Optn (optineurin) - Rat Genome Database

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Gene: Optn (optineurin) Rattus norvegicus
Analyze
Symbol: Optn
Name: optineurin
RGD ID: 628886
Description: Enables TFIIIA-class transcription factor binding activity; identical protein binding activity; and ubiquitin binding activity. Involved in several processes, including cellular response to L-glutamate; cellular response to hydrogen peroxide; and regulation of neuron apoptotic process. Located in several cellular components, including Golgi apparatus; neuronal cell body; and perinuclear region of cytoplasm. Biomarker of Parkinson's disease; bladder neck obstruction; proteinuria; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Paget's disease of bone; amyotrophic lateral sclerosis (multiple); and glaucoma (multiple). Orthologous to human OPTN (optineurin); PARTICIPATES IN mitochondrial autophagy pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 14.7K-interacting protein 2; FIP-2-like protein; Fip2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81778,118,847 - 78,169,543 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1778,118,866 - 78,169,543 (+)EnsemblGRCr8
mRatBN7.21773,209,572 - 73,260,251 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1773,209,575 - 73,260,251 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1776,713,602 - 76,763,945 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01780,537,897 - 80,588,798 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01774,588,565 - 74,639,381 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01777,167,700 - 77,218,374 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1777,167,740 - 77,218,389 (+)Ensemblrn6Rnor6.0
Rnor_5.01778,833,443 - 78,884,464 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41784,298,122 - 84,348,330 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1772,649,264 - 72,699,727 (+)NCBICelera
RGSC_v3.11784,317,800 - 84,359,163 (+)NCBI
Cytogenetic Map17q12.3NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
capsaicin  (ISO)
carbon nanotube  (ISO)
chloroquine  (ISO)
chromium(6+)  (ISO)
ciglitazone  (ISO)
cisplatin  (ISO)
clofibric acid  (EXP)
clotrimazole  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
dioxygen  (ISO)
elemental selenium  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
epoxomicin  (EXP,ISO)
ethyl methanesulfonate  (ISO)
fenthion  (ISO)
finasteride  (EXP)
flavonoids  (EXP)
fluvastatin  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
furfural  (ISO)
gentamycin  (EXP)
glyphosate  (EXP)
GSK-J4  (ISO)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP)
ivermectin  (ISO)
lactacystin  (EXP,ISO)
leflunomide  (EXP,ISO)
lipopolysaccharide  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylparaben  (ISO)
methylseleninic acid  (ISO)
N(4)-hydroxycytidine  (ISO)
N-nitrosodiethylamine  (EXP)
nickel dichloride  (ISO)
nocodazole  (ISO)
oxaliplatin  (EXP)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
propiconazole  (ISO)
puromycin  (ISO)
quercetin  (ISO)
rotenone  (EXP)
selenium atom  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
toluene  (EXP)
topotecan  (EXP,ISO)
Torularhodin  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
autophagosome  (IEA)
axon  (IDA)
cytoplasm  (IBA)
cytoplasmic vesicle  (IDA,IEA)
cytosol  (IEA,ISO)
Golgi apparatus  (IBA,IDA,IEA,ISO)
neuronal cell body  (IDA)
nucleus  (IBA)
perinuclear region of cytoplasm  (IDA,IEA,ISO)
recycling endosome  (IEA)
trans-Golgi network  (IEA,ISO,ISS)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Genome-wide association study identifies variants at CSF1, OPTN and TNFRSF11A as genetic risk factors for Paget's disease of bone. Albagha OM, etal., Nat Genet. 2010 Jun;42(6):520-4. Epub 2010 May 2.
2. Lack of association between optineurin gene variants T34T, E50K, M98K, 691_692insAG and R545Q and primary open angle glaucoma in Brazilian patients. Caixeta-Umbelino C, etal., Ophthalmic Genet. 2009 Mar;30(1):13-8. doi: 10.1080/13816810802502970.
3. Overexpression of optineurin E50K disrupts Rab8 interaction and leads to a progressive retinal degeneration in mice. Chi ZL, etal., Hum Mol Genet. 2010 Jul 1;19(13):2606-15. Epub 2010 Apr 13.
4. Novel optineurin mutations in patients with familial and sporadic amyotrophic lateral sclerosis. Del Bo R, etal., J Neurol Neurosurg Psychiatry. 2011 Nov;82(11):1239-43. Epub 2011 May 25.
5. Differential involvement of optineurin in amyotrophic lateral sclerosis with or without SOD1 mutations. Deng HX, etal., Arch Neurol. 2011 Aug;68(8):1057-61.
6. The three 'P's of mitophagy: PARKIN, PINK1, and post-translational modifications. Durcan TM and Fon EA, Genes Dev. 2015 May 15;29(10):989-99. doi: 10.1101/gad.262758.115.
7. SNPs and interaction analyses of myocilin, optineurin, and apolipoprotein E in primary open angle glaucoma patients. Fan BJ, etal., Mol Vis. 2005 Aug 29;11:625-31.
8. Variants in optineurin gene and their association with tumor necrosis factor-alpha polymorphisms in Japanese patients with glaucoma. Funayama T, etal., Invest Ophthalmol Vis Sci. 2004 Dec;45(12):4359-67.
9. Molecular genetic analysis of optineurin gene for primary open-angle and normal tension glaucoma in the Japanese population. Fuse N, etal., J Glaucoma. 2004 Aug;13(4):299-303.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Optineurin inclusions occur in a minority of TDP-43 positive ALS and FTLD-TDP cases and are rarely observed in other neurodegenerative disorders. Hortobagyi T, etal., Acta Neuropathol. 2011 Apr;121(4):519-27. Epub 2011 Mar 1.
12. Parkin overexpression protects retinal ganglion cells against glutamate excitotoxicity. Hu X, etal., Mol Vis. 2017 Jul 19;23:447-456. eCollection 2017.
13. Analysis of rare variants and common haplotypes in the optineurin gene in Swedish glaucoma cases. Jansson M, etal., Ophthalmic Genet. 2005 Jun;26(2):85-9.
14. Gel-based protease proteomics for identifying the novel calpain substrates in dopaminergic neuronal cell. Kim C, etal., J Biol Chem. 2013 Dec 20;288(51):36717-32. doi: 10.1074/jbc.M113.492876. Epub 2013 Nov 14.
15. Investigation of early protein changes in the urinary bladder following partial bladder outlet obstruction by proteomic approach. Kim HJ, etal., J Korean Med Sci. 2005 Dec;20(6):1000-5.
16. Effects of optineurin siRNA on apoptotic genes and apoptosis in RGC-5 cells. Li H, etal., Mol Vis. 2011;17:3314-25. Epub 2011 Dec 17.
17. Optineurin coding variants in Ghanaian patients with primary open-angle glaucoma. Liu Y, etal., Mol Vis. 2008;14:2367-72. Epub 2008 Dec 18.
18. Mutations of optineurin in amyotrophic lateral sclerosis. Maruyama H, etal., Nature. 2010 May 13;465(7295):223-6. Epub 2010 Apr 28.
19. The M98K variant of the OPTINEURIN (OPTN) gene modifies initial intraocular pressure in patients with primary open angle glaucoma. Melki R, etal., J Med Genet. 2003 Nov;40(11):842-4.
20. Identification of a transcription factor IIIA-interacting protein. Moreland RJ, etal., Nucleic Acids Res. 2000 May 1;28(9):1986-93.
21. Optineurin immunoreactivity in neuronal nuclear inclusions of polyglutamine diseases (Huntington's, DRPLA, SCA2, SCA3) and intranuclear inclusion body disease. Mori F, etal., Acta Neuropathol. 2012 Feb 9.
22. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
23. Isolation and expression of FIP-2 in wounded pulp of the rat. Oyama M, etal., J Dent Res. 2005 Sep;84(9):842-7.
24. Interaction between two glaucoma genes, optineurin and myocilin. Park BC, etal., Genes Cells. 2007 Aug;12(8):969-79.
25. RefSeq and LocusLink: NCBI gene-centered resources Pruitt KD and Maglott DR, Nucleic Acids Res. 2001 Jan 1;29(1):137-40.
26. Adult-onset primary open-angle glaucoma caused by mutations in optineurin. Rezaie T, etal., Science. 2002 Feb 8;295(5557):1077-9.
27. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
28. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
29. Information Derived from GenBank Report RGD, Sept. 2003
30. Optineurin links myosin VI to the Golgi complex and is involved in Golgi organization and exocytosis. Sahlender DA, etal., J Cell Biol. 2005 Apr 25;169(2):285-95. Epub 2005 Apr 18.
31. Expression of optineurin isolated from rat-injured dental pulp and the effects on inflammatory signals in normal rat kidney cells. Senoo K, etal., Odontology. 2017 Aug 3. doi: 10.1007/s10266-017-0314-5.
32. Processing of optineurin in neuronal cells. Shen X, etal., J Biol Chem. 2011 Feb 4;286(5):3618-29. doi: 10.1074/jbc.M110.175810. Epub 2010 Nov 8.
33. Optineurin associates with the podocyte Golgi complex to maintain its structure. Sippl C, etal., Cell Tissue Res. 2014 Nov;358(2):567-83. doi: 10.1007/s00441-014-1968-8. Epub 2014 Aug 7.
34. Depletion of optineurin in RGC-5 cells derived from retinal neurons causes apoptosis and reduces the secretion of neurotrophins. Sippl C, etal., Exp Eye Res. 2011 Nov;93(5):669-80. doi: 10.1016/j.exer.2011.08.011. Epub 2011 Aug 27.
35. Expression of optineurin, a glaucoma-linked gene, is influenced by elevated intraocular pressure. Vittitow J and Borras T, Biochem Biophys Res Commun 2002 Oct 18;298(1):67-74.
36. Disease gene candidates revealed by expression profiling of retinal ganglion cell development. Wang JT, etal., J Neurosci. 2007 Aug 8;27(32):8593-603.
37. From the Cover: Alterations in Optineurin Expression and Localization in Pre-clinical Parkinson's Disease Models. Wise JP and Cannon J, Toxicol Sci. 2016 Oct;153(2):372-81. doi: 10.1093/toxsci/kfw133. Epub 2016 Jul 29.
38. [Effects of decreased OPTN expression on the survival of the rat retinal ganglion cell line RGC5]. Xu Z, etal., Zhonghua Yan Ke Za Zhi. 2014 Aug;50(8):598-605.
39. Posttranslational modifications, localization, and protein interactions of optineurin, the product of a glaucoma gene. Ying H, etal., PLoS One. 2010 Feb 11;5(2):e9168.
Additional References at PubMed
PMID:12477932   PMID:15489334   PMID:15607428   PMID:16091361   PMID:17646400   PMID:17702576   PMID:19959812   PMID:20174559   PMID:21617041   PMID:22854040   PMID:22871113   PMID:23414517  
PMID:24983867   PMID:25294927   PMID:25416956   PMID:25803835   PMID:25910212   PMID:26871637   PMID:27534431   PMID:30100066   PMID:31934852  


Genomics

Comparative Map Data
Optn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81778,118,847 - 78,169,543 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1778,118,866 - 78,169,543 (+)EnsemblGRCr8
mRatBN7.21773,209,572 - 73,260,251 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1773,209,575 - 73,260,251 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1776,713,602 - 76,763,945 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01780,537,897 - 80,588,798 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01774,588,565 - 74,639,381 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01777,167,700 - 77,218,374 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1777,167,740 - 77,218,389 (+)Ensemblrn6Rnor6.0
Rnor_5.01778,833,443 - 78,884,464 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41784,298,122 - 84,348,330 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1772,649,264 - 72,699,727 (+)NCBICelera
RGSC_v3.11784,317,800 - 84,359,163 (+)NCBI
Cytogenetic Map17q12.3NCBI
OPTN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381013,100,082 - 13,138,308 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1013,099,449 - 13,140,320 (+)Ensemblhg38GRCh38
GRCh371013,142,082 - 13,180,308 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361013,182,088 - 13,220,282 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341013,182,087 - 13,220,282NCBI
Celera1013,068,965 - 13,107,102 (+)NCBICelera
Cytogenetic Map10p13NCBI
HuRef1013,055,075 - 13,092,916 (+)NCBIHuRef
CHM1_11013,142,092 - 13,180,464 (+)NCBICHM1_1
T2T-CHM13v2.01013,114,413 - 13,152,929 (+)NCBIT2T-CHM13v2.0
Optn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3925,023,902 - 5,069,210 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl25,025,453 - 5,068,862 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3825,020,521 - 5,064,399 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl25,020,642 - 5,064,051 (-)Ensemblmm10GRCm38
MGSCv3724,941,688 - 4,984,984 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3624,937,914 - 4,981,210 (-)NCBIMGSCv36mm8
Celera24,975,403 - 5,009,506 (-)NCBICelera
Cytogenetic Map2A1NCBI
cM Map23.15NCBI
Optn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554621,107,510 - 1,151,269 (+)Ensembl
ChiLan1.0NW_0049554621,098,118 - 1,150,291 (+)NCBIChiLan1.0ChiLan1.0
OPTN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2825,624,996 - 25,661,783 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11025,630,396 - 25,667,111 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01013,104,335 - 13,142,725 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11013,077,345 - 13,115,773 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1013,077,345 - 13,115,773 (+)EnsemblpanPan2panpan1.1
OPTN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1223,356,471 - 23,390,569 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl223,357,237 - 23,392,511 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha220,366,503 - 20,408,197 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0223,726,267 - 23,767,964 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl223,724,291 - 23,767,912 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1220,852,635 - 20,894,292 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0221,695,361 - 21,737,080 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0222,411,832 - 22,453,523 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC101956249
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244093442,868,730 - 2,952,140 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936862488,591 - 516,819 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OPTN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1048,530,843 - 48,582,860 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11048,532,029 - 48,582,952 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21077,689,153 - 77,740,521 (-)NCBISscrofa10.2Sscrofa10.2susScr3
OPTN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1913,142,036 - 13,176,996 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl913,150,426 - 13,177,021 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605118,674,614 - 18,710,695 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Optn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248055,683,021 - 5,721,336 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248055,683,095 - 5,717,558 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Optn
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11411,368,481 - 11,413,630 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Optn
176 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1884
Count of miRNA genes:318
Interacting mature miRNAs:429
Transcripts:ENSRNOT00000024162, ENSRNOT00000042881, ENSRNOT00000074087
Prediction methods:Microtar, Miranda, Pita, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172413612784432719Rat
631502Cm26Cardiac mass QTL 263.71heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)177061350286062352Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)174238816487388164Rat
1354588Bvd4Brain ventricular dilatation QTL 45.310.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)175819406487388164Rat
1354654Spl7Serum phospholipid level QTL 75.5blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)173803135483031354Rat
2317038Ginf3Gastrointestinal inflammation QTL 32.890.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)175482950393515804Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174096801789341781Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172723344583975845Rat
1354629Scl31Serum cholesterol level QTL 314.1blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)173803135483031354Rat
152025238Slep14Serum leptin concentration QTL 144.62blood leptin amount (VT:0005667)172439059584432719Rat
61466Niddm12Non-insulin dependent diabetes mellitus QTL 123.20.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)176515487293515804Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)173803135483031354Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)173803135483031354Rat
12904736Cm121Cardiac mass QTL 1210.043heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)174238816487388164Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)174605012691050126Rat
4889894Eae33Experimental allergic encephalomyelitis QTL 335.20.0001nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)175560459793006569Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)174265489587654895Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)173768787782687877Rat
1300131Bp193Blood pressure QTL 1933.3arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)176855004093515804Rat
7488963Bp369Blood pressure QTL 3690.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)176369714782818564Rat
1300129Rf25Renal function QTL 253.03blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)174106235286062352Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173219953486201342Rat
152023740Bp406Blood pressure QTL 4066.06arterial blood pressure trait (VT:2000000)172413612784432719Rat
152023737Bp405Blood pressure QTL 4055.06arterial blood pressure trait (VT:2000000)2413612784432719Rat
152023736Bp404Blood pressure QTL 4043.78arterial blood pressure trait (VT:2000000)172413612784432719Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173604553781045537Rat
2302365Gluco40Glucose level QTL 404.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)176456982086954580Rat

Markers in Region
BI294994  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21773,259,873 - 73,260,029 (+)MAPPERmRatBN7.2
Rnor_6.01777,217,997 - 77,218,152NCBIRnor6.0
Rnor_5.01778,884,089 - 78,884,244UniSTSRnor5.0
RGSC_v3.41784,348,260 - 84,348,415UniSTSRGSC3.4
Celera1772,699,657 - 72,699,812UniSTS
RH 3.4 Map17725.8UniSTS
Cytogenetic Map17q12.3UniSTS
RH136760  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21773,259,970 - 73,260,113 (+)MAPPERmRatBN7.2
Rnor_6.01777,218,094 - 77,218,236NCBIRnor6.0
Rnor_5.01778,884,186 - 78,884,328UniSTSRnor5.0
RGSC_v3.41784,348,357 - 84,348,499UniSTSRGSC3.4
Celera1772,699,754 - 72,699,896UniSTS
Cytogenetic Map17q12.3UniSTS
BM387785  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21773,229,026 - 73,229,241 (+)MAPPERmRatBN7.2
Rnor_6.01777,187,154 - 77,187,368NCBIRnor6.0
Rnor_5.01778,853,241 - 78,853,455UniSTSRnor5.0
RGSC_v3.41784,317,417 - 84,317,631UniSTSRGSC3.4
Celera1772,668,531 - 72,668,745UniSTS
RH 3.4 Map17729.6UniSTS
Cytogenetic Map17q12.3UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_145081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006254263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006254264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039095343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB050777 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB069907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB194259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB194260 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB222073 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB222074 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC105577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC086976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223875 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000024162   ⟹   ENSRNOP00000024162
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1777,176,716 - 77,216,243 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000042881   ⟹   ENSRNOP00000045795
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1778,118,895 - 78,169,543 (+)Ensembl
mRatBN7.2 Ensembl1773,209,575 - 73,260,251 (+)Ensembl
Rnor_6.0 Ensembl1777,167,740 - 77,218,389 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000074087   ⟹   ENSRNOP00000066459
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1778,118,866 - 78,169,543 (+)Ensembl
mRatBN7.2 Ensembl1773,209,575 - 73,260,251 (+)Ensembl
Rnor_6.0 Ensembl1777,195,715 - 77,218,374 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000081940   ⟹   ENSRNOP00000068551
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1777,195,247 - 77,216,240 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000083342   ⟹   ENSRNOP00000069034
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1777,176,716 - 77,216,243 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000091561   ⟹   ENSRNOP00000072832
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1778,118,866 - 78,169,543 (+)Ensembl
mRatBN7.2 Ensembl1773,209,575 - 73,260,251 (+)Ensembl
Rnor_6.0 Ensembl1777,185,053 - 77,218,061 (+)Ensembl
RefSeq Acc Id: NM_145081   ⟹   NP_659549
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81778,118,869 - 78,169,543 (+)NCBI
mRatBN7.21773,209,573 - 73,260,251 (+)NCBI
Rnor_6.01777,167,860 - 77,218,067 (+)NCBI
Rnor_5.01778,833,443 - 78,884,464 (+)NCBI
RGSC_v3.41784,298,122 - 84,348,330 (+)RGD
Celera1772,649,264 - 72,699,727 (+)RGD
Sequence:
RefSeq Acc Id: XM_006254264   ⟹   XP_006254326
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81778,118,847 - 78,169,543 (+)NCBI
mRatBN7.21773,209,575 - 73,260,251 (+)NCBI
Rnor_6.01777,167,701 - 77,218,374 (+)NCBI
Rnor_5.01778,833,443 - 78,884,464 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039095343   ⟹   XP_038951271
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81778,118,847 - 78,169,543 (+)NCBI
mRatBN7.21773,209,574 - 73,260,251 (+)NCBI
RefSeq Acc Id: XM_063276060   ⟹   XP_063132130
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81778,118,847 - 78,169,543 (+)NCBI
RefSeq Acc Id: XM_063276061   ⟹   XP_063132131
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81778,118,847 - 78,169,543 (+)NCBI
RefSeq Acc Id: XM_063276062   ⟹   XP_063132132
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81778,118,868 - 78,169,543 (+)NCBI
RefSeq Acc Id: XM_063276063   ⟹   XP_063132133
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81778,149,584 - 78,169,543 (+)NCBI
RefSeq Acc Id: NP_659549   ⟸   NM_145081
- UniProtKB: Q8R5M4 (UniProtKB/Swiss-Prot),   Q5PQX8 (UniProtKB/Swiss-Prot),   M0RAB4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006254326   ⟸   XM_006254264
- Peptide Label: isoform X4
- UniProtKB: Q8R5M4 (UniProtKB/Swiss-Prot),   Q5PQX8 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000024162   ⟸   ENSRNOT00000024162
Ensembl Acc Id: ENSRNOP00000072832   ⟸   ENSRNOT00000091561
Ensembl Acc Id: ENSRNOP00000068551   ⟸   ENSRNOT00000081940
Ensembl Acc Id: ENSRNOP00000069034   ⟸   ENSRNOT00000083342
Ensembl Acc Id: ENSRNOP00000045795   ⟸   ENSRNOT00000042881
Ensembl Acc Id: ENSRNOP00000066459   ⟸   ENSRNOT00000074087
RefSeq Acc Id: XP_038951271   ⟸   XM_039095343
- Peptide Label: isoform X3
- UniProtKB: Q8R5M4 (UniProtKB/Swiss-Prot),   Q5PQX8 (UniProtKB/Swiss-Prot),   F1M9C4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132130   ⟸   XM_063276060
- Peptide Label: isoform X1
- UniProtKB: Q8R5M4 (UniProtKB/Swiss-Prot),   Q5PQX8 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063132131   ⟸   XM_063276061
- Peptide Label: isoform X2
- UniProtKB: Q8R5M4 (UniProtKB/Swiss-Prot),   Q5PQX8 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063132132   ⟸   XM_063276062
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063132133   ⟸   XM_063276063
- Peptide Label: isoform X6
Protein Domains
CCHC NOA-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8R5M4-F1-model_v2 AlphaFold Q8R5M4 1-585 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700577
Promoter ID:EPDNEW_R11095
Type:initiation region
Name:Optn_1
Description:optineurin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01777,167,718 - 77,167,778EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628886 AgrOrtholog
BioCyc Gene G2FUF-8690 BioCyc
Ensembl Genes ENSRNOG00000017941 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000042881 ENTREZGENE
  ENSRNOT00000074087 ENTREZGENE
Gene3D-CATH L1 transposable element, trimerization domain UniProtKB/Swiss-Prot
  Nemo cc2-lz domain - 1d5 darpin complex UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7111026 IMAGE-MGC_LOAD
InterPro CC2-LZ_dom UniProtKB/Swiss-Prot
  NEMO_N UniProtKB/Swiss-Prot
  NEMO_ZF UniProtKB/Swiss-Prot
  Optineurin/NFkB_EssMod UniProtKB/Swiss-Prot
KEGG Report rno:246294 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93070 IMAGE-MGC_LOAD
NCBI Gene 246294 ENTREZGENE
PANTHER NF-KAPPA-B ESSENTIAL MODULATOR UniProtKB/Swiss-Prot
  PTHR31553:SF2 UniProtKB/Swiss-Prot
Pfam CC2-LZ UniProtKB/Swiss-Prot
  NEMO UniProtKB/Swiss-Prot
  zf_C2H2_10 UniProtKB/Swiss-Prot
PhenoGen Optn PhenoGen
PROSITE ZF_CCHC_NOA UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017941 RatGTEx
UniProt A0A0G2K3Z1_RAT UniProtKB/TrEMBL
  A6JLZ0_RAT UniProtKB/TrEMBL
  F1M9C4 ENTREZGENE, UniProtKB/TrEMBL
  M0RAB4 ENTREZGENE, UniProtKB/TrEMBL
  OPTN_RAT UniProtKB/Swiss-Prot
  Q5PQX8 ENTREZGENE
  Q8R5M4 ENTREZGENE
UniProt Secondary Q5PQX8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Optn  optineurin      Symbol and Name status set to approved 625702 APPROVED
2003-02-27 Optn  optineurin      Symbol and Name status set to provisional 70820 PROVISIONAL