Disc1 (DISC1 scaffold protein) - Rat Genome Database

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Gene: Disc1 (DISC1 scaffold protein) Rattus norvegicus
Analyze
Symbol: Disc1
Name: DISC1 scaffold protein
RGD ID: 631359
Description: Enables kinesin binding activity. Involved in several processes, including positive regulation of cell projection organization; protein localization to centrosome; and pyramidal neuron migration to cerebral cortex. Acts upstream of or within regulation of glutamatergic synaptic transmission. Located in several cellular components, including central region of growth cone; microtubule cytoskeleton; and perinuclear region of cytoplasm. Part of dynein complex and kinesin complex. Human ortholog(s) of this gene implicated in autism spectrum disorder (multiple); bipolar disorder; chronic fatigue syndrome; major depressive disorder; and psychotic disorder (multiple). Orthologous to human DISC1 (DISC1 scaffold protein); INTERACTS WITH 17alpha-ethynylestradiol; acetamide; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: disrupted in schizophrenia 1; disrupted in schizophrenia 1 homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Disc1em1Rst
Genetic Models: SD-Disc1em1Rst
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81969,911,548 - 70,120,970 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1969,911,976 - 70,120,970 (+)EnsemblGRCr8
mRatBN7.21953,014,201 - 53,223,617 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1953,014,616 - 53,219,778 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1959,798,589 - 60,006,037 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01960,649,615 - 60,856,157 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01962,725,049 - 62,932,128 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01957,818,838 - 58,069,992 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1957,820,260 - 58,066,152 (+)Ensemblrn6Rnor6.0
Rnor_5.01968,711,386 - 68,769,050 (+)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.01968,529,791 - 68,641,620 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41955,265,116 - 55,449,375 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1952,376,528 - 52,580,211 (+)NCBICelera
RGSC_v3.11955,270,004 - 55,427,798 (+)NCBI
Cytogenetic Map19q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-amphetamine  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2-hydroxypropanoic acid  (ISO)
3',5'-cyclic AMP  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (ISO)
chlorpyrifos  (ISO)
clozapine  (ISO)
copper(II) sulfate  (ISO)
D-glucose  (ISO)
dopamine  (ISO)
doxorubicin  (ISO)
ethylbenzene  (ISO)
FR900359  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (ISO)
glucose  (ISO)
herbicide  (ISO)
ketamine  (EXP)
lead diacetate  (EXP)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
malathion  (ISO)
maneb  (ISO)
melatonin  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-nitrosodiethylamine  (EXP)
naled  (ISO)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
Ortho-topolin riboside  (ISO)
paraquat  (ISO)
PCB138  (ISO)
permethrin  (EXP,ISO)
phenethyl caffeate  (EXP)
phenylmercury acetate  (ISO)
potassium dichromate  (ISO)
propanal  (ISO)
rac-lactic acid  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
T-2 toxin  (EXP)
titanium dioxide  (ISO)
toluene  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. The effect of amygdala kindling on hippocampal neurogenesis coincides with decreased reelin and DISC1 expression in the adult dentate gyrus. Fournier NM, etal., Hippocampus. 2009 Jun 4.
2. A functional polymorphism in the disrupted-in schizophrenia 1 gene is associated with chronic fatigue syndrome. Fukuda S, etal., Life Sci. 2010 May 8;86(19-20):722-5. Epub 2010 Mar 20.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Impact of the DISC1 Ser704Cys polymorphism on risk for major depression, brain morphology and ERK signaling. Hashimoto R, etal., Hum Mol Genet. 2006 Oct 15;15(20):3024-33. Epub 2006 Sep 7.
6. A novel DISC1-interacting partner DISC1-Binding Zinc-finger protein: implication in the modulation of DISC1-dependent neurite outgrowth. Hattori T, etal., Mol Psychiatry. 2007 Apr;12(4):398-407. Epub 2007 Jan 23.
7. DISC1 regulates cell-cell adhesion, cell-matrix adhesion and neurite outgrowth. Hattori T, etal., Mol Psychiatry. 2010 Aug;15(8):778, 798-809. Epub 2010 May 18.
8. Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1. Hayashi-Takagi A, etal., Nat Neurosci. 2010 Mar;13(3):327-32. Epub 2010 Feb 7.
9. PAKs inhibitors ameliorate schizophrenia-associated dendritic spine deterioration in vitro and in vivo during late adolescence. Hayashi-Takagi A, etal., Proc Natl Acad Sci U S A. 2014 Apr 29;111(17):6461-6. doi: 10.1073/pnas.1321109111. Epub 2014 Apr 3.
10. DISC1 association, heterogeneity and interplay in schizophrenia and bipolar disorder. Hennah W, etal., Mol Psychiatry. 2009 Sep;14(9):865-73. Epub 2008 Mar 4.
11. Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder. Hodgkinson CA, etal., Am J Hum Genet. 2004 Nov;75(5):862-72. Epub 2004 Sep 22.
12. Recruitment of PCM1 to the centrosome by the cooperative action of DISC1 and BBS4: a candidate for psychiatric illnesses. Kamiya A, etal., Arch Gen Psychiatry. 2008 Sep;65(9):996-1006. doi: 10.1001/archpsyc.65.9.996.
13. DISC1-NDEL1/NUDEL protein interaction, an essential component for neurite outgrowth, is modulated by genetic variations of DISC1. Kamiya A, etal., Hum Mol Genet. 2006 Nov 15;15(22):3313-23. Epub 2006 Oct 11.
14. A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development. Kamiya A, etal., Nat Cell Biol. 2005 Dec;7(12):1167-78. Epub 2005 Nov 20.
15. Association of DISC1 gene with schizophrenia in families from two distinct French and Algerian populations. Lepagnol-Bestel AM, etal., Psychiatr Genet. 2010 Dec;20(6):298-303.
16. DISC1 regulates primary cilia that display specific dopamine receptors. Marley A and von Zastrow M, PLoS One. 2010 May 28;5(5):e10902.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. Disruption of two novel genes by a translocation co-segregating with schizophrenia. Millar JK, etal., Hum Mol Genet. 2000 May 22;9(9):1415-23.
19. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
20. Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth. Ozeki Y, etal., Proc Natl Acad Sci U S A 2003 Jan 7;100(1):289-94.
21. PC12 cell model of inducible expression of mutant DISC1: new evidence for a dominant-negative mechanism of abnormal neuronal differentiation. Pletnikov MV, etal., Neurosci Res. 2007 Jul;58(3):234-44. Epub 2007 Mar 16.
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. A form of DISC1 enriched in nucleus: altered subcellular distribution in orbitofrontal cortex in psychosis and substance/alcohol abuse. Sawamura N, etal., Proc Natl Acad Sci U S A. 2005 Jan 25;102(4):1187-92. Epub 2005 Jan 18.
25. DISC1 regulates neurotrophin-induced axon elongation via interaction with Grb2. Shinoda T, etal., J Neurosci. 2007 Jan 3;27(1):4-14.
26. DISC1 regulates the transport of the NUDEL/LIS1/14-3-3epsilon complex through kinesin-1. Taya S, etal., J Neurosci. 2007 Jan 3;27(1):15-26.
27. Limited association between Disrupted in Schizophrenia 1 (DISC1) gene and bipolar disorder in the Chinese population. Xiao Y, etal., Psychiatr Genet. 2011 Feb;21(1):42-6.
28. Evidence for association between Disrupted-in-Schizophrenia 1 (DISC1) gene polymorphisms and autism in Chinese Han population: a family-based association study. Zheng F, etal., Behav Brain Funct. 2011 May 15;7:14.
Additional References at PubMed
PMID:12874605   PMID:15057822   PMID:17825401   PMID:18955030   PMID:18983980   PMID:19303846   PMID:19368862   PMID:19502360   PMID:19778506   PMID:20624590   PMID:20685985   PMID:20838393  
PMID:20880836   PMID:20956536   PMID:21323643   PMID:21471969   PMID:22031837   PMID:22479520   PMID:24301646   PMID:24516667   PMID:24560582   PMID:25224257   PMID:25399920   PMID:25738396  
PMID:26078884   PMID:26385055   PMID:26424793   PMID:30409224   PMID:30723982   PMID:30745562   PMID:31103832   PMID:33960643   PMID:35461978   PMID:35715502  


Genomics

Comparative Map Data
Disc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81969,911,548 - 70,120,970 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1969,911,976 - 70,120,970 (+)EnsemblGRCr8
mRatBN7.21953,014,201 - 53,223,617 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1953,014,616 - 53,219,778 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1959,798,589 - 60,006,037 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01960,649,615 - 60,856,157 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01962,725,049 - 62,932,128 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01957,818,838 - 58,069,992 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1957,820,260 - 58,066,152 (+)Ensemblrn6Rnor6.0
Rnor_5.01968,711,386 - 68,769,050 (+)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.01968,529,791 - 68,641,620 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41955,265,116 - 55,449,375 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1952,376,528 - 52,580,211 (+)NCBICelera
RGSC_v3.11955,270,004 - 55,427,798 (+)NCBI
Cytogenetic Map19q12NCBI
DISC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381231,626,790 - 232,041,272 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1231,626,790 - 232,041,272 (+)Ensemblhg38GRCh38
GRCh371231,762,536 - 232,177,018 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361229,829,184 - 230,243,641 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341228,069,295 - 228,483,607NCBI
Celera1205,027,310 - 205,445,842 (+)NCBICelera
Cytogenetic Map1q42.2NCBI
HuRef1202,246,109 - 202,664,353 (+)NCBIHuRef
CHM1_11233,036,406 - 233,450,761 (+)NCBICHM1_1
T2T-CHM13v2.01231,009,996 - 231,426,811 (+)NCBIT2T-CHM13v2.0
Disc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398125,773,928 - 125,991,882 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8125,780,934 - 125,988,597 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm388125,048,767 - 125,265,143 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8125,054,195 - 125,261,858 (+)Ensemblmm10GRCm38
MGSCv378127,578,095 - 127,785,051 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv368127,940,285 - 128,148,274 (+)NCBIMGSCv36mm8
Celera8129,364,004 - 129,569,546 (+)NCBICelera
Cytogenetic Map8E2NCBI
cM Map873.26NCBI
Disc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554926,953,389 - 7,239,328 (-)Ensembl
ChiLan1.0NW_0049554926,946,528 - 7,239,328 (-)NCBIChiLan1.0ChiLan1.0
DISC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2117,161,052 - 17,575,242 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1117,356,795 - 17,771,144 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01207,180,513 - 207,594,684 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11212,320,582 - 212,616,406 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1212,265,520 - 212,612,079 (+)EnsemblpanPan2panpan1.1
DISC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.147,524,336 - 7,825,143 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl47,524,397 - 7,822,558 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha47,518,316 - 7,865,131 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.047,547,601 - 7,896,939 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl47,547,642 - 7,897,205 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.147,555,426 - 7,902,062 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.047,676,276 - 8,023,319 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.047,902,898 - 8,249,898 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Disc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934442,878,559 - 43,045,852 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648419,047,215 - 19,237,306 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648419,151,752 - 19,237,435 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DISC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1458,606,464 - 58,963,563 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11458,606,441 - 58,963,954 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21463,056,095 - 63,124,157 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DISC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12568,886,451 - 69,274,774 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2568,946,430 - 69,263,198 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605570,799,188 - 71,196,506 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Disc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477517,831,272 - 18,165,668 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462477517,820,590 - 18,165,640 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Disc1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11744,564,262 - 44,767,939 (+)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:60
Count of miRNA genes:54
Interacting mature miRNAs:59
Transcripts:ENSRNOT00000057945
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)194438513474246245Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)193253961574246245Rat
5135224Leukc1Leukocyte quantity QTL 1eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)196124916174246245Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)193177788874246245Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032907674246245Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)194622677874246245Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)193236531174246245Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)194172254674246245Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191083361874246245Rat

Markers in Region
D19Rat60  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81970,114,813 - 70,115,007 (+)Marker Load Pipeline
mRatBN7.21953,217,458 - 53,217,652 (+)MAPPERmRatBN7.2
Rnor_6.01958,063,836 - 58,064,029NCBIRnor6.0
Rnor_5.01968,766,731 - 68,766,924UniSTSRnor5.0
RGSC_v3.41955,447,056 - 55,447,249UniSTSRGSC3.4
RGSC_v3.41955,447,055 - 55,447,249RGDRGSC3.4
Celera1952,577,892 - 52,578,085UniSTS
RGSC_v3.11955,451,937 - 55,452,130RGD
RH 3.4 Map19719.2RGD
RH 3.4 Map19719.2UniSTS
SHRSP x BN Map1943.6299UniSTS
SHRSP x BN Map1943.6299RGD
Cytogenetic Map19q12UniSTS
BI296374  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21953,185,564 - 53,185,784 (+)MAPPERmRatBN7.2
Rnor_6.01958,033,016 - 58,033,235NCBIRnor6.0
Rnor_5.01968,736,026 - 68,736,245UniSTSRnor5.0
RGSC_v3.41955,415,475 - 55,415,694UniSTSRGSC3.4
Celera1952,546,340 - 52,546,559UniSTS
RH 3.4 Map19721.2UniSTS
Cytogenetic Map19q12UniSTS
BF415610  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21953,131,507 - 53,131,642 (+)MAPPERmRatBN7.2
Rnor_6.01957,944,392 - 57,944,526NCBIRnor6.0
Rnor_5.01968,652,854 - 68,652,988UniSTSRnor5.0
RGSC_v3.41955,347,455 - 55,347,589UniSTSRGSC3.4
Celera1952,491,163 - 52,491,297UniSTS
RH 3.4 Map19718.4UniSTS
Cytogenetic Map19q12UniSTS
fi45a03.x1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21953,074,621 - 53,076,085 (+)MAPPERmRatBN7.2
Rnor_6.01957,887,854 - 57,889,317NCBIRnor6.0
Rnor_5.01968,597,827 - 68,599,290UniSTSRnor5.0
RGSC_v3.41955,290,605 - 55,292,068UniSTSRGSC3.4
Celera1952,434,546 - 52,436,005UniSTS
Cytogenetic Map19q12UniSTS


Genetic Models
This gene Disc1 is modified in the following models/strains:
SD-Disc1em1Rst    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
19 12 89 248 91 90 59 177 59 6 507 308 20 234 113 127 31 45 45

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_175596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097794 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010060004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010060005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010060006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010060007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010060008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AY177674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000057945   ⟹   ENSRNOP00000054753
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1969,932,225 - 70,120,970 (+)Ensembl
mRatBN7.2 Ensembl1953,034,869 - 53,219,778 (+)Ensembl
Rnor_6.0 Ensembl1957,820,260 - 58,066,152 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000119995   ⟹   ENSRNOP00000095161
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1969,911,976 - 70,120,970 (+)Ensembl
mRatBN7.2 Ensembl1953,014,616 - 53,219,778 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000158574   ⟹   ENSRNOP00000108588
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1969,911,976 - 70,120,970 (+)Ensembl
RefSeq Acc Id: NM_175596   ⟹   NP_783186
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81969,911,976 - 70,120,970 (+)NCBI
mRatBN7.21953,014,620 - 53,223,615 (+)NCBI
Rnor_6.01957,820,260 - 58,066,155 (+)NCBI
Rnor_5.01968,529,791 - 68,641,620 (+)NCBI
Rnor_5.01968,711,386 - 68,769,050 (+)NCBI
RGSC_v3.41955,265,116 - 55,449,375 (+)RGD
Celera1952,376,528 - 52,580,211 (+)RGD
Sequence:
RefSeq Acc Id: XM_039097792   ⟹   XP_038953720
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81969,911,552 - 70,108,171 (+)NCBI
mRatBN7.21953,014,202 - 53,210,810 (+)NCBI
RefSeq Acc Id: XM_039097793   ⟹   XP_038953721
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81969,911,551 - 70,090,316 (+)NCBI
mRatBN7.21953,014,202 - 53,192,968 (+)NCBI
RefSeq Acc Id: XM_039097794   ⟹   XP_038953722
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81969,911,552 - 70,023,107 (+)NCBI
mRatBN7.21953,014,202 - 53,125,894 (+)NCBI
RefSeq Acc Id: XM_063278075   ⟹   XP_063134145
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81969,911,551 - 70,120,970 (+)NCBI
RefSeq Acc Id: XM_063278076   ⟹   XP_063134146
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81969,911,550 - 70,120,970 (+)NCBI
RefSeq Acc Id: XM_063278077   ⟹   XP_063134147
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81969,911,552 - 70,108,236 (+)NCBI
RefSeq Acc Id: XM_063278078   ⟹   XP_063134148
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81969,911,552 - 70,108,236 (+)NCBI
RefSeq Acc Id: XR_010060004
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81969,911,549 - 70,120,970 (+)NCBI
RefSeq Acc Id: XR_010060005
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81969,911,549 - 70,120,970 (+)NCBI
RefSeq Acc Id: XR_010060006
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81969,911,548 - 70,120,970 (+)NCBI
RefSeq Acc Id: XR_010060007
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81969,911,548 - 70,120,970 (+)NCBI
RefSeq Acc Id: XR_010060008
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81969,911,552 - 70,117,132 (+)NCBI
RefSeq Acc Id: NP_783186   ⟸   NM_175596
- UniProtKB: A6KJ31 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000054753   ⟸   ENSRNOT00000057945
RefSeq Acc Id: XP_038953720   ⟸   XM_039097792
- Peptide Label: isoform X3
- UniProtKB: A6KJ31 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953721   ⟸   XM_039097793
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038953722   ⟸   XM_039097794
- Peptide Label: isoform X5
Ensembl Acc Id: ENSRNOP00000095161   ⟸   ENSRNOT00000119995
RefSeq Acc Id: XP_063134146   ⟸   XM_063278076
- Peptide Label: isoform X2
- UniProtKB: A6KJ31 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063134145   ⟸   XM_063278075
- Peptide Label: isoform X1
- UniProtKB: A6KJ31 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063134147   ⟸   XM_063278077
- Peptide Label: isoform X6
- UniProtKB: A6KJ31 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063134148   ⟸   XM_063278078
- Peptide Label: isoform X7
Ensembl Acc Id: ENSRNOP00000108588   ⟸   ENSRNOT00000158574

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q810H6-F1-model_v2 AlphaFold Q810H6 1-846 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:631359 AgrOrtholog
BioCyc Gene G2FUF-5217 BioCyc
Ensembl Genes ENSRNOG00000019779 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000119995 ENTREZGENE
  ENSRNOT00000119995.1 UniProtKB/Swiss-Prot
InterPro DISC1 UniProtKB/Swiss-Prot
KEGG Report rno:307940 UniProtKB/Swiss-Prot
NCBI Gene 307940 ENTREZGENE
PANTHER DISRUPTED IN SCHIZOPHRENIA 1 PROTEIN UniProtKB/Swiss-Prot
  PTHR14332 UniProtKB/Swiss-Prot
PhenoGen Disc1 PhenoGen
RatGTEx ENSRNOG00000019779 RatGTEx
UniProt A0A8L2QR08_RAT UniProtKB/TrEMBL
  A0ABK0M0W7_RAT UniProtKB/TrEMBL
  A6KJ31 ENTREZGENE, UniProtKB/TrEMBL
  DISC1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-03-16 Disc1  DISC1 scaffold protein  Disc1  disrupted in schizophrenia 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-11 Disc1  disrupted in schizophrenia 1      Symbol and Name status set to approved 625702 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_mutations_overexpression expression of mutant form reduces neurite extension in PC12 cells 629536
gene_physical_interaction interacts with NudE-like (NUDEL) 629536