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Gene: Nfkbib (NFKB inhibitor beta) Rattus norvegicus

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Symbol:

Nfkbib

Name:

NFKB inhibitor beta

RGD ID:

621887

Description:

Predicted to be involved in cellular response to lipopolysaccharide. Predicted to act upstream of or within inflammatory response and regulation of canonical NF-kappaB signal transduction. Predicted to be located in cytoplasm and nucleus. Orthologous to human NFKBIB (NFKB inhibitor beta); PARTICIPATES IN nuclear factor kappa B signaling pathway; B cell receptor signaling pathway; chemokine mediated signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,2',5,5'-tetrachlorobiphenyl.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

I-kappa-B-beta; ikappaBbeta; ikB-B; ikB-beta; MGC93398; NF-kappa-B inhibitor beta; NF-kappa-BIB; nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, beta; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	93,173,817 - 93,181,387 (-)	NCBI		GRCr8
mRatBN7.2	1	84,046,292 - 84,053,862 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	84,046,295 - 84,053,862 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	89,456,147 - 89,463,702 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	97,915,267 - 97,922,812 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	91,212,004 - 91,219,559 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	86,941,073 - 86,948,845 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	86,941,074 - 86,948,845 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	88,122,205 - 88,129,977 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	83,865,440 - 83,873,010 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	83,943,551 - 83,951,121 (-)	NCBI
Celera	1	78,438,451 - 78,446,021 (-)	NCBI		Celera
Cytogenetic Map	1	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

maturity-onset diabetes of the young type 1 (ISO)

type 2 diabetes mellitus (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

1,2-dimethylhydrazine (ISO)

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (EXP,ISO)

17beta-hydroxy-17-methylestra-4,9,11-trien-3-one (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,2',5,5'-tetrachlorobiphenyl (EXP)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-acetamidofluorene (EXP)

2-amino-2-deoxy-D-glucopyranose (EXP)

3,4-dihydroxybenzoic acid (ISO)

3-chloropropane-1,2-diol (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

acetaldehyde (EXP)

acetylsalicylic acid (ISO)

acrolein (ISO)

acrylamide (EXP,ISO)

aflatoxin B1 (EXP,ISO)

alachlor (ISO)

aldehydo-D-glucosamine (EXP)

all-trans-retinoic acid (ISO)

alpha-pinene (ISO)

ammonium chloride (EXP)

aniline (EXP)

apigenin (ISO)

aristolochic acid A (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

astragaloside IV (EXP)

auranofin (ISO)

azoxystrobin (ISO)

baicalein (ISO)

benzene (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

beta-D-glucosamine (EXP)

beta-lapachone (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

bisphenol F (ISO)

bortezomib (ISO)

cadmium dichloride (ISO)

cannabidiol (ISO)

captan (ISO)

carbon nanotube (ISO)

casticin (ISO)

CCCP (ISO)

cerium trichloride (ISO)

chloroform (EXP)

chlorogenic acid (ISO)

cholesterol (ISO)

chromium(6+) (ISO)

copper atom (ISO)

copper(0) (ISO)

curcumin (EXP)

cyclosporin A (ISO)

cylindrospermopsin (ISO)

cyproterone acetate (ISO)

deoxynivalenol (ISO)

dexamethasone (ISO)

diarsenic trioxide (ISO)

Diosbulbin B (ISO)

disulfiram (ISO)

doxorubicin (ISO)

elemental selenium (ISO)

erythromycin estolate (EXP)

fenofibrate (EXP)

fenpyroximate (ISO)

finasteride (EXP)

flutamide (EXP)

folic acid (ISO)

folpet (ISO)

gallic acid (ISO)

gentamycin (EXP)

glafenine (EXP)

glycine (ISO)

hexadecanoic acid (EXP)

homocysteine (ISO)

hydrogen peroxide (ISO)

hydroquinone (ISO)

indometacin (EXP,ISO)

irbesartan (ISO)

L-arginine (EXP)

L-cysteine (ISO)

lead nitrate (ISO)

lead(0) (ISO)

lipopolysaccharide (EXP,ISO)

luteolin (ISO)

LY294002 (ISO)

mangiferin (ISO)

methapyrilene (ISO)

methidathion (ISO)

methyl methanesulfonate (ISO)

monosodium L-glutamate (EXP)

N(gamma)-nitro-L-arginine methyl ester (EXP)

N-acetyl-L-cysteine (ISO)

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal (ISO)

N-nitrosodiethylamine (EXP)

N-tosyl-L-phenylalanyl chloromethyl ketone (ISO)

nefazodone (EXP)

nickel atom (ISO)

o-anisidine (ISO)

ozone (ISO)

paracetamol (EXP,ISO)

phorbol 13-acetate 12-myristate (ISO)

picoxystrobin (ISO)

pioglitazone (ISO)

potassium chromate (ISO)

quercetin (EXP,ISO)

reactive oxygen species (EXP)

resveratrol (EXP,ISO)

rotenone (ISO)

scutellarin (ISO)

selenium atom (ISO)

silicon dioxide (ISO)

sincalide (EXP)

sodium arsenite (ISO)

sodium dichromate (ISO)

streptozocin (ISO)

sulforaphane (ISO)

sunitinib (ISO)

syringic acid (EXP)

tacrolimus hydrate (ISO)

tamoxifen (ISO)

taurocholic acid (EXP)

testosterone (ISO)

tetrachloromethane (EXP)

tetracycline (EXP)

thapsigargin (ISO)

thiram (ISO)

titanium dioxide (ISO)

trichloroethene (EXP,ISO)

triphenyl phosphate (ISO)

valproic acid (EXP)

vanadyl sulfate (ISO)

vitamin E (ISO)

zinc sulfate (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to lipopolysaccharide (IBA,ISO)

inflammatory response (ISO)

regulation of canonical NF-kappaB signal transduction (ISO)

Cellular Component

cytoplasm (IEA)

nucleus (IEA)

Molecular Function

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

B cell receptor signaling pathway (IEA)

chemokine mediated signaling pathway (IEA)

influenza A pathway (IEA)

Leishmaniasis pathway (IEA)

measles pathway (IEA)

neurotrophic factor signaling pathway (IEA)

NOD-like receptor signaling pathway (IEA)

nuclear factor kappa B signaling pathway (ISO)

Retinoic acid-inducible gene (RIG) I-like receptor signaling pathway (IEA)

T cell receptor signaling pathway (IEA)

toxoplasmosis pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Synergistic activation of NF-kappaB by tumor necrosis factor alpha and gamma interferon via enhanced I kappaB alpha degradation and de novo I kappaBbeta degradation.	Cheshire JL and Baldwin AS Jr, Mol Cell Biol. 1997 Nov;17(11):6746-54.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Shared principles in NF-kappaB signaling.	Hayden MS and Ghosh S, Cell. 2008 Feb 8;132(3):344-62.
5.	Specific pancreatic enzymes activate macrophages to produce tumor necrosis factor-alpha: role of nuclear factor kappa B and inhibitory kappa B proteins.	Jaffray C, etal., J Gastrointest Surg. 2000 Jul-Aug;4(4):370-7; discussion 377-8.
6.	Differential suppression of endotoxin-inducible inflammatory cytokines by nuclear factor kappa B (NFkappaB) inhibitor in rat microglia.	Nakajima K, etal., Neurosci Lett. 2006 Jul 3;401(3):199-202. Epub 2006 Mar 31.
7.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
8.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
9.	GOA pipeline	RGD automated data pipeline
10.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
11.	Inhibitory and stimulatory effects of lactacystin on expression of nitric oxide synthase type 2 in brain glial cells. The role of Ikappa B-beta.	Stasiolek M, etal., J Biol Chem 2000 Aug 11;275(32):24847-56.

Additional References at PubMed

PMID:12477932	PMID:16822942	PMID:20060382	PMID:31451219

Genomics

Comparative Map Data

Nfkbib
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	93,173,817 - 93,181,387 (-)	NCBI		GRCr8
mRatBN7.2	1	84,046,292 - 84,053,862 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	84,046,295 - 84,053,862 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	89,456,147 - 89,463,702 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	97,915,267 - 97,922,812 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	91,212,004 - 91,219,559 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	86,941,073 - 86,948,845 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	86,941,074 - 86,948,845 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	88,122,205 - 88,129,977 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	83,865,440 - 83,873,010 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	83,943,551 - 83,951,121 (-)	NCBI
Celera	1	78,438,451 - 78,446,021 (-)	NCBI		Celera
Cytogenetic Map	1	q21	NCBI

NFKBIB
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	38,899,666 - 38,908,889 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	38,899,700 - 38,908,893 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	39,390,306 - 39,399,529 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	44,082,455 - 44,091,374 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	19	44,082,454 - 44,091,373	NCBI
Celera	19	36,193,052 - 36,201,968 (+)	NCBI		Celera
Cytogenetic Map	19	q13.2	NCBI
HuRef	19	35,837,132 - 35,846,241 (+)	NCBI		HuRef
CHM1_1	19	39,390,808 - 39,399,934 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	19	41,703,721 - 41,712,860 (+)	NCBI		T2T-CHM13v2.0

Nfkbib
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	28,457,676 - 28,466,069 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	28,457,676 - 28,466,937 (-)	Ensembl		GRCm39 Ensembl
GRCm38	7	28,758,251 - 28,766,644 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	28,758,251 - 28,767,512 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	29,543,270 - 29,551,543 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	28,467,011 - 28,475,284 (-)	NCBI		MGSCv36	mm8
Celera	7	23,319,046 - 23,327,301 (-)	NCBI		Celera
Cytogenetic Map	7	B1	NCBI
cM Map	7	16.91	NCBI

Nfkbib
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955468	617,078 - 626,151 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955468	617,078 - 626,151 (-)	NCBI	ChiLan1.0	ChiLan1.0

NFKBIB
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	45,202,707 - 45,212,748 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	47,073,324 - 47,083,339 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	36,005,797 - 36,015,897 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	44,554,486 - 44,565,128 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

NFKBIB
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	114,206,537 - 114,217,429 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	114,206,534 - 114,217,644 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	113,608,175 - 113,618,992 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	114,806,385 - 114,817,213 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	114,806,387 - 114,817,162 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	114,364,149 - 114,374,967 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	113,997,319 - 114,008,132 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	114,993,059 - 115,003,891 (-)	NCBI		UU_Cfam_GSD_1.0

Nfkbib
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	13,422,102 - 13,429,688 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936661	1,850,058 - 1,862,035 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936661	1,850,185 - 1,857,757 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NFKBIB
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	47,703,647 - 47,712,654 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	47,703,644 - 47,712,661 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	43,241,118 - 43,250,615 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NFKBIB
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	33,518,909 - 33,529,953 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	33,518,963 - 33,529,891 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666073	11,540,577 - 11,552,485 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Nfkbib
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624794	12,259,577 - 12,266,642 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624794	12,259,567 - 12,266,642 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	10
Count of miRNA genes:	10
Interacting mature miRNAs:	10
Transcripts:	ENSRNOT00000027212
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1578649	Bmd8	Bone mineral density QTL 8	4.9		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	1	51940904	101229020	Rat
1582234	Gluco18	Glucose level QTL 18	3.4	0.0003	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	87889942	132889942	Rat
1358359	Sradr1	Stress Responsive Adrenal Weight QTL 1	4.74		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	1	39728272	132889942	Rat
634314	Niddm44	Non-insulin dependent diabetes mellitus QTL 44			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	51941022	208479811	Rat
1578654	Bss10	Bone structure and strength QTL 10	4		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	1	51940904	168768703	Rat
2300324	Fetw1	Fetal weight QTL 1	12.1	0.005	fetal growth trait (VT:0004201)	fetal body weight (CMO:0002080)	1	92963855	109494029	Rat
1331800	Scl25	Serum cholesterol level QTL 25	3.013		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	1	87785026	142582336	Rat
7421628	Bp361	Blood pressure QTL 361		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	83019780	128019780	Rat
631495	Bp96	Blood pressure QTL 96	4.52		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	66404680	111404680	Rat
70225	Bp58	Blood pressure QTL 58	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	34184556	172281316	Rat
631512	Scl6	Serum cholesterol level QTL 6	9.6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	1	81269860	99645535	Rat
2298545	Neuinf8	Neuroinflammation QTL 8	4.6		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	1	66009857	160501508	Rat
10059597	Bp377	Blood pressure QTL 377	3.42	0.025	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	34565911	208798288	Rat
1302788	Scl19	Serum cholesterol QTL 19	4.6	0.001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	1	66400974	132889942	Rat
1549903	Bp267	Blood pressure QTL 267			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	84107164	115183752	Rat
2313083	Bmd74	Bone mineral density QTL 74	4	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	1	91302413	136302413	Rat
2313402	Anxrr24	Anxiety related response QTL 24			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	1	51511344	153680016	Rat
61342	Bp27	Blood pressure QTL 27	3.4	0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	65405637	96805205	Rat
1358192	Ept13	Estrogen-induced pituitary tumorigenesis QTL 13	3.4		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	1	86622262	131622262	Rat
6903308	Scl36	Serum cholesterol QTL 36	2	0.0125	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	1	58769992	103769992	Rat
2300164	Bmd44	Bone mineral density QTL 44	5.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	1	66077886	111077886	Rat
738022	Anxrr13	Anxiety related response QTL 13	4.6	0.00039	locomotor behavior trait (VT:0001392)	number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)	1	92683681	137683681	Rat
10054135	Gmadr2	Adrenal mass QTL 2	1.97	0.0129	adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	1	86993904	131993904	Rat
7411712	Strs4	Sensitivity to stroke QTL 4	8.7		cerebrum integrity trait (VT:0010549)	percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)	1	87558587	132558587	Rat
1331749	Hrtrt11	Heart rate QTL 11	2.973		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	1	92683681	137683681	Rat

Markers in Region

RH128905

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	1	93,173,891 - 93,174,602 (+)	Marker Load Pipeline
mRatBN7.2	1	84,046,366 - 84,047,077 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	86,941,148 - 86,941,858	NCBI	Rnor6.0
Rnor_5.0	1	88,122,280 - 88,122,990	UniSTS	Rnor5.0
RGSC_v3.4	1	83,865,515 - 83,866,225	UniSTS	RGSC3.4
Celera	1	78,438,526 - 78,439,236	UniSTS
RH 3.4 Map	7	46.1	UniSTS
Cytogenetic Map	1	q21	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_030867	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF246634	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC085729	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473979	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ228042	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ235103	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000027212 ⟹ ENSRNOP00000027212

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	84,046,727 - 84,053,862 (-)	Ensembl
Rnor_6.0 Ensembl	1	86,941,074 - 86,948,845 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000098249 ⟹ ENSRNOP00000086277

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	84,046,295 - 84,049,727 (-)	Ensembl

RefSeq Acc Id:

NM_030867 ⟹ NP_110494

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	93,173,817 - 93,181,387 (-)	NCBI
mRatBN7.2	1	84,046,292 - 84,053,862 (-)	NCBI
Rnor_6.0	1	86,941,073 - 86,948,845 (-)	NCBI
Rnor_5.0	1	88,122,205 - 88,129,977 (-)	NCBI
RGSC_v3.4	1	83,865,440 - 83,873,010 (-)	RGD
Celera	1	78,438,451 - 78,446,021 (-)	RGD

Sequence:

show sequence

CAAAAGGCTTGGCGCCGGCGGCCATATTAATAAAGGGCGTCTGGAAAATCTGGGGAAACTCAGC
GAGCGAATGTCCATCTCATTATTCTGATTGGTTCTGGTGCAGTACAGAGGCGGGGTGTGGCTAT
TTAACACAGTTTGATTGGGTATATGAGGGGGCGTGTTGGGGAATTCCCAATAGGGCGGAAGCGC
TGGAGCTCTCGGCAGAACCCAGCGTCAGGCAGGCGACCGCAGGGGGCCACCCGAGGTGGCAGGG
GCAATGGCCGGGGTCGCGTGCTTGGGGAAAACTGCAGACGCCGATGAATGGTGCGACAGTGGCC
TGGGCTCTCTAGGTCCCGACGCAGCAGCTCCCGGAGGACCAGGTCTGGTCGCAGAGCTTAGCCC
AGAGCTGTCTTGGGCGCCCTTAGTCTTTGGCTACGTCACTGAGGATGGGGACACAGCCCTGCAC
TTGGCCGTGATACATCAGCACGAGCCCTTCCTGGATTTCCTCCTGGGCTTCTCTGCCGGCACTG
AGTACCTGGACTTGCAGAACGACCTAGGCCAAACAGCCCTGCACCTAGCAGCCATCCTTGGAGA
GGCATCTACAGTAGAGAAACTCTATGCAGCTGGCGCAGGAGTGTTGGTGACTGAGAGAGGGGGC
CACACAGCACTGCACTTGGCCTGCCGTGTGAGGGCACACACGTGTGCATATGTACTGCTTCAGC
CCCGTCCCAGCCACCCAAGAGATGCCTCAGATACCTACCTCACTCAGAGCCAGGACCACACCCC
AGACACCAGCCATGCCCCTGTTGCCACGGACCCCCAACCCAACCCAGGGAACGAAGAGGAGCTG
CGTGATGAAGATTGGAGGCTGCAGCTAGAAGCTGAAAACTATGATGGCCACACCCCACTCCATG
TAGCTGTCATCCACAAAGATGCAGAGATGGTCCAACTGCTCAGGGATGCTGGGGCCGACCTCAA
TAAACCGGAGCCTACGTGTGGCCGGACCCCTCTGCACCTGGCAGTAGAAGGCCAGGCAGCCGGC
GTGCTGGCGCTTCTCCTCAAAGCTGGCGCTGACCCCACCGCACGCATGTATGGGGGCCGCACCC
CACTTGGCAGTGCCCTGCTCCGGCCCAACCCTGTCCTCGCCCGCCTCCTCCGTGCACATGGGGC
TCCTGAGCCCGAGGATGAGGATGATAAGCTTAGCCCTTGCAGCAACAGCAGCAGTGACAGCGAC
AGTGACAACAGAGATGAAGGCGATGAATATGATGACATCGTGGTTCACAGTCGCAGGAGCCAAA
ACCAGCCACCTCCTTCCCCAGCAGCCAAACCTCTTCCTGATGACCCCAACCCTGCCTGACTTAA
GATCTAATATTAATATAGTTTCCAATTTAATAAAATTTCAGACCTGACAACCAGAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_110494	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAF64191	(Get FASTA)	NCBI Sequence Viewer
	AAH85729	(Get FASTA)	NCBI Sequence Viewer
	EDM07877	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000027212.4
	ENSRNOP00000086277.1
GenBank Protein	Q9JIA3	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_110494 ⟸ NM_030867

- UniProtKB:

Q9JIA3 (UniProtKB/Swiss-Prot), Q5U342 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAGVACLGKTADADEWCDSGLGSLGPDAAAPGGPGLVAELSPELSWAPLVFGYVTEDGDTALHL
AVIHQHEPFLDFLLGFSAGTEYLDLQNDLGQTALHLAAILGEASTVEKLYAAGAGVLVTERGGH
TALHLACRVRAHTCAYVLLQPRPSHPRDASDTYLTQSQDHTPDTSHAPVATDPQPNPGNEEELR
DEDWRLQLEAENYDGHTPLHVAVIHKDAEMVQLLRDAGADLNKPEPTCGRTPLHLAVEGQAAGV
LALLLKAGADPTARMYGGRTPLGSALLRPNPVLARLLRAHGAPEPEDEDDKLSPCSNSSSDSDS
DNRDEGDEYDDIVVHSRRSQNQPPPSPAAKPLPDDPNPA

hide sequence

Ensembl Acc Id:

ENSRNOP00000027212 ⟸ ENSRNOT00000027212

Ensembl Acc Id:

ENSRNOP00000086277 ⟸ ENSRNOT00000098249

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9JIA3-F1-model_v2	AlphaFold	Q9JIA3	1-359	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13689881

Promoter ID:

EPDNEW_R406

Type:

multiple initiation site

Name:

Nfkbib_1

Description:

NFKB inhibitor beta

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	86,948,639 - 86,948,699	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:621887	AgrOrtholog
BioCyc Gene	G2FUF-60221	BioCyc
Ensembl Genes	ENSRNOG00000020063	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000027212.6	UniProtKB/TrEMBL
	ENSRNOT00000098249.1	UniProtKB/TrEMBL
Gene3D-CATH	1.25.40.20	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7114624	IMAGE-MGC_LOAD
InterPro	Ankyrin_rpt	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ankyrin_rpt-contain_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:81525	UniProtKB/TrEMBL
MGC_CLONE	MGC:93398	IMAGE-MGC_LOAD
NCBI Gene	81525	ENTREZGENE
PANTHER	NF-KAPPA-B INHIBITOR BETA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR47303	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Ank	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ank_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Nfkbib	PhenoGen
PRINTS	ANKYRIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	ANK_REP_REGION	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ANK_REPEAT	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000020063	RatGTEx
SMART	ANK	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF48403	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I6A5K2_RAT	UniProtKB/TrEMBL
	F7F6B7_RAT	UniProtKB/TrEMBL
	IKBB_RAT	UniProtKB/Swiss-Prot
	Q5U342	ENTREZGENE, UniProtKB/TrEMBL
	Q9JIA3	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-03-01	Nfkbib	NFKB inhibitor beta	Nfkbib	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-25	Nfkbib	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta	Nfkbib	nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, beta	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-09-10	Nfkbib	nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, beta		I-kappa-B-beta	Name updated	1299863	APPROVED
2002-08-07	Nfkbib	I-kappa-B-beta			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_process	inhibits NOS2 induction	633403

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - KEGG (archival)