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Gene: Alk (ALK receptor tyrosine kinase) Rattus norvegicus

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Symbol:

Alk

Name:

ALK receptor tyrosine kinase

RGD ID:

628622

Description:

Predicted to enable several functions, including heparin binding activity; identical protein binding activity; and receptor signaling protein tyrosine kinase activator activity. Involved in nervous system development. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human ALK (ALK receptor tyrosine kinase); INTERACTS WITH 6-propyl-2-thiouracil; amitrole; ammonium chloride.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

ALK tyrosine kinase receptor; ALK tyrosine kinase receptor-like; anaplastic lymphoma kinase; anaplastic lymphoma receptor tyrosine kinase; LOC108351182

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ALK (ALK receptor tyrosine kinase)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Alk (anaplastic lymphoma kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Alk (ALK receptor tyrosine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ALK (ALK receptor tyrosine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ALK (ALK receptor tyrosine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Alk (ALK receptor tyrosine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ALK (ALK receptor tyrosine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ALK (ALK receptor tyrosine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Alk (ALK receptor tyrosine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Alk (ALK receptor tyrosine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	ALK (ALK receptor tyrosine kinase)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Alk (anaplastic lymphoma kinase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	alk (ALK receptor tyrosine kinase)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Danio rerio (zebrafish):	alk (ALK receptor tyrosine kinase)	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ltk (leukocyte receptor tyrosine kinase)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoInspector\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Alk	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	scd-2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	ltk	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoInspector\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	alk	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	28,631,431 - 29,351,321 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	6	28,632,197 - 29,349,721 (+)	Ensembl				GRCr8
mRatBN7.2	6	22,879,653 - 23,599,636 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	22,880,625 - 23,598,034 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	6	23,211,130 - 23,929,220 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	23,526,957 - 24,245,096 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	23,008,575 - 23,732,971 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	22,696,415 - 23,203,791 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	22,696,397 - 23,203,775 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	6	32,580,744 - 33,082,977 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Rnor_5.0	6	33,690,337 - 33,703,521 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	6	23,009,061 - 23,730,939 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	6	22,414,691 - 23,129,629 (+)	NCBI		Celera
RGSC_v3.1	6	23,700,711 - 23,727,905 (+)	NCBI
Cytogenetic Map	6	q14	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

alcohol dependence (ISO)

anaplastic large cell lymphoma (ISO)

Brain Neoplasms (ISO)

Breast Neoplasms (ISO)

diffuse large B-cell lymphoma (ISO)

diffuse pediatric-type high-grade glioma, H3-wildtype and IDH-wildtype (ISO)

Familial Isolated Pituitary Adenoma (ISO)

Granuloma, Plasma Cell (ISO)

Hereditary Neoplastic Syndromes (ISO)

Inflammatory Breast Neoplasms (ISO)

lung adenocarcinoma (ISO)

lung cancer (ISO)

lung non-small cell carcinoma (ISO)

lung squamous cell carcinoma (ISO)

multiple endocrine neoplasia type 2A (ISO)

Neoplasm Metastasis (ISO)

Neoplasm Recurrence, Local (ISO)

Neoplastic Cell Transformation (ISO)

neuroblastoma (ISO)

Neuroblastoma 3 (ISO)

ovarian cancer (ISO)

pulmonary plasma cell granuloma (ISO)

renal cell carcinoma (ISO)

rhabdomyosarcoma (ISO)

tic disorder (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

2,2-(2-Chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-diaminopyridine (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

aldehydo-D-glucose (ISO)

aldrin (ISO)

alectinib (ISO)

all-trans-retinoic acid (ISO)

amiodarone (ISO)

amitrole (EXP)

ammonium chloride (EXP)

amphotericin B (ISO)

arsane (ISO)

arsenic atom (ISO)

ATP (ISO)

atrazine (EXP,ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP,ISO)

Butylbenzyl phthalate (ISO)

ceritinib (ISO)

chlorpyrifos (ISO)

choline (ISO)

crizotinib (ISO)

D-glucose (ISO)

DDD (ISO)

DDE (ISO)

DDT (ISO)

dieldrin (ISO)

endrin (ISO)

epoxiconazole (ISO)

ethanol (ISO)

folic acid (ISO)

fonofos (ISO)

fructose (ISO)

fulvestrant (ISO)

gamma-hexachlorocyclohexane (ISO)

genistein (ISO)

glucose (ISO)

hydrogen peroxide (ISO)

L-methionine (ISO)

lorlatinib (ISO)

masoprocol (ISO)

methapyrilene (ISO)

methoxychlor (EXP)

N-acetyl-L-cysteine (ISO)

N-ethyl-N-nitrosourea (ISO)

paracetamol (EXP)

parathion (ISO)

pemetrexed (ISO)

propiconazole (EXP)

pyrimidine-2,4-diamine (ISO)

simvastatin (ISO)

tanespimycin (ISO)

terbufos (ISO)

titanium dioxide (ISO)

trimellitic anhydride (ISO)

vanadium atom (ISO)

vanadium(0) (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adult behavior (ISO)

brain development (ISO)

cell surface receptor protein tyrosine kinase signaling pathway (IBA,IEA,ISO)

energy homeostasis (IEA,ISO)

hippocampus development (ISO)

negative regulation of lipid catabolic process (IEA,ISO)

nervous system development (IDA,IEA)

peptidyl-tyrosine autophosphorylation (ISO)

phosphorylation (ISO)

positive regulation of dendrite development (IEA,ISO)

protein autophosphorylation (ISO)

regulation of cell population proliferation (IBA,ISO)

regulation of dopamine receptor signaling pathway (ISO)

regulation of neuron differentiation (IBA)

regulation of primary metabolic process (IEA)

response to environmental enrichment (ISO)

response to stress (ISO)

swimming behavior (ISO)

Cellular Component

membrane (IEA)

plasma membrane (IBA,IEA,ISO)

protein-containing complex (IEA,ISO)

receptor complex (IBA)

Molecular Function

ATP binding (IEA)

heparin binding (IEA,ISO)

identical protein binding (IEA,ISO)

kinase activity (IEA)

nucleotide binding (IEA)

protein binding (ISO)

protein kinase activity (IEA)

protein tyrosine kinase activity (IEA,ISO)

receptor signaling protein tyrosine kinase activator activity (IEA,ISO)

transferase activity (IEA)

transmembrane receptor protein tyrosine kinase activity (IBA,IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	NPM mutations in acute myelogenous leukemia.	Grisendi S and Pandolfi PP, N Engl J Med. 2005 Jan 20;352(3):291-2.
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
6.	GOA pipeline	RGD automated data pipeline
7.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	Activation of anaplastic lymphoma kinase receptor tyrosine kinase induces neuronal differentiation through the mitogen-activated protein kinase pathway.	Souttou B, etal., J Biol Chem 2001 Mar 23;276(12):9526-31.
10.	A meta-analysis of two genome-wide association studies identifies 3 new loci for alcohol dependence.	Wang KS, etal., J Psychiatr Res. 2011 Nov;45(11):1419-25. doi: 10.1016/j.jpsychires.2011.06.005. Epub 2011 Jun 24.

Additional References at PubMed

PMID:9174053	PMID:15886198	PMID:16880530	PMID:17487225	PMID:19056867	PMID:19200234	PMID:23382219	PMID:25326243	PMID:25517749	PMID:30497772

Genomics

Comparative Map Data

Alk
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	28,631,431 - 29,351,321 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	6	28,632,197 - 29,349,721 (+)	Ensembl				GRCr8
mRatBN7.2	6	22,879,653 - 23,599,636 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	22,880,625 - 23,598,034 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	6	23,211,130 - 23,929,220 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	23,526,957 - 24,245,096 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	23,008,575 - 23,732,971 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	22,696,415 - 23,203,791 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	22,696,397 - 23,203,775 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	6	32,580,744 - 33,082,977 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Rnor_5.0	6	33,690,337 - 33,703,521 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	6	23,009,061 - 23,730,939 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	6	22,414,691 - 23,129,629 (+)	NCBI		Celera
RGSC_v3.1	6	23,700,711 - 23,727,905 (+)	NCBI
Cytogenetic Map	6	q14	NCBI

ALK
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	29,192,774 - 29,921,586 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	29,192,774 - 29,921,586 (-)	Ensembl			hg38	GRCh38
GRCh37	2	29,415,640 - 30,144,452 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	29,269,144 - 29,997,936 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	2	29,327,292 - 30,056,083	NCBI
Celera	2	29,260,042 - 29,988,141 (-)	NCBI		Celera
Cytogenetic Map	2	p23.2-p23.1	NCBI
HuRef	2	29,156,646 - 29,883,927 (-)	NCBI		HuRef
CHM1_1	2	29,345,879 - 30,074,503 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	2	29,236,229 - 29,965,553 (-)	NCBI		T2T-CHM13v2.0

Alk
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	72,174,206 - 72,911,719 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	72,175,967 - 72,911,622 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	17	71,868,988 - 72,604,702 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	71,868,972 - 72,604,627 (-)	Ensembl			mm10	GRCm38
MGSCv37	17	72,218,328 - 72,953,647 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	17	71,009,971 - 71,745,160 (-)	NCBI		MGSCv36	mm8
MGSCv36	17	71,773,845 - 72,508,684 (-)	NCBI		MGSCv36	mm8
Celera	17	76,136,594 - 76,877,724 (-)	NCBI		Celera
Cytogenetic Map	17	E1.3	NCBI
cM Map	17	43.77	NCBI

Alk
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955469	11,047,048 - 11,548,233 (-)	Ensembl
ChiLan1.0	NW_004955469	11,049,373 - 11,751,235 (-)	NCBI	ChiLan1.0	ChiLan1.0

ALK
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	96,583,820 - 97,316,156 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	96,587,794 - 97,320,129 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	29,196,195 - 29,930,062 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	29,276,041 - 30,007,687 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	29,276,041 - 30,006,735 (-)	Ensembl			panPan2	panpan1.1

ALK
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	23,010,308 - 23,688,841 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	23,010,308 - 23,688,841 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	22,797,195 - 23,482,846 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	23,570,633 - 24,250,513 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	17	23,572,834 - 24,250,519 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	17	22,869,939 - 23,549,638 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	22,932,402 - 23,612,861 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	23,038,591 - 23,719,569 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Alk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	67,167,996 - 67,810,992 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936493	3,028,608 - 3,671,874 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936493	3,624,288 - 3,671,567 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ALK
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	3	109,411,146 - 110,105,755 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	116,847,214 - 116,923,998 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ALK
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	77,632,809 - 78,408,307 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666045	33,719,552 - 34,471,342 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Alk
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624738	11,095,134 - 11,288,891 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624738	11,094,699 - 12,010,349 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Alk
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	7	21,317,511 - 21,352,336 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Alk
3333 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	235
Count of miRNA genes:	165
Interacting mature miRNAs:	183
Transcripts:	ENSRNOT00000011630
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
8552962	Pigfal16	Plasma insulin-like growth factor 1 level QTL 16	9.4		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	6	1975879	46975879	Rat
8693645	Alc31	Alcohol consumption QTL 31	3.7	0.038	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	6	23284664	29732046	Rat
10401812	Kidm54	Kidney mass QTL 54			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	6	20097635	65097635	Rat
8552910	Pigfal5	Plasma insulin-like growth factor 1 level QTL 5	4.3		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	6	22653889	67653889	Rat
10401800	Kidm49	Kidney mass QTL 49			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	6	20097635	65097635	Rat
1300164	Rf15	Renal function QTL 15	3.12		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	6	3239989	48239989	Rat
9589129	Insul24	Insulin level QTL 24	19.06	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	6	1975879	46975879	Rat
7411603	Foco13	Food consumption QTL 13	5.5	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	6	1975879	46975879	Rat
1598843	Cm63	Cardiac mass QTL 63	2.6		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	6	1	44788383	Rat
7411542	Bw127	Body weight QTL 127	5.5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	1975879	46975879	Rat
2292616	Ept15	Estrogen-induced pituitary tumorigenesis QTL 15	4.4		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	6	1	44788383	Rat
9589048	Scfw3	Subcutaneous fat weight QTL 3	4.57	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	6	1975879	46975879	Rat
2293839	Kiddil2	Kidney dilation QTL 2	4.8		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	26618314	86868070	Rat
1576309	Emca7	Estrogen-induced mammary cancer QTL 7	4		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	6	20859430	113082285	Rat
2301964	Bp323	Blood pressure QTL 323	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	1	86868070	Rat
2293709	Bss23	Bone structure and strength QTL 23	5.18	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	6	3239989	48239989	Rat
2293650	Bss31	Bone structure and strength QTL 31	5.05	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	6	3239989	48239989	Rat
2293841	Kiddil4	Kidney dilation QTL 4	4.4		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	26618314	86868070	Rat
1300128	Rf16	Renal function QTL 16	3.89		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	6	1	40163351	Rat
70199	Coreg1	Compensatory renal growth QTL 1	11.8		kidney mass (VT:0002707)	compensatory renal growth score (CMO:0001894)	6	14599473	63457687	Rat
2301972	Bp325	Blood pressure QTL 325	4.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	16089372	61967788	Rat
1358190	Ept1	Estrogen-induced pituitary tumorigenesis QTL 1	4.4		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	6	1	44788383	Rat
2293656	Bss28	Bone structure and strength QTL 28	6.79	0.0001	femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	6	3239989	48239989	Rat
1359023	Bp272	Blood pressure QTL 272	2.5		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	6	22288257	32981219	Rat
1354664	Slep2	Serum leptin concentration QTL 2	4.49		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	6	22288257	67288257	Rat

Markers in Region

D6Rat54

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	22,959,009 - 22,959,164 (-)	MAPPER	mRatBN7.2
Rnor_6.0	6	23,764,495 - 23,764,649	NCBI	Rnor6.0
Rnor_5.0	6	33,624,543 - 33,624,697	UniSTS	Rnor5.0
RGSC_v3.4	6	23,089,262 - 23,089,417	RGD	RGSC3.4
RGSC_v3.4	6	23,089,263 - 23,089,417	UniSTS	RGSC3.4
Celera	6	22,493,624 - 22,493,778	UniSTS
RGSC_v3.1	6	23,092,215 - 23,092,370	RGD
RH 2.0 Map	6	192.5	RGD
FHH x ACI Map	6	20.5099	RGD
Cytogenetic Map	6	q13	UniSTS

D6Got14

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	6	29,309,405 - 29,309,690 (+)	Marker Load Pipeline
mRatBN7.2	6	23,557,699 - 23,557,984 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	23,164,038 - 23,164,322	NCBI	Rnor6.0
Rnor_5.0	6	33,043,224 - 33,043,508	UniSTS	Rnor5.0
RGSC_v3.4	6	23,690,605 - 23,690,890	RGD	RGSC3.4
RGSC_v3.4	6	23,690,606 - 23,690,890	UniSTS	RGSC3.4
Celera	6	23,089,298 - 23,089,582	UniSTS
RGSC_v3.1	6	23,693,558 - 23,693,843	RGD
RH 2.0 Map	6	188.6	RGD
Cytogenetic Map	6	q13	UniSTS

D6Got12

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	6	28,905,023 - 28,905,171 (+)	Marker Load Pipeline
mRatBN7.2	6	23,153,282 - 23,153,430 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	22,757,499 - 22,757,646	NCBI	Rnor6.0
Rnor_5.0	6	32,642,231 - 32,642,378	UniSTS	Rnor5.0
RGSC_v3.4	6	23,285,110 - 23,285,258	RGD	RGSC3.4
RGSC_v3.4	6	23,285,111 - 23,285,258	UniSTS	RGSC3.4
Celera	6	22,687,007 - 22,687,154	UniSTS
RGSC_v3.1	6	23,288,063 - 23,288,211	RGD
RH 2.0 Map	6	191.3	RGD
Cytogenetic Map	6	q13	UniSTS

RH131901

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	23,592,890 - 23,593,106 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	23,198,633 - 23,198,848	NCBI	Rnor6.0
Rnor_5.0	6	33,077,819 - 33,078,034	UniSTS	Rnor5.0
RGSC_v3.4	6	23,725,781 - 23,725,996	UniSTS	RGSC3.4
Celera	6	23,124,471 - 23,124,686	UniSTS
Cytogenetic Map	6	q13	UniSTS

AU048193

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	23,137,820 - 23,137,970 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	22,742,038 - 22,742,187	NCBI	Rnor6.0
Rnor_5.0	6	32,626,770 - 32,626,919	UniSTS	Rnor5.0
RGSC_v3.4	6	23,269,650 - 23,269,799	UniSTS	RGSC3.4
Celera	6	22,671,544 - 22,671,693	UniSTS
Cytogenetic Map	6	q13	UniSTS

RH136724

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	23,597,413 - 23,597,546 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	23,203,155 - 23,203,287	NCBI	Rnor6.0
Rnor_5.0	6	33,082,341 - 33,082,473	UniSTS	Rnor5.0
RGSC_v3.4	6	23,730,303 - 23,730,435	UniSTS	RGSC3.4
Celera	6	23,128,993 - 23,129,125	UniSTS
Cytogenetic Map	6	q13	UniSTS

RH138197

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	23,198,095 - 23,198,238 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	22,800,737 - 22,800,879	NCBI	Rnor6.0
Rnor_5.0	6	32,685,469 - 32,685,611	UniSTS	Rnor5.0
RGSC_v3.4	6	23,329,524 - 23,329,666	UniSTS	RGSC3.4
Celera	6	22,731,709 - 22,731,851	UniSTS
Cytogenetic Map	6	q13	UniSTS

Alk^{WKYc42g04_r1_396}

Rat Assembly	Chr	Position (strand)	Source	JBrowse
RGSC_v3.4	6	23,316,677 - 23,316,677 (+)	RGD	RGSC3.4

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
9	8	57	143	54	53	25	25	25	6	214	111	11	122	62	85	28	12	12

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001169101	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039111819	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063261571	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005505446	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB073169	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000011630 ⟹ ENSRNOP00000011630

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	6	28,632,197 - 29,349,721 (+)	Ensembl
mRatBN7.2 Ensembl	6	22,880,625 - 23,598,034 (+)	Ensembl
Rnor_6.0 Ensembl	6	22,696,397 - 23,203,775 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000135358 ⟹ ENSRNOP00000106560

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	6	28,632,197 - 29,349,721 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000136068 ⟹ ENSRNOP00000103544

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	6	28,632,197 - 29,349,721 (+)	Ensembl

RefSeq Acc Id:

NM_001169101 ⟹ NP_001162572

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	28,631,477 - 29,349,737 (+)	NCBI
mRatBN7.2	6	22,879,706 - 23,598,050 (+)	NCBI
Rnor_6.0	6	22,696,415 - 23,203,791 (+)	NCBI
Rnor_5.0	6	32,580,744 - 33,082,977 (+)	NCBI
Rnor_5.0	6	33,690,337 - 33,703,521 (-)	NCBI
RGSC_v3.4	6	23,009,061 - 23,730,939 (+)	RGD
Celera	6	22,414,691 - 23,129,629 (+)	RGD

Sequence:

show sequence

GCAGCTCTGGGGGCGGCAGCGGCGGTGGCAACTGGCTCCTCCCGCTTCTTCTGTCCAGGGGTTC
TCGGGGCAGTAAGACGCTTTCCGTTCGCCCCCTGGCCAGTCAACAAAACCGCGGGCGCTGCTGG
TAGGTAAGGAGGGAGCTGGCTACGTTGCGGGCTCCTCTGCCCCGAATGTTTTCACTCGGCGGCA
CGGCCGGGGCGCTCTGGTGCTTGGGAGTGAACTCCGAGGAACGAAGACGTCGGTGACAGCAAGG
ACGCTGCAAACTTGTGCGCGTGGAGGCAGCGGGACCTCCTCTCCGCAACGCAGAGCTCGCGTTC
ACGCCCAGAAGTTCAGCGGGCAGGGTGATCGATCCGAAGACTTCCTGCAGCGGAGGTCACTTGA
GGGGGCGCTAGAAAGCAGCCCCCTCCGGTGGTCCTTGCCTAGACCTGGGAAGGAGCGCAGAGGA
GGTGACAGGAACGGAGGACGTGGGCAAGACAGTGACCGACTCAGAACCGCGGCTCGCAGCCTGG
AAAGTTGCAGAAGATTGGAGGCGAAGAGGAGAGCTCTGGTCACCGAGGGCTCCTTGAACGGTAC
CTAATTGCCACCTCCCTCAACCATAGTGATTTCTCTGGTCCCTGAGCAAATGGGGCGCAGCATG
GCGAGAGGCGCAGGATCCAGCTGTTGAACCCAAGGTGTCTCACTGTCTCCGAACTCCCCCCTGA
CTTTCTCATCCGTTTTGCTGAGAACCCTTTTTGCCTCCTTGTAGACTGGGGAAAGCAGGGCGCT
CTATAGTGTACACAGTCCTTGAGACCAAGTGGAAGGAGCCGTTCAGGACCAAGGACTATTTGGA
GCCCCTTTCTGTTTAGGGGAGAGTGAAAGGTGAGGCTGGACCAGGCAGGGAAGGGAGTCTAGTG
TAAACTCGCCCTCCGGAGGGATGGGAGCCCTTGGGTTCCTGTGGCTGCTGCCGCCGCTGCTTTT
GACAGCAGCCTCGTACTCCGGAGCTGCAACCGATCAGCGCGCGGGTTCTCCAGCCTCAGGGCCG
CCTCTGCAGCCCCGGGAGCCGCTCAGCTATTCGCGCCTGCAGAGGAAGAGTCTGGCGGTGGACT
TCGTGGTGCCCTCACTCTTCCGCGTCTATGCCCGAGACCTGCTGCTGCCGCAGCCACCGTCCCC
CTCGGAGCCCGGGGCTGGCGGGCTGGAGGCGCGGGGATCACTGGCTCTGGACTGCGACCCTCTG
CTCAGGTTGCTGGGGCCATCGCCTGGAATCTCCTGGGCAGAGGGAGCCAGTTCTCCTAGTCCGG
AGGCGGCTCCGACGCTGTCCAGGGTGCTGAAGGGCGGCTCGGTGCGCAAGCTCAGGCGTGCCAA
ACAGCTGGTGCTGGAGCTGGGCGAGGAGACGATCCTTGAAGGCTGCATTGGTCCCCCAGAGGAG
GCGGCGGCTGTGGGGATACTCCAGTTCAACCTTAGCGAGCTGTTCAGCTGGTGGATTCTACACG
GCGAAGGGCGGCTGAGGATCCGCCTGATGCCTGAGAAGAAGGCATCGGAAGTGGGCAGGGAGGG
AAGGCTATCCACTGCGATCCGAGCCTCCCAGCCCCGCCTTCTCTTCCAGATCTTCGGGACCGGT
CACAGCTCCTTGGAATCACCCTCAGAAATGCCTTCTCCTCCTGGTAACTTTCTATGGAATCTCA
CCTGGACAATGAAAGACTCCTTCCCTTTCCTTTCCCACCGCAGTCGATATGGTCTGGAGTGCAG
CTTCGATTTTCCCTGTGAGCTAGAATACTCCCCTCCCCTCCACACCCATGGGAACCAGAGCTGG
TCCTGGCGCCGTGTGCCCTCTGAGGAGGCCTCGAGGATGAACTTGTTGGATGGGCCAGAGGCAG
AGCATTTGAAAGAGATGCCCAGAGGCTCCTTCCTCCTCCTGAACACCTCTGCAGATTCCAAGCA
TACCATCCTGAGCCCCTGGATGAGGAGCAGTAGTGAGCACTGCACGCTGGCTGTCTCAGTGCAC
AGACATCTACAGCCTTCTGGGAGATATGTTGCCCAGCTCCTACCCCACAATGAAGCTGGAAGAG
AGATTCTTCTGGTGCCTACCCCGGGGAAACATGGCTGGACAGTGCTGCATGGGAGAGTCGGGCG
CCCAGAGAACCCATTCCGAGTGGCCCTGGAATACATCTCGAGTGGAAACCGGAGCTTGTCTGCG
GTGGATTTCTTTGCCCTGAAGAACTGCAGTGAAGGAACATCCCCAGGCTCCAAGATGGCCTTGC
AGAGTTCCTTCACTTGTTGGAACGGGACAGTCCTCCAGCTCGGGCAAGCCTGTGACTTCCACCA
GAACTGTGCCCAAGGAGAAGATGAGGGTCAGCTATGCAGTAAACTTCCTGCTGGGTTTTACTGT
AACTTCGAGGATGGCTTCTGTGGCTGGACCCAAAGTCCACTCTCACCCCGTGTGCCCCGATGGC
AAGTGAAGACCCTGAAAGATACCCATTCCCAGGGCCACCAAGGCCATGCCCTGTTGCTCAGCAC
CACTGACGACCCCACTTCAGAAAGTGCAACAGTGACCAGTGCTACATTCCCCGCACCAATGAAG
AGCTCTCCTTGTGAGCTCCGGATGTCCTGGCTCATCCGTGGGGTTCTGAAAGGAAATGTATCTT
TGGTGCTGGTGGAGAACAAAACTGGAAAGGAGCAAAGCCGGACCGTCTGGCATGTTGCCACCAA
TGAAGGCCTAAGCCTGTGGCAGTGGACAGTGTTGTCGCTCCTCGATGTGACTGACAGGTTCTGG
CTGCAAATAGTCACATGGTGGGGCCCAGGATCCAGGGCAACCGTGGCATTTGACAACATTTCCA
TCAGCCTCGACTGCTACCTCACCATCAGTGGGGAGGAGAAAATGTCCCTGAATGCAGTACCCAA
ATCCAGAAATCTGTTTGAGAAAAACCCAAACAAGGAGCCAAAACCCTGGGCAAACATATCAGGA
CCAACTCCCATCTTCGACCCTACAGTTCACTGGCTGTTCACCACATGTGGGGCCAGTGGCCCTC
ATGGCCCCACACAGGCACAGTGCAACAACGCCTACCAGAACTCCAACCTGAGCGTGGTGGTGGG
AAGTGAAGGGCCCTTGAGGGGCATCCAGATTTGGAAAGTGCCAGCTACTGACACCTACAGTATC
TCAGGCTATGGAGCAGCTGGCGGAAAAGGTGGGAAGAACACCATGATGCGGTCCCATGGCGTGT
CTGTCCTGGGCATCTTCAATCTGGAGAAAGATGACACGCTCTACATCCTTGTCGGTCAACAAGG
GGAAGATGCCTGTCCCAGGGCAAACCAACTAATCCAGAAAGTATGTGTCGGCGAGAACAATGTG
ATAGAAGAAGAGATCCGAGTGAACAGAAGCGTTCACGAGTGGGCAGGAGGAGGAGGAGGTGGGG
GTGGAGCCACCTACGTGTTTAAGATGAAAGACGGCGTGCCCGTGCCCCTGATTATTGCGGCCGG
CGGTGGTGGCAGGGCCTATGGGGCCAAGACAGAAACGTTCCACCCAGAGAGACTGGAGAATAAC
TCCTCAGTTCTAGGGCTGAACGGCAATTCCGGAGCCGCAGGTGGTGGAGGCGGCTGGAATGATA
ACACTTCCTTGCTCTGGGCCGGAAAGTCTTTGTTGGAGGGCGCCGCCGGAGGACATTCCTGCCC
CCAGGCCATGAAGAAGTGGGGGTGGGAGACAAGAGGGGGTTTCGGAGGGGGTGGAGGGGGGTGC
TCCTCAGGTGGAGGAGGCGGAGGATATATAGGTGGCAACGCAGCATCAAACAATGACCCCGAAA
TGGATGGGGAAGATGGGGTTTCCTTCATCAGTCCATTGGGTATCCTGTATACCCCGGCCTTAAA
AGTGATGGAGGGCCATGGGGAAGTGAATATCAAGCACTATCTAAACTGCAGCCACTGTGAGGTA
GACGAATGTCACATGGACCCCGAGAGCCACAAAGTCATCTGCTTCTGTGACCATGGGACCGTGC
TGGCTGACGATGGTGTCTCCTGCATTGTGTCGCCCACCCCGGAACCCCACCTGCCGCTCTCATT
GATCCTCTCCGTCGTGACCTCTGCCCTGGTGGCCGCTCTCGTTCTGGCATTCTCCGGCATCATG
ATTGTGTACCGCCGGAAGCACCAGGAGTTGCAAGCTATGCAGATGGAGCTGCAGAGCCCTGAGT
ATAAGCTGAGCAAGCTACGGACCTCGACCATCATGACAGACTACAACCCCAACTACTGCTTTGC
TGGCAAGACTTCATCCATCAGTGACCTGAAGGAGGTGCCTCGGAAAAACATCACCCTCATCCGG
GGCCTAGGCCATGGCGCATTTGGGGAGGTGTATGAAGGCCAGGTATCTGGAATGCCCAATGACC
CAAGCCCTCTACAAGTGGCTGTAAAGACGCTGCCGGAAGTGTGTTCAGAGCAAGATGAGCTGGA
CTTCCTCATGGAAGCTCTGATCATCAGTAAATTCAACCACCAGAACATTGTCCGCTGCATCGGG
GTGAGTCTGCAAGCCCTGCCCCGCTTCATCCTGCTGGAGCTCATGGCTGGTGGAGACCTCAAGT
CCTTCCTCAGGGAGACACGTCCTCGCCCGAACCAGCCCACCTCCCTGGCCATGTTGGATCTTCT
GCACGTAGCTCGGGACATTGCCTGTGGCTGTCAGTACCTGGAGGAAAATCACTTTATCCACCGC
GATATTGCTGCTAGAAACTGTCTGCTGACCTGTCCGGGAGCTGGGAGGATAGCGAAGATCGGAG
ACTTCGGGATGGCCCGAGATATCTACAGGGCCAGCTACTACAGAAAGGGAGGCTGTGCCATGCT
GCCAGTGAAGTGGATGCCCCCGGAGGCCTTCATGGAAGGAATATTTACTTCTAAAACAGATACA
TGGTCTTTTGGAGTGTTGCTGTGGGAAATATTTTCTCTTGGATATATGCCATACCCCAGCAAGA
GCAACCAGGAAGTTCTGGAGTTTGTCACCAGTGGAGGACGGATGGACCCACCTAAGAACTGCCC
CGGACCTGTATACCGGATAATGACTCAGTGCTGGCAGCATCAGCCTGAGGACAGACCCAACTTT
GCCATCATTCTGGAGAGGATCGAATACTGCACCCAGGACCCCGATGTCATCAATACAGCTCTGC
CCATCGAATATGGCCCCGTAGTAGAGGAGGAGGAGAAAGTGCCCATGCGCCCCAAAGACCCTGA
GGGGATGCCTCCTCTGCTGGTGTCTCCCCAGTCTGCGAAGCACGAGGAGGCGTCCTCAGCCCCC
CAACCCTCAGCCCTGGCAGCGCCAGGCCCGCTGGTGAAGAAGCCCTCGGGTGCAGGCGCGGGAG
CGGGTGCCGGTCCGGTGCCCCGAGGTGCAGCCGATCGGGGCCACGTGAACATGGCGTTCTCTCA
GCCCAACCCTCCCCCAGAGCTGCACAAAGGCCCGGGCTCCAGAAACAAGCCGACCAGCCTGTGG
AACCCCACCTACGGCTCGTGGTTCACCGAGAAGCCAGCCAAAAAGACCCATCCCCCACCGGGCG
CGGAGCCGCAGGCCCGGGCAGGAGCGGCGGAGGGTGGCTGGACCGGGCCGGGTGCGGGGCCCCG
CAGAGCCGAGGCTGCGCTGCTGCTCGAGCCGTCGGCGCTCAGCGCCACCATGAAGGAGGTGCCC
CTGTTCAGGCTGCGCCACTTCCCCTGCGGCAACGTCAACTATGGTTACCAGCAACAGGGTCTCC
CCTTGGAAGCCACTGCTGCCCCGGGGGACACCGTGCTGAAAAGCAAGACTAAGGTCACCCAGCC
AGGGCCCTGAGCCCGGCGTCCCACTAGCTTTTCTCCCTGGCTGGAGCTGAAGCCCACCGGGAGG
GAGACGGACAGAATGACTCCACCACAATTCCGAGACCAAATGTCACTCACTTTCATTTTTGTGC
CAACTTGTTTTGAAGTGCCACATTTAAAAGAGAAAAAGAAGAAAAAAAAAAGAGGAAAACTTGT
TTTCAAGATGTGTTAGAAAGGTTTTTGAGCATGGGTTCATCCATCCTCAAAGAAGAAAATGCCG
TTCTTAAGAAAGCGATCAGTACAAGGCCCAGATTGGTTGCGTAGTTTTGGTGCATGATCTGCTG
TACAGTCCCCTCAGGCTTCTTTCCGATTTGTGTGTGCTCTCTGCTTCCGTGTAGTCAGAAATAG
CTGCCTCCATGTCTCATAGGGGGAGTCGTAGGTGTTTCCTTGCCTTGTGGATATGAACCATTCG
AGGGGCGAGGGAACAGAAATAAAGGAATTAATTTCAATGACTCAGCATGAGGAGAGACGTTATT
TACGTGGAAAAGAAATATCATACACTGTCATCGCTGTGGGTGGTGGTTAGAGGCTTTTAATTGT
TCTAACTCATTGCCTATTGTAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039111819 ⟹ XP_038967747

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	29,093,154 - 29,351,321 (+)	NCBI
mRatBN7.2	6	23,350,304 - 23,599,636 (+)	NCBI

RefSeq Acc Id:

XM_063261571 ⟹ XP_063117641

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	29,314,513 - 29,351,321 (+)	NCBI

RefSeq Acc Id:

XR_005505446

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	28,631,431 - 29,316,620 (+)	NCBI
mRatBN7.2	6	22,879,653 - 23,564,923 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001162572	(Get FASTA)	NCBI Sequence Viewer
	XP_038967747	(Get FASTA)	NCBI Sequence Viewer
	XP_063117641	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	BAC21663	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000011630
	ENSRNOP00000011630.7
	ENSRNOP00000103544.1
	ENSRNOP00000106560.1

RefSeq Acc Id:	NP_001162572 ⟸ NM_001169101
- Peptide Label:	precursor
- UniProtKB:	F1LRZ0 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGALGFLWLLPPLLLTAASYSGAATDQRAGSPASGPPLQPREPLSYSRLQRKSLAVDFVVPSLF RVYARDLLLPQPPSPSEPGAGGLEARGSLALDCDPLLRLLGPSPGISWAEGASSPSPEAAPTLS RVLKGGSVRKLRRAKQLVLELGEETILEGCIGPPEEAAAVGILQFNLSELFSWWILHGEGRLRI RLMPEKKASEVGREGRLSTAIRASQPRLLFQIFGTGHSSLESPSEMPSPPGNFLWNLTWTMKDS FPFLSHRSRYGLECSFDFPCELEYSPPLHTHGNQSWSWRRVPSEEASRMNLLDGPEAEHLKEMP RGSFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGRYVAQLLPHNEAGREILLVPT PGKHGWTVLHGRVGRPENPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCW NGTVLQLGQACDFHQNCAQGEDEGQLCSKLPAGFYCNFEDGFCGWTQSPLSPRVPRWQVKTLKD THSQGHQGHALLLSTTDDPTSESATVTSATFPAPMKSSPCELRMSWLIRGVLKGNVSLVLVENK TGKEQSRTVWHVATNEGLSLWQWTVLSLLDVTDRFWLQIVTWWGPGSRATVAFDNISISLDCYL TISGEEKMSLNAVPKSRNLFEKNPNKEPKPWANISGPTPIFDPTVHWLFTTCGASGPHGPTQAQ CNNAYQNSNLSVVVGSEGPLRGIQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFN LEKDDTLYILVGQQGEDACPRANQLIQKVCVGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVF KMKDGVPVPLIIAAGGGGRAYGAKTETFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWA GKSLLEGAAGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGV SFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLADDGVS CIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLR TSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVA VKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQALPRFILLELMAGGDLKSFLRETR PRPNQPTSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGAGRIAKIGDFGMARD IYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLE FVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPV VEEEEKVPMRPKDPEGMPPLLVSPQSAKHEEASSAPQPSALAAPGPLVKKPSGAGAGAGAGPVP RGAADRGHVNMAFSQPNPPPELHKGPGSRNKPTSLWNPTYGSWFTEKPAKKTHPPPGAEPQARA GAAEGGWTGPGAGPRRAEAALLLEPSALSATMKEVPLFRLRHFPCGNVNYGYQQQGLPLEATAA PGDTVLKSKTKVTQPGP hide sequence

Ensembl Acc Id:

ENSRNOP00000011630 ⟸ ENSRNOT00000011630

RefSeq Acc Id:	XP_038967747 ⟸ XM_039111819
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_063117641 ⟸ XM_063261571
- Peptide Label:	isoform X2

Ensembl Acc Id:

ENSRNOP00000106560 ⟸ ENSRNOT00000135358

Ensembl Acc Id:

ENSRNOP00000103544 ⟸ ENSRNOT00000136068

Protein Domains

MAM Protein kinase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F1LRZ0-F1-model_v2	AlphaFold	F1LRZ0	1-1396	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:628622	AgrOrtholog
BioCyc Gene	G2FUF-38404	BioCyc
Ensembl Genes	ENSRNOG00000008683	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000011630	ENTREZGENE
	ENSRNOT00000011630.8	UniProtKB/TrEMBL
	ENSRNOT00000135358.1	UniProtKB/TrEMBL
	ENSRNOT00000136068.1	UniProtKB/TrEMBL
Gene3D-CATH	2.60.120.200	UniProtKB/TrEMBL
	Phosphorylase Kinase, domain 1	UniProtKB/TrEMBL
	Transferase(Phosphotransferase) domain 1	UniProtKB/TrEMBL
InterPro	ALK/LTK-like_GRD	UniProtKB/TrEMBL
	ConA-like_dom	UniProtKB/TrEMBL
	Kinase-like_dom	UniProtKB/TrEMBL
	MAM_dom	UniProtKB/TrEMBL
	Prot_kinase_cat_dom	UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/TrEMBL
	RTK	UniProtKB/TrEMBL
	Ser-Thr/Tyr-Pkinase	UniProtKB/TrEMBL
	Tyr_Pkinase_cat_dom	UniProtKB/TrEMBL
	Tyr_prot_kinase_AS	UniProtKB/TrEMBL
	Tyr_prot_kinase_rcpt_2_CS	UniProtKB/TrEMBL
KEGG Report	rno:266802	UniProtKB/TrEMBL
NCBI Gene	266802	ENTREZGENE
PANTHER	PTHR24416:SF276	UniProtKB/TrEMBL
	TYROSINE-PROTEIN KINASE RECEPTOR	UniProtKB/TrEMBL
Pfam	Gly_rich	UniProtKB/TrEMBL
	MAM	UniProtKB/TrEMBL
	Pkinase_Tyr	UniProtKB/TrEMBL
PhenoGen	Alk	PhenoGen
PRINTS	TYRKINASE	UniProtKB/TrEMBL
PROSITE	MAM_2	UniProtKB/TrEMBL
	PROTEIN_KINASE_ATP	UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/TrEMBL
	PROTEIN_KINASE_TYR	UniProtKB/TrEMBL
	RECEPTOR_TYR_KIN_II	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000008683	RatGTEx
SMART	TyrKc	UniProtKB/TrEMBL
Superfamily-SCOP	ConA_like_lec_gl	UniProtKB/TrEMBL
	Kinase_like	UniProtKB/TrEMBL
UniProt	A0ABK0LQS7_RAT	UniProtKB/TrEMBL
	A0ABK0LS30_RAT	UniProtKB/TrEMBL
	F1LRZ0	ENTREZGENE, UniProtKB/TrEMBL
	Q8CJH1_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	Alk	ALK receptor tyrosine kinase	LOC108351182	ALK tyrosine kinase receptor-like	Data merged from RGD:11485359	737654	PROVISIONAL
2017-03-09	Alk	ALK receptor tyrosine kinase	Alk	anaplastic lymphoma receptor tyrosine kinase	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2016-08-02	LOC108351182	ALK tyrosine kinase receptor-like			Symbol and Name status set to provisional	70820	PROVISIONAL
2012-07-13	Alk	anaplastic lymphoma receptor tyrosine kinase	Alk	anaplastic lymphoma kinase	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-20	Alk	anaplastic lymphoma kinase			Symbol and Name status set to approved	1299863	APPROVED
2003-02-27	Alk	anaplastic lymphoma kinase			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_disease	rearrangement and truncation of the human homolog occurs in some cases of non-Hodgkin lymphoma	634542

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

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