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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628622
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Alk
Name: ALK receptor tyrosine kinase
Acc ID: CHEBI:15422
Term: ATP
Definition: An adenosine 5'-phosphate in which the 5'-phosphate is a triphosphate group. It is involved in the transportation of chemical energy during metabolic pathways.
Chemical ID: MESH:D000255
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Alkaffects bindingISOALK (Homo sapiens)6480464CTDALK protein binds to Adenosine TriphosphatePMID:22072639
Alkmultiple interactionsISOALK (Homo sapiens)6480464CTD[ALK protein mutant form promotes the reaction [ALK protein binds to Adenosine Triphosphate]] which results in decreased susceptibility to crizotinib; ALK protein mutant form promotes the reaction [ALK protein binds to Adenosine Triphosphate]PMID:22072639
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