Npc2 (NPC intracellular cholesterol transporter 2) - Rat Genome Database

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Gene: Npc2 (NPC intracellular cholesterol transporter 2) Rattus norvegicus
Analyze
Symbol: Npc2
Name: NPC intracellular cholesterol transporter 2
RGD ID: 628756
Description: Predicted to enable cholesterol binding activity; cholesterol transfer activity; and enzyme binding activity. Predicted to be involved in cholesterol homeostasis; cholesterol transport; and response to virus. Predicted to act upstream of or within several processes, including cholesterol storage; sterol metabolic process; and sterol transport. Predicted to be located in extracellular space and late endosome. Predicted to be active in lysosome. Human ortholog(s) of this gene implicated in Niemann-Pick disease and Niemann-Pick disease type C2. Orthologous to human NPC2 (NPC intracellular cholesterol transporter 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: epididymal secretory protein 1; epididymal secretory protein E1; Niemann Pick type C2; Niemann-Pick disease, type C2; re1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86110,128,325 - 110,149,245 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6110,128,325 - 110,150,004 (-)EnsemblGRCr8
mRatBN7.26104,397,239 - 104,418,161 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6104,378,644 - 104,418,155 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6104,566,714 - 104,587,594 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06104,865,873 - 104,886,753 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06104,235,225 - 104,256,103 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd6111,389,338 - 111,410,448 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive6110,798,870 - 110,819,980 (-)NCBILyon_Normotensive
Lyon_Hypertensive6108,592,474 - 108,613,584 (-)NCBILyon_Hypertensive
F344_StmMcwi6107,744,521 - 107,765,633 (-)NCBIF344_StmMcwi
Rnor_6.06108,467,410 - 108,488,330 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6108,467,410 - 108,488,330 (-)Ensemblrn6Rnor6.0
Rnor_5.06117,060,860 - 117,081,780 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46108,793,935 - 108,814,703 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6102,222,115 - 102,243,035 (-)NCBICelera
RGSC_v3.16108,797,391 - 108,818,159 (-)NCBI
Cytogenetic Map6q31NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acrolein  (ISO)
acrylamide  (EXP)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
ampicillin  (EXP)
Archazolid B  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol AF  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloropicrin  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
curcumin  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenvalerate  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
gentamycin  (EXP)
GSK-J4  (ISO)
isoflavones  (ISO)
ivermectin  (ISO)
methapyrilene  (EXP)
methyl methanesulfonate  (ISO)
metronidazole  (EXP)
miconazole  (ISO)
neomycin  (EXP)
nimesulide  (EXP)
okadaic acid  (ISO)
ouabain  (ISO)
ozone  (ISO)
paracetamol  (ISO)
perfluorooctanoic acid  (ISO)
phenylmercury acetate  (ISO)
phenylpropanolamine  (ISO)
potassium dichromate  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
tamibarotene  (ISO)
tetrachloromethane  (EXP,ISO)
titanium dioxide  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)
vinclozolin  (EXP)
Yessotoxin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Niemann-Pick disease type C: spectrum of HE1 mutations and genotype/phenotype correlations in the NPC2 group. Millat G, etal., Am J Hum Genet. 2001 Nov;69(5):1013-21. Epub 2001 Sep 20.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
8. Information Derived from GenBank Report RGD, Sept. 2003
9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:10366780   PMID:11125141   PMID:12719428   PMID:15110773   PMID:15937921   PMID:16141411   PMID:16548883   PMID:17018531   PMID:18772377   PMID:18823126   PMID:19723497   PMID:21315718  
PMID:22367786   PMID:23376485   PMID:23533145   PMID:24006456   PMID:27238017   PMID:29514215   PMID:29522534  


Genomics

Comparative Map Data
Npc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86110,128,325 - 110,149,245 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6110,128,325 - 110,150,004 (-)EnsemblGRCr8
mRatBN7.26104,397,239 - 104,418,161 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6104,378,644 - 104,418,155 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6104,566,714 - 104,587,594 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06104,865,873 - 104,886,753 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06104,235,225 - 104,256,103 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd6111,389,338 - 111,410,448 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive6110,798,870 - 110,819,980 (-)NCBILyon_Normotensive
Lyon_Hypertensive6108,592,474 - 108,613,584 (-)NCBILyon_Hypertensive
F344_StmMcwi6107,744,521 - 107,765,633 (-)NCBIF344_StmMcwi
Rnor_6.06108,467,410 - 108,488,330 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6108,467,410 - 108,488,330 (-)Ensemblrn6Rnor6.0
Rnor_5.06117,060,860 - 117,081,780 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46108,793,935 - 108,814,703 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6102,222,115 - 102,243,035 (-)NCBICelera
RGSC_v3.16108,797,391 - 108,818,159 (-)NCBI
Cytogenetic Map6q31NCBI
NPC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381474,479,935 - 74,493,512 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1474,476,192 - 74,494,177 (-)Ensemblhg38GRCh38
GRCh371474,946,638 - 74,960,215 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361474,016,396 - 74,029,837 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341474,016,396 - 74,029,837NCBI
Celera1454,985,030 - 54,998,469 (-)NCBICelera
Cytogenetic Map14q24.3NCBI
HuRef1455,115,095 - 55,128,528 (-)NCBIHuRef
CHM1_11474,886,183 - 74,899,622 (-)NCBICHM1_1
T2T-CHM13v2.01468,688,905 - 68,702,483 (-)NCBIT2T-CHM13v2.0
Npc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391284,801,333 - 84,819,886 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1284,801,336 - 84,819,926 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381284,754,559 - 84,773,112 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1284,754,562 - 84,773,152 (-)Ensemblmm10GRCm38
MGSCv371286,095,509 - 86,114,062 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361285,644,307 - 85,662,860 (-)NCBIMGSCv36mm8
Celera1286,210,583 - 86,229,366 (-)NCBICelera
Cytogenetic Map12D1NCBI
cM Map1239.37NCBI
Npc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555231,010,976 - 1,021,144 (+)Ensembl
ChiLan1.0NW_0049555231,010,976 - 1,021,048 (+)NCBIChiLan1.0ChiLan1.0
NPC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21575,563,794 - 75,577,953 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11474,780,300 - 74,794,459 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01455,033,129 - 55,046,564 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11473,875,856 - 73,894,628 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1473,875,889 - 73,894,628 (-)EnsemblpanPan2panpan1.1
NPC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1847,641,185 - 47,650,543 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl847,628,077 - 47,650,576 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha847,325,075 - 47,334,437 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0847,868,101 - 47,877,468 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl847,866,650 - 47,877,427 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1847,539,316 - 47,548,676 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0847,560,539 - 47,569,881 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0847,958,527 - 47,967,885 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Npc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864028,392,518 - 28,404,797 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364883,663,655 - 3,676,505 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364883,664,171 - 3,676,438 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NPC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl797,730,516 - 97,740,331 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1797,730,532 - 97,740,087 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27103,573,100 - 103,582,358 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NPC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12451,685,699 - 51,700,557 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2451,685,609 - 51,700,557 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605339,920,625 - 39,935,553 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Npc2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473427,166,880 - 27,177,229 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473427,166,867 - 27,177,229 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Npc2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1798,860,259 - 98,881,423 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Npc2
121 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:321
Count of miRNA genes:197
Interacting mature miRNAs:223
Transcripts:ENSRNOT00000016076
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)671278722116278722Rat
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)688019181136741135Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)690871046135871046Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)693560258136550638Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)698944780143944780Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)6100704576136029228Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6106095977147156653Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)646050607116278722Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)693778632138778632Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)684490437129490437Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)690871046135871046Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)693560258136550638Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6101593607138161926Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)678204640123204640Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)693560258136550638Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)676937178121937178Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)686494122112380234Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)699437079125323237Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)6101593607146593607Rat
1331722Thshl1Thyroid stimulating hormone level QTL 111.70.0001blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)699708426112483760Rat

Markers in Region
RH128345  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26104,397,491 - 104,397,693 (+)MAPPERmRatBN7.2
Rnor_6.06108,467,663 - 108,467,864NCBIRnor6.0
Rnor_5.06117,081,326 - 117,081,527UniSTSRnor5.0
RGSC_v3.46108,794,101 - 108,794,302UniSTSRGSC3.4
Celera6102,222,368 - 102,222,569UniSTS
RH 3.4 Map6780.5UniSTS
Cytogenetic Map6q31UniSTS
RH143366  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26104,418,809 - 104,419,046 (+)MAPPERmRatBN7.2
mRatBN7.21467,719,188 - 67,719,310 (+)MAPPERmRatBN7.2
Rnor_6.01472,259,518 - 72,259,639NCBIRnor6.0
Rnor_6.06108,488,979 - 108,489,215NCBIRnor6.0
Rnor_5.01472,287,979 - 72,288,100UniSTSRnor5.0
Rnor_5.06117,059,975 - 117,060,211UniSTSRnor5.0
RGSC_v3.46108,815,417 - 108,815,653UniSTSRGSC3.4
RGSC_v3.41472,887,023 - 72,887,144UniSTSRGSC3.4
Celera1466,671,454 - 66,671,575UniSTS
Celera6102,243,684 - 102,243,920UniSTS
RH 3.4 Map14486.07UniSTS
Cytogenetic Map14q21UniSTS
Cytogenetic Map6q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_173118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC113727 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ515237 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC058132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216545 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219863 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220225 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220660 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228456 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229422 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229782 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229783 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230107 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000016076   ⟹   ENSRNOP00000016076
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6110,128,325 - 110,150,004 (-)Ensembl
mRatBN7.2 Ensembl6104,378,644 - 104,418,155 (-)Ensembl
Rnor_6.0 Ensembl6108,467,410 - 108,488,330 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117875   ⟹   ENSRNOP00000093242
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6110,128,325 - 110,139,552 (-)Ensembl
mRatBN7.2 Ensembl6104,397,393 - 104,418,141 (-)Ensembl
RefSeq Acc Id: NM_173118   ⟹   NP_775141
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86110,128,325 - 110,149,245 (-)NCBI
mRatBN7.26104,397,239 - 104,418,161 (-)NCBI
Dahl_SR_JrHsd6111,389,338 - 111,410,448 (-)NCBI
Lyon_Normotensive6110,798,870 - 110,819,980 (-)NCBI
Lyon_Hypertensive6108,592,474 - 108,613,584 (-)NCBI
F344_StmMcwi6107,744,521 - 107,765,633 (-)NCBI
Rnor_6.06108,467,410 - 108,488,330 (-)NCBI
Rnor_5.06117,060,860 - 117,081,780 (+)NCBI
RGSC_v3.46108,793,935 - 108,814,703 (-)RGD
Celera6102,222,115 - 102,243,035 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_775141 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH58132 (Get FASTA)   NCBI Sequence Viewer  
  CAD56199 (Get FASTA)   NCBI Sequence Viewer  
  EDL81526 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000016076
  ENSRNOP00000016076.4
  ENSRNOP00000093242.1
RefSeq Acc Id: NP_775141   ⟸   NM_173118
- Peptide Label: precursor
- UniProtKB: F7FJQ3 (UniProtKB/TrEMBL),   A6JDY2 (UniProtKB/TrEMBL),   Q8CHN5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016076   ⟸   ENSRNOT00000016076
Ensembl Acc Id: ENSRNOP00000093242   ⟸   ENSRNOT00000117875
Protein Domains
MD-2-related lipid-recognition

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F7FJQ3-F1-model_v2 AlphaFold F7FJQ3 1-152 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694730
Promoter ID:EPDNEW_R5254
Type:initiation region
Name:Npc2_1
Description:NPC intracellular cholesterol transporter 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06108,488,253 - 108,488,313EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628756 AgrOrtholog
BioCyc Gene G2FUF-36808 BioCyc
Ensembl Genes ENSRNOG00000012062 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016076 ENTREZGENE
  ENSRNOT00000016076.7 UniProtKB/TrEMBL
  ENSRNOT00000117875.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.770 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6920130 IMAGE-MGC_LOAD
InterPro Ig_E-set UniProtKB/TrEMBL
  MD-2_lipid-recog UniProtKB/TrEMBL
  ML_Npc2-like UniProtKB/TrEMBL
  NPC2-like UniProtKB/TrEMBL
KEGG Report rno:286898 UniProtKB/TrEMBL
MGC_CLONE MGC:72659 IMAGE-MGC_LOAD
NCBI Gene 286898 ENTREZGENE
PANTHER NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 2 UniProtKB/TrEMBL
  PTHR11306 UniProtKB/TrEMBL
Pfam E1_DerP2_DerF2 UniProtKB/TrEMBL
PhenoGen Npc2 PhenoGen
RatGTEx ENSRNOG00000012062 RatGTEx
SMART SM00737 UniProtKB/TrEMBL
Superfamily-SCOP Ig_E-set UniProtKB/TrEMBL
UniProt A0A8I6AWS0_RAT UniProtKB/TrEMBL
  A6JDY2 ENTREZGENE, UniProtKB/TrEMBL
  F7FJQ3 ENTREZGENE, UniProtKB/TrEMBL
  Q8CHN5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-12 Npc2  NPC intracellular cholesterol transporter 2  Npc2  Niemann-Pick disease, type C2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-08-29 Npc2  Niemann-Pick disease, type C2  Npc2  Niemann Pick type C2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Npc2  Niemann Pick type C2  re1  epididymal secretory protein 1  Symbol and Name updated 1299863 APPROVED
2003-02-27 re1  epididymal secretory protein 1      Symbol and Name status set to provisional 70820 PROVISIONAL