swiss-Prot
MGC_CLONE MGC:188355 IMAGE-MGC_LOAD
NCBI Gene 306487 ENTREZGENE
PANTHER PTHR24200:SF7 UniProtKB/Swiss-Prot
  TOUCAN, ISOFORM A UniProtKB/Swiss-Prot
PharmGKB MTUS1 RGD
PhenoGen Mtus1 PhenoGen
RatGTEx ENSRNOG00000010748 RatGTEx
UniProt A0A8I5ZY91 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QL23 ENTREZGENE, UniProtKB/TrEMBL
  A6JPU3_RAT UniProtKB/TrEMBL
  A6JPU4 ENTREZGENE, UniProtKB/TrEMBL
  B1A2U8 ENTREZGENE, UniProtKB/TrEMBL
  B2GVA4_RAT UniProtKB/TrEMBL
  D2XRB8 ENTREZGENE, UniProtKB/TrEMBL
  I7GGY1 ENTREZGENE, UniProtKB/TrEMBL
  MTUS1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6XUU5 ENTREZGENE
  Q80Z99 ENTREZGENE
UniProt Secondary Q6XUU5 UniProtKB/Swiss-Prot
  Q80Z99 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Mtus1  microtubule associated scaffold protein 1  LOC100911065  microtubule-associated tumor suppressor 1 homolog  Data merged from RGD:6495469 737654 PROVISIONAL
2017-03-29 Mtus1  microtubule associated scaffold protein 1  Mtus1  microtubule associated tumor suppressor 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100911065  microtubule-associated tumor suppressor 1 homolog      Symbol and Name status set to provisional 70820 PROVISIONAL
2011-08-02 Mtus1  microtubule associated tumor suppressor 1  Mtus1  mitochondrial tumor suppressor 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Mtus1  mitochondrial tumor suppressor 1  Mtsg1  mitochondrial tumor suppressor gene 1  Symbol and Name updated 1299863 APPROVED
2004-02-11 Slc1a7  mitochondrial tumor suppressor gene 1  Mtsg1  transcription factor MTSG1  Name updated to reflect Human and Mouse nomenclature 625702 APPROVED