Has3 (hyaluronan synthase 3) - Rat Genome Database

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Gene: Has3 (hyaluronan synthase 3) Rattus norvegicus
Analyze
Symbol: Has3
Name: hyaluronan synthase 3
RGD ID: 628656
Description: Predicted to enable hyaluronan synthase activity and identical protein binding activity. Predicted to be involved in several processes, including extracellular matrix assembly; hyaluronan biosynthetic process; and positive regulation of hyaluranon cable assembly. Predicted to be located in Golgi apparatus; hyaluranon cable; and nucleus. Predicted to be active in plasma membrane. Biomarker of pulmonary hypertension. Orthologous to human HAS3 (hyaluronan synthase 3); INTERACTS WITH ammonium chloride; bisphenol A; 1,4-phenylenediamine (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81951,668,276 - 51,691,042 (+)NCBIGRCr8GRCr8GRCr8
mRatBN7.21934,768,421 - 34,782,170 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1934,771,982 - 34,782,592 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1941,583,943 - 41,593,370 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01942,237,283 - 42,246,710 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01944,536,404 - 44,545,834 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01939,063,298 - 39,077,745 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1939,063,998 - 39,077,722 (+)Ensemblrn6Rnor6.0
Rnor_5.01949,928,282 - 49,942,033 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41936,718,156 - 36,727,586 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1934,192,486 - 34,201,862 (+)NCBICelera
RGSC_v3.11936,723,036 - 36,732,467 (+)NCBI
Cytogenetic Map19q12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Selective expression and functional characteristics of three mammalian hyaluronan synthases in oncogenic malignant transformation. Itano N, etal., J Biol Chem 2004 Apr 30;279(18):18679-87. Epub 2004 Jan 14.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. The enzymatic degradation of hyaluronan is associated with disease progression in experimental pulmonary hypertension. Ormiston ML, etal., Am J Physiol Lung Cell Mol Physiol. 2010 Feb;298(2):L148-57. doi: 10.1152/ajplung.00097.2009. Epub 2009 Nov 13.
6. EGF upregulates, whereas TGF-beta downregulates, the hyaluronan synthases Has2 and Has3 in organotypic keratinocyte cultures: correlations with epidermal proliferation and differentiation. Pasonen-Seppanen S, etal., J Invest Dermatol 2003 Jun;120(6):1038-44.
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9060470   PMID:10455188   PMID:12784612   PMID:14506240   PMID:16900089   PMID:19572173   PMID:23645665   PMID:24057227   PMID:25795779  


Genomics

Comparative Map Data
Has3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81951,668,276 - 51,691,042 (+)NCBIGRCr8GRCr8GRCr8
mRatBN7.21934,768,421 - 34,782,170 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1934,771,982 - 34,782,592 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1941,583,943 - 41,593,370 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01942,237,283 - 42,246,710 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01944,536,404 - 44,545,834 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01939,063,298 - 39,077,745 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1939,063,998 - 39,077,722 (+)Ensemblrn6Rnor6.0
Rnor_5.01949,928,282 - 49,942,033 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41936,718,156 - 36,727,586 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1934,192,486 - 34,201,862 (+)NCBICelera
RGSC_v3.11936,723,036 - 36,732,467 (+)NCBI
Cytogenetic Map19q12NCBI
HAS3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381669,083,484 - 69,118,719 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1669,105,653 - 69,118,719 (+)Ensemblhg38GRCh38
GRCh371669,139,556 - 69,152,622 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361667,697,661 - 67,710,123 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341667,697,660 - 67,710,118NCBI
Celera1653,649,484 - 53,661,945 (+)NCBICelera
Cytogenetic Map16q22.1NCBI
HuRef1655,012,157 - 55,025,357 (+)NCBIHuRef
CHM1_11670,547,541 - 70,560,696 (+)NCBICHM1_1
T2T-CHM13v2.01674,879,801 - 74,915,029 (+)NCBIT2T-CHM13v2.0
Has3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398107,596,874 - 107,609,534 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8107,596,874 - 107,611,198 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm388106,870,242 - 106,882,902 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8106,870,242 - 106,884,566 (+)Ensemblmm10GRCm38
MGSCv378109,394,142 - 109,406,802 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv368109,759,371 - 109,772,031 (+)NCBIMGSCv36mm8
Celera8111,096,197 - 111,108,800 (+)NCBICelera
Cytogenetic Map8D3NCBI
cM Map853.28NCBI
Has3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554847,542,286 - 7,570,684 (-)Ensembl
ChiLan1.0NW_0049554847,542,286 - 7,570,108 (-)NCBIChiLan1.0ChiLan1.0
HAS3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21878,639,756 - 78,658,963 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11684,551,375 - 84,570,563 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01649,476,561 - 49,488,820 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11668,864,318 - 68,876,678 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1668,868,416 - 68,877,476 (+)EnsemblpanPan2panpan1.1
HAS3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1580,520,261 - 80,530,769 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl580,520,261 - 80,529,434 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha580,511,151 - 80,538,585 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0580,954,678 - 80,982,141 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl580,953,670 - 80,962,846 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1580,781,897 - 80,809,330 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0580,464,448 - 80,491,878 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0581,104,369 - 81,131,818 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Has3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934940,306,192 - 40,334,622 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647519,270,830 - 19,282,907 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647519,270,788 - 19,282,922 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HAS3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl617,843,882 - 17,853,210 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1617,844,974 - 17,870,331 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
HAS3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1558,289,672 - 58,306,843 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl558,292,044 - 58,298,524 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604721,022,092 - 21,035,135 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Has3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474617,218,792 - 17,235,499 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Has3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11726,594,899 - 26,603,626 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Has3
323 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:106
Count of miRNA genes:79
Interacting mature miRNAs:96
Transcripts:ENSRNOT00000027422
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19799775052997750Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)191922068964220689Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19799775052997750Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)194622677874246245Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032907674246245Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)193236531174246245Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)192409397369093973Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
2303628Vencon9Ventilatory control QTL 90.005respiration trait (VT:0001943)minute ventilation (CMO:0000132)192318858668188586Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191083361874246245Rat
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)194438513474246245Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)193253961574246245Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)193177788874246245Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19799775052997750Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19799775052997750Rat
1554318Bmd5Bone mineral density QTL 512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)192318858668188586Rat
1354607Gmadr1Adrenal mass QTL 15.83adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)194072709254856850Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)192010930665109306Rat
1354600Salc2Saline consumption QTL 29.910.001drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)194072709254856850Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)194172254674246245Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat
1354633Bw28Body weight QTL 286.04body mass (VT:0001259)body weight (CMO:0000012)194072709254856850Rat

Markers in Region
RH136745  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21934,777,912 - 34,778,053 (+)MAPPERmRatBN7.2
Rnor_6.01939,073,488 - 39,073,628NCBIRnor6.0
Rnor_5.01949,937,776 - 49,937,916UniSTSRnor5.0
RGSC_v3.41936,727,649 - 36,727,789UniSTSRGSC3.4
Celera1934,201,925 - 34,202,065UniSTS
Cytogenetic Map19q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 66 161 84 83 52 84 52 6 338 183 11 140 79 92 31 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000081116   ⟹   ENSRNOP00000070661
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1934,771,982 - 34,777,850 (+)Ensembl
Rnor_6.0 Ensembl1939,063,998 - 39,073,425 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000083515   ⟹   ENSRNOP00000075458
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1939,067,363 - 39,077,722 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000119708   ⟹   ENSRNOP00000078304
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1934,771,982 - 34,782,592 (+)Ensembl
RefSeq Acc Id: NM_172319   ⟹   NP_758822
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81951,678,194 - 51,687,621 (+)NCBI
mRatBN7.21934,768,421 - 34,777,850 (+)NCBI
Rnor_6.01939,063,998 - 39,073,425 (+)NCBI
Rnor_5.01949,928,282 - 49,942,033 (+)NCBI
RGSC_v3.41936,718,156 - 36,727,586 (+)RGD
Celera1934,192,486 - 34,201,862 (+)RGD
Sequence:
RefSeq Acc Id: XM_006255561   ⟹   XP_006255623
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81951,668,276 - 51,691,042 (+)NCBI
mRatBN7.21934,768,657 - 34,782,170 (+)NCBI
Rnor_6.01939,063,298 - 39,077,745 (+)NCBI
Rnor_5.01949,928,282 - 49,942,033 (+)NCBI
Sequence:
RefSeq Acc Id: NP_758822   ⟸   NM_172319
- UniProtKB: Q8CH92 (UniProtKB/TrEMBL),   A6IYX8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006255623   ⟸   XM_006255561
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000070661   ⟸   ENSRNOT00000081116
Ensembl Acc Id: ENSRNOP00000075458   ⟸   ENSRNOT00000083515
Ensembl Acc Id: ENSRNOP00000078304   ⟸   ENSRNOT00000119708

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8CH92-F1-model_v2 AlphaFold Q8CH92 1-554 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628656 AgrOrtholog
BioCyc Gene G2FUF-5775 BioCyc
Ensembl Genes ENSRNOG00000022524 UniProtKB/TrEMBL
  ENSRNOG00000059362 Ensembl
Ensembl Transcript ENSRNOT00000081116.3 UniProtKB/TrEMBL
Gene3D-CATH Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A UniProtKB/TrEMBL
InterPro Nucleotide-diphossugar_trans UniProtKB/TrEMBL
KEGG Report rno:266805 UniProtKB/TrEMBL
NCBI Gene 266805 ENTREZGENE
PANTHER HYALURONAN SYNTHASE UniProtKB/TrEMBL
  HYALURONAN SYNTHASE 3 UniProtKB/TrEMBL
Pfam Glyco_tranf_2_3 UniProtKB/TrEMBL
PhenoGen Has3 PhenoGen
RatGTEx ENSRNOG00000022524 RatGTEx
  ENSRNOG00000059362 RatGTEx
Superfamily-SCOP SSF53448 UniProtKB/TrEMBL
UniProt A0A0G2JYH9_RAT UniProtKB/TrEMBL
  A6IYX8 ENTREZGENE, UniProtKB/TrEMBL
  Q811Y6_RAT UniProtKB/TrEMBL
  Q8CH92 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Has3  hyaluronan synthase 3      Symbol and Name status set to approved 1299863 APPROVED
2003-02-27 Has3  hyaluronan synthase 3      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation expression is upregulated by EGF and downregulated by TGF-beta in keratinocytes 708315