Klf6 (KLF transcription factor 6) - Rat Genome Database

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Gene: Klf6 (KLF transcription factor 6) Rattus norvegicus
Analyze
Symbol: Klf6
Name: KLF transcription factor 6
RGD ID: 62389
Description: Enables DNA-binding transcription factor activity and double-stranded DNA binding activity. Involved in cellular response to endothelin; cellular response to hydrogen peroxide; and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in prostate cancer and stomach cancer. Orthologous to human KLF6 (KLF transcription factor 6); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Aa1017; Copeb; core promoter element binding protein; core promoter element-binding protein; CPBP; Krueppel-like factor 6; Kruppel-like factor 6; transcription factor Zf9; Zf9
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Klf6m1Mcwi
Genetic Models: FHH-Klf6m1Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81769,449,483 - 69,458,478 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1769,441,493 - 69,498,601 (-)EnsemblGRCr8
mRatBN7.21764,539,456 - 64,548,451 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1764,531,463 - 64,588,570 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1768,038,144 - 68,047,153 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01771,866,987 - 71,875,996 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01765,913,871 - 65,922,847 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01767,887,939 - 67,945,052 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1767,887,939 - 67,945,037 (-)Ensemblrn6Rnor6.0
Rnor_5.01769,616,967 - 69,674,031 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41775,578,498 - 75,585,072 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1764,125,707 - 64,134,702 (-)NCBICelera
RGSC_v3.11775,589,332 - 75,595,905 (-)NCBI
Cytogenetic Map17q12.1NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-colchicine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-methylphenanthrene  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
acrolein  (ISO)
aflatoxin B1  (EXP,ISO)
alachlor  (EXP)
aldehydo-D-glucose  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
androstane-3,17-dione  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimony(0)  (ISO)
antimycin A  (ISO)
arachidonic acid  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
azathioprine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzoates  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP)
bisphenol F  (EXP,ISO)
bortezomib  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbonyl sulfide  (EXP)
CGP 52608  (ISO)
chloropicrin  (ISO)
chloroprene  (EXP)
choline  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (EXP,ISO)
cylindrospermopsin  (ISO)
D-glucose  (ISO)
DDE  (ISO)
Diallyl sulfide  (ISO)
dibutyl phthalate  (EXP,ISO)
dicoumarol  (ISO)
dieldrin  (ISO)
dioxygen  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
Enterolactone  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
fenthion  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fumonisin B1  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
glucose  (ISO)
Glutathione ethyl ester  (ISO)
GSK-J4  (ISO)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
indole-3-methanol  (EXP)
ionomycin  (ISO)
iron dichloride  (ISO)
isobutanol  (ISO)
kenpaullone  (EXP)
ketamine  (EXP)
L-methionine  (ISO)
lead diacetate  (EXP,ISO)
leflunomide  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
MeIQx  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
methamphetamine  (EXP,ISO)
methidathion  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methyltestosterone  (ISO)
mitomycin C  (ISO)
N-acetylsphingosine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-methylformamide  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP,ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
naled  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
nickel sulfate  (ISO)
O-methyleugenol  (EXP)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parathion  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phenol  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
raloxifene  (EXP)
ranitidine  (EXP)
reactive oxygen species  (ISO)
rifampicin  (ISO)
rimonabant  (ISO)
rotenone  (EXP)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
Salinomycin  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
Soman  (EXP)
succimer  (ISO)
T-2 toxin  (ISO)
tacrolimus hydrate  (EXP)
tebufenpyrad  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
torcetrapib  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP)
vincristine  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
wortmannin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)
nucleoplasm  (ISO)
nucleus  (IBA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Differential regulation of Kruppel-like factor family transcription factor expression in neonatal rat cardiac myocytes: effects of endothelin-1, oxidative stress and cytokines. Cullingford TE, etal., Biochim Biophys Acta. 2008 Jun;1783(6):1229-36. Epub 2008 Mar 25.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. KLF6, a candidate tumor suppressor gene mutated in prostate cancer. Narla G, etal., Science 2001 Dec 21;294(5551):2563-6.
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. Zf9, a Kruppel-like transcription factor up-regulated in vivo during early hepatic fibrosis. Ratziu V, etal., Proc Natl Acad Sci U S A 1998 Aug 4;95(16):9500-5.
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Localization of 54 rat genes, and definition of new synteny groups conserved in the human and the rat. Szpirer C, etal., Mamm Genome 2000 Sep;11(9):729-35
12. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:10880228   PMID:12477932   PMID:12971963   PMID:15557439   PMID:17196161   PMID:17903364   PMID:18753303   PMID:18755691   PMID:19808645   PMID:21396734   PMID:22357862   PMID:22820290  
PMID:24324791   PMID:24881871   PMID:31723124   PMID:32698645   PMID:36861147   PMID:36907288  


Genomics

Comparative Map Data
Klf6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81769,449,483 - 69,458,478 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1769,441,493 - 69,498,601 (-)EnsemblGRCr8
mRatBN7.21764,539,456 - 64,548,451 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1764,531,463 - 64,588,570 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1768,038,144 - 68,047,153 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01771,866,987 - 71,875,996 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01765,913,871 - 65,922,847 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01767,887,939 - 67,945,052 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1767,887,939 - 67,945,037 (-)Ensemblrn6Rnor6.0
Rnor_5.01769,616,967 - 69,674,031 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41775,578,498 - 75,585,072 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1764,125,707 - 64,134,702 (-)NCBICelera
RGSC_v3.11775,589,332 - 75,595,905 (-)NCBI
Cytogenetic Map17q12.1NCBI
KLF6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38103,775,996 - 3,785,209 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl103,775,996 - 3,785,281 (-)Ensemblhg38GRCh38
GRCh37103,818,188 - 3,827,401 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36103,811,234 - 3,817,455 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34103,811,240 - 3,817,455NCBI
Celera103,763,066 - 3,772,350 (-)NCBICelera
Cytogenetic Map10p15.2NCBI
HuRef103,754,750 - 3,764,030 (-)NCBIHuRef
CHM1_1103,818,788 - 3,828,068 (-)NCBICHM1_1
T2T-CHM13v2.0103,779,895 - 3,789,103 (-)NCBIT2T-CHM13v2.0
Klf6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39135,911,488 - 5,920,392 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl135,911,481 - 5,920,393 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38135,861,489 - 5,870,393 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl135,861,482 - 5,870,394 (+)Ensemblmm10GRCm38
MGSCv37135,860,735 - 5,869,639 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36135,860,735 - 5,869,639 (+)NCBIMGSCv36mm8
Celera135,806,926 - 5,815,830 (+)NCBICelera
Cytogenetic Map13A1NCBI
cM Map132.94NCBI
Klf6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554291,838,537 - 1,846,915 (+)Ensembl
ChiLan1.0NW_0049554291,838,537 - 1,846,915 (+)NCBIChiLan1.0ChiLan1.0
KLF6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2816,278,053 - 16,286,827 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11016,283,374 - 16,292,148 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0103,781,797 - 3,790,539 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1103,789,893 - 3,798,057 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl103,789,893 - 3,796,379 (-)EnsemblpanPan2panpan1.1
KLF6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1231,654,142 - 31,664,009 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl231,654,175 - 31,662,351 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha228,683,538 - 28,693,072 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0232,036,878 - 32,046,413 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl232,036,907 - 32,046,041 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1229,123,207 - 29,131,390 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0229,962,128 - 29,971,626 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0230,688,899 - 30,698,432 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Klf6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934434,305,208 - 34,311,507 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648410,470,332 - 10,478,119 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648410,470,384 - 10,476,682 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLF6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1066,488,391 - 66,497,844 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11066,488,445 - 66,497,830 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21072,992,298 - 73,001,801 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KLF6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.193,872,376 - 3,881,238 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl93,875,356 - 3,881,229 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660519,015,716 - 9,024,467 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Klf6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247961,531,910 - 1,539,970 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247961,531,934 - 1,539,728 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Klf6
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11418,752,601 - 18,761,618 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Klf6
37 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:86
Count of miRNA genes:69
Interacting mature miRNAs:72
Transcripts:ENSRNOT00000023033
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70210Cm15Cardiac mass QTL 156.5heart right ventricle mass (VT:0007033)heart right ventricle wet weight (CMO:0000072)173006647275066472Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172413612784432719Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)174238816487388164Rat
1354588Bvd4Brain ventricular dilatation QTL 45.310.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)175819406487388164Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)173310464578104645Rat
1354654Spl7Serum phospholipid level QTL 75.5blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)173803135483031354Rat
2317038Ginf3Gastrointestinal inflammation QTL 32.890.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)175482950393515804Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174096801789341781Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172723344583975845Rat
1354629Scl31Serum cholesterol level QTL 314.1blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)173803135483031354Rat
1600398Edcs5Endometrial carcinoma susceptibility QTL 52.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)173544694975762341Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)172652205171522051Rat
152025238Slep14Serum leptin concentration QTL 144.62blood leptin amount (VT:0005667)172439059584432719Rat
61466Niddm12Non-insulin dependent diabetes mellitus QTL 123.20.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)176515487293515804Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)173803135483031354Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)173803135483031354Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)173310464578104645Rat
12904736Cm121Cardiac mass QTL 1210.043heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)174238816487388164Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)174605012691050126Rat
4889891Eae32Experimental allergic encephalomyelitis QTL 324.80.0002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)172723344572233445Rat
4889894Eae33Experimental allergic encephalomyelitis QTL 335.20.0001nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)175560459793006569Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)174265489587654895Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)173768787782687877Rat
1300131Bp193Blood pressure QTL 1933.3arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)176855004093515804Rat
7488963Bp369Blood pressure QTL 3690.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)176369714782818564Rat
1300129Rf25Renal function QTL 253.03blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)174106235286062352Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173219953486201342Rat
152023740Bp406Blood pressure QTL 4066.06arterial blood pressure trait (VT:2000000)172413612784432719Rat
152023737Bp405Blood pressure QTL 4055.06arterial blood pressure trait (VT:2000000)2413612784432719Rat
152023736Bp404Blood pressure QTL 4043.78arterial blood pressure trait (VT:2000000)172413612784432719Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173604553781045537Rat
2302365Gluco40Glucose level QTL 404.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)176456982086954580Rat

Markers in Region
RH142262  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21764,539,803 - 64,540,002 (+)MAPPERmRatBN7.2
Rnor_6.01767,896,271 - 67,896,469NCBIRnor6.0
Rnor_5.01769,625,299 - 69,625,497UniSTSRnor5.0
RGSC_v3.41775,576,500 - 75,576,698UniSTSRGSC3.4
Celera1764,126,055 - 64,126,253UniSTS
Cytogenetic Map17q12.2UniSTS
RH128485  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21764,542,389 - 64,542,573 (+)MAPPERmRatBN7.2
Rnor_6.01767,898,857 - 67,899,040NCBIRnor6.0
Rnor_5.01769,627,885 - 69,628,068UniSTSRnor5.0
RGSC_v3.41775,579,086 - 75,579,269UniSTSRGSC3.4
Celera1764,128,641 - 64,128,824UniSTS
Cytogenetic Map17q12.2UniSTS
RH125200  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81769,452,147 - 69,452,272 (+)Marker Load Pipeline
mRatBN7.21764,542,120 - 64,542,245 (+)MAPPERmRatBN7.2
Rnor_6.01767,898,588 - 67,898,712NCBIRnor6.0
Rnor_5.01769,627,616 - 69,627,740UniSTSRnor5.0
RGSC_v3.41775,578,817 - 75,578,941UniSTSRGSC3.4
Celera1764,128,372 - 64,128,496UniSTS
Cytogenetic Map17q12.2UniSTS


Genetic Models
This gene Klf6 is modified in the following models/strains:
FHH-Klf6m1Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_031642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006254182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF001417 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY318957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC097306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FN806071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FN806281 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223269 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231451 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000023033   ⟹   ENSRNOP00000023033
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1769,441,493 - 69,498,601 (-)Ensembl
mRatBN7.2 Ensembl1764,531,463 - 64,588,570 (-)Ensembl
Rnor_6.0 Ensembl1767,887,939 - 67,945,037 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000078532   ⟹   ENSRNOP00000070743
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1769,449,483 - 69,458,132 (-)Ensembl
mRatBN7.2 Ensembl1764,539,467 - 64,548,421 (-)Ensembl
Rnor_6.0 Ensembl1767,899,033 - 67,904,674 (-)Ensembl
RefSeq Acc Id: NM_031642   ⟹   NP_113830
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81769,449,483 - 69,458,478 (-)NCBI
mRatBN7.21764,539,456 - 64,548,451 (-)NCBI
Rnor_6.01767,895,923 - 67,904,918 (-)NCBI
Rnor_5.01769,616,967 - 69,674,031 (-)NCBI
RGSC_v3.41775,578,498 - 75,585,072 (-)RGD
Celera1764,125,707 - 64,134,702 (-)NCBI
Sequence:
RefSeq Acc Id: NP_113830   ⟸   NM_031642
- UniProtKB: Q4V8M5 (UniProtKB/Swiss-Prot),   O35819 (UniProtKB/Swiss-Prot),   A0A8L2R4Q4 (UniProtKB/TrEMBL),   A6JLM9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070743   ⟸   ENSRNOT00000078532
Ensembl Acc Id: ENSRNOP00000023033   ⟸   ENSRNOT00000023033
Protein Domains
C2H2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35819-F1-model_v2 AlphaFold O35819 1-283 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:62389 AgrOrtholog
BioCyc Gene G2FUF-8861 BioCyc
Ensembl Genes ENSRNOG00000016885 Ensembl
Gene3D-CATH Classic Zinc Finger UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7444817 IMAGE-MGC_LOAD
InterPro Znf_C2H2_sf UniProtKB/Swiss-Prot
  Znf_C2H2_type UniProtKB/Swiss-Prot
MGC_CLONE MGC:114301 IMAGE-MGC_LOAD
NCBI Gene 58954 ENTREZGENE
PANTHER KRUEPPEL-LIKE FACTOR 6 UniProtKB/Swiss-Prot
  KRUEPPEL-LIKE TRANSCRIPTION FACTOR UniProtKB/Swiss-Prot
Pfam zf-C2H2 UniProtKB/Swiss-Prot
PhenoGen Klf6 PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/Swiss-Prot
  ZINC_FINGER_C2H2_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000016885 RatGTEx
SMART ZnF_C2H2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57667 UniProtKB/Swiss-Prot
TIGR TC230303
UniProt A0A8L2R4Q4 ENTREZGENE, UniProtKB/TrEMBL
  A6JLM8_RAT UniProtKB/TrEMBL
  A6JLM9 ENTREZGENE, UniProtKB/TrEMBL
  G3V880_RAT UniProtKB/TrEMBL
  KLF6_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q4V8M5 ENTREZGENE
UniProt Secondary Q4V8M5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-10-03 Klf6  KLF transcription factor 6  Klf6  Kruppel-like factor 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Klf6  Kruppel-like factor 6  Copeb  core promoter element binding protein   Symbol and Name updated 1299863 APPROVED
2002-06-10 Copeb  core promoter element binding protein       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference