Prb1 (proline-rich protein BstNI subfamily 1) - Rat Genome Database

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Gene: Prb1 (proline-rich protein BstNI subfamily 1) Rattus norvegicus
Analyze
Symbol: Prb1
Name: proline-rich protein BstNI subfamily 1
RGD ID: 628796
Description: Predicted to be located in extracellular region. Orthologous to several human genes including PRB1 (proline rich protein BstNI subfamily 1); PRB3 (proline rich protein BstNI subfamily 3); and PRB4 (proline rich protein BstNI subfamily 4); INTERACTS WITH 6-propyl-2-thiouracil; ammonium chloride; Cuprizon.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: acidic proline-rich protein PRP33; proline-rich proteoglycan 1; Prpg1
RGD Orthologs
Human
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84167,240,337 - 167,243,803 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4167,240,337 - 167,243,803 (-)EnsemblGRCr8
mRatBN7.24165,508,927 - 165,512,393 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4165,509,298 - 165,512,393 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4171,793,725 - 171,797,191 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04167,576,742 - 167,580,208 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04166,210,778 - 166,214,244 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04165,985,029 - 165,988,466 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4165,985,348 - 165,988,472 (-)Ensemblrn6Rnor6.0
Rnor_5.04228,551,785 - 228,554,903 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44169,555,514 - 169,558,606 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4154,106,655 - 154,109,747 (-)NCBICelera
RGSC_v3.14169,800,449 - 169,803,542 (-)NCBI
Cytogenetic Map4q42NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Novel secretory proline-rich proteoglycans from rat parotid. Cloning and characterization by expression in AtT-20 cells. Castle AM and Castle JD, J Biol Chem 1993 Sep 25;268(27):20490-6.
2. Novel multigene families encoding highly repetitive peptide sequences. Sequence analyses of rat and mouse proline-rich protein cDNAs. Clements S, etal., J Biol Chem 1985 Nov 5;260(25):13471-7.
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Nucleotide sequence analysis of a proline-rich protein cDNA and peptide homologies of rat and human proline-rich proteins. Ziemer MA, etal., J Biol Chem 1984 Aug 25;259(16):10475-80.

Genomics

Comparative Map Data
Prb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84167,240,337 - 167,243,803 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4167,240,337 - 167,243,803 (-)EnsemblGRCr8
mRatBN7.24165,508,927 - 165,512,393 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4165,509,298 - 165,512,393 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4171,793,725 - 171,797,191 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04167,576,742 - 167,580,208 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04166,210,778 - 166,214,244 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04165,985,029 - 165,988,466 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4165,985,348 - 165,988,472 (-)Ensemblrn6Rnor6.0
Rnor_5.04228,551,785 - 228,554,903 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44169,555,514 - 169,558,606 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4154,106,655 - 154,109,747 (-)NCBICelera
RGSC_v3.14169,800,449 - 169,803,542 (-)NCBI
Cytogenetic Map4q42NCBI
PRB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381211,351,821 - 11,355,591 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1211,351,823 - 11,355,591 (-)Ensemblhg38GRCh38
GRCh371211,504,755 - 11,508,525 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361211,396,024 - 11,399,791 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341211,396,023 - 11,399,791NCBI
Celera1216,647,011 - 16,650,779 (-)NCBICelera
Cytogenetic Map12p13.2NCBI
HuRef1211,269,097 - 11,272,891 (-)NCBIHuRef
CHM1_11211,469,942 - 11,473,466 (-)NCBICHM1_1
T2T-CHM13v2.01211,221,005 - 11,224,775 (-)NCBIT2T-CHM13v2.0

Variants

.
Variants in Prb1
31 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:26
Count of miRNA genes:25
Interacting mature miRNAs:25
Transcripts:ENSRNOT00000013887, ENSRNOT00000013943
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4146370897184426481Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4134095016179095016Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4149763204169799698Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4146370897184426481Rat
6478757Anxrr44Anxiety related response QTL 440.01087locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
1358364Sradr4Stress Responsive Adrenal Weight QTL 44.92adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)4131384565176384565Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4123870974168870974Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4140059299181024663Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4157292416184426481Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)494638356168870820Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4106848959168870974Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4127263297172263297Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4126334185171334185Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4147299608184426481Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
6478782Anxrr52Anxiety related response QTL 520.02091locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4123870974168870974Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4124700988169700988Rat
6478720Alc23Alcohol consumption QTL 230.00509drinking behavior trait (VT:0001422)ethanol drink intake rate to body weight ratio (CMO:0001616)4155834926184426481Rat
6478785Anxrr53Anxiety related response QTL 530.01397locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)4100752691179366077Rat
1581566Eae21Experimental allergic encephalomyelitis QTL 216.2body mass (VT:0001259)maximum body weight loss to initial body weight ratio (CMO:0001400)4137447185182447185Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4137430611182430611Rat
6478728Anxrr36Anxiety related response QTL 360.01061locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)486709649168870974Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4134199006168870974Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4148121375176967367Rat
6478733Anxrr37Anxiety related response QTL 370.00095locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4123870974168870974Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
6478737Anxrr38Anxiety related response QTL 380.00159locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4160623982184426481Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4148834094168870974Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
2 1 1 4 4 4 8 4 1 1 6 4

Sequence


Ensembl Acc Id: ENSRNOT00000013887   ⟹   ENSRNOP00000013885
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4167,240,337 - 167,243,803 (-)Ensembl
mRatBN7.2 Ensembl4165,509,298 - 165,512,393 (-)Ensembl
Rnor_6.0 Ensembl4165,985,372 - 165,988,472 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000077496   ⟹   ENSRNOP00000069163
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl4165,985,366 - 165,988,439 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000079259   ⟹   ENSRNOP00000069997
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl4165,985,348 - 165,988,440 (-)Ensembl
RefSeq Acc Id: NM_001395623   ⟹   NP_001382552
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84167,240,337 - 167,243,803 (-)NCBI
mRatBN7.24165,508,927 - 165,512,393 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001382552 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA03073 (Get FASTA)   NCBI Sequence Viewer  
  AAA41949 (Get FASTA)   NCBI Sequence Viewer  
  AAA41958 (Get FASTA)   NCBI Sequence Viewer  
  EDM01685 (Get FASTA)   NCBI Sequence Viewer  
  EDM01686 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000013885
GenBank Protein P04474 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Acc Id: ENSRNOP00000069997   ⟸   ENSRNOT00000079259
Ensembl Acc Id: ENSRNOP00000069163   ⟸   ENSRNOT00000077496
Ensembl Acc Id: ENSRNOP00000013885   ⟸   ENSRNOT00000013887
RefSeq Acc Id: NP_001382552   ⟸   NM_001395623
- Peptide Label: precursor
- UniProtKB: A6IMA3 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P04474-F1-model_v2 AlphaFold P04474 1-206 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628796 AgrOrtholog
BioCyc Gene G2FUF-42714 BioCyc
Ensembl Genes ENSRNOG00000010449 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000013887 ENTREZGENE
InterPro Pro-rich UniProtKB/Swiss-Prot
NCBI Gene 257652 ENTREZGENE
PANTHER BASIC SALIVARY PROLINE-RICH PROTEIN 1-RELATED UniProtKB/Swiss-Prot
  PTHR23203 UniProtKB/Swiss-Prot
Pfam Pro-rich UniProtKB/Swiss-Prot
PhenoGen Prb1 PhenoGen
RatGTEx ENSRNOG00000010449 RatGTEx
SMART Pro-rich UniProtKB/Swiss-Prot
UniProt A6IMA3 ENTREZGENE, UniProtKB/TrEMBL
  F1LMA2_RAT UniProtKB/TrEMBL
  P04474 ENTREZGENE, UniProtKB/Swiss-Prot
  Q07610_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-10 Prb1  proline-rich protein BstNI subfamily 1  Prpg1  proline-rich proteoglycan 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Prpg1  proline-rich proteoglycan 1      Symbol and Name status set to approved 1299863 APPROVED
2003-02-27 Prpg1  proline-rich proteoglycan 1      Symbol and Name status set to provisional 70820 PROVISIONAL