Aqp11 (aquaporin 11) - Rat Genome Database

Name: Aqp11
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Aqp11 (aquaporin 11) Rattus norvegicus

Analyze

Symbol:

Aqp11

Name:

aquaporin 11

RGD ID:

628763

Description:

Enables identical protein binding activity. Predicted to be involved in several processes, including glycerol transmembrane transport; hydrogen peroxide transmembrane transport; and intracellular oxygen homeostasis. Predicted to act upstream of or within with a positive effect on protein glycosylation. Predicted to act upstream of or within endosomal lumen acidification and kidney development. Located in cell surface and dendrite. Orthologous to human AQP11 (aquaporin 11); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

AQP-11; aquaporin-11

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	AQP11 (aquaporin 11)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Aqp11 (aquaporin 11)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Aqp11 (aquaporin 11)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	AQP11 (aquaporin 11)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	AQP11 (aquaporin 11)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Aqp11 (aquaporin 11)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	AQP11 (aquaporin 11)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	AQP11 (aquaporin 11)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Aqp11 (aquaporin 11)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	TBC1D24 (TBC1 domain family member 24)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	AQP11 (aquaporin 11)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Aqp11 (aquaporin 11)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	aqp11 (aquaporin 11)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	AQP	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	aqp-10	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|PANTHER)
Caenorhabditis elegans (roundworm):	aqp-11	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Caenorhabditis elegans (roundworm):	aqp-9	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	aqp11	Alliance	DIOPT (Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)

Candidate Gene For:

Bw192

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	161,457,752 - 161,467,918 (-)	NCBI		GRCr8
mRatBN7.2	1	152,046,515 - 152,056,675 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	152,046,517 - 152,056,725 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	160,033,373 - 160,043,515 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	167,213,553 - 167,223,696 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	160,087,040 - 160,097,182 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	162,703,394 - 162,713,560 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	162,703,442 - 162,713,610 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	168,910,171 - 168,920,337 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	154,973,796 - 154,983,962 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	155,052,203 - 155,062,368 (-)	NCBI
Celera	1	150,140,146 - 150,150,299 (-)	NCBI		Celera
Cytogenetic Map	1	q32	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

intellectual disability (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,1-dichloroethene (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-palmitoylglycerol (ISO)

3,3',4,4'-tetrachlorobiphenyl (ISO)

6-propyl-2-thiouracil (EXP)

acrylamide (EXP,ISO)

aflatoxin B1 (ISO)

amitrole (EXP)

ammonium chloride (EXP)

arsenite(3-) (ISO)

atrazine (ISO)

azathioprine (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

C60 fullerene (EXP)

carbamazepine (ISO)

carbon nanotube (ISO)

cisplatin (EXP,ISO)

clofibrate (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

decabromodiphenyl ether (ISO)

dextran sulfate (ISO)

dicrotophos (ISO)

dieldrin (EXP)

diprotium oxide (ISO)

flutamide (EXP)

folic acid (ISO)

heptachlor (EXP)

hydrogen peroxide (ISO)

lycopene (ISO)

menadione (ISO)

mercaptoethanol (ISO)

mercury dichloride (ISO)

methimazole (EXP)

paracetamol (EXP,ISO)

perfluorohexanesulfonic acid (ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

potassium dichromate (ISO)

quercetin (ISO)

resveratrol (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

succimer (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trichloroethene (EXP)

triptonide (ISO)

valproic acid (ISO)

vancomycin (ISO)

water (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

endosomal lumen acidification (ISO)

glycerol transmembrane transport (IDA,IEA,ISO,ISS)

hydrogen peroxide transmembrane transport (IEA,ISO,ISS)

intracellular oxygen homeostasis (ISO)

intracellular water homeostasis (IEA,ISO,ISS)

kidney development (ISO)

monoatomic ion transport (IDA,ISO)

negative regulation of epithelial cell proliferation (ISO,ISS)

negative regulation of ERAD pathway (ISO,ISS)

negative regulation of response to endoplasmic reticulum stress (ISO,ISS)

positive regulation of cell population proliferation (IEA,ISO,ISS)

protein glycosylation (ISO,ISS)

protein homooligomerization (IEA,ISO,ISS)

protein targeting to membrane (ISO,ISS)

proximal tubule development (ISO,ISS)

transmembrane transport (IEA)

urea transport (IDA,ISO)

water transport (IDA,IEA,ISO,ISS)

Cellular Component

cell surface (IDA,IEA,ISO)

cytoplasm (IBA,IEA,ISO)

cytoplasmic vesicle membrane (IEA)

dendrite (IDA)

endoplasmic reticulum (IEA,ISO,ISS)

endoplasmic reticulum membrane (IEA)

intracellular membrane-bounded organelle (ISO)

membrane (IEA)

perinuclear region of cytoplasm (ISO,ISS)

plasma membrane (IEA,ISO)

Molecular Function

channel activity (IBA,IEA)

glycerol channel activity (IEA,ISO,ISS)

identical protein binding (IPI)

water channel activity (IEA,ISO,ISS)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Aquaporin-11: a channel protein lacking apparent transport function expressed in brain.	Gorelick DA, etal., BMC Biochem. 2006 May 1;7:14.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	GOA pipeline	RGD automated data pipeline
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
6.	Comprehensive gene review and curation	RGD comprehensive gene curation
7.	Information Derived from GenBank Report	RGD, Sept. 2003
8.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:15489334	PMID:16107722	PMID:17178102	PMID:18606867	PMID:18701606	PMID:19812234	PMID:21118806	PMID:21251984	PMID:24845055	PMID:24854278	PMID:24918044	PMID:27582095
PMID:30337368	PMID:30563120	PMID:30656220	PMID:31546170

Genomics

Comparative Map Data

Aqp11
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	161,457,752 - 161,467,918 (-)	NCBI		GRCr8
mRatBN7.2	1	152,046,515 - 152,056,675 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	152,046,517 - 152,056,725 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	160,033,373 - 160,043,515 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	167,213,553 - 167,223,696 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	160,087,040 - 160,097,182 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	162,703,394 - 162,713,560 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	162,703,442 - 162,713,610 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	168,910,171 - 168,920,337 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	154,973,796 - 154,983,962 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	155,052,203 - 155,062,368 (-)	NCBI
Celera	1	150,140,146 - 150,150,299 (-)	NCBI		Celera
Cytogenetic Map	1	q32	NCBI

AQP11
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	77,589,953 - 77,610,356 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	77,589,391 - 77,610,356 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	77,300,998 - 77,321,401 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	76,978,328 - 76,998,342 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	76,978,327 - 76,998,339	NCBI
Celera	11	74,608,361 - 74,629,072 (+)	NCBI		Celera
Cytogenetic Map	11	q14.1	NCBI
HuRef	11	73,599,078 - 73,619,798 (+)	NCBI		HuRef
CHM1_1	11	77,183,785 - 77,204,503 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	77,523,008 - 77,543,410 (+)	NCBI		T2T-CHM13v2.0

Aqp11
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	97,375,586 - 97,387,454 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	97,373,213 - 97,387,496 (-)	Ensembl		GRCm39 Ensembl
GRCm38	7	97,726,379 - 97,738,247 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	97,724,006 - 97,738,289 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	104,874,889 - 104,886,757 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	97,601,571 - 97,613,439 (-)	NCBI		MGSCv36	mm8
Celera	7	98,046,312 - 98,058,532 (-)	NCBI		Celera
Cytogenetic Map	7	E1	NCBI
cM Map	7	53.57	NCBI

Aqp11
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955414	14,245,682 - 14,260,717 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955414	14,245,682 - 14,260,717 (-)	NCBI	ChiLan1.0	ChiLan1.0

AQP11
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	78,522,280 - 78,547,456 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	79,570,672 - 79,595,844 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	72,653,721 - 72,673,698 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	76,295,778 - 76,315,292 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	76,295,778 - 76,315,292 (+)	Ensembl	panpan1.1		panPan2

AQP11
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	21	21,170,760 - 21,185,709 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	21	21,171,008 - 21,185,429 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	21	21,062,597 - 21,077,580 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	21	21,368,876 - 21,383,901 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	21	21,367,271 - 21,383,947 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	21	21,145,467 - 21,160,437 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	21	21,361,689 - 21,376,239 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	21	21,285,087 - 21,299,649 (-)	NCBI		UU_Cfam_GSD_1.0

Aqp11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	64,613,980 - 64,634,881 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936498	6,213,583 - 6,237,273 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

AQP11
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	12,065,546 - 12,078,401 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	12,065,550 - 12,076,339 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	13,217,315 - 13,228,258 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

AQP11
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	68,805,354 - 68,824,017 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	68,807,025 - 68,824,792 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666043	56,947,167 - 56,965,056 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Aqp11
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624863	678,953 - 694,505 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624863	679,049 - 694,765 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Aqp11
50 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	149
Count of miRNA genes:	119
Interacting mature miRNAs:	125
Transcripts:	ENSRNOT00000018091
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
70225	Bp58	Blood pressure QTL 58	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	32356093	162846471	Rat
10059597	Bp377	Blood pressure QTL 377	3.42	0.025	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	32737458	199368955	Rat
1578654	Bss10	Bone structure and strength QTL 10	4		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	1	49393172	159356837	Rat
634314	Niddm44	Non-insulin dependent diabetes mellitus QTL 44			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	49393289	199050459	Rat
1578780	Cm52	Cardiac mass QTL 52	3.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	1	81591954	219808434	Rat
724521	Uae1	Urinary albumin excretion QTL 1	3.8	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	90508614	173018436	Rat
1358902	Bw47	Body weight QTL 47	1.67		body mass (VT:0001259)	body weight (CMO:0000012)	1	90508614	180359386	Rat
1331793	Bp200	Blood pressure QTL 200	3.71601		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	94494440	172949803	Rat
1331751	Bp199	Blood pressure QTL 199	3.60022		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	94494440	181830018	Rat
1331749	Hrtrt11	Heart rate QTL 11	2.973		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	1	94494440	198211706	Rat
70209	Niddm23	Non-insulin dependent diabetes mellitus QTL 23	2.82		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	94494440	198324465	Rat
731168	Bp154	Blood pressure QTL 154	3.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	94642644	214537671	Rat
8655649	Arrd1	Age-related retinal degeneration QTL 1	4.89		retinal layer morphology trait (VT:0003727)	percentage of study population developing retinopathy during a period of time (CMO:0002453)	1	100357752	183970443	Rat
1354591	Cm36	Cardiac mass QTL 36	4.1		heart left ventricle mass (VT:0007031)	calculated heart weight (CMO:0000073)	1	102813953	201278233	Rat
1354615	Cm32	Cardiac mass QTL 32	5.2		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	1	102813953	201278233	Rat
1354606	Bp246	Blood pressure QTL 246	3.6		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	1	102813953	218753816	Rat
1300158	Bp173	Blood pressure QTL 173	3.48		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	1	115540693	185145286	Rat
7794788	Mcs32	Mammary carcinoma susceptibility QTL 32	2.61		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	1	115540693	238914717	Rat
631199	Cm23	Cardiac mass QTL 23	4.6	0.0004	heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	1	115585465	172949803	Rat
7421630	Bp362	Blood pressure QTL 362		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	118608292	241799120	Rat
2313060	Bss71	Bone structure and strength QTL 71	2.6	0.0001	long bone metaphysis morphology trait (VT:0000133)	tibia midshaft total cross-sectional area (CMO:0001715)	1	118944747	163944747	Rat
631205	Bp196	Blood pressure QTL 196	4	0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	118944897	199050459	Rat
1598850	Bp297	Blood pressure QTL 297	2.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	121006655	166006655	Rat
1598866	Bp287	Blood pressure QTL 287	5.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	121006655	166006655	Rat
61442	Strs1	Sensitivity to stroke QTL 1	7.4		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	1	121767634	166767634	Rat
2293140	Bp313	Blood pressure QTL 313			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	121833674	166833674	Rat
631544	Bp84	Blood pressure QTL 84	5.6		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	123350408	181759564	Rat
1358189	Cstrr1	Cold stress response QTL 1		0.0001	catecholamine amount (VT:0010543)	urine norepinephrine level (CMO:0001629)	1	123350408	182418476	Rat
1641895	Bp298	Blood pressure QTL 298			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	123350408	182418476	Rat
1578770	Stresp23	Stress response QTL 23			kidney sympathetic nerve activity (VT:0004050)	stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)	1	123350408	182418476	Rat
631549	Bp89	Blood pressure QTL 89	5.7		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	123350581	201284552	Rat
634348	Bp138	Blood pressure QTL 138			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	125611501	168883176	Rat
9685799	Bp375	Blood pressure QTL 375			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	125611501	170611501	Rat
631654	Bp107	Blood pressure QTL 107			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	125611501	170611501	Rat
9685802	Bp376	Blood pressure QTL 376			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	126540680	171540680	Rat
738006	Anxrr14	Anxiety related response QTL 14	4	0.00035	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	1	130636910	175636910	Rat
738028	Anxrr12	Anxiety related response QTL 12	4.9	0.00001	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	1	130636910	175636910	Rat
631202	Gluco13	Glucose level QTL 13		0.0001	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	131763437	159756369	Rat
6893347	Bw98	Body weight QTL 98	0.2	0.53	body mass (VT:0001259)	body weight (CMO:0000012)	1	133680936	178680936	Rat
6893361	Bw104	Body weight QTL 104	0.59	0.27	body mass (VT:0001259)	body weight (CMO:0000012)	1	133680936	178680936	Rat
1558645	Bw55	Body weight QTL 55	3.2	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	1	133680936	178680936	Rat
631206	Niddm40	Non-insulin dependent diabetes mellitus QTL 40			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	136745990	163747690	Rat
71118	Thym1	Thymus enlargement QTL 1	10.17	0.001	thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	1	136829932	181829932	Rat
724550	Thym3	Thymus enlargement QTL 3	7.82	0.001	thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	1	136829932	181829932	Rat
631519	Pia11	Pristane induced arthritis QTL 11	5.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	1	136830018	181830018	Rat
1598853	Memor3	Memory QTL 3	4.5		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	1	143506580	212458660	Rat
61348	Bp30	Blood pressure QTL 30	2.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	144017057	197814409	Rat
70160	Bw18	Body weight QTL 18	5.7		body mass (VT:0001259)	body weight (CMO:0000012)	1	144267353	196383668	Rat
737828	Hcas3	Hepatocarcinoma susceptibility QTL 3	4.9		liver integrity trait (VT:0010547)	liver tumorous lesion volume to total liver volume ratio (CMO:0001082)	1	144267353	222987745	Rat
2302378	Insul11	Insulin level QTL 11	3.25		blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	1	144267353	251128347	Rat
634315	Niddm45	Non-insulin dependent diabetes mellitus QTL 45	7.16		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	144267916	172949660	Rat
61379	Bp44	Blood pressure QTL 44	19.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	144267916	174133260	Rat
7771612	Cm80	Cardiac mass QTL 80	8.4		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	1	149448574	221264292	Rat
724531	Uae5	Urinary albumin excretion QTL 5	4		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	1	150700142	252085212	Rat
1578759	Uae30	Urinary albumin excretion QTL 30	3.3	0.003	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	150700247	252085048	Rat
1578778	Pur4	Proteinuria QTL 4	3.3	0.003	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	1	150700247	252085048	Rat
1354602	Bw35	Body weight QTL 35	12.2		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	201278233	Rat
1354620	Kidm19	Kidney mass QTL 19	4		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	151162512	201278233	Rat
1354634	Kidm12	Kidney mass QTL 12	3.9		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	1	151162512	201278233	Rat
1354636	Lmblg1	Limb length QTL 1	6.4		tibia length (VT:0004357)	tibia length (CMO:0000450)	1	151162512	201278233	Rat
1354610	Bw34	Body weight QTL 34	4.1		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	256448636	Rat
1354646	Kidm18	Kidney mass QTL 18	5.7		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	151162512	256448636	Rat
1354661	Bw33	Body weight QTL 33	5.2		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	256448636	Rat
1358886	Bp260	Blood pressure QTL 260	3.67		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	151162766	225824951	Rat
61343	Bp28	Blood pressure QTL 28			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	151646613	196646613	Rat

Markers in Region

RH131672

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	152,046,590 - 152,046,770 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	162,703,470 - 162,703,649	NCBI	Rnor6.0
Rnor_5.0	1	168,910,247 - 168,910,426	UniSTS	Rnor5.0
RGSC_v3.4	1	154,973,872 - 154,974,051	UniSTS	RGSC3.4
Celera	1	150,140,222 - 150,140,401	UniSTS
RH 3.4 Map	1	1166.1	UniSTS
Cytogenetic Map	1	q32	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	2		29	29		29			32	19	9
Low	1	26	28	12	18	12	5	7	40	14	30	11	5
Below cutoff		17			1		3	4	2	2	2		3

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_173105	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB023644	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC133383	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC078694	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473956	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000018091 ⟹ ENSRNOP00000018091

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	152,046,517 - 152,056,725 (-)	Ensembl
Rnor_6.0 Ensembl	1	162,703,442 - 162,713,610 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000117732 ⟹ ENSRNOP00000090486

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	152,048,245 - 152,056,702 (-)	Ensembl

RefSeq Acc Id:

NM_173105 ⟹ NP_775128

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	161,457,752 - 161,467,918 (-)	NCBI
mRatBN7.2	1	152,046,515 - 152,056,675 (-)	NCBI
Rnor_6.0	1	162,703,394 - 162,713,560 (-)	NCBI
Rnor_5.0	1	168,910,171 - 168,920,337 (-)	NCBI
RGSC_v3.4	1	154,973,796 - 154,983,962 (-)	RGD
Celera	1	150,140,146 - 150,150,299 (-)	RGD

Sequence:

show sequence

CCAGGGACAGCTCCCTCGTCGCCTCGCCTCCTCCCCCCCCCCTCCCCGGCTCAGGTCACATCTG
CACAGCGCAGCCGGGGAGGGGAGGAGCCCTCCAGCGCGGAACCGGGCTTTCCACTCGGCCCGCC
CTGAGGGGCGTGGGAGGGCGGGGCCGCGGACTTCGGACTCCAGCCACCCGACGCTCCTCTTTCC
CTGACGCTCTCAGCCATCCCTAGCGGTGAGGGAACCATGTCCGCGCTACTGGGGCTCCCGCCCG
AGGTGCAGGACACCTGCATCTCGCTGGGACTAATGCTGTTGGTCGTGCTGTTCATGGGGCTGGC
CCGCGTGATCGCCCGGCAACAGCTGCACAGGCCCATGGTCCACGCCTTCGTCCTGGAGTTTCTA
GCTACCTTCCAGCTCTGCTACTGCACCCATGAGCTCCAACTGCTGAGCGAGCAGGACTCGGGGC
ACCCCACCTGGACGCTGACACTGATCTACTTCTTTTCCTTGGTGCATGGCCTGACCCTGGTGGG
CACAGCTAGCAACCCGTGCGGCGTGATGATGCAGATGATTCTGGGGGGCATGTCCCCCGAGATG
GGTGCGGTGAGGTTGATGGCTCAGCTGGTTAGTGCCCTATGCAGCAGGTACTGCATAAGTGCCC
TGTGGAGCCTGAGCCTGACCAAGTACCATTTCGACAAGAGGATTTTAGCTTGCAGGAATCCCAT
CAACACCGACATATCCAAAGCGATCATCATAGAAGCCATCTGCTCCTTTATTTTCCACAGCGCT
CTACTGCACTTCCAGGAGGTCCGAACCAAGCTTCGCATCCACGTGCTGGCTGCACTCATCACCT
TTTTGGCCTATGCAGGAGGGAGCCTCACAGGAGCGCTGTTTAACCCAGCACTGGCACTTTCGCT
GCACTTCCCGTGCTTTGACGAATCGTTCTATAAGTTTTTCGTAGTATATTGGGTTGCTCCTTCT
CTAGGCGTACTGCTGATGATCCTCATGTTCAGCTTCTTCCTTCCGTGGCTGCACAACAACCAAC
TGAGTAACAAGAAGGAATGACCACTCCCAAAGACTCAAACGAAGTCAGTGGACGATCAGGCTGG
ATGTGACGGTTTGGGCACCTTTCAAACTCTGGACTCATCCTGCTTCTCCTTCCTTTGTGGAAGG
TGTCTTACTGTTTTCACTACCTGGACTTCACTGTGAAAATGAGGCAGCCTGTATTTCTCAGTTA
AGACTTGTTCTTTTGAGTGATGTGTTAAATGCTGCTGGAAAAGGCTCATTCATTAAACCTCTGT
AAATCCCAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_775128	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH78694	(Get FASTA)	NCBI Sequence Viewer
	BAC45003	(Get FASTA)	NCBI Sequence Viewer
	EDM18465	(Get FASTA)	NCBI Sequence Viewer
	EDM18466	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000018091
	ENSRNOP00000018091.4
	ENSRNOP00000090486.1
	ENSRNOP00055042794
	ENSRNOP00060002788
	ENSRNOP00065029597
GenBank Protein	Q8CHM1	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_775128 ⟸ NM_173105

- UniProtKB:

Q6AZ79 (UniProtKB/Swiss-Prot), Q8CHM1 (UniProtKB/Swiss-Prot), A6I6B5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSALLGLPPEVQDTCISLGLMLLVVLFMGLARVIARQQLHRPMVHAFVLEFLATFQLCYCTHEL
QLLSEQDSGHPTWTLTLIYFFSLVHGLTLVGTASNPCGVMMQMILGGMSPEMGAVRLMAQLVSA
LCSRYCISALWSLSLTKYHFDKRILACRNPINTDISKAIIIEAICSFIFHSALLHFQEVRTKLR
IHVLAALITFLAYAGGSLTGALFNPALALSLHFPCFDESFYKFFVVYWVAPSLGVLLMILMFSF
FLPWLHNNQLSNKKE

hide sequence

RefSeq Acc Id:

ENSRNOP00000018091 ⟸ ENSRNOT00000018091

RefSeq Acc Id:

ENSRNOP00000090486 ⟸ ENSRNOT00000117732

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q8CHM1-F1-model_v2	AlphaFold	Q8CHM1	1-271	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13690210

Promoter ID:

EPDNEW_R735

Type:

initiation region

Name:

Aqp11_2

Description:

aquaporin 11

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_R736

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	162,713,357 - 162,713,417	EPDNEW

RGD ID:

13690211

Promoter ID:

EPDNEW_R736

Type:

initiation region

Name:

Aqp11_1

Description:

aquaporin 11

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_R735

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	162,713,597 - 162,713,657	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:628763	AgrOrtholog
BioCyc Gene	G2FUF-58439	BioCyc
Ensembl Genes	ENSRNOG00000013358	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSRNOG00055029934	UniProtKB/Swiss-Prot
	ENSRNOG00060002461	UniProtKB/Swiss-Prot
	ENSRNOG00065021617	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000018091	ENTREZGENE
	ENSRNOT00000018091.6	UniProtKB/TrEMBL
	ENSRNOT00000117732.1	UniProtKB/TrEMBL
	ENSRNOT00055051857	UniProtKB/Swiss-Prot
	ENSRNOT00060003947	UniProtKB/Swiss-Prot
	ENSRNOT00065036759	UniProtKB/Swiss-Prot
Gene3D-CATH	1.20.1080.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7111950	IMAGE-MGC_LOAD
InterPro	Aquaporin-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Aquaporin_11	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Aquaporin_11/12	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MIP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:286758	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:93078	IMAGE-MGC_LOAD
NCBI Gene	286758	ENTREZGENE
PANTHER	AQUAPORIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR21191:SF7	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	MIP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Aqp11	PhenoGen
PIRSF	Aquaporin_11/12	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS	AQUAPORIN11	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MINTRINSICP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000013358	RatGTEx
	ENSRNOG00055029934	RatGTEx
	ENSRNOG00060002461	RatGTEx
	ENSRNOG00065021617	RatGTEx
Superfamily-SCOP	SSF81338	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I6AAY4_RAT	UniProtKB/TrEMBL
	A0A8L2Q8X2_RAT	UniProtKB/TrEMBL
	A6I6B4_RAT	UniProtKB/TrEMBL
	A6I6B5	ENTREZGENE, UniProtKB/TrEMBL
	AQP11_RAT	UniProtKB/Swiss-Prot
	Q6AZ79	ENTREZGENE
	Q8CHM1	ENTREZGENE
UniProt Secondary	Q6AZ79	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-02-26	Aqp11	aquaporin 11			Symbol and Name status set to approved	625702	APPROVED
2003-02-27	Aqp11	aquaporin 11			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar