Gzma (granzyme A) - Rat Genome Database

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Gene: Gzma (granzyme A) Rattus norvegicus
Analyze
Symbol: Gzma
Name: granzyme A
RGD ID: 628640
Description: Predicted to enable protein homodimerization activity and serine-type endopeptidase activity. Predicted to be involved in several processes, including granzyme-mediated programmed cell death signaling pathway; proteolysis involved in protein catabolic process; and pyroptotic inflammatory response. Predicted to act upstream of or within cytotoxic T cell pyroptotic cell death and response to bacterium. Predicted to be located in cytolytic granule and nucleus. Predicted to be active in cytoplasm and extracellular space. Orthologous to human GZMA (granzyme A); PARTICIPATES IN interleukin-12 signaling pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-naphthyl isothiocyanate; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: VALIDATED
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8246,473,763 - 46,485,696 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl246,473,763 - 46,485,696 (-)EnsemblGRCr8
mRatBN7.2244,740,569 - 44,752,502 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl244,740,569 - 44,752,493 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx251,849,991 - 51,861,867 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0249,908,348 - 49,920,224 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0244,783,785 - 44,795,643 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0244,968,846 - 44,981,436 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl244,968,765 - 44,981,458 (-)Ensemblrn6Rnor6.0
Rnor_5.0264,004,695 - 64,017,285 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4244,488,295 - 44,500,128 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera240,513,802 - 40,525,612 (-)NCBICelera
RGSC_v3.1244,416,527 - 44,428,361 (-)NCBI
Cytogenetic Map2q14NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
Azoxymethane  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
bromobenzene  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium sulfate  (ISO)
capsaicin  (ISO)
carbon nanotube  (ISO)
chloroprene  (ISO)
cholesterol  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
clofibrate  (EXP)
curcumin  (EXP)
cyclophosphamide  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
Dibutyl phosphate  (ISO)
dichlorvos  (ISO)
diethylstilbestrol  (EXP,ISO)
dioxygen  (ISO)
diuron  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenpropathrin  (EXP)
folpet  (ISO)
genistein  (ISO)
gentamycin  (EXP)
GSK-J4  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
L-ethionine  (EXP)
Lasiocarpine  (EXP)
lipopolysaccharide  (ISO)
methotrexate  (ISO)
methylarsonic acid  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-nitrosodimethylamine  (EXP)
nevirapine  (EXP)
nickel atom  (ISO)
omeprazole  (EXP)
ozone  (ISO)
paracetamol  (ISO)
pirinixic acid  (EXP,ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (ISO)
senecionine  (EXP)
Senkirkine  (EXP)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium dichromate  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
tremolite asbestos  (ISO)
tributylstannane  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
vinclozolin  (EXP)
ziram  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytolytic granule  (ISO)
cytoplasm  (IEA,ISO)
extracellular space  (IBA,ISO)
nucleus  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Cathelicidin LL-37, granzymes, TGF-beta1 and cytokines levels in induced sputum from farmers with and without COPD. Golec M, etal., Ann Agric Environ Med. 2009 Dec;16(2):289-97.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Purification and identification of a binding protein for pancreatic secretory trypsin inhibitor: a novel role of the inhibitor as an anti-granzyme A. Tsuzuki S, etal., Biochem J 2003 May 15;372(Pt 1):227-33.
Additional References at PubMed
PMID:1860869   PMID:11331782   PMID:12524539   PMID:12819770   PMID:16618603   PMID:17213646   PMID:22206666   PMID:23012479  


Genomics

Comparative Map Data
Gzma
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8246,473,763 - 46,485,696 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl246,473,763 - 46,485,696 (-)EnsemblGRCr8
mRatBN7.2244,740,569 - 44,752,502 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl244,740,569 - 44,752,493 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx251,849,991 - 51,861,867 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0249,908,348 - 49,920,224 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0244,783,785 - 44,795,643 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0244,968,846 - 44,981,436 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl244,968,765 - 44,981,458 (-)Ensemblrn6Rnor6.0
Rnor_5.0264,004,695 - 64,017,285 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4244,488,295 - 44,500,128 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera240,513,802 - 40,525,612 (-)NCBICelera
RGSC_v3.1244,416,527 - 44,428,361 (-)NCBI
Cytogenetic Map2q14NCBI
GZMA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38555,102,646 - 55,110,252 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl555,102,646 - 55,110,252 (+)Ensemblhg38GRCh38
GRCh37554,398,474 - 54,406,080 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36554,434,230 - 54,441,818 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34554,434,229 - 54,441,818NCBI
Celera551,351,660 - 51,358,967 (+)NCBICelera
Cytogenetic Map5q11.2NCBI
HuRef551,372,038 - 51,379,264 (+)NCBIHuRef
CHM1_1554,401,713 - 54,409,574 (+)NCBICHM1_1
T2T-CHM13v2.0555,930,246 - 55,937,579 (+)NCBIT2T-CHM13v2.0
Gzma
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913113,230,358 - 113,237,515 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13113,230,359 - 113,237,515 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3813113,093,824 - 113,100,981 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13113,093,825 - 113,100,981 (-)Ensemblmm10GRCm38
MGSCv3713113,884,035 - 113,891,189 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3613114,214,703 - 114,221,857 (-)NCBIMGSCv36mm8
Celera13117,414,494 - 117,421,678 (-)NCBICelera
Cytogenetic Map13D2.2NCBI
cM Map1363.93NCBI
Gzma
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544612,560,658 - 12,568,053 (-)Ensembl
ChiLan1.0NW_00495544612,560,831 - 12,568,023 (-)NCBIChiLan1.0ChiLan1.0
GZMA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2458,830,039 - 58,837,338 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1556,983,664 - 56,990,990 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0558,919,129 - 58,926,620 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1560,540,988 - 60,548,274 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl560,540,988 - 60,548,506 (-)EnsemblpanPan2panpan1.1
GZMA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1242,490,712 - 42,498,655 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl242,490,069 - 42,498,464 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha239,536,721 - 39,544,284 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0242,950,252 - 42,957,426 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl242,949,874 - 42,957,230 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1240,020,302 - 40,027,904 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0240,830,532 - 40,838,091 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0241,653,466 - 41,660,635 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gzma
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213203,705,039 - 203,712,759 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648012,641,433 - 12,649,324 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648012,641,587 - 12,649,243 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GZMA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1634,282,120 - 34,290,477 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11634,282,160 - 34,290,422 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21636,385,694 - 36,393,956 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GZMA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1451,340,329 - 51,347,569 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl451,340,356 - 51,348,249 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666049209,615 - 216,838 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gzma
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247594,177,857 - 4,185,324 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247594,177,857 - 4,185,325 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Gzma
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v13183,671,524 - 183,683,071 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Gzma
180 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:18
Count of miRNA genes:18
Interacting mature miRNAs:18
Transcripts:ENSRNOT00000014134
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21332504158325041Rat
7387318Stl32Serum triglyceride level QTL 323.20.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)22411781369117813Rat
10755436Coatc8Coat color QTL 80.02431coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23675034481750344Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
9590080Insglur4Insulin/glucose ratio QTL 428.70.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)2615276751152767Rat
1300160Hrtrt3Heart rate QTL 33.62heart pumping trait (VT:2000009)absolute change in heart rate (CMO:0000534)23561408353462005Rat
1579916Bp270Blood pressure QTL 2700.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)21605188361051883Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22203804467038044Rat
731166Mamtr2Mammary tumor resistance QTL 20.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2962358154623581Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)240306867124537199Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
9685065Swd6Spike wave discharge measurement QTL 65.80.01brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge rate (CMO:0001739)24095742350526673Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22888999173889991Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)241801363104744824Rat
1331764Bp205Blood pressure QTL 2053.476arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)21436870759368707Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
631208Bw1Body weight QTL15.09mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)24490435585286097Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1300155Bp174Blood pressure QTL 1744.09arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)244537979112567334Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979159440891Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)27605533104774005Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22865266683465677Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)2573632550736325Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
2306903Bp336Blood pressure QTL 3360.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)238426449111295694Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)228652666139067443Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21822713763227137Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat
61371Edpm1Estrogen-dependent pituitary mass QTL 140.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)23686864381868643Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)24490435589904355Rat
1582246Cm60Cardiac mass QTL 605.8heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)23326999678269996Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22865266673652666Rat

Markers in Region
RH140543  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map2282.8UniSTS
Cytogenetic Map2q14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 35 67 79 78 47 92 47 6 294 156 10 39 67 79 31 2 2

Sequence


Ensembl Acc Id: ENSRNOT00000014134   ⟹   ENSRNOP00000014134
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl246,473,763 - 46,485,696 (-)Ensembl
mRatBN7.2 Ensembl244,740,569 - 44,752,493 (-)Ensembl
Rnor_6.0 Ensembl244,968,765 - 44,981,458 (-)Ensembl
RefSeq Acc Id: NM_153468   ⟹   NP_703198
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8246,473,763 - 46,485,696 (-)NCBI
mRatBN7.2244,740,569 - 44,752,502 (-)NCBI
Rnor_6.0244,968,846 - 44,981,436 (-)NCBI
Rnor_5.0264,004,695 - 64,017,285 (-)NCBI
RGSC_v3.4244,488,295 - 44,500,128 (-)RGD
Celera240,513,802 - 40,525,612 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_703198 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAC16549 (Get FASTA)   NCBI Sequence Viewer  
  EDM10367 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000014134
  ENSRNOP00000014134.1
RefSeq Acc Id: NP_703198   ⟸   NM_153468
- Peptide Label: precursor
- UniProtKB: G3V7E3 (UniProtKB/TrEMBL),   A6I5Q9 (UniProtKB/TrEMBL),   Q8CJF4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000014134   ⟸   ENSRNOT00000014134
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V7E3-F1-model_v2 AlphaFold G3V7E3 1-261 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691142
Promoter ID:EPDNEW_R1666
Type:single initiation site
Name:Gzma_1
Description:granzyme A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0244,981,467 - 44,981,527EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628640 AgrOrtholog
BioCyc Gene G2FUF-54375 BioCyc
Ensembl Genes ENSRNOG00000010603 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000014134 ENTREZGENE
  ENSRNOT00000014134.5 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/TrEMBL
InterPro Pept_cys/ser_Trypsin-like UniProtKB/TrEMBL
  Peptidase_S1/S6_AS UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1_S6 UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
KEGG Report rno:266708 UniProtKB/TrEMBL
NCBI Gene 266708 ENTREZGENE
PANTHER GRANZYME A UniProtKB/TrEMBL
  KALLIKREIN-RELATED UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/TrEMBL
PhenoGen Gzma PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/TrEMBL
PROSITE TRYPSIN_DOM UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010603 RatGTEx
SMART Tryp_SPc UniProtKB/TrEMBL
Superfamily-SCOP Pept_Ser_Cys UniProtKB/TrEMBL
UniProt A6I5Q9 ENTREZGENE, UniProtKB/TrEMBL
  G3V7E3 ENTREZGENE, UniProtKB/TrEMBL
  Q8CJF4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Gzma  granzyme A      Symbol and Name status set to approved 1299863 APPROVED
2003-02-27 Gzma  granzyme A      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed by lymphocytes in small intestine 633017