LGR6 (leucine rich repeat containing G protein-coupled receptor 6) - Rat Genome Database

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Gene: LGR6 (leucine rich repeat containing G protein-coupled receptor 6) Homo sapiens
Analyze
Symbol: LGR6
Name: leucine rich repeat containing G protein-coupled receptor 6
RGD ID: 1353750
HGNC Page HGNC:19719
Description: Predicted to enable Roundabout binding activity; heparin binding activity; and transmembrane signaling receptor activity. Involved in positive regulation of Wnt signaling pathway and positive regulation of cell migration. Located in vesicle.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: FLJ14471; gonadotropin receptor; GPCR; leucine-rich repeat containing G protein-coupled receptor 6; leucine-rich repeat-containing G protein-coupled receptor 6; leucine-rich repeat-containing G-protein coupled receptor 6; VTS20631
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381202,193,799 - 202,319,761 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1202,193,799 - 202,319,781 (+)EnsemblGRCh38hg38GRCh38
GRCh371202,162,927 - 202,288,889 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361200,429,741 - 200,555,512 (+)NCBINCBI36Build 36hg18NCBI36
Build 341198,904,520 - 199,020,474NCBI
Celera1175,287,040 - 175,412,795 (+)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1173,328,458 - 173,454,974 (+)NCBIHuRef
CHM1_11203,585,351 - 203,710,810 (+)NCBICHM1_1
T2T-CHM13v2.01201,451,367 - 201,581,866 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients. Xiong Y, etal., Emerg Microbes Infect. 2020 Dec;9(1):761-770. doi: 10.1080/22221751.2020.1747363.
Additional References at PubMed
PMID:8889548   PMID:10935549   PMID:12044878   PMID:12477932   PMID:12975309   PMID:14702039   PMID:15489334   PMID:16710414   PMID:21727895   PMID:21873635   PMID:22615920   PMID:22889411  
PMID:22944692   PMID:23535733   PMID:25456346   PMID:27798604   PMID:28005267   PMID:28013222   PMID:29625528   PMID:29693156   PMID:29971639   PMID:30862715   PMID:31657786   PMID:31917882  
PMID:32244172   PMID:33109540   PMID:33644029   PMID:33742100   PMID:34489551   PMID:34494532   PMID:34943945   PMID:37770230   PMID:37802707   PMID:38014454  


Genomics

Comparative Map Data
LGR6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381202,193,799 - 202,319,761 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1202,193,799 - 202,319,781 (+)EnsemblGRCh38hg38GRCh38
GRCh371202,162,927 - 202,288,889 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361200,429,741 - 200,555,512 (+)NCBINCBI36Build 36hg18NCBI36
Build 341198,904,520 - 199,020,474NCBI
Celera1175,287,040 - 175,412,795 (+)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1173,328,458 - 173,454,974 (+)NCBIHuRef
CHM1_11203,585,351 - 203,710,810 (+)NCBICHM1_1
T2T-CHM13v2.01201,451,367 - 201,581,866 (+)NCBIT2T-CHM13v2.0
Lgr6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391134,911,038 - 135,033,112 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1134,911,039 - 135,033,014 (-)EnsemblGRCm39 Ensembl
GRCm381134,983,300 - 135,105,374 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1134,983,301 - 135,105,276 (-)EnsemblGRCm38mm10GRCm38
MGSCv371136,882,930 - 137,001,853 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361136,802,764 - 136,921,687 (-)NCBIMGSCv36mm8
MGSCv361135,854,826 - 135,974,265 (-)NCBIMGSCv36mm8
Celera1137,616,448 - 137,732,474 (-)NCBICelera
Cytogenetic Map1E4NCBI
cM Map158.24NCBI
Lgr6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81348,976,193 - 49,095,870 (-)NCBIGRCr8
mRatBN7.21346,424,382 - 46,544,074 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1346,424,383 - 46,543,945 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01351,811,904 - 51,931,193 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1351,815,215 - 51,930,972 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01356,863,272 - 56,982,530 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41347,948,678 - 48,066,214 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1346,750,175 - 46,869,935 (-)NCBICelera
Cytogenetic Map13q13NCBI
Lgr6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540638,274,958 - 38,383,822 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540638,274,998 - 38,381,677 (+)NCBIChiLan1.0ChiLan1.0
LGR6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2147,062,776 - 47,190,707 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1147,027,337 - 47,155,332 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01177,789,079 - 177,917,234 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11182,118,610 - 182,215,376 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1182,101,420 - 182,214,825 (+)Ensemblpanpan1.1panPan2
LGR6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.17731,934 - 837,092 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl7731,931 - 834,893 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha7784,167 - 889,920 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.07739,811 - 845,587 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl7740,587 - 843,239 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.17728,259 - 834,891 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.07836,626 - 942,290 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.07860,484 - 966,247 (-)NCBIUU_Cfam_GSD_1.0
Lgr6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934473,003,623 - 73,121,245 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365672,238,299 - 2,355,824 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365672,238,036 - 2,355,836 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LGR6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1024,359,774 - 24,454,428 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11024,358,946 - 24,454,430 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21028,756,951 - 28,850,239 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LGR6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12527,093,242 - 27,218,694 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2527,092,717 - 27,215,943 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605527,871,818 - 27,995,141 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lgr6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248078,437,424 - 8,552,282 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248078,437,923 - 8,551,913 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in LGR6
62 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1q31.1-42.11(chr1:187143981-224299417)x3 copy number gain See cases [RCV000051857] Chr1:187143981..224299417 [GRCh38]
Chr1:187113113..224487119 [GRCh37]
Chr1:185379736..222553742 [NCBI36]
Chr1:1q31.1-42.11		 pathogenic
NM_001017403.1(LGR6):c.2668G>A (p.Gly890Arg) single nucleotide variant Malignant melanoma [RCV000064459] Chr1:202318971 [GRCh38]
Chr1:202288099 [GRCh37]
Chr1:200554722 [NCBI36]
Chr1:1q32.1		 not provided
NM_001017403.1(LGR6):c.2766G>A (p.Gly922=) single nucleotide variant Malignant melanoma [RCV000064460] Chr1:202319069 [GRCh38]
Chr1:202288197 [GRCh37]
Chr1:200554820 [NCBI36]
Chr1:1q32.1		 not provided
NM_001017403.1(LGR6):c.999G>A (p.Leu333=) single nucleotide variant Malignant melanoma [RCV000060048] Chr1:202304559 [GRCh38]
Chr1:202273687 [GRCh37]
Chr1:200540310 [NCBI36]
Chr1:1q32.1		 not provided
NM_001017403.1(LGR6):c.1162G>A (p.Glu388Lys) single nucleotide variant Malignant melanoma [RCV000060049] Chr1:202306893 [GRCh38]
Chr1:202276021 [GRCh37]
Chr1:200542644 [NCBI36]
Chr1:1q32.1		 not provided
GRCh38/hg38 1q32.1(chr1:200144603-203112078)x1 copy number loss See cases [RCV000133625] Chr1:200144603..203112078 [GRCh38]
Chr1:200113731..203081206 [GRCh37]
Chr1:198380354..201347829 [NCBI36]
Chr1:1q32.1		 pathogenic
GRCh37/hg19 1q31.3-42.13(chr1:197811907-228997888)x3 copy number gain See cases [RCV000240137] Chr1:197811907..228997888 [GRCh37]
Chr1:1q31.3-42.13		 pathogenic
GRCh37/hg19 1q31.3-44(chr1:195483439-249213000)x3 copy number gain See cases [RCV000449172] Chr1:195483439..249213000 [GRCh37]
Chr1:1q31.3-44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
NM_001017403.2(LGR6):c.2522T>C (p.Leu841Pro) single nucleotide variant Inborn genetic diseases [RCV003295689] Chr1:202318825 [GRCh38]
Chr1:202287953 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001017403.2(LGR6):c.614C>T (p.Ala205Val) single nucleotide variant Inborn genetic diseases [RCV003265089] Chr1:202276491 [GRCh38]
Chr1:202245619 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001017403.2(LGR6):c.2564C>T (p.Ala855Val) single nucleotide variant Inborn genetic diseases [RCV003248478] Chr1:202318867 [GRCh38]
Chr1:202287995 [GRCh37]
Chr1:1q32.1		 uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1q25.3-41(chr1:185644663-221698833)x3 copy number gain not provided [RCV000749265] Chr1:185644663..221698833 [GRCh37]
Chr1:1q25.3-41		 pathogenic
NM_001017403.2(LGR6):c.1010G>A (p.Arg337His) single nucleotide variant not provided [RCV000971466] Chr1:202304570 [GRCh38]
Chr1:202273698 [GRCh37]
Chr1:1q32.1		 benign|likely benign
NM_001017403.2(LGR6):c.1809G>A (p.Ala603=) single nucleotide variant not provided [RCV000926453] Chr1:202318112 [GRCh38]
Chr1:202287240 [GRCh37]
Chr1:1q32.1		 likely benign
NM_001017403.2(LGR6):c.2334C>T (p.Leu778=) single nucleotide variant not provided [RCV000967929] Chr1:202318637 [GRCh38]
Chr1:202287765 [GRCh37]
Chr1:1q32.1		 benign
NM_001017403.2(LGR6):c.2533G>A (p.Ala845Thr) single nucleotide variant not provided [RCV000883030] Chr1:202318836 [GRCh38]
Chr1:202287964 [GRCh37]
Chr1:1q32.1		 benign
GRCh37/hg19 1q25.3-44(chr1:182388773-249111240)x3 copy number gain not provided [RCV000845852] Chr1:182388773..249111240 [GRCh37]
Chr1:1q25.3-44		 pathogenic
GRCh37/hg19 1q31.3-32.2(chr1:194356425-210988710)x3 copy number gain not provided [RCV001249273] Chr1:194356425..210988710 [GRCh37]
Chr1:1q31.3-32.2		 not provided
NM_001017403.2(LGR6):c.2598T>C (p.Ser866=) single nucleotide variant not provided [RCV000911265] Chr1:202318901 [GRCh38]
Chr1:202288029 [GRCh37]
Chr1:1q32.1		 benign
NM_001017403.2(LGR6):c.1407-6C>G single nucleotide variant not provided [RCV000958054] Chr1:202310191 [GRCh38]
Chr1:202279319 [GRCh37]
Chr1:1q32.1		 benign
NC_000001.10:g.(?_130980840)_(248900000_?)dup duplication Gastrointestinal stromal tumor [RCV001300221]|Parathyroid carcinoma [RCV001341077] Chr1:130980840..248900000 [GRCh37]
Chr1:1q12-44		 uncertain significance
NM_014176.3(UBE2T):c.-65+1253_*12383del deletion Fanconi anemia complementation group T [RCV001194884] Chr1:202288580..202309770 [GRCh37]
Chr1:1q32.1		 pathogenic
NC_000001.10:g.(?_200522516)_(206945780_?)dup duplication Epilepsy, familial adult myoclonic, 5 [RCV003116306] Chr1:200522516..206945780 [GRCh37]
Chr1:1q32.1		 uncertain significance
NC_000001.10:g.(?_200522516)_(208391267_?)dup duplication Hypokalemic periodic paralysis, type 1 [RCV003119239]|not provided [RCV003119240] Chr1:200522516..208391267 [GRCh37]
Chr1:1q32.1-32.2		 uncertain significance|no classifications from unflagged records
NM_001017403.2(LGR6):c.2342C>T (p.Ala781Val) single nucleotide variant Inborn genetic diseases [RCV003295918] Chr1:202318645 [GRCh38]
Chr1:202287773 [GRCh37]
Chr1:1q32.1		 uncertain significance
GRCh37/hg19 1q31.3-44(chr1:197867914-249224684)x3 copy number gain See cases [RCV002287837] Chr1:197867914..249224684 [GRCh37]
Chr1:1q31.3-44		 pathogenic
NM_001017403.2(LGR6):c.439G>A (p.Ala147Thr) single nucleotide variant Inborn genetic diseases [RCV003300507] Chr1:202276316 [GRCh38]
Chr1:202245444 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001017403.2(LGR6):c.431G>A (p.Arg144His) single nucleotide variant Inborn genetic diseases [RCV003262138] Chr1:202276308 [GRCh38]
Chr1:202245436 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001017403.2(LGR6):c.2501T>C (p.Phe834Ser) single nucleotide variant Inborn genetic diseases [RCV002906752] Chr1:202318804 [GRCh38]
Chr1:202287932 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001017403.2(LGR6):c.2296G>A (p.Val766Met) single nucleotide variant Inborn genetic diseases [RCV002689953] Chr1:202318599 [GRCh38]
Chr1:202287727 [GRCh37]
Chr1:1q32.1		 uncertain significance
GRCh37/hg19 1q25.3-32.3(chr1:181453460-213107248)x3 copy number gain not provided [RCV002475637] Chr1:181453460..213107248 [GRCh37]
Chr1:1q25.3-32.3		 pathogenic
NM_001017403.2(LGR6):c.590G>A (p.Arg197His) single nucleotide variant Inborn genetic diseases [RCV002778132] Chr1:202276467 [GRCh38]
Chr1:202245595 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001017403.2(LGR6):c.1677T>G (p.Phe559Leu) single nucleotide variant Inborn genetic diseases [RCV002693471] Chr1:202317980 [GRCh38]
Chr1:202287108 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001017403.2(LGR6):c.2207T>A (p.Leu736Gln) single nucleotide variant Inborn genetic diseases [RCV002822891] Chr1:202318510 [GRCh38]
Chr1:202287638 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001017403.2(LGR6):c.1153C>T (p.Arg385Cys) single nucleotide variant Inborn genetic diseases [RCV002910796] Chr1:202306884 [GRCh38]
Chr1:202276012 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001017403.2(LGR6):c.2060G>A (p.Arg687Gln) single nucleotide variant Inborn genetic diseases [RCV002848563] Chr1:202318363 [GRCh38]
Chr1:202287491 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001017403.2(LGR6):c.2387C>G (p.Ser796Cys) single nucleotide variant Inborn genetic diseases [RCV002998181] Chr1:202318690 [GRCh38]
Chr1:202287818 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001017403.2(LGR6):c.119A>C (p.His40Pro) single nucleotide variant Inborn genetic diseases [RCV002850825] Chr1:202194108 [GRCh38]
Chr1:202163236 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001017403.2(LGR6):c.2531G>A (p.Arg844His) single nucleotide variant Inborn genetic diseases [RCV002640984] Chr1:202318834 [GRCh38]
Chr1:202287962 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001017403.2(LGR6):c.2005G>A (p.Val669Ile) single nucleotide variant Inborn genetic diseases [RCV002664775] Chr1:202318308 [GRCh38]
Chr1:202287436 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001017403.2(LGR6):c.391G>A (p.Ala131Thr) single nucleotide variant Inborn genetic diseases [RCV002983381] Chr1:202235956 [GRCh38]
Chr1:202205084 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001017403.2(LGR6):c.2631T>A (p.Asp877Glu) single nucleotide variant Inborn genetic diseases [RCV002713088] Chr1:202318934 [GRCh38]
Chr1:202288062 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001017403.2(LGR6):c.2011G>A (p.Val671Ile) single nucleotide variant Inborn genetic diseases [RCV002665992] Chr1:202318314 [GRCh38]
Chr1:202287442 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001017403.2(LGR6):c.79C>A (p.Gln27Lys) single nucleotide variant Inborn genetic diseases [RCV002645026] Chr1:202194068 [GRCh38]
Chr1:202163196 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001017403.2(LGR6):c.1756G>A (p.Val586Met) single nucleotide variant Inborn genetic diseases [RCV002789592] Chr1:202318059 [GRCh38]
Chr1:202287187 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001017403.2(LGR6):c.1708G>A (p.Ala570Thr) single nucleotide variant Inborn genetic diseases [RCV003003974] Chr1:202318011 [GRCh38]
Chr1:202287139 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001017403.2(LGR6):c.515A>G (p.Asn172Ser) single nucleotide variant Inborn genetic diseases [RCV002956151] Chr1:202276392 [GRCh38]
Chr1:202245520 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001017403.2(LGR6):c.610T>G (p.Tyr204Asp) single nucleotide variant Inborn genetic diseases [RCV002835394] Chr1:202276487 [GRCh38]
Chr1:202245615 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001017403.2(LGR6):c.398C>T (p.Ala133Val) single nucleotide variant Inborn genetic diseases [RCV002934764] Chr1:202235963 [GRCh38]
Chr1:202205091 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001017403.2(LGR6):c.2569G>A (p.Gly857Arg) single nucleotide variant Inborn genetic diseases [RCV002747987] Chr1:202318872 [GRCh38]
Chr1:202288000 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001017403.2(LGR6):c.2660G>A (p.Arg887Gln) single nucleotide variant Inborn genetic diseases [RCV002961142] Chr1:202318963 [GRCh38]
Chr1:202288091 [GRCh37]
Chr1:1q32.1		 likely benign
NM_001017403.2(LGR6):c.1991C>T (p.Ala664Val) single nucleotide variant Inborn genetic diseases [RCV002792250] Chr1:202318294 [GRCh38]
Chr1:202287422 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001017403.2(LGR6):c.1513G>A (p.Glu505Lys) single nucleotide variant Inborn genetic diseases [RCV002920280] Chr1:202310303 [GRCh38]
Chr1:202279431 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001017403.2(LGR6):c.1624A>C (p.Ser542Arg) single nucleotide variant Inborn genetic diseases [RCV002989318] Chr1:202314858 [GRCh38]
Chr1:202283986 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001017403.2(LGR6):c.302A>G (p.His101Arg) single nucleotide variant Inborn genetic diseases [RCV002680329] Chr1:202227953 [GRCh38]
Chr1:202197081 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001017403.2(LGR6):c.2200G>A (p.Val734Met) single nucleotide variant Inborn genetic diseases [RCV002678753] Chr1:202318503 [GRCh38]
Chr1:202287631 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001017403.2(LGR6):c.2023C>T (p.Arg675Trp) single nucleotide variant Inborn genetic diseases [RCV002657112] Chr1:202318326 [GRCh38]
Chr1:202287454 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001017403.2(LGR6):c.1613A>G (p.Lys538Arg) single nucleotide variant Inborn genetic diseases [RCV002655301] Chr1:202314847 [GRCh38]
Chr1:202283975 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001017403.2(LGR6):c.2511C>A (p.Asp837Glu) single nucleotide variant Inborn genetic diseases [RCV003280681] Chr1:202318814 [GRCh38]
Chr1:202287942 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001017403.2(LGR6):c.1624A>G (p.Ser542Gly) single nucleotide variant Inborn genetic diseases [RCV003200385] Chr1:202314858 [GRCh38]
Chr1:202283986 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001017403.2(LGR6):c.1331G>T (p.Gly444Val) single nucleotide variant Inborn genetic diseases [RCV003220527] Chr1:202309101 [GRCh38]
Chr1:202278229 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001017403.2(LGR6):c.493C>T (p.Arg165Cys) single nucleotide variant Inborn genetic diseases [RCV003179614] Chr1:202276370 [GRCh38]
Chr1:202245498 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001017403.2(LGR6):c.413C>A (p.Pro138Gln) single nucleotide variant Inborn genetic diseases [RCV003343009] Chr1:202235978 [GRCh38]
Chr1:202205106 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001017403.2(LGR6):c.2276C>T (p.Pro759Leu) single nucleotide variant Inborn genetic diseases [RCV003361710] Chr1:202318579 [GRCh38]
Chr1:202287707 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001017403.2(LGR6):c.1808C>T (p.Ala603Val) single nucleotide variant Inborn genetic diseases [RCV003347997] Chr1:202318111 [GRCh38]
Chr1:202287239 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001017403.2(LGR6):c.2277G>A (p.Pro759=) single nucleotide variant not provided [RCV003414658] Chr1:202318580 [GRCh38]
Chr1:202287708 [GRCh37]
Chr1:1q32.1		 likely benign
GRCh37/hg19 1q32.1(chr1:202261387-202375150)x3 copy number gain not specified [RCV003986839] Chr1:202261387..202375150 [GRCh37]
Chr1:1q32.1		 uncertain significance
GRCh37/hg19 1q31.3-32.1(chr1:197216705-203683110)x1 copy number loss not specified [RCV003986384] Chr1:197216705..203683110 [GRCh37]
Chr1:1q31.3-32.1		 likely pathogenic
GRCh37/hg19 1q32.1(chr1:199373229-204335027)x3 copy number gain not specified [RCV003986684] Chr1:199373229..204335027 [GRCh37]
Chr1:1q32.1		 likely pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3227
Count of miRNA genes:1012
Interacting mature miRNAs:1267
Transcripts:ENST00000255432, ENST00000308543, ENST00000367278, ENST00000423542, ENST00000439764, ENST00000487787, ENST00000503519, ENST00000506931
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
D1S1727  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371202,184,078 - 202,184,184UniSTSGRCh37
Build 361200,450,701 - 200,450,807RGDNCBI36
Celera1175,307,991 - 175,308,097RGD
Cytogenetic Map1q32.1UniSTS
HuRef1173,349,694 - 173,349,800UniSTS
Marshfield Genetic Map1216.82RGD
Marshfield Genetic Map1216.82UniSTS
Genethon Genetic Map1220.8UniSTS
Whitehead-YAC Contig Map1 UniSTS
RH102679  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371202,288,534 - 202,288,708UniSTSGRCh37
Build 361200,555,157 - 200,555,331RGDNCBI36
Celera1175,412,440 - 175,412,614RGD
Cytogenetic Map1q32.1UniSTS
HuRef1173,454,619 - 173,454,793UniSTS
GeneMap99-GB4 RH Map1667.08UniSTS
SHGC-79247  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371202,270,062 - 202,270,357UniSTSGRCh37
Build 361200,536,685 - 200,536,980RGDNCBI36
Celera1175,393,968 - 175,394,263RGD
Cytogenetic Map1q32.1UniSTS
HuRef1173,436,074 - 173,436,369UniSTS
TNG Radiation Hybrid Map143899.0UniSTS
RH64613  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371202,275,800 - 202,275,918UniSTSGRCh37
Build 361200,542,423 - 200,542,541RGDNCBI36
Celera1175,399,706 - 175,399,824RGD
Cytogenetic Map1q32.1UniSTS
HuRef1173,441,812 - 173,441,930UniSTS
GeneMap99-GB4 RH Map1666.41UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High 1
Medium 122 1547 484 5 269 6 783 58 412 5 602 398 3 12 691 1
Low 1391 1064 868 468 918 316 2548 765 1837 171 736 1064 160 975 1314 2
Below cutoff 902 372 351 136 366 130 947 1327 1421 189 86 103 7 217 778

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001017403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001017404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_021636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005245404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011509838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011509839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011509840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011509841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011509842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011509843 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011509844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011509846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017001996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017001997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017001998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047426928 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047426929 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047426930 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047426931 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047426932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054338023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054338024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054338025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054338026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054338027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054338028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054338029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054338030 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054338031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054338032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054338033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054338034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054338035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054338036 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054338037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054338038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB049405 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB083616 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF088074 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF190501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK027377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK123055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL356953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY358119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC038795 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC047905 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM699180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CQ840811 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000255432   ⟹   ENSP00000255432
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1202,203,736 - 202,319,781 (+)Ensembl
RefSeq Acc Id: ENST00000308543
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1202,276,270 - 202,306,921 (+)Ensembl
RefSeq Acc Id: ENST00000367278   ⟹   ENSP00000356247
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1202,193,799 - 202,319,761 (+)Ensembl
RefSeq Acc Id: ENST00000423542   ⟹   ENSP00000402284
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1202,210,708 - 202,305,749 (+)Ensembl
RefSeq Acc Id: ENST00000439764   ⟹   ENSP00000387869
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1202,214,155 - 202,319,207 (+)Ensembl
RefSeq Acc Id: ENST00000487787   ⟹   ENSP00000422143
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1202,203,777 - 202,319,690 (+)Ensembl
RefSeq Acc Id: ENST00000503519
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1202,225,423 - 202,236,334 (+)Ensembl
RefSeq Acc Id: ENST00000506931
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1202,276,301 - 202,281,013 (+)Ensembl
RefSeq Acc Id: NM_001017403   ⟹   NP_001017403
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381202,193,799 - 202,319,761 (+)NCBI
GRCh371202,163,118 - 202,288,889 (+)RGD
Build 361200,429,741 - 200,555,512 (+)NCBI Archive
Celera1175,287,040 - 175,412,795 (+)RGD
HuRef1173,328,458 - 173,454,974 (+)ENTREZGENE
CHM1_11203,585,351 - 203,710,810 (+)NCBI
T2T-CHM13v2.01201,451,367 - 201,581,866 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001017404   ⟹   NP_001017404
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381202,214,079 - 202,319,761 (+)NCBI
GRCh371202,163,118 - 202,288,889 (+)RGD
Build 361200,449,906 - 200,555,512 (+)NCBI Archive
Celera1175,287,040 - 175,412,795 (+)RGD
HuRef1173,328,458 - 173,454,974 (+)ENTREZGENE
CHM1_11203,605,199 - 203,710,810 (+)NCBI
T2T-CHM13v2.01201,476,218 - 201,581,866 (+)NCBI
Sequence:
RefSeq Acc Id: NM_021636   ⟹   NP_067649
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381202,203,712 - 202,319,761 (+)NCBI
GRCh371202,163,118 - 202,288,889 (+)RGD
Build 361200,439,528 - 200,555,512 (+)NCBI Archive
Celera1175,287,040 - 175,412,795 (+)RGD
HuRef1173,328,458 - 173,454,974 (+)ENTREZGENE
CHM1_11203,595,134 - 203,710,810 (+)NCBI
T2T-CHM13v2.01201,461,277 - 201,581,866 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005245404   ⟹   XP_005245461
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381202,214,079 - 202,319,761 (+)NCBI
GRCh371202,163,118 - 202,288,889 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011509838   ⟹   XP_011508140
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381202,214,079 - 202,319,761 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011509839   ⟹   XP_011508141
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381202,214,079 - 202,319,761 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011509840   ⟹   XP_011508142
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381202,214,079 - 202,319,761 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011509841   ⟹   XP_011508143
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381202,239,407 - 202,319,761 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011509842   ⟹   XP_011508144
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381202,246,935 - 202,319,761 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011509843   ⟹   XP_011508145
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381202,239,138 - 202,319,761 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011509844   ⟹   XP_011508146
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381202,298,650 - 202,319,761 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011509846   ⟹   XP_011508148
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381202,239,021 - 202,319,761 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017001996   ⟹   XP_016857485
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381202,214,079 - 202,319,761 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017001997   ⟹   XP_016857486
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381202,236,533 - 202,319,761 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047426928   ⟹   XP_047282884
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381202,193,799 - 202,319,761 (+)NCBI
RefSeq Acc Id: XM_047426929   ⟹   XP_047282885
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381202,193,799 - 202,319,761 (+)NCBI
RefSeq Acc Id: XM_047426930   ⟹   XP_047282886
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381202,214,079 - 202,319,761 (+)NCBI
RefSeq Acc Id: XM_047426931   ⟹   XP_047282887
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381202,193,799 - 202,319,761 (+)NCBI
RefSeq Acc Id: XM_047426932   ⟹   XP_047282888
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381202,214,079 - 202,319,761 (+)NCBI
RefSeq Acc Id: XM_054338023   ⟹   XP_054193998
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01201,476,218 - 201,581,866 (+)NCBI
RefSeq Acc Id: XM_054338024   ⟹   XP_054193999
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01201,476,218 - 201,581,866 (+)NCBI
RefSeq Acc Id: XM_054338025   ⟹   XP_054194000
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01201,476,218 - 201,581,866 (+)NCBI
RefSeq Acc Id: XM_054338026   ⟹   XP_054194001
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01201,451,367 - 201,581,866 (+)NCBI
RefSeq Acc Id: XM_054338027   ⟹   XP_054194002
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01201,476,218 - 201,581,866 (+)NCBI
RefSeq Acc Id: XM_054338028   ⟹   XP_054194003
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01201,451,367 - 201,581,866 (+)NCBI
RefSeq Acc Id: XM_054338029   ⟹   XP_054194004
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01201,476,218 - 201,581,866 (+)NCBI
RefSeq Acc Id: XM_054338030   ⟹   XP_054194005
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01201,476,218 - 201,581,866 (+)NCBI
RefSeq Acc Id: XM_054338031   ⟹   XP_054194006
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01201,451,367 - 201,581,866 (+)NCBI
RefSeq Acc Id: XM_054338032   ⟹   XP_054194007
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01201,476,218 - 201,581,866 (+)NCBI
RefSeq Acc Id: XM_054338033   ⟹   XP_054194008
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01201,498,666 - 201,581,866 (+)NCBI
RefSeq Acc Id: XM_054338034   ⟹   XP_054194009
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01201,501,544 - 201,581,866 (+)NCBI
RefSeq Acc Id: XM_054338035   ⟹   XP_054194010
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01201,501,270 - 201,581,866 (+)NCBI
RefSeq Acc Id: XM_054338036   ⟹   XP_054194011
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01201,509,069 - 201,581,866 (+)NCBI
RefSeq Acc Id: XM_054338037   ⟹   XP_054194012
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01201,560,752 - 201,581,866 (+)NCBI
RefSeq Acc Id: XM_054338038   ⟹   XP_054194013
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01201,501,153 - 201,581,866 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001017403 (Get FASTA)   NCBI Sequence Viewer  
  NP_001017404 (Get FASTA)   NCBI Sequence Viewer  
  NP_067649 (Get FASTA)   NCBI Sequence Viewer  
  XP_005245461 (Get FASTA)   NCBI Sequence Viewer  
  XP_011508140 (Get FASTA)   NCBI Sequence Viewer  
  XP_011508141 (Get FASTA)   NCBI Sequence Viewer  
  XP_011508142 (Get FASTA)   NCBI Sequence Viewer  
  XP_011508143 (Get FASTA)   NCBI Sequence Viewer  
  XP_011508144 (Get FASTA)   NCBI Sequence Viewer  
  XP_011508145 (Get FASTA)   NCBI Sequence Viewer  
  XP_011508146 (Get FASTA)   NCBI Sequence Viewer  
  XP_011508148 (Get FASTA)   NCBI Sequence Viewer  
  XP_016857485 (Get FASTA)   NCBI Sequence Viewer  
  XP_016857486 (Get FASTA)   NCBI Sequence Viewer  
  XP_047282884 (Get FASTA)   NCBI Sequence Viewer  
  XP_047282885 (Get FASTA)   NCBI Sequence Viewer  
  XP_047282886 (Get FASTA)   NCBI Sequence Viewer  
  XP_047282887 (Get FASTA)   NCBI Sequence Viewer  
  XP_047282888 (Get FASTA)   NCBI Sequence Viewer  
  XP_054193998 (Get FASTA)   NCBI Sequence Viewer  
  XP_054193999 (Get FASTA)   NCBI Sequence Viewer  
  XP_054194000 (Get FASTA)   NCBI Sequence Viewer  
  XP_054194001 (Get FASTA)   NCBI Sequence Viewer  
  XP_054194002 (Get FASTA)   NCBI Sequence Viewer  
  XP_054194003 (Get FASTA)   NCBI Sequence Viewer  
  XP_054194004 (Get FASTA)   NCBI Sequence Viewer  
  XP_054194005 (Get FASTA)   NCBI Sequence Viewer  
  XP_054194006 (Get FASTA)   NCBI Sequence Viewer  
  XP_054194007 (Get FASTA)   NCBI Sequence Viewer  
  XP_054194008 (Get FASTA)   NCBI Sequence Viewer  
  XP_054194009 (Get FASTA)   NCBI Sequence Viewer  
  XP_054194010 (Get FASTA)   NCBI Sequence Viewer  
  XP_054194011 (Get FASTA)   NCBI Sequence Viewer  
  XP_054194012 (Get FASTA)   NCBI Sequence Viewer  
  XP_054194013 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAG17168 (Get FASTA)   NCBI Sequence Viewer  
  AAH47905 (Get FASTA)   NCBI Sequence Viewer  
  AAQ88486 (Get FASTA)   NCBI Sequence Viewer  
  BAB39854 (Get FASTA)   NCBI Sequence Viewer  
  BAB55071 (Get FASTA)   NCBI Sequence Viewer  
  BAB89329 (Get FASTA)   NCBI Sequence Viewer  
  CAH05693 (Get FASTA)   NCBI Sequence Viewer  
  EAW91407 (Get FASTA)   NCBI Sequence Viewer  
  EAW91408 (Get FASTA)   NCBI Sequence Viewer  
  EAW91409 (Get FASTA)   NCBI Sequence Viewer  
  EAW91410 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000255432
  ENSP00000255432.7
  ENSP00000356247
  ENSP00000356247.3
  ENSP00000387869
  ENSP00000387869.2
  ENSP00000402284.1
  ENSP00000422143.1
GenBank Protein Q9HBX8 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001017403   ⟸   NM_001017403
- Peptide Label: isoform 1 precursor
- UniProtKB: Q96K69 (UniProtKB/Swiss-Prot),   Q86VU0 (UniProtKB/Swiss-Prot),   Q6UY15 (UniProtKB/Swiss-Prot),   Q5T512 (UniProtKB/Swiss-Prot),   Q5T509 (UniProtKB/Swiss-Prot),   Q9BYD7 (UniProtKB/Swiss-Prot),   Q9HBX8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_067649   ⟸   NM_021636
- Peptide Label: isoform 2
- UniProtKB: Q9HBX8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001017404   ⟸   NM_001017404
- Peptide Label: isoform 3
- UniProtKB: Q9HBX8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_005245461   ⟸   XM_005245404
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_011508141   ⟸   XM_011509839
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_011508140   ⟸   XM_011509838
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_011508142   ⟸   XM_011509840
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_011508148   ⟸   XM_011509846
- Peptide Label: isoform X13
- Sequence:
RefSeq Acc Id: XP_011508145   ⟸   XM_011509843
- Peptide Label: isoform X13
- Sequence:
RefSeq Acc Id: XP_011508143   ⟸   XM_011509841
- Peptide Label: isoform X12
- Sequence:
RefSeq Acc Id: XP_011508144   ⟸   XM_011509842
- Peptide Label: isoform X13
- Sequence:
RefSeq Acc Id: XP_011508146   ⟸   XM_011509844
- Peptide Label: isoform X14
- Sequence:
RefSeq Acc Id: XP_016857485   ⟸   XM_017001996
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_016857486   ⟸   XM_017001997
- Peptide Label: isoform X11
- Sequence:
RefSeq Acc Id: ENSP00000402284   ⟸   ENST00000423542
RefSeq Acc Id: ENSP00000387869   ⟸   ENST00000439764
RefSeq Acc Id: ENSP00000255432   ⟸   ENST00000255432
RefSeq Acc Id: ENSP00000356247   ⟸   ENST00000367278
RefSeq Acc Id: ENSP00000422143   ⟸   ENST00000487787
RefSeq Acc Id: XP_047282884   ⟸   XM_047426928
- Peptide Label: isoform X4
RefSeq Acc Id: XP_047282885   ⟸   XM_047426929
- Peptide Label: isoform X6
RefSeq Acc Id: XP_047282887   ⟸   XM_047426931
- Peptide Label: isoform X9
RefSeq Acc Id: XP_047282886   ⟸   XM_047426930
- Peptide Label: isoform X8
RefSeq Acc Id: XP_047282888   ⟸   XM_047426932
- Peptide Label: isoform X10
RefSeq Acc Id: XP_054194001   ⟸   XM_054338026
- Peptide Label: isoform X4
RefSeq Acc Id: XP_054194003   ⟸   XM_054338028
- Peptide Label: isoform X6
RefSeq Acc Id: XP_054194006   ⟸   XM_054338031
- Peptide Label: isoform X9
RefSeq Acc Id: XP_054193998   ⟸   XM_054338023
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054194000   ⟸   XM_054338025
- Peptide Label: isoform X3
RefSeq Acc Id: XP_054194002   ⟸   XM_054338027
- Peptide Label: isoform X5
RefSeq Acc Id: XP_054193999   ⟸   XM_054338024
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054194005   ⟸   XM_054338030
- Peptide Label: isoform X8
RefSeq Acc Id: XP_054194004   ⟸   XM_054338029
- Peptide Label: isoform X7
RefSeq Acc Id: XP_054194007   ⟸   XM_054338032
- Peptide Label: isoform X10
RefSeq Acc Id: XP_054194008   ⟸   XM_054338033
- Peptide Label: isoform X11
RefSeq Acc Id: XP_054194013   ⟸   XM_054338038
- Peptide Label: isoform X13
RefSeq Acc Id: XP_054194010   ⟸   XM_054338035
- Peptide Label: isoform X13
RefSeq Acc Id: XP_054194009   ⟸   XM_054338034
- Peptide Label: isoform X12
RefSeq Acc Id: XP_054194011   ⟸   XM_054338036
- Peptide Label: isoform X13
RefSeq Acc Id: XP_054194012   ⟸   XM_054338037
- Peptide Label: isoform X14
Protein Domains
LRRNT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9HBX8-F1-model_v2 AlphaFold Q9HBX8 1-967 view protein structure

Promoters
RGD ID:6858582
Promoter ID:EPDNEW_H2456
Type:initiation region
Name:LGR6_2
Description:leucine rich repeat containing G protein-coupled receptor 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H2457  EPDNEW_H2458  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381202,193,979 - 202,194,039EPDNEW
RGD ID:6858584
Promoter ID:EPDNEW_H2457
Type:initiation region
Name:LGR6_3
Description:leucine rich repeat containing G protein-coupled receptor 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H2456  EPDNEW_H2458  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381202,203,744 - 202,203,804EPDNEW
RGD ID:6858586
Promoter ID:EPDNEW_H2458
Type:initiation region
Name:LGR6_1
Description:leucine rich repeat containing G protein-coupled receptor 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H2456  EPDNEW_H2457  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381202,214,079 - 202,214,139EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:19719 AgrOrtholog
COSMIC LGR6 COSMIC
Ensembl Genes ENSG00000133067 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000255432 ENTREZGENE
  ENST00000255432.11 UniProtKB/Swiss-Prot
  ENST00000367278 ENTREZGENE
  ENST00000367278.8 UniProtKB/Swiss-Prot
  ENST00000423542.5 UniProtKB/TrEMBL
  ENST00000439764 ENTREZGENE
  ENST00000439764.2 UniProtKB/Swiss-Prot
  ENST00000487787.5 UniProtKB/TrEMBL
Gene3D-CATH 3.80.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
GTEx ENSG00000133067 GTEx
HGNC ID HGNC:19719 ENTREZGENE
Human Proteome Map LGR6 Human Proteome Map
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot
  Gphrmn_rcpt_fam UniProtKB/Swiss-Prot
  Leu-rich_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRRNT UniProtKB/Swiss-Prot
KEGG Report hsa:59352 UniProtKB/Swiss-Prot
NCBI Gene 59352 ENTREZGENE
OMIM 606653 OMIM
PANTHER 2MIT, ISOFORM B UniProtKB/TrEMBL
  GLYCOPROTEIN HORMONE RECEPTOR UniProtKB/Swiss-Prot
  LEUCINE RICH REPEAT FAMILY PROTEIN UniProtKB/TrEMBL
  LP13728P UniProtKB/Swiss-Prot
  SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN UniProtKB/TrEMBL
Pfam LRR_1 UniProtKB/TrEMBL
  LRR_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA134927114 PharmGKB
PRINTS GLYCHORMONER UniProtKB/Swiss-Prot
  GPCRRHODOPSN UniProtKB/Swiss-Prot
PROSITE LRR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART LRR_BAC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_SD22 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_TYP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRRNT UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
  L domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNI-like UniProtKB/Swiss-Prot
UniProt D6R9F0_HUMAN UniProtKB/TrEMBL
  LGR6_HUMAN UniProtKB/Swiss-Prot
  Q5T508_HUMAN UniProtKB/TrEMBL
  Q5T509 ENTREZGENE
  Q5T512 ENTREZGENE
  Q6UY15 ENTREZGENE
  Q86VU0 ENTREZGENE
  Q96K69 ENTREZGENE
  Q9BYD7 ENTREZGENE
  Q9HBX8 ENTREZGENE
UniProt Secondary Q5T509 UniProtKB/Swiss-Prot
  Q5T512 UniProtKB/Swiss-Prot
  Q6UY15 UniProtKB/Swiss-Prot
  Q86VU0 UniProtKB/Swiss-Prot
  Q96K69 UniProtKB/Swiss-Prot
  Q9BYD7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-14 LGR6  leucine rich repeat containing G protein-coupled receptor 6  LGR6  leucine-rich repeat containing G protein-coupled receptor 6  Symbol and/or name change 5135510 APPROVED
2011-07-27 LGR6  leucine-rich repeat containing G protein-coupled receptor 6  LGR6  leucine-rich repeat-containing G protein-coupled receptor 6  Symbol and/or name change 5135510 APPROVED