Ly49i2 (Ly49 inhibitory receptor 2) - Rat Genome Database

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Gene: Ly49i2 (Ly49 inhibitory receptor 2) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Ly49i2
Name: Ly49 inhibitory receptor 2
RGD ID: 628669
Description: ENCODES a protein that exhibits carbohydrate binding (inferred); INVOLVED IN negative regulation of signal transduction; FOUND IN membrane (inferred); plasma membrane (inferred); INTERACTS WITH ammonium chloride; bis(2-ethylhexyl) phthalate; flavonoids
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: killer cell lectin-like receptor 5-like; LOC100911121; LOC102549874
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84166,156,061 - 166,206,865 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4166,156,062 - 166,180,672 (-)EnsemblGRCr8
mRatBN7.24164,470,840 - 164,495,461 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4164,470,841 - 164,495,451 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4170,704,860 - 170,729,479 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04166,487,864 - 166,512,483 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04165,121,899 - 165,146,518 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04164,876,252 - 164,901,832 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4164,470,397 - 164,900,857 (-)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl4162,627,304 - 162,649,618 (-)Ensemblrn6Rnor6.0
Rnor_5.04213,550,956 - 213,575,577 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44168,339,391 - 168,364,012 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4153,137,961 - 153,162,582 (-)NCBICelera
RGSC_v3.14168,584,327 - 168,608,948 (-)NCBI
Cytogenetic Map4q42NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Ly49i2 is an inhibitory rat natural killer cell receptor for an MHC class Ia molecule (RT1-A1c). Naper C, etal., Eur J Immunol 2002 Jul;32(7):2031-6.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:21841133  


Genomics

Variants

.
Variants in Ly49i2
468 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4146370897184426481Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4134095016179095016Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4149763204169799698Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4146370897184426481Rat
6478757Anxrr44Anxiety related response QTL 440.01087locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
1358364Sradr4Stress Responsive Adrenal Weight QTL 44.92adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)4131384565176384565Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4123870974168870974Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4140059299181024663Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4157292416184426481Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)494638356168870820Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4106848959168870974Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4127263297172263297Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4126334185171334185Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4147299608184426481Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
6478782Anxrr52Anxiety related response QTL 520.02091locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4123870974168870974Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4124700988169700988Rat
6478720Alc23Alcohol consumption QTL 230.00509drinking behavior trait (VT:0001422)ethanol drink intake rate to body weight ratio (CMO:0001616)4155834926184426481Rat
6478785Anxrr53Anxiety related response QTL 530.01397locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)4100752691179366077Rat
1581566Eae21Experimental allergic encephalomyelitis QTL 216.2body mass (VT:0001259)maximum body weight loss to initial body weight ratio (CMO:0001400)4137447185182447185Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4137430611182430611Rat
6478728Anxrr36Anxiety related response QTL 360.01061locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)486709649168870974Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4134199006168870974Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4148121375176967367Rat
6478733Anxrr37Anxiety related response QTL 370.00095locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4123870974168870974Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
6478737Anxrr38Anxiety related response QTL 380.00159locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4160623982184426481Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4148834094168870974Rat

Markers in Region
D4Won17  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24164,489,954 - 164,490,186 (+)MAPPERmRatBN7.2
Rnor_6.04162,645,944 - 162,646,175NCBIRnor6.0
Rnor_6.04164,895,367 - 164,895,598NCBIRnor6.0
Rnor_5.04213,570,071 - 213,570,302UniSTSRnor5.0
Rnor_5.04227,841,488 - 227,841,719UniSTSRnor5.0
RGSC_v3.44168,358,506 - 168,358,737UniSTSRGSC3.4
Celera4153,157,076 - 153,157,307UniSTS
Cytogenetic Map4q42UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 6 17 51 36 42 16 71 16 2 166 103 5 37 35 37 26 5 5

Sequence


Ensembl Acc Id: ENSRNOT00000050861   ⟹   ENSRNOP00000043859
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl4162,627,304 - 162,649,618 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000078219   ⟹   ENSRNOP00000072569
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl4164,515,106 - 164,691,417 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000078690   ⟹   ENSRNOP00000068787
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4166,156,062 - 166,180,672 (-)Ensembl
mRatBN7.2 Ensembl4164,470,841 - 164,495,451 (-)Ensembl
Rnor_6.0 Ensembl4164,876,253 - 164,900,857 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000085454   ⟹   ENSRNOP00000072897
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4164,336,450 - 164,339,870 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000087796   ⟹   ENSRNOP00000073809
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4165,852,010 - 165,873,606 (-)Ensembl
mRatBN7.2 Ensembl4164,166,785 - 164,186,528 (-)Ensembl
Rnor_6.0 Ensembl4164,515,148 - 164,536,556 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000090316   ⟹   ENSRNOP00000073194
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl4164,515,528 - 164,899,041 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000091932   ⟹   ENSRNOP00000072678
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4164,122,072 - 164,341,692 (-)Ensembl
Rnor_6.0 Ensembl4164,470,397 - 164,691,405 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117297   ⟹   ENSRNOP00000088840
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4164,316,945 - 164,339,870 (-)Ensembl
RefSeq Acc Id: NM_152848   ⟹   NP_690061
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84166,156,061 - 166,180,682 (-)NCBI
mRatBN7.24164,470,840 - 164,495,461 (-)NCBI
Rnor_6.04164,876,252 - 164,900,873 (-)NCBI
Rnor_5.04213,550,956 - 213,575,577 (-)NCBI
RGSC_v3.44168,339,391 - 168,364,012 (-)RGD
Celera4153,137,961 - 153,162,582 (-)RGD
Sequence:
RefSeq Acc Id: XM_063285635   ⟹   XP_063141705
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84166,156,061 - 166,206,865 (-)NCBI
RefSeq Acc Id: XM_063285636   ⟹   XP_063141706
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84166,156,061 - 166,206,865 (-)NCBI
Protein Sequences
Protein RefSeqs NP_690061 (Get FASTA)   NCBI Sequence Viewer  
  XP_063141705 (Get FASTA)   NCBI Sequence Viewer  
  XP_063141706 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAM56042 (Get FASTA)   NCBI Sequence Viewer  
  EDM01700 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000068787
  ENSRNOP00000068787.3
RefSeq Acc Id: NP_690061   ⟸   NM_152848
- UniProtKB: Q8K3G1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073809   ⟸   ENSRNOT00000087796
Ensembl Acc Id: ENSRNOP00000073194   ⟸   ENSRNOT00000090316
Ensembl Acc Id: ENSRNOP00000072569   ⟸   ENSRNOT00000078219
Ensembl Acc Id: ENSRNOP00000043859   ⟸   ENSRNOT00000050861
Ensembl Acc Id: ENSRNOP00000072678   ⟸   ENSRNOT00000091932
Ensembl Acc Id: ENSRNOP00000068787   ⟸   ENSRNOT00000078690
Ensembl Acc Id: ENSRNOP00000088840   ⟸   ENSRNOT00000117297
Ensembl Acc Id: ENSRNOP00000072897   ⟸   ENSRNOT00000085454
RefSeq Acc Id: XP_063141706   ⟸   XM_063285636
- Peptide Label: isoform X2
- UniProtKB: A6IM89 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063141705   ⟸   XM_063285635
- Peptide Label: isoform X1
Protein Domains
C-type lectin   Ly49-like N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K3B3-F1-model_v2 AlphaFold A0A0G2K3B3 1-290 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628669 AgrOrtholog
BioCyc Gene G2FUF-42740 BioCyc
Ensembl Genes ENSRNOG00000046046 Ensembl
  ENSRNOG00000051600 Ensembl
  ENSRNOG00000069072 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000078690 ENTREZGENE
  ENSRNOT00000078690.3 UniProtKB/TrEMBL
Gene3D-CATH 3.10.100.10 UniProtKB/TrEMBL
InterPro C-type_lectin UniProtKB/TrEMBL
  C-type_lectin-like UniProtKB/TrEMBL
  C-type_lectin_fold UniProtKB/TrEMBL
  Ly49 UniProtKB/TrEMBL
  Mouse_KLRs UniProtKB/TrEMBL
  NKR-like_CTLD UniProtKB/TrEMBL
KEGG Report rno:260324 UniProtKB/TrEMBL
NCBI Gene 260324 ENTREZGENE
PANTHER KILLER CELL LECTIN-LIKE RECEPTOR 2 UniProtKB/TrEMBL
  KILLER CELL LECTIN-LIKE RECEPTOR, SUBFAMILY A, MEMBER 17 UniProtKB/TrEMBL
Pfam Lectin_C UniProtKB/TrEMBL
  Ly49 UniProtKB/TrEMBL
PhenoGen Ly49i2 PhenoGen
PROSITE C_TYPE_LECTIN_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000046046 RatGTEx
  ENSRNOG00000051600 RatGTEx
  ENSRNOG00000069072 RatGTEx
SMART CLECT UniProtKB/TrEMBL
Superfamily-SCOP C-type_lectin_fold UniProtKB/TrEMBL
UniProt A0A0G2JTP1_RAT UniProtKB/TrEMBL
  A6IM89 ENTREZGENE, UniProtKB/TrEMBL
  Q8K3G1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Ly49i2  Ly49 inhibitory receptor 2  LOC102549874  killer cell lectin-like receptor 5-like  Data merged from RGD:7726035 737654 PROVISIONAL
2015-07-29 Ly49i2  Ly49 inhibitory receptor 2  LOC100911121  killer cell lectin-like receptor 5-like  Data merged from RGD:6495174 737654 PROVISIONAL
2013-12-18 LOC102549874  killer cell lectin-like receptor 5-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2012-07-05 LOC100911121  killer cell lectin-like receptor 5-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2003-02-27 Ly49i2  Ly49 inhibitory receptor 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains an immunoreceptor tyrosine-based inhibitory motif 633225
gene_process inhibits natural killing of lymphoblast targets by NK cells 633225