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Gene: Faim2 (Fas apoptotic inhibitory molecule 2) Rattus norvegicus

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Symbol:

Faim2

Name:

Fas apoptotic inhibitory molecule 2

RGD ID:

628744

Description:

Predicted to enable calcium channel activity. Predicted to be involved in apoptotic signaling pathway; cerebellar cortex development; and negative regulation of apoptotic process. Predicted to act upstream of or within negative regulation of apoptotic signaling pathway and response to ischemia. Predicted to be located in Golgi membrane and membrane raft. Predicted to be active in Golgi apparatus; endoplasmic reticulum; and membrane. Biomarker of chronic obstructive pulmonary disease. Orthologous to human FAIM2 (Fas apoptotic inhibitory molecule 2); PARTICIPATES IN FasL mediated signaling pathway; INTERACTS WITH 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

Lfg; lifeguard; LOC102551901; MGC105316; neural membrane protein 35; NMP35; protein lifeguard 2; protein lifeguard 2-like

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	FAIM2 (Fas apoptotic inhibitory molecule 2)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, Panther, PhylomeDB
Mus musculus (house mouse):	Faim2 (Fas apoptotic inhibitory molecule 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Faim2 (Fas apoptotic inhibitory molecule 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	FAIM2 (Fas apoptotic inhibitory molecule 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	FAIM2 (Fas apoptotic inhibitory molecule 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Faim2 (Fas apoptotic inhibitory molecule 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	FAIM2 (Fas apoptotic inhibitory molecule 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	FAIM2 (Fas apoptotic inhibitory molecule 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Faim2 (Fas apoptotic inhibitory molecule 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Faim2 (Fas apoptotic inhibitory molecule 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	TACC2 (transforming acidic coiled-coil containing protein 2)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Faim2 (Fas apoptotic inhibitory molecule 2)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	FAIM2 (Fas apoptotic inhibitory molecule 2)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	faim2b (Fas apoptotic inhibitory molecule 2b)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	faim2a (Fas apoptotic inhibitory molecule 2a)	Alliance	DIOPT (InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	faim2a (Fas apoptotic inhibitory molecule 2a)	Alliance	DIOPT (InParanoid\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	BXI1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoInspector\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	BXI1	Alliance	DIOPT (InParanoid\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Caenorhabditis elegans (roundworm):	Y42H9AR.2	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	Y42H9AR.2	Alliance	DIOPT (InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	tag-120	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	tag-120	Alliance	DIOPT (InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	xbx-6	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	xbx-6	Alliance	DIOPT (InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	faim2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	faim2	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	132,512,095 - 132,539,192 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	7	132,512,210 - 132,538,026 (-)	Ensembl				GRCr8
mRatBN7.2	7	130,632,368 - 130,659,353 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	130,633,348 - 130,659,168 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	7	132,436,973 - 132,462,777 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	134,662,553 - 134,688,359 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	134,575,068 - 134,600,878 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	141,158,769 - 141,185,781 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	141,157,963 - 141,185,710 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	X	115,663,275 - 115,689,093 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	7	138,246,372 - 138,272,190 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	7	127,115,377 - 127,141,090 (-)	NCBI		Celera
RGSC_v3.1	7	138,322,809 - 138,348,627 (-)	NCBI
Cytogenetic Map	7	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

chronic obstructive pulmonary disease (IEP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

17beta-estradiol 3-benzoate (EXP)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2,4,4'-trichlorobiphenyl (ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

2-hydroxypropanoic acid (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

4,4'-sulfonyldiphenol (ISO)

acrolein (ISO)

acrylamide (ISO)

afimoxifene (ISO)

aflatoxin B1 (ISO)

ammonium chloride (EXP)

arsane (ISO)

arsenic atom (ISO)

atrazine (EXP)

beauvericin (ISO)

benzo[a]pyrene (ISO)

beta-carotene (ISO)

beta-lapachone (ISO)

bisphenol A (EXP,ISO)

C60 fullerene (EXP)

carbon nanotube (ISO)

choline (ISO)

cocaine (EXP)

copper atom (EXP)

copper(0) (EXP)

cordycepin (ISO)

dieldrin (EXP)

ethanol (ISO)

ethylparaben (ISO)

fenamidone (ISO)

folic acid (ISO)

furan (EXP)

graphite (EXP)

L-methionine (ISO)

mono(2-ethylhexyl) phthalate (ISO)

monosodium L-glutamate (ISO)

N-methyl-4-phenylpyridinium (EXP,ISO)

N-methyl-N-nitrosourea (EXP)

ozone (ISO)

paraquat (EXP)

PCB138 (ISO)

perfluorooctanoic acid (ISO)

potassium dichromate (ISO)

rac-lactic acid (ISO)

resveratrol (ISO)

rofecoxib (ISO)

sodium arsenite (ISO)

sodium dichromate (EXP)

testosterone (ISO)

tunicamycin (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

apoptotic process (IEA)

calcium ion transmembrane transport (IEA)

cerebellar granular layer development (IEA,ISO,ISS)

cerebellar Purkinje cell differentiation (IEA,ISO,ISS)

cerebellar Purkinje cell layer development (IEA,ISO,ISS)

cerebellum development (IEA,ISO,ISS)

negative regulation of apoptotic signaling pathway (ISO)

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors (IBA,ISO)

negative regulation of neuron apoptotic process (IBA,ISO)

regulation of neuron apoptotic process (IEA,ISO,ISS)

response to ischemia (ISO)

Cellular Component

endoplasmic reticulum (IBA,IEA,ISO)

Golgi apparatus (IBA,IEA,ISO)

Golgi membrane (IEA,ISO)

membrane (IBA,IEA,ISO)

membrane raft (IEA,ISO,ISS)

plasma membrane (IEA)

postsynaptic membrane (IEA)

Molecular Function

calcium channel activity (IBA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

FasL mediated signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
4.	GOA pipeline	RGD automated data pipeline
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	Neural membrane protein 35/Lifeguard is localized at postsynaptic sites and in dendrites.	Schweitzer B, etal., Brain Res Mol Brain Res 2002 Oct 30;107(1):47-56.
8.	Neural membrane protein 35 (NMP35): a novel member of a gene family which is highly expressed in the adult nervous system.	Schweitzer B, etal., Mol Cell Neurosci 1998 Aug;11(5-6):260-73.
9.	MiR-3202 protects smokers from chronic obstructive pulmonary disease through inhibiting FAIM2: An in vivo and in vitro study.	Shen W, etal., Exp Cell Res. 2018 Jan 15;362(2):370-377. doi: 10.1016/j.yexcr.2017.11.038. Epub 2017 Dec 5.

Additional References at PubMed

PMID:12477932	PMID:15489334	PMID:16033886	PMID:17635665	PMID:21209208	PMID:21957071	PMID:22627920	PMID:22871113	PMID:23097042	PMID:26582200

Genomics

Comparative Map Data

Faim2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	132,512,095 - 132,539,192 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	7	132,512,210 - 132,538,026 (-)	Ensembl				GRCr8
mRatBN7.2	7	130,632,368 - 130,659,353 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	130,633,348 - 130,659,168 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	7	132,436,973 - 132,462,777 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	134,662,553 - 134,688,359 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	134,575,068 - 134,600,878 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	141,158,769 - 141,185,781 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	141,157,963 - 141,185,710 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	X	115,663,275 - 115,689,093 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	7	138,246,372 - 138,272,190 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	7	127,115,377 - 127,141,090 (-)	NCBI		Celera
RGSC_v3.1	7	138,322,809 - 138,348,627 (-)	NCBI
Cytogenetic Map	7	q36	NCBI

FAIM2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	49,866,896 - 49,903,900 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	49,866,896 - 49,904,217 (-)	Ensembl			hg38	GRCh38
GRCh37	12	50,260,679 - 50,297,683 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	48,546,947 - 48,583,987 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	12	48,546,946 - 48,583,987	NCBI
Celera	12	49,056,734 - 49,093,776 (-)	NCBI		Celera
Cytogenetic Map	12	q13.12	NCBI
HuRef	12	47,291,842 - 47,330,172 (-)	NCBI		HuRef
CHM1_1	12	50,227,016 - 50,263,951 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	12	49,829,908 - 49,867,294 (-)	NCBI		T2T-CHM13v2.0

Faim2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	99,394,886 - 99,432,757 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	99,394,893 - 99,426,046 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	15	99,497,005 - 99,534,880 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	99,497,012 - 99,528,165 (-)	Ensembl			mm10	GRCm38
MGSCv37	15	99,327,436 - 99,358,448 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	15	99,325,039 - 99,356,051 (-)	NCBI		MGSCv36	mm8
Celera	15	101,652,607 - 101,683,625 (-)	NCBI		Celera
Cytogenetic Map	15	F1	NCBI
cM Map	15	56.13	NCBI

Faim2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955547	466,777 - 501,490 (-)	Ensembl
ChiLan1.0	NW_004955547	467,331 - 501,172 (-)	NCBI	ChiLan1.0	ChiLan1.0

FAIM2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	44,283,833 - 44,320,109 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	44,280,595 - 44,316,871 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	38,850,588 - 38,886,614 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	39,744,705 - 39,780,702 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	39,744,700 - 39,780,702 (+)	Ensembl			panPan2	panpan1.1

FAIM2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	27	4,802,711 - 4,831,230 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	27	4,798,235 - 4,827,917 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	27	41,426,513 - 41,459,677 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	27	4,847,381 - 4,880,528 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	27	4,847,346 - 4,880,527 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	27	4,813,057 - 4,846,157 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	27	4,802,365 - 4,835,546 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	27	41,821,388 - 41,854,554 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Faim2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	65,588,905 - 65,620,783 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936512	7,544,003 - 7,576,315 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936512	7,544,047 - 7,575,922 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FAIM2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	15,779,334 - 15,812,543 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	5	15,779,329 - 15,813,029 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

FAIM2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	46,100,437 - 46,131,046 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	46,099,895 - 46,131,155 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666037	199,989,447 - 200,026,442 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Faim2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624816	2,386,647 - 2,420,274 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624816	2,386,995 - 2,418,312 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Faim2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	1	272,310,308 - 272,336,614 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Faim2
216 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	124
Count of miRNA genes:	90
Interacting mature miRNAs:	97
Transcripts:	ENSRNOT00000048934
Prediction methods:	Miranda, Pita, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331748	Bp215	Blood pressure QTL 215	4.043		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	110725024	135371468	Rat
1354582	Stl11	Serum triglyceride level QTL 11	3.42		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	7	121393075	137014596	Rat
634331	Pia17	Pristane induced arthritis QTL 17	4.7		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	7	132099939	137014596	Rat
731176	Glom5	Glomerulus QTL 5	2.5	0.0035	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	7	98549867	137014596	Rat
1300112	Bp183	Blood pressure QTL 183	3.51		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	7	119280025	135560836	Rat
61428	Scl3	Serum cholesterol level QTL 3	3.2		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	7	100548246	137014596	Rat
61397	Bw17	Body weight QTL 17	6.3		body mass (VT:0001259)	body weight (CMO:0000012)	7	95485047	137014596	Rat
1331746	Kidm9	Kidney mass QTL 9	3.934		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	7	82111245	134948181	Rat
1358914	Bp266	Blood pressure QTL 266			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	115313999	136544683	Rat
1331731	Bp216	Blood pressure QTL 216	2.851		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	104186212	135371468	Rat
1549899	Stresp8	Stress response QTL 8	4.37	0.0008	stress-related behavior trait (VT:0010451)	defensive burying duration (CMO:0001961)	7	92362341	137014596	Rat
1358891	Bp265	Blood pressure QTL 265	2.21		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	71827901	136544683	Rat

Markers in Region

RH135379

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	7	132,512,126 - 132,512,309 (+)	Marker Load Pipeline
mRatBN7.2	7	130,633,264 - 130,633,447 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	141,159,667 - 141,159,849	NCBI	Rnor6.0
Rnor_5.0	X	115,663,193 - 115,663,375	UniSTS	Rnor5.0
RGSC_v3.4	7	138,246,290 - 138,246,472	UniSTS	RGSC3.4
Celera	7	127,115,294 - 127,115,477	UniSTS
RH 3.4 Map	7	1064.7	UniSTS
Cytogenetic Map	7	q36	UniSTS

RH144326

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	130,637,976 - 130,638,192 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	141,164,379 - 141,164,594	NCBI	Rnor6.0
Rnor_6.0	7	139,042,493 - 139,042,708	NCBI	Rnor6.0
Rnor_5.0	7	138,662,899 - 138,663,114	UniSTS	Rnor5.0
Rnor_5.0	X	115,667,905 - 115,668,120	UniSTS	Rnor5.0
RGSC_v3.4	7	138,251,002 - 138,251,217	UniSTS	RGSC3.4
Celera	7	127,120,007 - 127,120,222	UniSTS
RH 3.4 Map	7	1077.3	UniSTS
Cytogenetic Map	7	q36	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
11	4	11	148	36	38	13	32	13	6	154	62	1	134	65	76	25	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_144756	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017594665	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC129346	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF044201	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC087606	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474035	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000072309 ⟹ ENSRNOP00000064487

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	132,512,210 - 132,538,026 (-)	Ensembl
mRatBN7.2 Ensembl	7	130,633,348 - 130,659,168 (-)	Ensembl
Rnor_6.0 Ensembl	7	139,047,263 - 139,063,752 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000085033 ⟹ ENSRNOP00000075485

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	7	141,157,963 - 141,185,710 (-)	Ensembl

RefSeq Acc Id:

NM_144756 ⟹ NP_653357

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	132,512,209 - 132,538,026 (-)	NCBI
mRatBN7.2	7	130,633,347 - 130,659,168 (-)	NCBI
Rnor_6.0	7	141,159,749 - 141,185,567 (-)	NCBI
Rnor_5.0	X	115,663,275 - 115,689,093 (-)	NCBI
RGSC_v3.4	7	138,246,372 - 138,272,190 (-)	RGD
Celera	7	127,115,377 - 127,141,090 (-)	RGD

Sequence:

show sequence

GAGACGCAGGCAGGCTGCGGTGACCCAAGCGGCCACCCCCCGCTTCAGGGACCCCTTCCTCGAG
AGACGACACCATGACCCAGGGAAAGCTCTCTGTGGCTAACAAGGCCCCTGGGACTGAGGGGCAG
CAGCAGGCAAATGGAGAGAAGAAGGATGCCCCAGCAGTGCCCTCGGCACCACCCTCCTACGAGG
AGGCCACCTCTGGAGAGGGGCTGAAGGCAGGGGCCTTCCCCCAGGGTCCCACAGCTGTACCACT
CCATCCAAGCTGGGCCTATGTGGACCCCAGCAGCAGCTCTGGCTATGAAGGTGGTTTCCCTGCA
GGACACCATGAGCTTTTCAGCACCTTCAGCTGGGATGACCAGAAAGTTCGTCAGCTTTTCATCA
GAAAGGTCTATACCATCCTGTTGGTTCAGCTGCTGGTGACCTTGGCTGTGGTGGCTCTCTTTAC
CTTCTGTGACGTCGTTAAGGACTATGTCCAGGCCAACCCAGGCTGGTACTGGGCATCCTATGCC
GTATTCTTTGCAACATACCTGACTCTGGCTTGCTGTTCTGGGCCCAGGAGACACTTCCCTTGGA
ACCTGATTCTGCTGACCATCTTTACCCTGTCCATGGCCTACCTCACTGGGATGCTGTCCAGTTA
CTACAACACCACGTCTGTCCTGCTGTGCCTGGGCATCACAGCTCTTGTCTGCCTCTCAGTCACC
ATCTTCAGTTTCCAGACCAAGTTTGACTTCACCTCCTGTCACGGTGTGCTATTTGTACTGCTCA
TGACTCTCTTCTTCAGTGGACTCCTCCTCGCCATCCTCCTGCCCTTCCAATATGTCCCCTGGCT
CCACGCCGTCTATGCTGTGCTAGGAGCGGGTGTGTTCACGTTGTTCCTGGCATTTGATACCCAG
CTGCTGATGGGTAACCGTCGACACTCGCTGAGTCCTGAGGAGTATATTTTTGGAGCCCTCAACA
TCTACCTAGACATTATCTATATCTTCACCTTCTTCCTGCAGCTTTTTGGCACCAACCGGGAATG
AGGAGCCCTCCCCCCACCCCCGCCCTCCTCCAGAGAATGCCCCTCCCCTGTCCTGTGACCCTCT
CAGAGCTCCTGCAAGACCAGACATAAACTTGCTGCAGCCAGCTTGTGTGCAGCCGCTCCCTCCT
GCAGCCAGCCCTCACCTCGAGCCCTCTGCAGCTTGTACATATGCCATCCTTGGAGCCCCGCAGA
TCTGAGGCCACACCATCCCCTGTGGTGCCCCCAGCACCCGATTGCATCTTCCAAGTGGCACAGT
CATGGCTGAGGGCATCTCTGGGTTTGCAGAGACCCCAGAAATGAGTGGGAGGAGCCCAGAGGTG
GGAAGGAGCCCCCAGGAAGCCTGGCTGAGACTGTGACTCCCCACCACCAAGTCTTGTAGGGCTC
CATTTTCTCTTTCAGTTCAAGGAACCAAGCTTTGTAAGAAAAAAAGAAAAAAGACTGAGGGGAC
ATGGCTGGAACTTGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_017594665 ⟹ XP_017450154

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	132,512,095 - 132,539,192 (-)	NCBI
mRatBN7.2	7	130,632,368 - 130,659,346 (-)	NCBI
Rnor_6.0	7	141,158,769 - 141,185,781 (-)	NCBI

Sequence:

show sequence

AATGCTCCCCGGTCTCCTGGGGTGGCTGAAGTGTGTGGGAGACGCAGAGGAGGTCAAAGCGCAT
GTCTTGCCCGCTCTCAGGTCCGCAGCATCCTGCGTCCGTCCGCAGCAGCATCCTCTCAGGCCCT
CCCCCTCCCCCGTGTGCGGATGGTACGCTCCGCTAAGCCTGGCCGGGTTGCAGTGGATGTTGCT
AGAATCCACGCGGAGGAAAGAAGAGACGCAGGCAGGCTGCGGTGACCCAAGCGGCCACCCCCCG
CTTCAGGGACCCCTTCCTCGAGAGACGACACCATGACCCAGGGAAAGCTCTCTGTGGCTAACAA
GGCCCCTGGGACTGAGGGGCAGCAGCAGGCAAATGGAGAGAAGAAGGATGCCCCAGCAGTGCCC
TCGGCACCACCCTCCTACGAGGAGGCCACCTCTGGAGAGGGGCTGAAGGCAGGGGCCTTCCCCC
AGGGTCCCACAGCTGTACCACTCCATCCAAGCTGGGCCTATGTGGACCCCAGACACCATGAGCT
TTTCAGCACCTTCAGCTGGGATGACCAGAAAGTTCGTCAGCTTTTCATCAGAAAGGTCTATACC
ATCCTGTTGGTTCAGCTGCTGGTGACCTTGGCTGTGGTGGCTCTCTTTACCTTCTGTGACGTCG
TTAAGGACTATGTCCAGGCCAACCCAGGCTGGTACTGGGCATCCTATGCCGTATTCTTTGCAAC
ATACCTGACTCTGGCTTGCTGTTCTGGGCCCAGGAGACACTTCCCTTGGAACCTGATTCTGCTG
ACCATCTTTACCCTGTCCATGGCCTACCTCACTGGGATGCTGTCCAGTTACTACAACACCACGT
CTGTCCTGCTGTGCCTGGGCATCACAGCTCTTGTCTGCCTCTCAGTCACCATCTTCAGTTTCCA
GACCAAGTTTGACTTCACCTCCTGTCACGGTGTGCTATTTGTACTGCTCATGACTCTCTTCTTC
AGTGGACTCCTCCTCGCCATCCTCCTGCCCTTCCAATATGTCCCCTGGCTCCACGCCGTCTATG
CTGTGCTAGGAGCGGGTGTGTTCACGTTGTTCCTGGCATTTGATACCCAGCTGCTGATGGGTAA
CCGTCGACACTCGCTGAGTCCTGAGGAGTATATTTTTGGAGCCCTCAACATCTACCTAGACATT
ATCTATATCTTCACCTTCTTCCTGCAGCTTTTTGGCACCAACCGGGAATGAGGAGCCCTCCCCC
CACCCCCGCCCTCCTCCAGAGAATGCCCCTCCCCTGTCCTGTGACCCTCTCAGAGCTCCTGCAA
GACCAGACATAAACTTGCTGCAGCCAGCTTGTGTGCAGCCGCTCCCTCCTGCAGCCAGCCCTCA
CCTCGAGCCCTCTGCAGCTTGTACATATGCCATCCTTGGAGCCCCGCAGATCTGAGGCCACACC
ATCCCCTGTGGTGCCCCCAGCACCCGATTGCATCTTCCAAGTGGCACAGTCATGGCTGAGGGCA
TCTCTGGGTTTGCAGAGACCCCAGAAATGAGTGGGAGGAGCCCAGAGGTGGGAAGGAGCCCCCA
GGAAGCCTGGCTGAGACTGTGACTCCCCACCACCAAGTCTTGTAGGGCTCCATTTTCTCTTTCA
GTTCAAGGAACCAAGCTTTGTAAGAAAAAAAGAAAAAAGACTGAGGGGACATGGCTGGAACTTG
AGAATGGGCTCTGTGGTACAGGGCAAAGCTTTTCCCGCCGCTGTCACTCTCTCAGCTGTAGGCC
AGTTGCTTGTTCTAGGGATCTGAACAATATAAAAGGAAGCTGCTGCTTTCATTACTTGCCTCAG
TTTGCCCTTCTGGGTCATCCGGGTCATAGAACAGGGGGATATGCTAAGTCTGTCCTGAGCTCCC
AGGCAGGGGAAGGCAAGGAGAAGCTGGGAGGGTGAACTGGGGCTGTCAATCAAATCCCATCCAT
TGGAAAGGCTCATATGACTGCAGGACTAAAGCCCATCTCTGTTTCCCCACTCTGTGCTGTTACC
ACAGGCCTGAGGGGAAAGTGGGGTAGGAGGTCTGGTGGAAGCAGTTCTGTCGTCTGGACTAGCC
CTTACCGGGGGCTGCCCTTCAGTTCCCTCCACACCGATTTCCTAGGTCTTCCCCTATCTTCTGC
AGCATTCTGTCTTATCTCCAGCAGGCCTCCTGCGGCCCTAAGAGCAGAGGTATCCATCTTTATC
CCTCCCCCAGCTTCCCTGGCCACTCAGCCCAGAGTTCCTGGGCCCTTGCCCCCTTATCTCCACA
TCTCTGTAATTTGGAAGCTGTCCAGCTAATGGTCACAGCAAGGGCCAGTCCCCTGAGCCTGTCC
CGGGTGATGAGGCCAGAGCTCCTTCCTTATCAACTTCCAGGCTGCTGGGATCTCAGGCAGAATT
GTGCGTCAACCATCCTGCCCTGGCTGAGTGCCTGCTGCAGTGGGGACCAGGGACCCACACCTGG
GGCAGCATGCAGGCTGCACATGCACACGGCCAGCTCTAGGCCAGTGGAAAGTTACTGGGTGAAG
GCGAGAAGGTTCTGAGTGGATGTAGAGGACCCTGTTTACCCCAGGAAAGGGAACTAGGTAGCCT
ATCCATTCCCACCCCAGCCCCTGCCTCTCCCCACTCTGCCTACTCTCTAGCCTTCAAGAAATAT
TACAGAAGCATTTGAAGTTTT

hide sequence

Protein Sequences


Protein RefSeqs	NP_653357	(Get FASTA)	NCBI Sequence Viewer
	XP_017450154	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAC32463	(Get FASTA)	NCBI Sequence Viewer
	AAH87606	(Get FASTA)	NCBI Sequence Viewer
	EDL86983	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000064487
	ENSRNOP00000064487.3
GenBank Protein	O88407	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_653357 ⟸ NM_144756

- UniProtKB:

O88407 (UniProtKB/Swiss-Prot), A6KCF9 (UniProtKB/TrEMBL), M0R531 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MTQGKLSVANKAPGTEGQQQANGEKKDAPAVPSAPPSYEEATSGEGLKAGAFPQGPTAVPLHPS
WAYVDPSSSSGYEGGFPAGHHELFSTFSWDDQKVRQLFIRKVYTILLVQLLVTLAVVALFTFCD
VVKDYVQANPGWYWASYAVFFATYLTLACCSGPRRHFPWNLILLTIFTLSMAYLTGMLSSYYNT
TSVLLCLGITALVCLSVTIFSFQTKFDFTSCHGVLFVLLMTLFFSGLLLAILLPFQYVPWLHAV
YAVLGAGVFTLFLAFDTQLLMGNRRHSLSPEEYIFGALNIYLDIIYIFTFFLQLFGTNRE

hide sequence

RefSeq Acc Id:	XP_017450154 ⟸ XM_017594665
- Peptide Label:	isoform X1
- UniProtKB:	M0R531 (UniProtKB/TrEMBL)
- Sequence:	show sequence MTQGKLSVANKAPGTEGQQQANGEKKDAPAVPSAPPSYEEATSGEGLKAGAFPQGPTAVPLHPS WAYVDPRHHELFSTFSWDDQKVRQLFIRKVYTILLVQLLVTLAVVALFTFCDVVKDYVQANPGW YWASYAVFFATYLTLACCSGPRRHFPWNLILLTIFTLSMAYLTGMLSSYYNTTSVLLCLGITAL VCLSVTIFSFQTKFDFTSCHGVLFVLLMTLFFSGLLLAILLPFQYVPWLHAVYAVLGAGVFTLF LAFDTQLLMGNRRHSLSPEEYIFGALNIYLDIIYIFTFFLQLFGTNRE hide sequence

Ensembl Acc Id:

ENSRNOP00000075485 ⟸ ENSRNOT00000085033

Ensembl Acc Id:

ENSRNOP00000064487 ⟸ ENSRNOT00000072309

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-M0R531-F1-model_v2	AlphaFold	M0R531	1-310	view protein structure
AF-O88407-F1-model_v2	AlphaFold	O88407	1-316	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:628744	AgrOrtholog
BioCyc Gene	G2FUF-32068	BioCyc
Ensembl Genes	ENSRNOG00000045554	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOG00000053258	Ensembl
Ensembl Transcript	ENSRNOT00000072309	ENTREZGENE
	ENSRNOT00000072309.3	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7314068	IMAGE-MGC_LOAD
InterPro	Bax_inhibitor_1-related	UniProtKB/Swiss-Prot
KEGG Report	rno:246274	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:105316	IMAGE-MGC_LOAD
NCBI Gene	246274	ENTREZGENE
PANTHER	PROTEIN LIFEGUARD 2	UniProtKB/Swiss-Prot
	PTHR23291	UniProtKB/Swiss-Prot
Pfam	Bax1-I	UniProtKB/Swiss-Prot
PhenoGen	Faim2	PhenoGen
RatGTEx	ENSRNOG00000045554	RatGTEx
	ENSRNOG00000053258	RatGTEx
UniProt	A6KCF9	ENTREZGENE, UniProtKB/TrEMBL
	LFG2_RAT	UniProtKB/Swiss-Prot
	M0R531	ENTREZGENE, UniProtKB/TrEMBL
	O88407	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	Faim2	Fas apoptotic inhibitory molecule 2	LOC102551901	protein lifeguard 2-like	Data merged from RGD:7636626	737654	PROVISIONAL
2013-12-18	LOC102551901	protein lifeguard 2-like			Symbol and Name status set to provisional	70820	PROVISIONAL
2004-09-10	Faim2	Fas apoptotic inhibitory molecule 2	Lfg	lifeguard	Symbol and Name updated	1299863	APPROVED
2003-02-27	Lfg	lifeguard			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed in brain and spinal cord	633222
gene_homology	sequence highly homologous to glutamate-binding protein (GBP)	633222

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Annotations - PID (archival)