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Gene: Slco1c1 (solute carrier organic anion transporter family, member 1c1) Rattus norvegicus

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Symbol:

Slco1c1

Name:

solute carrier organic anion transporter family, member 1c1

RGD ID:

628660

Description:

Enables bile acid transmembrane transporter activity. Involved in bile acid and bile salt transport. Located in basolateral plasma membrane. Biomarker of primary biliary cholangitis. Orthologous to human SLCO1C1 (solute carrier organic anion transporter family member 1C1); PARTICIPATES IN multispecific organic anion transporter mediated transport pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

BAST1; BBB-specific anion transporter type 1; blood-brain barrier specific anion transporter; blood-brain barrier-specific anion transporter 1; Bsat1; OATP-14; Oatp14; OATP1C1; Oatp2; organic anion transporter 1C1; organic anion-transporting polypeptide 14; Slc21a14; solute carrier family 21 (organic anion transporter), member 14; solute carrier family 21 member 14; solute carrier organic anion transporter family member 1C1; thyroxine transporter

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	176,197,736 - 176,244,401 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	4	176,197,741 - 176,244,395 (+)	Ensembl				GRCr8
mRatBN7.2	4	174,466,621 - 174,513,290 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	174,466,631 - 174,513,289 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	4	180,761,522 - 180,808,184 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	176,545,790 - 176,592,460 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	175,166,330 - 175,212,987 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	175,729,709 - 175,776,749 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	175,729,726 - 175,776,808 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	4	239,951,715 - 239,997,944 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	4	178,959,893 - 179,006,727 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	4	163,007,118 - 163,053,764 (+)	NCBI		Celera
RGSC_v3.1	4	179,205,016 - 179,251,850 (+)	NCBI
Cytogenetic Map	4	q44	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autism spectrum disorder (ISO)

primary biliary cholangitis (IEP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

ammonium chloride (EXP)

benzo[a]pyrene (ISO)

biochanin A (EXP)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bosentan (EXP)

bromobenzene (EXP)

CGP 52608 (ISO)

chlorpyrifos (ISO)

clothianidin (ISO)

ethanol (ISO)

glyphosate (EXP)

hispidulin (EXP)

isoliquiritigenin (EXP)

isoniazide (EXP)

kaempferol (EXP)

ketamine (EXP)

Licochalcone A (EXP)

luteolin (EXP)

methamphetamine (EXP)

methotrexate (EXP)

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine (ISO)

ozone (EXP)

paraquat (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

pirinixic acid (ISO)

resveratrol (ISO)

rifampicin (EXP)

rotenone (ISO)

sinensetin (EXP)

sodium arsenite (ISO)

Soman (EXP)

toluene (EXP)

valproic acid (ISO)

zinc atom (ISO)

zinc sulfate (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

bile acid and bile salt transport (IBA,IDA)

lipid transport (IEA)

monoatomic ion transport (IEA)

positive regulation of thyroid hormone generation (IEA,ISO)

sodium-independent organic anion transport (IBA)

thyroid hormone transport (IEA,ISO)

transmembrane transport (IEA,ISO)

Cellular Component

basolateral plasma membrane (IBA,IDA,IEA,ISO)

membrane (IEA)

plasma membrane (IDA,IEA,ISO)

Molecular Function

bile acid transmembrane transporter activity (IBA,IDA)

protein binding (ISO)

thyroid hormone transmembrane transporter activity (IEA,ISO)

transmembrane transporter activity (IEA,ISO,ISS)

Molecular Pathway Annotations Click to see Annotation Detail View

multispecific organic anion transporter mediated transport pathway (IDA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Distribution of organic anion-transporting polypeptide 2 (oatp2) and oatp3 in the rat retina.	Ito A, etal., Invest Ophthalmol Vis Sci 2002 Mar;43(3):858-63.
3.	Blood-brain barrier genomics.	Li JY, etal., J Cereb Blood Flow Metab. 2001 Jan;21(1):61-8.
4.	Transport of the sulfated, amidated bile acid, sulfolithocholyltaurine, into rat hepatocytes is mediated by Oatp1 and Oatp2.	Meng LJ, etal., Hepatology 2002 May;35(5):1031-40.
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	Magnetic resonance imaging with hepatospecific contrast agents in cirrhotic rat livers.	Planchamp C, etal., Invest Radiol. 2005 Apr;40(4):187-94.
7.	GOA pipeline	RGD automated data pipeline
8.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
10.	Expression of the thyroid hormone transporters monocarboxylate transporter-8 (SLC16A2) and organic ion transporter-14 (SLCO1C1) at the blood-brain barrier.	Roberts LM, etal., Endocrinology. 2008 Dec;149(12):6251-61. doi: 10.1210/en.2008-0378. Epub 2008 Aug 7.
11.	Messenger RNA profiles in liver injury and stress: a comparison of lethal and nonlethal rat models.	Tygstrup N, etal., Biochem Biophys Res Commun 2002 Jan 11;290(1):518-25.

Additional References at PubMed

PMID:12130705	PMID:12351693	PMID:12702494	PMID:12830001	PMID:12883478	PMID:12923172	PMID:17667996	PMID:18566113	PMID:18845642	PMID:19819953	PMID:22871113	PMID:24143363
PMID:24143376	PMID:24763672	PMID:25594699	PMID:26861177	PMID:28688524	PMID:31561916	PMID:32636400

Genomics

Comparative Map Data

Slco1c1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	176,197,736 - 176,244,401 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	4	176,197,741 - 176,244,395 (+)	Ensembl				GRCr8
mRatBN7.2	4	174,466,621 - 174,513,290 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	174,466,631 - 174,513,289 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	4	180,761,522 - 180,808,184 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	176,545,790 - 176,592,460 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	175,166,330 - 175,212,987 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	175,729,709 - 175,776,749 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	175,729,726 - 175,776,808 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	4	239,951,715 - 239,997,944 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	4	178,959,893 - 179,006,727 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	4	163,007,118 - 163,053,764 (+)	NCBI		Celera
RGSC_v3.1	4	179,205,016 - 179,251,850 (+)	NCBI
Cytogenetic Map	4	q44	NCBI

SLCO1C1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	20,695,332 - 20,753,386 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	20,695,332 - 20,753,386 (+)	Ensembl			hg38	GRCh38
GRCh37	12	20,848,266 - 20,906,320 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	20,739,666 - 20,797,587 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	12	20,739,665 - 20,797,585	NCBI
Celera	12	26,003,971 - 26,061,652 (+)	NCBI		Celera
Cytogenetic Map	12	p12.2	NCBI
HuRef	12	20,620,269 - 20,677,924 (+)	NCBI		HuRef
CHM1_1	12	20,814,189 - 20,871,884 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	20,573,918 - 20,631,651 (+)	NCBI		T2T-CHM13v2.0

Slco1c1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	141,470,080 - 141,515,903 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	141,470,094 - 141,515,903 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	6	141,524,354 - 141,570,177 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	141,524,368 - 141,570,177 (+)	Ensembl			mm10	GRCm38
MGSCv37	6	141,472,907 - 141,518,698 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	6	141,486,956 - 141,532,122 (+)	NCBI		MGSCv36	mm8
Celera	6	144,586,311 - 144,632,101 (+)	NCBI		Celera
Cytogenetic Map	6	G2	NCBI
cM Map	6	72.38	NCBI

Slco1c1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955413	16,654,618 - 16,705,720 (+)	Ensembl
ChiLan1.0	NW_004955413	16,654,655 - 16,705,638 (+)	NCBI	ChiLan1.0	ChiLan1.0

SLCO1C1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	26,142,465 - 26,199,535 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	26,139,229 - 26,196,299 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	20,698,207 - 20,755,434 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	21,079,431 - 21,136,631 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	21,079,437 - 21,136,631 (+)	Ensembl			panPan2	panpan1.1

SLCO1C1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	27	26,497,639 - 26,553,790 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	27	26,498,292 - 26,553,314 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	27	19,902,986 - 19,958,946 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	27	26,823,633 - 26,879,842 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	27	26,823,643 - 26,879,686 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	27	26,686,400 - 26,742,130 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	27	26,671,581 - 26,727,757 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	27	19,607,438 - 19,663,420 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Slco1c1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	87,775,315 - 87,823,044 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936548	5,698,199 - 5,745,876 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936548	5,698,218 - 5,745,870 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SLCO1C1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	52,234,398 - 52,315,026 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	5	52,234,396 - 52,315,311 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	55,511,431 - 55,592,551 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SLCO1C1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	20,555,953 - 20,612,455 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	20,555,846 - 20,612,761 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666069	14,539,339 - 14,596,159 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Slco1c1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624752	17,720,716 - 17,765,561 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624752	17,718,696 - 17,765,705 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Slco1c1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	6	8,008,086 - 8,054,010 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Slco1c1
365 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	150
Count of miRNA genes:	113
Interacting mature miRNAs:	127
Transcripts:	ENSRNOT00000013230
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
6478754	Anxrr43	Anxiety related response QTL 43		0.14035	locomotor behavior trait (VT:0001392)	distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)	4	146370897	184426481	Rat
724558	Plsm2	Polydactyly-luxate syndrome (PLS) morphotypes QTL 2		0.0003	hindlimb integrity trait (VT:0010563)	hind foot phalanges count (CMO:0001949)	4	134095016	179095016	Rat
6478693	Anxrr32	Anxiety related response QTL 32		0.00092	locomotor behavior trait (VT:0001392)	measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)	4	146370897	184426481	Rat
6478757	Anxrr44	Anxiety related response QTL 44		0.01087	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155834926	184426481	Rat
1358364	Sradr4	Stress Responsive Adrenal Weight QTL 4	4.92		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	4	131384565	176384565	Rat
1331738	Bp209	Blood pressure QTL 209	2.979		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	140059299	181024663	Rat
6478700	Anxrr33	Anxiety related response QTL 33		0.00896	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	146370897	184426481	Rat
1298524	Oia8	Oil induced arthritis QTL 8			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	140059299	184426481	Rat
10053718	Scort25	Serum corticosterone level QTL 25	2.15	0.0097	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	157292416	184426481	Rat
738009	Sach4	Saccharine consumption QTL 4	4.9	0.000016	consumption behavior trait (VT:0002069)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	4	60916264	184426481	Rat
10401796	Kidm48	Kidney mass QTL 48			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	4	147299608	184426481	Rat
6478718	Anxrr34	Anxiety related response QTL 34		0.00896	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	146370897	184426481	Rat
6478782	Anxrr52	Anxiety related response QTL 52		0.02091	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155834926	184426481	Rat
6478720	Alc23	Alcohol consumption QTL 23		0.00509	drinking behavior trait (VT:0001422)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	155834926	184426481	Rat
6478785	Anxrr53	Anxiety related response QTL 53		0.01397	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155834926	184426481	Rat
1576316	Ept5	Estrogen-induced pituitary tumorigenesis QTL 5	3.8		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	4	100752691	179366077	Rat
1581566	Eae21	Experimental allergic encephalomyelitis QTL 21	6.2		body mass (VT:0001259)	maximum body weight loss to initial body weight ratio (CMO:0001400)	4	137447185	182447185	Rat
1578674	Bmd12	Bone mineral density QTL 12	3.8		femur mineral mass (VT:0010011)	compact volumetric bone mineral density (CMO:0001730)	4	137430611	182430611	Rat
6478728	Anxrr36	Anxiety related response QTL 36		0.01061	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155834926	184426481	Rat
738016	Alc16	Alcohol consumption QTL 16	3.6	0.00015	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	60916264	184426481	Rat
634342	Cia24	Collagen induced arthritis QTL 24	4.5		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	148121375	176967367	Rat
6478733	Anxrr37	Anxiety related response QTL 37		0.00095	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155834926	184426481	Rat
61362	Oia2	Oil induced arthritis QTL 2		0.001	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	140059299	184426481	Rat
6478737	Anxrr38	Anxiety related response QTL 38		0.00159	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155834926	184426481	Rat
2293659	Bmd35	Bone mineral density QTL 35	4.5	0.0001	femur strength trait (VT:0010010)	femoral neck ultimate force (CMO:0001703)	4	160623982	184426481	Rat
2316958	Gluco58	Glucose level QTL 58	10		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	12212457	182430611	Rat
6478748	Anxrr42	Anxiety related response QTL 42		0.28008	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	146370897	184426481	Rat

Markers in Region

D4Got111

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	174,506,997 - 174,507,207 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	175,770,067 - 175,770,276	NCBI	Rnor6.0
Rnor_5.0	4	239,991,877 - 239,992,086	UniSTS	Rnor5.0
RGSC_v3.4	4	179,000,664 - 179,000,874	RGD	RGSC3.4
RGSC_v3.4	4	179,000,665 - 179,000,874	UniSTS	RGSC3.4
Celera	4	163,047,472 - 163,047,681	UniSTS
RGSC_v3.1	4	179,245,788 - 179,245,998	RGD
RH 3.4 Map	4	1031.32	UniSTS
RH 3.4 Map	4	1031.32	RGD
RH 2.0 Map	4	892.4	RGD
Cytogenetic Map	4	q44	UniSTS

AU046632

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	4	176,198,800 - 176,198,965 (+)	Marker Load Pipeline
mRatBN7.2	4	174,467,690 - 174,467,855 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	175,730,769 - 175,730,933	NCBI	Rnor6.0
Rnor_5.0	4	239,952,786 - 239,952,950	UniSTS	Rnor5.0
RGSC_v3.4	4	178,960,953 - 178,961,117	UniSTS	RGSC3.4
Celera	4	163,008,178 - 163,008,342	UniSTS
Cytogenetic Map	4	q44	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
10	5	59	141	64	67	51	10	51	5	177	77	3	131	34	67	16	13	13

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053441	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039108471	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC142420	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF306546	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473964	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000013230 ⟹ ENSRNOP00000013230

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	176,197,741 - 176,244,395 (+)	Ensembl
mRatBN7.2 Ensembl	4	174,466,631 - 174,513,289 (+)	Ensembl
Rnor_6.0 Ensembl	4	175,729,726 - 175,776,808 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000116390 ⟹ ENSRNOP00000091816

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	176,197,741 - 176,244,395 (+)	Ensembl
mRatBN7.2 Ensembl	4	174,466,631 - 174,513,289 (+)	Ensembl

RefSeq Acc Id:

NM_053441 ⟹ NP_445893

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	176,197,741 - 176,244,396 (+)	NCBI
mRatBN7.2	4	174,466,631 - 174,513,290 (+)	NCBI
Rnor_6.0	4	175,729,709 - 175,776,749 (+)	NCBI
Rnor_5.0	4	239,951,715 - 239,997,944 (+)	NCBI
RGSC_v3.4	4	178,959,893 - 179,006,727 (+)	RGD
Celera	4	163,007,118 - 163,053,764 (+)	RGD

Sequence:

show sequence

GCAAATTGCAAAGAAATGGCTCAAAGGCTCCAGCTCTTTCCGTGCCCTGGGAGCTGAGATGCAG
GGCAGTGCCCTTGCCAGGGTGCCCAATTCCCTGCAGACTGCCAGAAAAAAAAGAGGCCAACTGG
AAAGGCGAAAGAGAAAGATTGCCTAGGGGAGAGATCAGACCCTTGGGCTCTTCTTTGCTCTAAT
CTGTCCTGTCTGTGCCCACCACCTCTCCTGACTTGCCAGAACGATTCAGAGCTGCTGTGGGGGT
ACTGCCTCAGTTTCCTCATTCAGGCTGGGCTCTGTGATCCAGCGTCTCGCTGAACGTTCTGAAA
GAACTGGAGAGCTTTGACTTCTACCTCCAGGCCGGGATAAGAAATATTTTCATAATGGACACTT
CATCCAAAGAAAATGCCCATTTGTTCCACAAAAATTCAGCGCAACCTGCCGGAGGGCCATCTTT
TAAAGCGGGATATCCGTCCACAGAGGAAGCGCGGCCATGCTGTGGAAAACTCAAGGTGTTCTTA
GGTGCCCTGTCTTTTGTTTACTTTGCCAAAGCATTGACAGAAGGCTACCTGAAGAGCACTATTA
CTCAGATAGAGAGAAGGTTTGATATCCCTTCCTCTCTGGTGGGAATAATTGATGGTAGTTTCGA
AATTGGGAATCTCCTGGTCATAACATTCGTTAGCTACTTTGGTGCCAAACTTCACAGGCCAAAA
ATAATTGGAGCAGGATGCCTGGTCATGGGCTTTGGAACTATGCTCATCGCAGTTCCCCAGTTCT
TCATGGAGAAGTACAGCTATGAGAAATATGAGAGGTATTCTCCCTCCTCCAACCTCACTCCCAA
CATCTCTCCGTGCTACCTAGAGTCCAGCAGTCCATCACCACGCTCAATCGTGGGGAAATCACAA
AACAAGATAAACGATGAGTGTGAAGTGGATACCAGTTCCTCCATGTGGGTTTATGTCTTCCTGG
GAAACCTTCTCCGAGGATTAGGGGAAACTCCTATCCAACCCCTGGGCATCGCCTACCTGGATGA
TTTCGCCAGTGAAGACAATGCTGCCTTCTACATCGGGTGTGTGCAGACAGTGGCAATTATAGGG
CCCATTTTCGGCTTCCTCTTGGGTTCATTATGTGCCAAACTCTATGTTGATATTGGCTTTGTGA
ATCTAGACCACATAACTATCACCCCAAAGGATCCCCAGTGGGTCGGGGCCTGGTGGCTTGGTTA
CCTAATAGCAGGGTTCCTAAGTCTTCTTGCAGCCGTGCCTTTCTGGTGCTTACCCAAGACTCTA
CCAAGATCCCAAAGTAGAGAGGACTCCGGCTCCTCCTCTGAGAAATCCAAGTTCATTACAGATG
ACCCTGTTAACTACCAAATGGCCCCCAGAGAAGAAAGCATGAAAATCATGGAAATGGCGAGGGA
TTTTCTTCCATCACTGAAGAGTCTTTTTAGAAATCCAGTATACATCTTATACTTGTGTGCAAGC
ACTGTTCAGTTCAATTCTCTATTCGGCATGGTCACATATAAACCAAAGTACATTGAGCAGCAGT
ATGGGCAGTCTTCCTCCAAAGCCAACTTTGTCATTGGTCTCATCAATATTCCTGCAGTGGCCCT
TGGAATATTCTCTGGGGGAATAGTTATGAAAAAATTCAGGCTGGGTATTTGTGAAGCTACAAAA
CTCTACTTGGGATCATCTGTCTTTGGCTACCTCCTCTTCCTCTCTCTGTTTGCACTGGGATGTG
AAAATTCCAGTGTGGCCGGACTAACTGTCTCCTACCAAGGAACCAAACCTGTCTCTTATCATGA
ACGAGCTCTCTTTTCAGATTGCAACTCAAGATGCAAATGTTCAGACTCAAAATGGGAGCCCATG
TGTGGGGACAATGGGATTACCTATGCGTCGGCTTGTCTTGCTGGCTGTCAATCCTCCAGCCGGA
GTGGAAAGAACATTATATTTTCTAACTGCACTTGTGTGGGATTTGCTGCCCCTAAATCAGGAAA
CTGGTCAGGCATGATGGGCAGGTGTCAGAAAGATAATGGATGTTCCCAAATGTTTCTGTATTTC
CTTGTGATTTCAGTCATCACATCATATACATTATCTCTAGGTGGCATACCTGGATATATATTAC
TCTTGAGGTGCATTCAACCACAACTTAAGTCTTTTGCTCTGGGCATCTACACCTTAGCAGTAAG
AGTTCTTGCAGGAATCCCAGCCCCCGTGTACTTTGGTGTTTTAATCGACACTTCGTGCCTCAAG
TGGGGATTTAAGAAATGTGGAAGCAGAGGCTCCTGCAGACTGTACGACTCTCATGCTTTCAGAC
ATATATACCTGGGACTAACCACGCTCTTGGGCACGGTGTCTGTCTTCCTAAGCACGGCTGTGCT
TTTGGTTTTAAAGAAAAAATACGTCTCAAAACGCAGCAGCTTCATAACCGCAAGAGAAAAAATA
GTGATGTCCTCAAGCGTCAAAAAGGAGACGTGTGCCGCAAGGGATCATGGGTTGCAGCCCAAGT
ACTGGCCAGGCAAGGAGACCCGACTTTAAGAACAAGAAATCACGGAAACGAACAAACATGAAGG
TCATTTTTATCCAATATATGTAAATGAATAAAATCATAATCAAAAGGGCCTCAACGTGTAATTT
CGTCCTGCTTTCAAAGGTATGCCTGCTTTGTTTTTGACCCTAAGCATTAGATGATGAACCTCTA
AAAATGTCATTAAATTTATTTTAAAACTTTTAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039108471 ⟹ XP_038964399

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	176,197,736 - 176,244,401 (+)	NCBI
mRatBN7.2	4	174,466,621 - 174,513,290 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_445893	(Get FASTA)	NCBI Sequence Viewer
	XP_038964399	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAG37066	(Get FASTA)	NCBI Sequence Viewer
	EDM01549	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000013230
GenBank Protein	Q9EPZ7	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_445893 ⟸ NM_053441

- UniProtKB:

Q9EPZ7 (UniProtKB/Swiss-Prot), A0A8I6GJ93 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDTSSKENAHLFHKNSAQPAGGPSFKAGYPSTEEARPCCGKLKVFLGALSFVYFAKALTEGYLK
STITQIERRFDIPSSLVGIIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCLVMGFGTMLIAV
PQFFMEKYSYEKYERYSPSSNLTPNISPCYLESSSPSPRSIVGKSQNKINDECEVDTSSSMWVY
VFLGNLLRGLGETPIQPLGIAYLDDFASEDNAAFYIGCVQTVAIIGPIFGFLLGSLCAKLYVDI
GFVNLDHITITPKDPQWVGAWWLGYLIAGFLSLLAAVPFWCLPKTLPRSQSREDSGSSSEKSKF
ITDDPVNYQMAPREESMKIMEMARDFLPSLKSLFRNPVYILYLCASTVQFNSLFGMVTYKPKYI
EQQYGQSSSKANFVIGLINIPAVALGIFSGGIVMKKFRLGICEATKLYLGSSVFGYLLFLSLFA
LGCENSSVAGLTVSYQGTKPVSYHERALFSDCNSRCKCSDSKWEPMCGDNGITYASACLAGCQS
SSRSGKNIIFSNCTCVGFAAPKSGNWSGMMGRCQKDNGCSQMFLYFLVISVITSYTLSLGGIPG
YILLLRCIQPQLKSFALGIYTLAVRVLAGIPAPVYFGVLIDTSCLKWGFKKCGSRGSCRLYDSH
AFRHIYLGLTTLLGTVSVFLSTAVLLVLKKKYVSKRSSFITAREKIVMSSSVKKETCAARDHGL
QPKYWPGKETRL

hide sequence

Ensembl Acc Id:

ENSRNOP00000013230 ⟸ ENSRNOT00000013230

RefSeq Acc Id:	XP_038964399 ⟸ XM_039108471
- Peptide Label:	isoform X1
- UniProtKB:	G3V795 (UniProtKB/TrEMBL), A6IMP0 (UniProtKB/TrEMBL), A0A8I6GJ93 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000091816 ⟸ ENSRNOT00000116390

Protein Domains

Kazal-like Major facilitator superfamily (MFS) profile

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9EPZ7-F1-model_v2	AlphaFold	Q9EPZ7	1-716	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:628660	AgrOrtholog
BioCyc Gene	G2FUF-42514	BioCyc
Ensembl Genes	ENSRNOG00000009740	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000013230	ENTREZGENE
Gene3D-CATH	1.20.1250.20	UniProtKB/Swiss-Prot
	3.30.60.30	UniProtKB/Swiss-Prot
InterPro	Kazal_dom	UniProtKB/Swiss-Prot
	Kazal_dom_sf	UniProtKB/Swiss-Prot
	MFS_dom	UniProtKB/Swiss-Prot
	MFS_trans_sf	UniProtKB/Swiss-Prot
	OATP	UniProtKB/Swiss-Prot
KEGG Report	rno:84511	UniProtKB/Swiss-Prot
NCBI Gene	84511	ENTREZGENE
PANTHER	PTHR11388	UniProtKB/Swiss-Prot
	PTHR11388:SF99	UniProtKB/Swiss-Prot
Pfam	Kazal_2	UniProtKB/Swiss-Prot
	OATP	UniProtKB/Swiss-Prot
PhenoGen	Slco1c1	PhenoGen
PROSITE	KAZAL_2	UniProtKB/Swiss-Prot
	MFS	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000009740	RatGTEx
Superfamily-SCOP	SSF100895	UniProtKB/Swiss-Prot
	SSF103473	UniProtKB/Swiss-Prot
UniProt	A0A8I6GJ93	ENTREZGENE, UniProtKB/TrEMBL
	A6IMP0	ENTREZGENE, UniProtKB/TrEMBL
	G3V795	ENTREZGENE, UniProtKB/TrEMBL
	Q9EPZ7	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-09-10	Slco1c1	solute carrier organic anion transporter family, member 1c1	Slc21a14	solute carrier family 21 (organic anion transporter), member 14	Symbol and Name updated	1299863	APPROVED
2003-02-27	Slc21a14	solute carrier family 21 (organic anion transporter), member 14			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_expression	mRNA signals seen in the retinal pigment epithelium and the inner nuclear layer	70527
gene_expression	expressed in apical membrane of the choroid plexus	70527
gene_process	transports organic anions in ocular tissue	70527
gene_regulation	bile acid transporter activity does not require sodium ions	634158

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

RGD Manual Annotations

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Imported Disease Annotations - CTD

RGD Manual Annotations