RGD Reference Report - Aquaporin-11: a channel protein lacking apparent transport function expressed in brain. - Rat Genome Database

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Aquaporin-11: a channel protein lacking apparent transport function expressed in brain.

Authors: Gorelick, DA  Praetorius, J  Tsunenari, T  Nielsen, S  Agre, P 
Citation: Gorelick DA, etal., BMC Biochem. 2006 May 1;7:14.
RGD ID: 2292708
Pubmed: PMID:16650285   (View Abstract at PubMed)
PMCID: PMC1475587   (View Article at PubMed Central)
DOI: DOI:10.1186/1471-2091-7-14   (Journal Full-text)

BACKGROUND: The aquaporins are a family of integral membrane proteins composed of two subfamilies: the orthodox aquaporins, which transport only water, and the aquaglyceroporins, which transport glycerol, urea, or other small solutes. Two recently described aquaporins, numbers 11 and 12, appear to be more distantly related to the other mammalian aquaporins and aquaglyceroporins. RESULTS: We report on the characterization of Aquaporin-11 (AQP11). AQP11 RNA and protein is found in multiple rat tissues, including kidney, liver, testes and brain. AQP11 has a unique distribution in brain, appearing in Purkinje cell dendrites, hippocampal neurons of CA1 and CA2, and cerebral cortical neurons. Immunofluorescent staining of Purkinje cells indicates that AQP11 is intracellular. Unlike other aquaporins, Xenopus oocytes expressing AQP11 in the plasma membrane failed to transport water, glycerol, urea, or ions. CONCLUSION: AQP11 is functionally distinct from other proteins of the aquaporin superfamily and could represent a new aquaporin subfamily. Further studies are necessary to elucidate the role of AQP11 in the brain.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
glycerol transmembrane transport NOT|involved_inIDA 2292708PMID:16650285UniProt 
monoatomic ion transport NOT|involved_inIDA 2292708PMID:16650285UniProt 
urea transport NOT|involved_inIDA 2292708PMID:16650285UniProt 
water transport NOT|involved_inIDA 2292708PMID:16650285UniProt 

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
cell surface located_inIDA 2292708PMID:16650285UniProt 
dendrite  IDA 2292708Purkinje cellsRGD 

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
identical protein binding  IPIAqp11 (Rattus norvegicus)2292708homooligomerizationRGD 
identical protein binding  IPIAqp4 (Rattus norvegicus)2292708homooligomerizationRGD 

Objects Annotated

Genes (Rattus norvegicus)
Aqp11  (aquaporin 11)
Aqp4  (aquaporin 4)


Additional Information