Lgr4 (leucine-rich repeat-containing G protein-coupled receptor 4) - Rat Genome Database

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Gene: Lgr4 (leucine-rich repeat-containing G protein-coupled receptor 4) Rattus norvegicus
Analyze
Symbol: Lgr4
Name: leucine-rich repeat-containing G protein-coupled receptor 4
RGD ID: 628615
Description: Predicted to enable Roundabout binding activity; heparin binding activity; and transmembrane signaling receptor activity. Predicted to be involved in several processes, including metanephric nephron development; regulation of gene expression; and regulation of signal transduction. Predicted to act upstream of or within several processes, including epithelial cell proliferation involved in renal tubule morphogenesis; intestinal stem cell homeostasis; and male genitalia development. Predicted to be located in plasma membrane. Orthologous to human LGR4 (leucine rich repeat containing G protein-coupled receptor 4); PARTICIPATES IN Wnt signaling, canonical pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: G protein-coupled receptor 48; G-protein coupled receptor 48; Gpr48; leucine-rich repeat-containing G-protein coupled receptor 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83116,901,968 - 117,004,584 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3116,901,968 - 117,004,153 (+)EnsemblGRCr8
mRatBN7.2396,447,385 - 96,550,006 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl396,447,858 - 96,548,899 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3100,007,532 - 100,109,518 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03108,606,494 - 108,708,483 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03106,370,036 - 106,472,231 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03101,051,960 - 101,152,119 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3101,051,955 - 101,152,119 (+)Ensemblrn6Rnor6.0
Rnor_5.03107,652,233 - 107,752,743 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4395,370,049 - 95,471,040 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera395,472,374 - 95,573,289 (+)NCBICelera
RGSC_v3.1395,266,473 - 95,367,468 (+)NCBI
Cytogenetic Map3q34NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methoxyethanol  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acrolein  (EXP,ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
CGP 52608  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
hydralazine  (ISO)
hydroquinone  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (EXP,ISO)
methamphetamine  (EXP)
methoxyacetic acid  (ISO)
methyl methanesulfonate  (ISO)
mitoxantrone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
nickel atom  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
potassium chromate  (ISO)
potassium dichromate  (ISO)
quercetin  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)
plasma membrane  (IEA,ISO,ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Secreted and transmembrane wnt inhibitors and activators. Cruciat CM and Niehrs C, Cold Spring Harb Perspect Biol. 2013 Mar 1;5(3):a015081. doi: 10.1101/cshperspect.a015081.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Characterization of two LGR genes homologous to gonadotropin and thyrotropin receptors with extracellular leucine-rich repeats and a G protein-coupled, seven-transmembrane region. Hsu SY, etal., Mol Endocrinol 1998 Dec;12(12):1830-45.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
8. Ablation of LGR4 promotes energy expenditure by driving white-to-brown fat switch. Wang J, etal., Nat Cell Biol. 2013 Dec;15(12):1455-63. doi: 10.1038/ncb2867. Epub 2013 Nov 10.
Additional References at PubMed
PMID:16406039   PMID:19605502   PMID:21523854   PMID:21693646   PMID:21727895   PMID:22815884   PMID:23393138   PMID:23589304   PMID:24280058   PMID:24353284   PMID:24680895   PMID:25188337  
PMID:35772369  


Genomics

Comparative Map Data
Lgr4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83116,901,968 - 117,004,584 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3116,901,968 - 117,004,153 (+)EnsemblGRCr8
mRatBN7.2396,447,385 - 96,550,006 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl396,447,858 - 96,548,899 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3100,007,532 - 100,109,518 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03108,606,494 - 108,708,483 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03106,370,036 - 106,472,231 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03101,051,960 - 101,152,119 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3101,051,955 - 101,152,119 (+)Ensemblrn6Rnor6.0
Rnor_5.03107,652,233 - 107,752,743 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4395,370,049 - 95,471,040 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera395,472,374 - 95,573,289 (+)NCBICelera
RGSC_v3.1395,266,473 - 95,367,468 (+)NCBI
Cytogenetic Map3q34NCBI
LGR4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381127,365,961 - 27,472,790 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1127,365,961 - 27,472,821 (-)Ensemblhg38GRCh38
GRCh371127,387,508 - 27,494,337 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361127,344,084 - 27,450,910 (-)NCBIBuild 36Build 36hg18NCBI36
Celera1127,532,862 - 27,640,072 (-)NCBICelera
Cytogenetic Map11p14.1NCBI
HuRef1127,084,852 - 27,193,084 (-)NCBIHuRef
CHM1_11127,386,916 - 27,493,708 (-)NCBICHM1_1
T2T-CHM13v2.01127,506,453 - 27,613,276 (-)NCBIT2T-CHM13v2.0
Lgr4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392109,747,919 - 109,844,602 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2109,747,992 - 109,844,602 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm382109,917,647 - 110,014,257 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2109,917,647 - 110,014,257 (+)Ensemblmm10GRCm38
MGSCv372109,757,804 - 109,854,414 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362109,709,007 - 109,815,096 (+)NCBIMGSCv36mm8
Celera2111,078,651 - 111,175,891 (+)NCBICelera
Cytogenetic Map2E3NCBI
cM Map256.65NCBI
Lgr4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554766,610,103 - 6,629,264 (-)Ensembl
ChiLan1.0NW_0049554766,611,102 - 6,629,294 (-)NCBIChiLan1.0ChiLan1.0
LGR4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2929,576,585 - 29,683,037 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11129,577,034 - 29,683,557 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01127,330,279 - 27,437,201 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11127,232,801 - 27,291,571 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1127,229,963 - 27,291,571 (-)EnsemblpanPan2panpan1.1
LGR4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12147,952,019 - 47,995,530 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2147,952,890 - 47,996,288 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2147,448,894 - 47,548,000 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02149,092,130 - 49,194,350 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2149,093,704 - 49,165,497 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12148,077,244 - 48,176,850 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02148,247,673 - 48,347,510 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02148,839,453 - 48,939,290 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Lgr4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494736,597,365 - 36,690,743 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365405,752,197 - 5,845,159 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365405,752,319 - 5,846,074 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LGR4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl232,871,871 - 32,979,148 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1232,871,837 - 32,979,150 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2235,582,601 - 35,614,283 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LGR4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1137,632,748 - 37,741,100 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl137,632,710 - 37,741,330 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666038134,942,734 - 135,051,210 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lgr4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476617,112,909 - 17,147,785 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476617,110,809 - 17,147,585 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Lgr4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1588,218,436 - 88,314,808 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Lgr4
761 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:84
Count of miRNA genes:65
Interacting mature miRNAs:81
Transcripts:ENSRNOT00000007681
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358293Bw38Body weight QTL 3860.0000031body mass (VT:0001259)body weight (CMO:0000012)374364268119364268Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)396509147141509147Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)373592512136118980Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)3116582412136118980Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)385062224136118980Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)385062224136118980Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)3104545086149545086Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)393829559138829559Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)3112250810157250810Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)3101255536134750886Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)396509147141509147Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3110225882155225882Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)381541464126563126Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)390755164141509147Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)342158111124558371Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
1582252Sual1Serum uric acid level QTL 13.40.0123blood uric acid amount (VT:0010302)blood uric acid level (CMO:0000501)3116582412122654872Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)342158111124558371Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3110634702155634702Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)3116188400161188400Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 79 59 6 343 179 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000007681   ⟹   ENSRNOP00000007681
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3116,901,968 - 117,004,153 (+)Ensembl
mRatBN7.2 Ensembl396,447,858 - 96,548,899 (+)Ensembl
Rnor_6.0 Ensembl3101,051,955 - 101,152,119 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000103127   ⟹   ENSRNOP00000093244
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3116,902,448 - 117,004,153 (+)Ensembl
mRatBN7.2 Ensembl396,447,865 - 96,548,899 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000164755   ⟹   ENSRNOP00000112687
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3116,901,968 - 117,004,153 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000168733   ⟹   ENSRNOP00000110387
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3116,901,968 - 117,004,153 (+)Ensembl
RefSeq Acc Id: NM_173328   ⟹   NP_775450
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83116,901,968 - 117,004,153 (+)NCBI
mRatBN7.2396,447,385 - 96,549,575 (+)NCBI
Rnor_6.03101,051,960 - 101,152,119 (+)NCBI
Rnor_5.03107,652,233 - 107,752,743 (+)NCBI
RGSC_v3.4395,370,049 - 95,471,040 (+)RGD
Celera395,472,374 - 95,573,289 (+)RGD
Sequence:
RefSeq Acc Id: XM_039104411   ⟹   XP_038960339
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83116,925,546 - 117,004,584 (+)NCBI
mRatBN7.2396,470,950 - 96,550,006 (+)NCBI
Protein Sequences
Protein RefSeqs NP_775450 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960339 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC77910 (Get FASTA)   NCBI Sequence Viewer  
  EDL79759 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000007681
  ENSRNOP00000007681.3
GenBank Protein Q9Z2H4 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_775450   ⟸   NM_173328
- Peptide Label: precursor
- UniProtKB: Q9Z2H4 (UniProtKB/Swiss-Prot),   G3V6R1 (UniProtKB/Swiss-Prot),   A0A8I6AJN3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000007681   ⟸   ENSRNOT00000007681
RefSeq Acc Id: XP_038960339   ⟸   XM_039104411
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000093244   ⟸   ENSRNOT00000103127
Ensembl Acc Id: ENSRNOP00000110387   ⟸   ENSRNOT00000168733
Ensembl Acc Id: ENSRNOP00000112687   ⟸   ENSRNOT00000164755
Protein Domains
G-protein coupled receptors family 1 profile   LRRNT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z2H4-F1-model_v2 AlphaFold Q9Z2H4 1-951 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692282
Promoter ID:EPDNEW_R2806
Type:single initiation site
Name:Lgr4_1
Description:leucine-rich repeat-containing G protein-coupled receptor 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03101,051,964 - 101,052,024EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628615 AgrOrtholog
BioCyc Gene G2FUF-48477 BioCyc
Ensembl Genes ENSRNOG00000005715 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000007681 ENTREZGENE
  ENSRNOT00000007681.5 UniProtKB/Swiss-Prot
Gene3D-CATH 3.80.10.10 UniProtKB/Swiss-Prot
  Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  Gphrmn_rcpt_fam UniProtKB/Swiss-Prot
  Leu-rich_rpt UniProtKB/Swiss-Prot
  Leu-rich_rpt_typical-subtyp UniProtKB/Swiss-Prot
  LRR_dom_sf UniProtKB/Swiss-Prot
  LRRNT UniProtKB/Swiss-Prot
KEGG Report rno:286994 UniProtKB/Swiss-Prot
NCBI Gene 286994 ENTREZGENE
PANTHER GLYCOPROTEIN HORMONE RECEPTOR UniProtKB/Swiss-Prot
  LEUCINE-RICH REPEAT-CONTAINING G-PROTEIN COUPLED RECEPTOR 4 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
  LRR_1 UniProtKB/Swiss-Prot
  LRR_8 UniProtKB/Swiss-Prot
  LRRNT UniProtKB/Swiss-Prot
PhenoGen Lgr4 PhenoGen
PRINTS GLYCHORMONER UniProtKB/Swiss-Prot
  GPCRRHODOPSN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
  LRR UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000005715 RatGTEx
SMART LRR_BAC UniProtKB/Swiss-Prot
  LRR_SD22 UniProtKB/Swiss-Prot
  LRR_TYP UniProtKB/Swiss-Prot
  LRRNT UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
  L domain-like UniProtKB/Swiss-Prot
UniProt A0A8I6AJN3 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0M0H6_RAT UniProtKB/TrEMBL
  A0ABK0M336_RAT UniProtKB/TrEMBL
  G3V6R1 ENTREZGENE
  LGR4_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary G3V6R1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Lgr4  leucine-rich repeat-containing G protein-coupled receptor 4  Gpr48  G protein-coupled receptor 48  Symbol and Name updated 1299863 APPROVED
2004-02-26 Gpr48  G protein-coupled receptor 48      Symbol and Name status set to approved 625702 APPROVED
2003-02-27 Gpr48  G protein-coupled receptor 48      Symbol and Name status set to provisional 70820 PROVISIONAL