Shank2 (SH3 and multiple ankyrin repeat domains 2) - Rat Genome Database

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Gene: Shank2 (SH3 and multiple ankyrin repeat domains 2) Rattus norvegicus
Analyze
Symbol: Shank2
Name: SH3 and multiple ankyrin repeat domains 2
RGD ID: 628772
Description: Enables SH3 domain binding activity. A structural constituent of postsynaptic density. Involved in several processes, including adult locomotory behavior; associative learning; and social behavior. Located in several cellular components, including cell projection membrane; growth cone; and presynaptic active zone. Is active in glutamatergic synapse; hippocampal mossy fiber to CA3 synapse; and postsynaptic density. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human SHANK2 (SH3 and multiple ankyrin repeat domains 2); PARTICIPATES IN glutamate signaling pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; alpha-Zearalanol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cortactin-binding protein 1; CortBP1; GKAP/SAPAP-interacting protein; LOC103690160; proline rich synapse associated protein 1; proline-rich synapse-associated protein 1; ProSAP1; SH3 and multiple ankyrin repeat domains protein 2; SH3 and multiple ankyrin repeat domains protein 2-like; SH3/ankyrin domain gene 2; Shank2E; Spank-3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Shank2em13Sage
Genetic Models: SD-Shank2em13Sage
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81208,575,144 - 209,020,300 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1208,598,772 - 209,018,736 (+)EnsemblGRCr8
mRatBN7.21199,146,210 - 199,590,962 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1199,169,429 - 199,589,394 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1207,554,601 - 207,972,754 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01214,636,692 - 215,056,974 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01207,310,858 - 207,731,152 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01217,149,156 - 217,593,950 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1217,151,166 - 217,592,763 (+)Ensemblrn6Rnor6.0
Rnor_5.01224,028,791 - 224,450,737 (+)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.01222,118,530 - 222,150,341 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41204,399,856 - 204,855,474 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1196,732,183 - 197,149,084 (+)NCBICelera
RGSC_v3.11204,553,308 - 205,005,561 (+)NCBI
Cytogenetic Map1q42NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(S)-colchicine  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
4,4'-sulfonyldiphenol  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
androgen antagonist  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (EXP,ISO)
Butylparaben  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (EXP)
cocaine  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (EXP)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
DDE  (EXP)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dichloroacetic acid  (ISO)
dicrotophos  (ISO)
dimethyl sulfoxide  (ISO)
dorsomorphin  (ISO)
elemental selenium  (ISO)
enzacamene  (EXP)
epoxiconazole  (EXP,ISO)
ethanol  (ISO)
fenvalerate  (ISO)
fipronil  (EXP)
fumonisin B1  (ISO)
gabapentin  (ISO)
GW 4064  (ISO)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
imipramine  (ISO)
lead(0)  (ISO)
linuron  (EXP)
lithium chloride  (ISO)
melphalan  (ISO)
menadione  (ISO)
methapyrilene  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylphenidate  (EXP)
N-methyl-D-aspartic acid  (ISO)
N-Nitrosopyrrolidine  (ISO)
naled  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nitroglycerin  (EXP)
NMN zwitterion  (ISO)
Nor-9-carboxy-delta9-THC  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
potassium atom  (EXP)
prochloraz  (EXP)
procymidone  (EXP)
propanal  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sulfadiazine  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tributylstannane  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc dichloride  (EXP)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. An architectural framework that may lie at the core of the postsynaptic density. Baron MK, etal., Science. 2006 Jan 27;311(5760):531-5.
2. Proline-rich synapse-associated protein-1/cortactin binding protein 1 (ProSAP1/CortBP1) is a PDZ-domain protein highly enriched in the postsynaptic density. Boeckers TM, etal., J Neurosci 1999 Aug 1;19(15):6506-18.
3. Identification of a novel cortactin SH3 domain-binding protein and its localization to growth cones of cultured neurons. Du Y, etal., Mol Cell Biol 1998 Oct;18(10):5838-51.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Concerted action of zinc and ProSAP/Shank in synaptogenesis and synapse maturation. Grabrucker AM, etal., EMBO J. 2011 Feb 2;30(3):569-81. doi: 10.1038/emboj.2010.336. Epub 2011 Jan 7.
6. Shank2 associates with and regulates Na+/H+ exchanger 3. Han W, etal., J Biol Chem. 2006 Jan 20;281(3):1461-9. Epub 2005 Nov 17.
7. The interaction of phospholipase C-beta3 with Shank2 regulates mGluR-mediated calcium signal. Hwang JI, etal., J Biol Chem. 2005 Apr 1;280(13):12467-73. Epub 2005 Jan 4.
8. Solution structures of the SH3 domains from Shank scaffold proteins and their interactions with Cav1.3 calcium channels. Ishida H, etal., FEBS Lett. 2018 Aug;592(16):2786-2797. doi: 10.1002/1873-3468.13209. Epub 2018 Aug 12.
9. Inhibitory regulation of cystic fibrosis transmembrane conductance regulator anion-transporting activities by Shank2. Kim JY, etal., J Biol Chem. 2004 Mar 12;279(11):10389-96. doi: 10.1074/jbc.M312871200. Epub 2003 Dec 16.
10. The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins. Kreienkamp HJ, etal., J Biol Chem. 2000 Oct 20;275(42):32387-90.
11. Identification of proteins interacting with the rat somatostatin receptor subtype 2. Kreienkamp HJ, etal., J Physiol Paris. 2000 May-Aug;94(3-4):193-8.
12. Dynamic regulation of cystic fibrosis transmembrane conductance regulator by competitive interactions of molecular adaptors. Lee JH, etal., J Biol Chem. 2007 Apr 6;282(14):10414-22. Epub 2007 Jan 23.
13. BetaPix up-regulates Na+/H+ exchanger 3 through a Shank2-mediated protein-protein interaction. Lee JS, etal., J Biol Chem. 2010 Mar 12;285(11):8104-13. doi: 10.1074/jbc.M109.055079. Epub 2010 Jan 14.
14. Characterization of the Shank family of synaptic proteins. Multiple genes, alternative splicing, and differential expression in brain and development. Lim S, etal., J Biol Chem 1999 Oct 8;274(41):29510-8.
15. Shank2E binds NaP(i) cotransporter at the apical membrane of proximal tubule cells. McWilliams RR, etal., Am J Physiol Cell Physiol. 2005 Oct;289(4):C1042-51. Epub 2005 May 25.
16. Hyperactivity and Hypermotivation Associated With Increased Striatal mGluR1 Signaling in a Shank2 Rat Model of Autism. Modi ME, etal., Front Mol Neurosci. 2018 Jun 19;11:107. doi: 10.3389/fnmol.2018.00107. eCollection 2018.
17. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
18. The Shank family of postsynaptic density proteins interacts with and promotes synaptic accumulation of the beta PIX guanine nucleotide exchange factor for Rac1 and Cdc42. Park E, etal., J Biol Chem. 2003 May 23;278(21):19220-9. Epub 2003 Mar 7.
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. Linkage of the actin cytoskeleton to the postsynaptic density via direct interactions of Abp1 with the ProSAP/Shank family. Qualmann B, etal., J Neurosci. 2004 Mar 10;24(10):2481-95.
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Scaffolding proteins in highly purified rat olfactory cilia membranes. Saavedra MV, etal., Neuroreport. 2008 Jul 16;19(11):1123-6. doi: 10.1097/WNR.0b013e3283086797.
24. The G protein-coupled receptor CL1 interacts directly with proteins of the Shank family. Tobaben S, etal., J Biol Chem 2000 Nov 17;275(46):36204-10.
25. DGKiota regulates presynaptic release during mGluR-dependent LTD. Yang J, etal., EMBO J. 2011 Jan 5;30(1):165-80. doi: 10.1038/emboj.2010.286. Epub 2010 Nov 30.
Additional References at PubMed
PMID:10373412   PMID:10527873   PMID:10806096   PMID:11583995   PMID:14977424   PMID:15207857   PMID:15458844   PMID:16606358   PMID:16758162   PMID:17120053   PMID:19299912   PMID:20131911  
PMID:20473310   PMID:20800661   PMID:20810910   PMID:21795692   PMID:22699619   PMID:22699620   PMID:25775468   PMID:26627310   PMID:27890541   PMID:29250591   PMID:29476059   PMID:32564287  
PMID:37574039  


Genomics

Comparative Map Data
Shank2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81208,575,144 - 209,020,300 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1208,598,772 - 209,018,736 (+)EnsemblGRCr8
mRatBN7.21199,146,210 - 199,590,962 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1199,169,429 - 199,589,394 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1207,554,601 - 207,972,754 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01214,636,692 - 215,056,974 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01207,310,858 - 207,731,152 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01217,149,156 - 217,593,950 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1217,151,166 - 217,592,763 (+)Ensemblrn6Rnor6.0
Rnor_5.01224,028,791 - 224,450,737 (+)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.01222,118,530 - 222,150,341 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41204,399,856 - 204,855,474 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1196,732,183 - 197,149,084 (+)NCBICelera
RGSC_v3.11204,553,308 - 205,005,561 (+)NCBI
Cytogenetic Map1q42NCBI
SHANK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381170,467,854 - 71,253,234 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1170,467,805 - 71,252,844 (-)Ensemblhg38GRCh38
GRCh371170,313,959 - 70,963,623 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361169,991,609 - 70,185,520 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341170,012,765 - 70,185,520NCBI
Celera1167,575,145 - 68,227,408 (-)NCBICelera
Cytogenetic Map11q13.3-q13.4NCBI
HuRef1166,575,130 - 67,004,438 (-)NCBIHuRef
HuRef1167,062,872 - 67,229,732 (-)NCBIHuRef
CHM1_11170,197,402 - 70,819,749 (-)NCBICHM1_1
T2T-CHM13v2.01170,488,279 - 71,179,623 (-)NCBIT2T-CHM13v2.0
Shank2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397143,531,819 - 143,979,780 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7143,555,665 - 143,978,231 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm387143,978,077 - 144,426,043 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7144,001,928 - 144,424,494 (+)Ensemblmm10GRCm38
MGSCv377151,361,425 - 151,608,580 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv367143,840,654 - 144,232,065 (+)NCBIMGSCv36mm8
Celera7143,939,514 - 144,185,177 (+)NCBICelera
Cytogenetic Map7F5NCBI
cM Map788.45NCBI
Shank2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542215,295,772 - 15,814,711 (+)Ensembl
ChiLan1.0NW_00495542215,295,800 - 15,818,067 (+)NCBIChiLan1.0ChiLan1.0
SHANK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2971,441,934 - 72,138,948 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11172,486,126 - 73,180,580 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01165,570,677 - 66,268,139 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11168,857,186 - 69,495,237 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1168,860,606 - 69,437,925 (-)EnsemblpanPan2panpan1.1
SHANK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11847,477,625 - 47,915,557 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1847,635,788 - 47,912,117 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1846,010,915 - 46,522,454 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01848,113,005 - 48,589,823 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1848,098,110 - 48,589,819 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11847,525,882 - 48,036,670 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01847,111,601 - 47,622,440 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01847,858,659 - 48,368,562 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Shank2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049473,637,810 - 4,021,398 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936599217,138 - 463,771 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936599196,512 - 463,749 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SHANK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl22,864,331 - 3,015,314 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.122,517,853 - 3,016,959 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22924,313 - 1,073,976 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SHANK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.113,453,268 - 4,104,515 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666038100,644,177 - 101,362,369 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Shank2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476716,380,751 - 16,823,577 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476716,296,053 - 16,828,714 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Shank2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v125,298,441 - 5,687,447 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Shank2
2703 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:264
Count of miRNA genes:92
Interacting mature miRNAs:105
Transcripts:ENSRNOT00000071484, ENSRNOT00000071741, ENSRNOT00000075078
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1207243873252243873Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1177339686222339686Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1181059071226059071Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1181059071226059071Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1182039247227039247Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1183564652228564652Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1193964073238964073Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1160573753210707719Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1181059071226059071Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1160573753210707719Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1165278545210278545Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1181059071226059071Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1194575422239575422Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1168063662213063662Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1193400541238400541Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1163992710208992710Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1200449456256003563Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1182535316227535316Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1207163993269633915Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1181059071226059071Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1181059071226059071Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1207243873252243873Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1202543537247543537Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1208479811269633915Rat
1358292Cm37Cardiac mass QTL 376.28e-07heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1205674651250674651Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1207243873252243873Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1203300512229359342Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1180739993225739993Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1191190115223964326Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1172718770228180370Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1194786607262083703Rat
2292218Kidm35Kidney mass QTL 35kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1208798288253798288Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1188241285250779312Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
1300168Bp170Blood pressure QTL 1702.76arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1192995199237995199Rat
61403Niddm4Non-insulin dependent diabetes mellitus QTL 4blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1201464383246464383Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1203675682248675682Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1205674651250674651Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1185979875230979875Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1197807365233480676Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
6480773Gluco64Glucose level QTL 645.09blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1208479811209116975Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753210707719Rat
634338Hcar4Hepatocarcinoma resistance QTL 44.6liver integrity trait (VT:0010547)liver tumorous lesion number to liver area ratio (CMO:0001210)1202851915223964440Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1193400541238400541Rat
6480783Insul19Insulin level QTL 194.33blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1203300512213659238Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1207099883252099883Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1165707719210707719Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1173363824227535316Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1191260175236260175Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2325727Pia41Pristane induced arthritis QTL 41joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1188241285233241285Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1160573753210707719Rat

Markers in Region
D1Rat168  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81208,798,288 - 208,798,499 (+)Marker Load Pipeline
mRatBN7.21199,368,955 - 199,369,166 (+)MAPPERmRatBN7.2
Rnor_6.01217,372,257 - 217,372,467NCBIRnor6.0
Rnor_5.01224,224,750 - 224,224,960UniSTSRnor5.0
RGSC_v3.41204,621,918 - 204,622,129RGDRGSC3.4
RGSC_v3.41204,621,919 - 204,622,129UniSTSRGSC3.4
Celera1196,929,409 - 196,929,619UniSTS
RGSC_v3.11204,775,371 - 204,775,582RGD
RH 2.0 Map11104.7RGD
SHRSP x BN Map1104.5599RGD
Cytogenetic Map1q41UniSTS
D1Got184  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21199,463,338 - 199,463,553 (+)MAPPERmRatBN7.2
Rnor_6.01217,466,279 - 217,466,493NCBIRnor6.0
Rnor_5.01224,319,717 - 224,319,931UniSTSRnor5.0
Rnor_5.01224,808,843 - 224,809,057UniSTSRnor5.0
RGSC_v3.41204,729,897 - 204,730,112RGDRGSC3.4
RGSC_v3.41204,729,898 - 204,730,112UniSTSRGSC3.4
Celera1197,023,455 - 197,023,669UniSTS
RGSC_v3.11204,883,350 - 204,883,565RGD
RH 2.0 Map11103.1RGD
Cytogenetic Map1q41UniSTS
D1Wox81  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21199,587,887 - 199,588,094 (+)MAPPERmRatBN7.2
Rnor_6.01217,590,876 - 217,591,082NCBIRnor6.0
Rnor_6.01215,243,564 - 215,243,770NCBIRnor6.0
Rnor_5.01222,147,267 - 222,147,473UniSTSRnor5.0
Rnor_5.01224,447,663 - 224,447,869UniSTSRnor5.0
RGSC_v3.41204,853,947 - 204,854,153UniSTSRGSC3.4
Celera1197,147,557 - 197,147,763UniSTS
Cytogenetic Map1q41UniSTS
RH138116  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21199,341,510 - 199,341,650 (+)MAPPERmRatBN7.2
Rnor_6.01217,344,812 - 217,344,951NCBIRnor6.0
Rnor_5.01224,196,988 - 224,197,127UniSTSRnor5.0
RGSC_v3.41204,586,021 - 204,586,160UniSTSRGSC3.4
RH 3.4 Map11561.9UniSTS
Cytogenetic Map1q41UniSTS


Genetic Models
This gene Shank2 is modified in the following models/strains:
SD-Shank2em13Sage    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 9 62 163 91 90 59 36 59 6 292 129 10 142 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001004133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_133440 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_133441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_201350 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008760068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588724 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588727 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039087396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274282 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274330 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274415 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274452 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274485 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274595 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005490582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC125304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC131216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF060116 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF141903 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF159048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ131899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ249562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY298755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000071235   ⟹   ENSRNOP00000065594
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1215,214,853 - 215,241,723 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000071484   ⟹   ENSRNOP00000064763
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1208,775,132 - 209,018,736 (+)Ensembl
mRatBN7.2 Ensembl1199,345,799 - 199,589,394 (+)Ensembl
Rnor_6.0 Ensembl1217,151,166 - 217,592,763 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000071741   ⟹   ENSRNOP00000067841
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1208,598,772 - 209,015,387 (+)Ensembl
mRatBN7.2 Ensembl1199,169,429 - 199,586,049 (+)Ensembl
Rnor_6.0 Ensembl1217,345,545 - 217,589,035 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000075078   ⟹   ENSRNOP00000065891
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1199,169,429 - 199,586,049 (+)Ensembl
Rnor_6.0 Ensembl1217,173,199 - 217,589,037 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000080442   ⟹   ENSRNOP00000074205
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1215,214,853 - 215,241,723 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000092278   ⟹   ENSRNOP00000075778
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1217,349,493 - 217,566,581 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000092357   ⟹   ENSRNOP00000075800
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1208,836,164 - 209,018,736 (+)Ensembl
mRatBN7.2 Ensembl1199,407,033 - 199,589,394 (+)Ensembl
Rnor_6.0 Ensembl1217,459,321 - 217,589,488 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000092386   ⟹   ENSRNOP00000075919
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1199,456,274 - 199,589,394 (+)Ensembl
Rnor_6.0 Ensembl1217,459,215 - 217,592,403 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000092516   ⟹   ENSRNOP00000075839
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1208,771,186 - 209,018,736 (+)Ensembl
mRatBN7.2 Ensembl1199,341,853 - 199,589,394 (+)Ensembl
Rnor_6.0 Ensembl1217,345,154 - 217,592,403 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000092579   ⟹   ENSRNOP00000075896
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1217,349,497 - 217,577,938 (+)Ensembl
RefSeq Acc Id: NM_001004133   ⟹   NP_001004133
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81208,885,732 - 209,015,838 (+)NCBI
mRatBN7.21199,456,380 - 199,586,500 (+)NCBI
Rnor_6.01217,459,321 - 217,589,488 (+)NCBI
Rnor_5.01224,028,791 - 224,450,737 (+)NCBI
RGSC_v3.41204,399,856 - 204,855,474 (+)RGD
Celera1197,016,496 - 197,146,169 (+)NCBI
Sequence:
RefSeq Acc Id: NM_133440   ⟹   NP_597684
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81208,885,626 - 209,018,753 (+)NCBI
mRatBN7.21199,456,274 - 199,589,415 (+)NCBI
Rnor_6.01217,459,215 - 217,592,403 (+)NCBI
Rnor_5.01224,028,791 - 224,450,737 (+)NCBI
RGSC_v3.41204,399,856 - 204,855,474 (+)RGD
Celera1197,016,390 - 197,149,084 (+)NCBI
Sequence:
RefSeq Acc Id: NM_133441   ⟹   NP_597685
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81208,771,186 - 209,018,753 (+)NCBI
mRatBN7.21199,341,853 - 199,589,415 (+)NCBI
Rnor_6.01217,345,154 - 217,592,403 (+)NCBI
Rnor_5.01224,028,791 - 224,450,737 (+)NCBI
RGSC_v3.41204,399,856 - 204,855,474 (+)RGD
Celera1196,902,548 - 197,149,084 (+)NCBI
Sequence:
RefSeq Acc Id: NM_201350   ⟹   NP_958738
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81208,598,772 - 209,015,387 (+)NCBI
mRatBN7.21199,169,429 - 199,586,049 (+)NCBI
Rnor_6.01217,173,199 - 217,589,037 (+)NCBI
Rnor_5.01224,028,791 - 224,450,737 (+)NCBI
RGSC_v3.41204,399,856 - 204,855,474 (+)RGD
Celera1196,732,183 - 197,145,718 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008760068   ⟹   XP_008758290
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81208,576,345 - 209,020,300 (+)NCBI
mRatBN7.21199,147,005 - 199,586,047 (+)NCBI
Rnor_6.01217,150,473 - 217,593,950 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017588727   ⟹   XP_017444216
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81208,576,345 - 209,020,300 (+)NCBI
mRatBN7.21199,147,005 - 199,590,962 (+)NCBI
Rnor_6.01217,150,473 - 217,593,950 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039087396   ⟹   XP_038943324
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81208,885,698 - 209,020,300 (+)NCBI
mRatBN7.21199,456,804 - 199,586,047 (+)NCBI
RefSeq Acc Id: XM_063274252   ⟹   XP_063130322
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81208,576,345 - 209,020,300 (+)NCBI
RefSeq Acc Id: XM_063274282   ⟹   XP_063130352
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81208,575,534 - 209,020,300 (+)NCBI
RefSeq Acc Id: XM_063274304   ⟹   XP_063130374
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81208,575,144 - 209,020,300 (+)NCBI
RefSeq Acc Id: XM_063274330   ⟹   XP_063130400
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81208,575,892 - 209,020,300 (+)NCBI
RefSeq Acc Id: XM_063274364   ⟹   XP_063130434
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81208,576,345 - 209,020,300 (+)NCBI
RefSeq Acc Id: XM_063274415   ⟹   XP_063130485
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81208,576,345 - 209,020,300 (+)NCBI
RefSeq Acc Id: XM_063274452   ⟹   XP_063130522
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81208,576,345 - 209,020,300 (+)NCBI
RefSeq Acc Id: XM_063274485   ⟹   XP_063130555
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81208,576,345 - 209,020,300 (+)NCBI
RefSeq Acc Id: XM_063274526   ⟹   XP_063130596
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81208,576,344 - 209,020,300 (+)NCBI
RefSeq Acc Id: XM_063274560   ⟹   XP_063130630
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81208,576,345 - 209,020,300 (+)NCBI
RefSeq Acc Id: XM_063274595   ⟹   XP_063130665
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81208,576,345 - 209,020,300 (+)NCBI
RefSeq Acc Id: XM_063274623   ⟹   XP_063130693
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81208,576,345 - 209,020,300 (+)NCBI
RefSeq Acc Id: XM_063274697   ⟹   XP_063130767
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81208,757,724 - 209,020,300 (+)NCBI
RefSeq Acc Id: XM_063274743   ⟹   XP_063130813
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81208,835,863 - 209,020,300 (+)NCBI
RefSeq Acc Id: XR_005490582
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81208,576,131 - 209,001,536 (+)NCBI
mRatBN7.21199,146,990 - 199,572,198 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001004133 (Get FASTA)   NCBI Sequence Viewer  
  NP_597684 (Get FASTA)   NCBI Sequence Viewer  
  NP_597685 (Get FASTA)   NCBI Sequence Viewer  
  NP_958738 (Get FASTA)   NCBI Sequence Viewer  
  XP_008758290 (Get FASTA)   NCBI Sequence Viewer  
  XP_017444216 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943324 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130322 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130352 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130374 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130400 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130434 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130485 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130522 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130555 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130596 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130630 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130665 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130693 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130767 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130813 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC62226 (Get FASTA)   NCBI Sequence Viewer  
  AAD42977 (Get FASTA)   NCBI Sequence Viewer  
  AAF02497 (Get FASTA)   NCBI Sequence Viewer  
  AAP85236 (Get FASTA)   NCBI Sequence Viewer  
  CAB44312 (Get FASTA)   NCBI Sequence Viewer  
  CAB44313 (Get FASTA)   NCBI Sequence Viewer  
  CAB44314 (Get FASTA)   NCBI Sequence Viewer  
  CAB56522 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000065891.2
  ENSRNOP00000067841
  ENSRNOP00000075800
  ENSRNOP00000075839
  ENSRNOP00000075839.1
  ENSRNOP00000075919.2
GenBank Protein Q9QX74 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_958738   ⟸   NM_201350
- Peptide Label: isoform a
- UniProtKB: A0A8L2QYJ0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_597685   ⟸   NM_133441
- Peptide Label: isoform d
- UniProtKB: M0R5T5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_597684   ⟸   NM_133440
- Peptide Label: isoform c
- UniProtKB: A0A8L2RC58 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001004133   ⟸   NM_001004133
- Peptide Label: isoform b
- UniProtKB: A0A8L2RC58 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008758290   ⟸   XM_008760068
- Peptide Label: isoform X2
- UniProtKB: A0A8L2QYJ0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017444216   ⟸   XM_017588727
- Peptide Label: isoform X10
- UniProtKB: A0A8L2QYJ0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075778   ⟸   ENSRNOT00000092278
Ensembl Acc Id: ENSRNOP00000075919   ⟸   ENSRNOT00000092386
Ensembl Acc Id: ENSRNOP00000075800   ⟸   ENSRNOT00000092357
Ensembl Acc Id: ENSRNOP00000075839   ⟸   ENSRNOT00000092516
Ensembl Acc Id: ENSRNOP00000075896   ⟸   ENSRNOT00000092579
Ensembl Acc Id: ENSRNOP00000065891   ⟸   ENSRNOT00000075078
Ensembl Acc Id: ENSRNOP00000064763   ⟸   ENSRNOT00000071484
Ensembl Acc Id: ENSRNOP00000067841   ⟸   ENSRNOT00000071741
RefSeq Acc Id: XP_038943324   ⟸   XM_039087396
- Peptide Label: isoform X13
- UniProtKB: A0A8L2RC58 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000065594   ⟸   ENSRNOT00000071235
Ensembl Acc Id: ENSRNOP00000074205   ⟸   ENSRNOT00000080442
RefSeq Acc Id: XP_063130374   ⟸   XM_063274304
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QYJ0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130352   ⟸   XM_063274282
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QYJ0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130400   ⟸   XM_063274330
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QYJ0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130596   ⟸   XM_063274526
- Peptide Label: isoform X6
- UniProtKB: A0A8L2QYJ0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130485   ⟸   XM_063274415
- Peptide Label: isoform X3
- UniProtKB: A0A8L2QYJ0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130630   ⟸   XM_063274560
- Peptide Label: isoform X7
- UniProtKB: A0A8L2QYJ0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130693   ⟸   XM_063274623
- Peptide Label: isoform X9
- UniProtKB: A0A8L2QYJ0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130322   ⟸   XM_063274252
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QYJ0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130522   ⟸   XM_063274452
- Peptide Label: isoform X4
- UniProtKB: A0A8L2QYJ0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130665   ⟸   XM_063274595
- Peptide Label: isoform X8
- UniProtKB: A0A8L2QYJ0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130555   ⟸   XM_063274485
- Peptide Label: isoform X5
- UniProtKB: A0A8L2QYJ0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130434   ⟸   XM_063274364
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QYJ0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130767   ⟸   XM_063274697
- Peptide Label: isoform X11
- UniProtKB: Q9WV46 (UniProtKB/Swiss-Prot),   Q9WUW0 (UniProtKB/Swiss-Prot),   Q9WUV9 (UniProtKB/Swiss-Prot),   Q9QZZ9 (UniProtKB/Swiss-Prot),   Q9QX93 (UniProtKB/Swiss-Prot),   Q9QX74 (UniProtKB/Swiss-Prot),   Q6WB19 (UniProtKB/Swiss-Prot),   O70470 (UniProtKB/Swiss-Prot),   M0R5T5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130813   ⟸   XM_063274743
- Peptide Label: isoform X12
- UniProtKB: A0A8L2RC58 (UniProtKB/TrEMBL)
Protein Domains
PDZ   SAM   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R805-F1-model_v2 AlphaFold M0R805 1-1167 view protein structure
AF-Q9QX74-F1-model_v2 AlphaFold Q9QX74 1-1474 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690583
Promoter ID:EPDNEW_R1107
Type:single initiation site
Name:Shank2_1
Description:SH3 and multiple ankyrin repeat domains 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01217,459,268 - 217,459,328EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628772 AgrOrtholog
BioCyc Gene G2FUF-56853 BioCyc
Ensembl Genes ENSRNOG00000047651 Ensembl
  ENSRNOG00000050206 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000071741 ENTREZGENE
  ENSRNOT00000075078.4 UniProtKB/Swiss-Prot
  ENSRNOT00000092357 ENTREZGENE
  ENSRNOT00000092386.2 UniProtKB/Swiss-Prot
  ENSRNOT00000092516 ENTREZGENE
  ENSRNOT00000092516.2 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.150.50 UniProtKB/Swiss-Prot
  2.30.42.10 UniProtKB/Swiss-Prot
  SH3 Domains UniProtKB/Swiss-Prot
InterPro PDZ UniProtKB/Swiss-Prot
  PDZ_6 UniProtKB/Swiss-Prot
  PDZ_sf UniProtKB/Swiss-Prot
  SAM UniProtKB/Swiss-Prot
  SAM/pointed_sf UniProtKB/Swiss-Prot
  SH3-like_dom_sf UniProtKB/Swiss-Prot
  SH3_domain UniProtKB/Swiss-Prot
  SHANK UniProtKB/Swiss-Prot
KEGG Report rno:171093 UniProtKB/Swiss-Prot
NCBI Gene 171093 ENTREZGENE
PANTHER SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN UniProtKB/Swiss-Prot
  SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN 2 UniProtKB/Swiss-Prot
Pfam PDZ_6 UniProtKB/Swiss-Prot
  SAM_1 UniProtKB/Swiss-Prot
  SH3_2 UniProtKB/Swiss-Prot
PhenoGen Shank2 PhenoGen
PROSITE PDZ UniProtKB/Swiss-Prot
  SAM_DOMAIN UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000047651 RatGTEx
  ENSRNOG00000050206 RatGTEx
SMART PDZ UniProtKB/Swiss-Prot
  SAM UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47769 UniProtKB/Swiss-Prot
  SSF50044 UniProtKB/Swiss-Prot
  SSF50156 UniProtKB/Swiss-Prot
UniProt A0A8L2QYJ0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2RC58 ENTREZGENE, UniProtKB/TrEMBL
  M0R5T5 ENTREZGENE, UniProtKB/TrEMBL
  O70470 ENTREZGENE
  Q6WB19 ENTREZGENE
  Q9QX74 ENTREZGENE
  Q9QX93 ENTREZGENE
  Q9QZZ9 ENTREZGENE
  Q9WUV9 ENTREZGENE
  Q9WUW0 ENTREZGENE
  Q9WV46 ENTREZGENE
  SHAN2_RAT UniProtKB/Swiss-Prot
UniProt Secondary O70470 UniProtKB/Swiss-Prot
  Q6WB19 UniProtKB/Swiss-Prot
  Q9QX93 UniProtKB/Swiss-Prot
  Q9QZZ9 UniProtKB/Swiss-Prot
  Q9WUV9 UniProtKB/Swiss-Prot
  Q9WUW0 UniProtKB/Swiss-Prot
  Q9WV46 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Shank2  SH3 and multiple ankyrin repeat domains 2  LOC103690160  SH3 and multiple ankyrin repeat domains protein 2-like  Data merged from RGD:9143352 737654 PROVISIONAL
2014-08-25 LOC103690160  SH3 and multiple ankyrin repeat domains protein 2-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-11-04 Shank2  SH3 and multiple ankyrin repeat domains 2  Shank2  SH3/ankyrin domain gene 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Shank2  SH3/ankyrin domain gene 2    proline rich synapse associated protein 1  Name updated 1299863 APPROVED
2003-02-27 Shank2  proline rich synapse associated protein 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains a PDZ domain 633972