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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628756
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Npc2
Name: NPC intracellular cholesterol transporter 2
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Npc2increases expressionEXP 6480464CTDbisphenol A results in increased expression of NPC2 mRNAPMID:25181051
Npc2multiple interactionsEXP 6480464CTD[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of NPC2 mRNA; [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of NPC2 promoterPMID:23359474 PMID:36041667
Npc2increases expressionISONPC2 (Homo sapiens)6480464CTDbisphenol A results in increased expression of NPC2 mRNA; bisphenol A results in increased expression of NPC2 proteinPMID:25047013 PMID:29275510 PMID:37567409
Npc2increases expressionISONpc2 (Mus musculus)6480464CTDbisphenol A results in increased expression of NPC2 mRNAPMID:33221593
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