Mapkapk2 (MAPK activated protein kinase 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Mapkapk2 (MAPK activated protein kinase 2) Rattus norvegicus
Analyze
Symbol: Mapkapk2
Name: MAPK activated protein kinase 2
RGD ID: 631362
Description: Predicted to enable calmodulin binding activity; mitogen-activated protein kinase binding activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including macropinocytosis; regulation of gene expression; and response to lipopolysaccharide. Predicted to act upstream of or within inner ear development; p38MAPK cascade; and positive regulation of gene expression. Predicted to be located in cytosol; microtubule organizing center; and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human MAPKAPK2 (MAPK activated protein kinase 2); PARTICIPATES IN interleukin-2 signaling pathway; p38 MAPK signaling pathway; vascular endothelial growth factor signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MAP kinase-activated protein kinase 2; mitogen-activated protein kinase-activated protein kinase 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81345,066,027 - 45,112,326 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1345,066,031 - 45,112,326 (-)EnsemblGRCr8
mRatBN7.21342,513,762 - 42,560,061 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1342,513,762 - 42,560,457 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1345,120,561 - 45,166,993 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01346,408,685 - 46,455,124 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01343,672,789 - 43,719,216 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01347,785,157 - 47,871,684 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1347,785,161 - 47,831,110 (-)Ensemblrn6Rnor6.0
Rnor_5.01352,865,897 - 52,912,481 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41343,994,943 - 44,041,504 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1342,861,470 - 42,906,683 (-)NCBICelera
RGSC_v3.11344,008,985 - 44,055,547 (-)NCBI
Cytogenetic Map13q13NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-anisomycin  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2'-Methylenebis(4-methyl-6-tert-butylphenol)  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-nitrotoluene  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
5-aza-2'-deoxycytidine  (ISO)
7H-xanthine  (EXP)
9H-xanthine  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
aripiprazole  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
azoxystrobin  (EXP)
benzene  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzoates  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
bortezomib  (ISO)
bromochloroacetic acid  (EXP)
butan-1-ol  (ISO)
cadmium dichloride  (EXP,ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpromazine  (EXP)
chlorpyrifos  (EXP)
cisplatin  (ISO)
clofibrate  (ISO)
coniferyl aldehyde  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (EXP)
D-glucitol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
etoposide  (ISO)
fipronil  (EXP)
flurbiprofen  (ISO)
folic acid  (ISO)
geldanamycin  (ISO)
gentamycin  (EXP)
glyphosate  (EXP,ISO)
GSK-J4  (ISO)
hydrogen peroxide  (ISO)
hydroxytyrosol  (EXP)
ibuprofen  (ISO)
imidacloprid  (EXP)
indometacin  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (EXP,ISO)
methotrexate  (ISO)
methylmercury(1+)  (EXP)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
nefazodone  (EXP)
nickel subsulfide  (ISO)
nickel sulfate  (ISO)
nimesulide  (EXP)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (ISO)
phenobarbital  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
picoxystrobin  (ISO)
potassium dichromate  (ISO)
quercetin  (EXP)
raloxifene  (ISO)
ranitidine  (EXP)
retinyl acetate  (ISO)
rifampicin  (ISO)
rotenone  (EXP)
rottlerin  (ISO)
SB 203580  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
streptozocin  (ISO)
sulfates  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
telmisartan  (ISO)
tetrachloromethane  (ISO)
thiabendazole  (EXP)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. MAPKAP kinases - MKs - two's company, three's a crowd. Gaestel M Nat Rev Mol Cell Biol. 2006 Feb;7(2):120-30.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. beta-Amyloid peptide induces formation of actin stress fibers through p38 mitogen-activated protein kinase. Song C, etal., J Neurochem 2002 Nov;83(4):828-36.
8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:7799959   PMID:8774846   PMID:8846784   PMID:9628873   PMID:10559880   PMID:11741878   PMID:12456657   PMID:14517288   PMID:15014438   PMID:15084475   PMID:15538386   PMID:15850461  
PMID:15856211   PMID:16278218   PMID:17906627   PMID:18440775   PMID:18570454   PMID:20932473   PMID:21139061   PMID:21795542   PMID:24020373   PMID:24927932   PMID:31505169  


Genomics

Comparative Map Data
Mapkapk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81345,066,027 - 45,112,326 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1345,066,031 - 45,112,326 (-)EnsemblGRCr8
mRatBN7.21342,513,762 - 42,560,061 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1342,513,762 - 42,560,457 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1345,120,561 - 45,166,993 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01346,408,685 - 46,455,124 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01343,672,789 - 43,719,216 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01347,785,157 - 47,871,684 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1347,785,161 - 47,831,110 (-)Ensemblrn6Rnor6.0
Rnor_5.01352,865,897 - 52,912,481 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41343,994,943 - 44,041,504 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1342,861,470 - 42,906,683 (-)NCBICelera
RGSC_v3.11344,008,985 - 44,055,547 (-)NCBI
Cytogenetic Map13q13NCBI
MAPKAPK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381206,684,905 - 206,734,281 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1206,684,886 - 206,734,284 (+)Ensemblhg38GRCh38
GRCh371206,858,250 - 206,907,626 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361204,924,912 - 204,974,249 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1180,109,718 - 180,159,069 (+)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1177,556,640 - 177,605,949 (+)NCBIHuRef
CHM1_11208,130,566 - 208,179,829 (+)NCBICHM1_1
T2T-CHM13v2.01205,949,085 - 205,998,488 (+)NCBIT2T-CHM13v2.0
Mapkapk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391130,981,437 - 131,025,580 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1130,981,437 - 131,025,563 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381131,053,700 - 131,097,871 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1131,053,700 - 131,097,826 (-)Ensemblmm10GRCm38
MGSCv371132,950,281 - 132,994,120 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361132,881,250 - 132,925,089 (-)NCBIMGSCv36mm8
Celera1133,676,280 - 133,720,582 (-)NCBICelera
Cytogenetic Map1E4NCBI
cM Map156.89NCBI
Mapkapk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540642,231,858 - 42,276,477 (+)Ensembl
ChiLan1.0NW_00495540642,231,858 - 42,276,477 (+)NCBIChiLan1.0ChiLan1.0
MAPKAPK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2142,642,075 - 42,691,540 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1142,607,605 - 42,657,057 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01182,286,854 - 182,336,306 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11186,609,836 - 186,615,466 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1186,608,158 - 186,613,911 (+)EnsemblpanPan2panpan1.1
MAPKAPK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.175,873,088 - 5,903,484 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl75,814,201 - 5,902,220 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha75,422,392 - 5,467,592 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.075,547,527 - 5,592,752 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl75,546,052 - 5,590,777 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.175,482,144 - 5,527,321 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.075,583,083 - 5,628,202 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.075,622,716 - 5,667,925 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mapkapk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934468,626,900 - 68,670,925 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365575,867,211 - 5,911,213 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365575,867,182 - 5,911,207 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAPKAPK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl967,314,609 - 67,366,470 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1967,314,651 - 67,365,060 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2973,667,427 - 73,717,087 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MAPKAPK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12522,632,180 - 22,681,250 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2522,629,729 - 22,681,373 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605523,329,820 - 23,378,654 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mapkapk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248074,724,234 - 4,796,143 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248074,726,511 - 4,774,945 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Mapkapk2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1104,711,512 - 4,759,968 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Mapkapk2
157 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:463
Count of miRNA genes:232
Interacting mature miRNAs:289
Transcripts:ENSRNOT00000061070
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133721624190057603Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)131186625456866254Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132485392569853925Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133996821183286298Rat
1300163Cardf1Cardiac cell morphology QTL 14.18aorta morphology trait (VT:0000272)artery lesion measurement (CMO:0000975)131244842147969993Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131238432057384320Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131746828262468282Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131238432057384320Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13742179187286911Rat
2303032Bp328Blood pressure QTL 328arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134373632747969993Rat
61339Bp24Blood pressure QTL 240.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13600200847359539Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)132433543255601132Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133708798382087983Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)134098358585983585Rat
2302275Gluco37Glucose level QTL 373.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)131244842148744906Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132624480871244808Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133379409678794096Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133483494779834947Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133379409660914504Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)13308875548088755Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133981472684814726Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133996821184968211Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132624480871244808Rat
11530006Niddm72Non-insulin dependent diabetes mellitus QTL 720.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)133828629883286298Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131771133662711336Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)131186625456866254Rat

Markers in Region
AA960234  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21342,513,836 - 42,514,076 (+)MAPPERmRatBN7.2
Rnor_6.01347,785,236 - 47,785,475NCBIRnor6.0
Rnor_5.01352,865,972 - 52,866,211UniSTSRnor5.0
RGSC_v3.41343,995,018 - 43,995,257UniSTSRGSC3.4
Celera1342,861,545 - 42,861,784UniSTS
Cytogenetic Map13q13UniSTS
RH141120  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21342,513,827 - 42,514,008 (+)MAPPERmRatBN7.2
Rnor_6.01347,785,227 - 47,785,407NCBIRnor6.0
Rnor_5.01352,865,963 - 52,866,143UniSTSRnor5.0
RGSC_v3.41343,995,009 - 43,995,189UniSTSRGSC3.4
Celera1342,861,536 - 42,861,716UniSTS
RH 3.4 Map1777.9UniSTS
Cytogenetic Map13q13UniSTS
Mapkapk2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21342,514,050 - 42,515,053 (+)MAPPERmRatBN7.2
Rnor_6.01347,785,450 - 47,786,452NCBIRnor6.0
Rnor_5.01352,866,186 - 52,867,188UniSTSRnor5.0
RGSC_v3.41343,995,232 - 43,996,234UniSTSRGSC3.4
Celera1342,861,759 - 42,862,761UniSTS
Cytogenetic Map13q13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000061070   ⟹   ENSRNOP00000057786
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1342,513,762 - 42,560,457 (-)Ensembl
Rnor_6.0 Ensembl1347,785,161 - 47,831,110 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100098   ⟹   ENSRNOP00000076947
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1345,066,031 - 45,112,326 (-)Ensembl
mRatBN7.2 Ensembl1342,513,762 - 42,560,061 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111595   ⟹   ENSRNOP00000085497
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1342,513,762 - 42,523,444 (-)Ensembl
RefSeq Acc Id: NM_178102   ⟹   NP_835203
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81345,066,031 - 45,112,326 (-)NCBI
mRatBN7.21342,513,762 - 42,560,061 (-)NCBI
Rnor_6.01347,785,161 - 47,871,684 (-)NCBI
Rnor_5.01352,865,897 - 52,912,481 (-)NCBI
RGSC_v3.41343,994,943 - 44,041,504 (-)RGD
Celera1342,861,470 - 42,906,683 (-)RGD
Sequence:
RefSeq Acc Id: XM_063272066   ⟹   XP_063128136
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81345,066,027 - 45,111,775 (-)NCBI
Protein Sequences
Protein RefSeqs NP_835203 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128136 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH62048 (Get FASTA)   NCBI Sequence Viewer  
  AAO34665 (Get FASTA)   NCBI Sequence Viewer  
  EDM09835 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000076947
  ENSRNOP00000076947.1
RefSeq Acc Id: NP_835203   ⟸   NM_178102
- UniProtKB: Q80ZF4 (UniProtKB/TrEMBL),   A0A8I5Y100 (UniProtKB/TrEMBL),   F1M9C0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000057786   ⟸   ENSRNOT00000061070
Ensembl Acc Id: ENSRNOP00000085497   ⟸   ENSRNOT00000111595
Ensembl Acc Id: ENSRNOP00000076947   ⟸   ENSRNOT00000100098
RefSeq Acc Id: XP_063128136   ⟸   XM_063272066
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZZC5 (UniProtKB/TrEMBL)
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M9C0-F1-model_v2 AlphaFold F1M9C0 1-370 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698791
Promoter ID:EPDNEW_R9316
Type:single initiation site
Name:Mapkapk2_1
Description:mitogen-activated protein kinase-activated protein kinase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01347,831,080 - 47,831,140EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:631362 AgrOrtholog
BioCyc Gene G2FUF-18357 BioCyc
Ensembl Genes ENSRNOG00000004726 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000100098 ENTREZGENE
  ENSRNOT00000100098.2 UniProtKB/TrEMBL
Gene3D-CATH 4.10.1170.10 UniProtKB/TrEMBL
  Phosphorylase Kinase, domain 1 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5598069 IMAGE-MGC_LOAD
InterPro Kinase-like_dom UniProtKB/TrEMBL
  MAPKAPK_C UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_prot_kinase_AS UniProtKB/TrEMBL
KEGG Report rno:289014 UniProtKB/TrEMBL
MGC_CLONE MGC:72264 IMAGE-MGC_LOAD
NCBI Gene 289014 ENTREZGENE
PANTHER SERINE/THREONINE-PROTEIN KINASE UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PhenoGen Mapkapk2 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004726 RatGTEx
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
UniProt A0A8I5Y100 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZZC5 ENTREZGENE
  F1M9C0 ENTREZGENE
  Q80ZF4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-08 Mapkapk2  MAPK activated protein kinase 2  Mapkapk2  mitogen-activated protein kinase-activated protein kinase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-06 Mapkapk2  mitogen-activated protein kinase-activated protein kinase 2  Mapkapk2  MAP kinase-activated protein kinase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-11 Mapkapk2  MAP kinase-activated protein kinase 2      Symbol and Name status set to approved 625702 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation activated by beta-amyloid precursor protein APP-V642I (IAPP) and mutant presenilin-1 L286V (mPS1) 724429